Publications by authors named "Laure Metayer"

2 Publications

  • Page 1 of 1

Unusual 131Iodine uptake in a joint demonstrated by SPECT/CT in a patient with differentiated thyroid cancer.

Clin Nucl Med 2015 Apr;40(4):332-4

From the *Department of Nuclear Medicine and Thyroid Unit, Centre François Baclesse, Caen, France; and †Department of Endocrinology, Centre Hospitalo-Universitaire, Caen, France.

An 84-year-old woman was referred for radioiodine ablation 2 months after total thyroidectomy for papillary thyroid cancer. Whole-body scan showed an 131Iodine focus in the left hand. 131Iodine uptake persisted after skin decontamination. SPECT/CT revealed focal uptake in the metacarpophalangeal joint of the thumb. Hybrid CT scan and medical history with clinical examination suggested osteoarthritis of the first metacarpophalangeal joint.
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http://dx.doi.org/10.1097/RLU.0000000000000710DOI Listing
April 2015

Neuromuscular electrostimulation and insulin sensitivity in patients with type 2 diabetes: the ELECTRODIAB pilot study.

Acta Diabetol 2015 Apr 9;52(2):285-91. Epub 2014 Aug 9.

Diabetes Care Unit, University Hospital of Caen, Caen, France,

Aim: Physical activity (PA) improves insulin sensitivity and is particularly important for type 2 diabetes (T2D) management; however, patient adherence is poor. Neuromuscular electrostimulation (NMES) is widely used for rehabilitation issues, but the metabolic impact of provoked involuntary muscular contractions has never been investigated.

Materials And Methods: ELECTRODIAB is a prospective, bi-centric, and 4-week-long pilot study that enrolled 18 patients with T2D who did not require insulin treatment. Insulin sensitivity was evaluated by euglycemic hyperinsulinemic clamp before and after (1) a single NMES session and (2) a week of daily NMES training. Energy expenditure (EE) at baseline and during NMES was evaluated by indirect calorimetry. Dietary and background PA were monitored to avoid bias.

Results: After a single session (T1) or a week (T2) of NMES training, insulin sensitivity (M value) increased by 9.3 ± 38.2 % (ns) and 24.9 ± 35.8 % (p = 0.009), respectively, compared with the baseline (T0). Insulin sensitivity increased up to 46.2 ± 33.8 % (p = 0.002) at T2 in the more insulin-resistant subjects (baseline M value ≤4 mg/Kg/min, n = 10). The NMES session-generated EE was 1.42 ± 9.27 kcal/h, which was not significantly increased from the baseline.

Conclusions: Insulin sensitivity was significantly improved in patients with T2D after 1 week of daily NMES training, with very low EE. NMES could be an alternative to conventional PA, but the putative mechanisms of action must still be investigated.
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http://dx.doi.org/10.1007/s00592-014-0636-5DOI Listing
April 2015