Publications by authors named "Laura Silvestri"

61Publications

Hepcidin levels predict COVID-19 severity and mortality in a cohort of hospitalized Italian patients.

Am J Hematol 2020 Oct 19. Epub 2020 Oct 19.

Regulation of Iron Metabolism Unit-Div, Genetics & Cell Biology-IRCCS San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1002/ajh.26027DOI Listing
October 2020

Hemochromatosis proteins are dispensable for the acute hepcidin response to BMP2.

Haematologica 2020 Feb 13;105(10):e493. Epub 2020 Feb 13.

Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.3324/haematol.2019.241984DOI Listing
February 2020

Cell-type-specific insights into iron regulatory processes.

Am J Hematol 2020 Sep 17. Epub 2020 Sep 17.

Regulation of Iron Metabolism Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1002/ajh.26001DOI Listing
September 2020

Iron metabolism and iron disorders revisited in the hepcidin era.

Haematologica 2020 31;105(2):260-272. Epub 2020 Jan 31.

Regulation of Iron Metabolism Unit, Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan.

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http://dx.doi.org/10.3324/haematol.2019.232124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012465PMC
January 2020

Hepcidin and Anemia: A Tight Relationship.

Front Physiol 2019 9;10:1294. Epub 2019 Oct 9.

Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.3389/fphys.2019.01294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794341PMC
October 2019

Hepcidin and the BMP-SMAD pathway: An unexpected liaison.

Vitam Horm 2019 10;110:71-99. Epub 2019 Feb 10.

Regulation of Iron Metabolism Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milano, Italy.

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http://dx.doi.org/10.1016/bs.vh.2019.01.004DOI Listing
June 2019

A severe hemojuvelin mutation leading to late onset of HFE2-hemochromatosis.

Dig Liver Dis 2018 Aug 27;50(8):859-862. Epub 2018 Apr 27.

University of Milano-Bicocca - Department of Medicine and Surgery, Monza, Italy; Centre for Rare Diseases - Disorders of Iron Metabolism - ASST-Monza, S. Gerardo Hospital Monza, Italy; Medical Genetics - ASST-Monza, S. Gerardo Hospital, Monza, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.dld.2018.04.018DOI Listing
August 2018

The Iron Tale: If It Does Not Kill You, It Makes You Stronger (and Hepcidin Helps).

Authors:
Laura Silvestri

Hemasphere 2018 Jan-Feb;2(1):e27. Epub 2018 Feb 14.

Regulation of Iron Metabolism Unit, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1097/HS9.0000000000000027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745947PMC
February 2018

The immunophilin FKBP12 inhibits hepcidin expression by binding the BMP type I receptor ALK2 in hepatocytes.

Blood 2017 11 1;130(19):2111-2120. Epub 2017 Sep 1.

Vita Salute University and Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1182/blood-2017-04-780692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755682PMC
November 2017

Transferrin receptor 2 mutations in patients with juvenile hemochromatosis phenotype.

Am J Hematol 2015 Dec 17;90(12):E226-7. Epub 2015 Nov 17.

Department of Health Sciences, University of Milano-Bicocca, Monza, Italy.

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http://dx.doi.org/10.1002/ajh.24202DOI Listing
December 2015

Comment on: PACE4 (PCSK6): another proprotein convertase linked to iron homeostasis?

Haematologica 2015 Sep;100(9):e380

Vita Salute University, Milan, Italy San Raffaele Scientific Institute, Milan, Italy

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http://dx.doi.org/10.3324/haematol.2015.128348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800693PMC
September 2015

Identification of TMPRSS6 cleavage sites of hemojuvelin.

J Cell Mol Med 2015 Apr 22;19(4):879-88. Epub 2015 Feb 22.

Division of Genetics and Cell Biology, IRCCS Ospedale San Raffaele, Milan, Italy; Vita Salute University, Milan, Italy.

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http://dx.doi.org/10.1111/jcmm.12462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395201PMC
April 2015

Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form.

Haematologica 2015 Apr 30;100(4):458-65. Epub 2015 Jan 30.

Vita Salute San Raffaele University, Milan, Italy Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy

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http://dx.doi.org/10.3324/haematol.2014.118521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380718PMC
April 2015

The second transferrin receptor regulates red blood cell production in mice.

Blood 2015 Feb 11;125(7):1170-9. Epub 2014 Dec 11.

Vita Salute San Raffaele University, Milan, Italy; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy; and.

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http://dx.doi.org/10.1182/blood-2014-08-596254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399753PMC
February 2015

Circulating factors are involved in hypoxia-induced hepcidin suppression.

Blood Cells Mol Dis 2014 Dec 22;53(4):204-10. Epub 2014 Jul 22.

Department of Health Science, University Milano-Bicocca, Monza, Italy; San Gerardo Hospital, Monza, Italy; Consortium of Human Molecular Genetics, Monza, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bcmd.2014.06.006DOI Listing
December 2014

The extrahepatic role of TFR2 in iron homeostasis.

Front Pharmacol 2014 7;5:93. Epub 2014 May 7.

Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Università Vita-Salute San Raffaele Milan, Italy.

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http://dx.doi.org/10.3389/fphar.2014.00093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019842PMC
June 2014

How to assess causality of TMPRSS6 mutations?

Hum Mutat 2013 Jul 17;34(7):1043-5. Epub 2013 Apr 17.

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http://dx.doi.org/10.1002/humu.22321DOI Listing
July 2013

Inhibiting the hepcidin inhibitor for treatment of iron overload.

Authors:
Laura Silvestri

Blood 2013 Feb;121(7):1068-9

Vita-Salute University.

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http://dx.doi.org/10.1182/blood-2012-12-472597DOI Listing
February 2013

Histone deacetylase inhibitors: structure-based modeling and isoform-selectivity prediction.

J Chem Inf Model 2012 Aug 19;52(8):2215-35. Epub 2012 Jul 19.

Rome Center for Molecular Design, Dipartimento di Chimica e Tecnologie del Farmaco, Facoltà di Farmacia e Medicina, Sapienza Università di Roma, P.le A. Moro 5, 00185 Rome, Italy.

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http://dx.doi.org/10.1021/ci300160yDOI Listing
August 2012

TMPRSS6 rs855791 modulates hepcidin transcription in vitro and serum hepcidin levels in normal individuals.

Blood 2011 Oct 26;118(16):4459-62. Epub 2011 Aug 26.

Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Verona, Italy.

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http://dx.doi.org/10.1182/blood-2011-06-364034DOI Listing
October 2011

Molecular mechanisms regulating hepcidin revealed by hepcidin disorders.

ScientificWorldJournal 2011 Jul 7;11:1357-66. Epub 2011 Jul 7.

Vita-Salute University and Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.

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http://downloads.hindawi.com/journals/tswj/2011/392715.pdf
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http://www.hindawi.com/journals/tswj/2011/392715/
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http://dx.doi.org/10.1100/tsw.2011.130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720007PMC
July 2011

The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin.

Cell Metab 2008 Dec 30;8(6):502-11. Epub 2008 Oct 30.

Vita-Salute San Raffaele University, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele, Milan, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S15504131080031
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http://dx.doi.org/10.1016/j.cmet.2008.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648389PMC
December 2008

Hemojuvelin N-terminal mutants reach the plasma membrane but do not activate the hepcidin response.

Haematologica 2008 Oct;93(10):1466-72

Vita Salute University IRCCS San Raffaele, Milan, Italy.

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http://dx.doi.org/10.3324/haematol.12508DOI Listing
October 2008

New and old players in the hepcidin pathway.

Haematologica 2008 Oct;93(10):1441-4

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http://dx.doi.org/10.3324/haematol.13724DOI Listing
October 2008

A potential pathogenetic role of iron in Alzheimer's disease.

J Cell Mol Med 2008 Sep-Oct;12(5A):1548-50. Epub 2008 May 1.

Vita-Salute San Raffaele University - IRCCS San Raffaele, Milan, Italy.

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http://dx.doi.org/10.1111/j.1582-4934.2008.00356.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918070PMC
February 2009

Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis.

Blood 2008 Jan 15;111(2):924-31. Epub 2007 Oct 15.

Vita-Salute San Raffaele University-Istituto di Ricovero e Cura a Carattere Scientifico, San Raffaele, Milan, Italy.

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http://dx.doi.org/10.1182/blood-2007-07-100677DOI Listing
January 2008

Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism.

Hum Mol Genet 2005 Nov 5;14(22):3477-92. Epub 2005 Oct 5.

Human Molecular Genetics Unit, Dibit-San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1093/hmg/ddi377DOI Listing
November 2005

Structural characterization of cyclic kallidin analogues in DMSO by nuclear magnetic resonance and molecular dynamics.

J Pept Sci 2005 Jan;11(1):3-16

Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131 Padova, Italy.

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http://dx.doi.org/10.1002/psc.586DOI Listing
January 2005

Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2.

Nat Genet 2003 Feb 21;33(2):192-6. Epub 2003 Jan 21.

Human Molecular Genetics Unit, Dibit-San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy.

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http://dx.doi.org/10.1038/ng1081DOI Listing
February 2003

Mutations of mitochondrial DNA polymerase gammaA are a frequent cause of autosomal dominant or recessive progressive external ophthalmoplegia.

Ann Neurol 2002 Aug;52(2):211-9

Unit of Molecular Neurogenetics-Pierfranco and Luisa Mariani Center for the Study of Children's Mitochondrial Disorders, National Neurological Institute C. Besta, Milan, Italy.

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http://dx.doi.org/10.1002/ana.10278DOI Listing
August 2002