Laura Sanz

Laura Sanz

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Laura Sanz

Laura Sanz

Publications by authors named "Laura Sanz"

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Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Proc Natl Acad Sci U S A 2019 04 20;116(14):7015-7020. Epub 2019 Mar 20.

Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1814685116
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http://dx.doi.org/10.1073/pnas.1814685116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452685PMC
April 2019

T Cell-Redirecting Strategies to 'STAb' Tumors: Beyond CARs and Bispecific Antibodies.

Trends Immunol 2019 03;40(3):243-257

Cancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain; Immuno-Oncology and Immunotherapy Group, Instituto de Investigación Sanitaria 12 de Octubre (i+12), 28041 Madrid, Spain; Immunotherapy and Cell Engineering Laboratory, Department of Engineering, Aarhus University, 8000 C Aarhus, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.it.2019.01.008DOI Listing
March 2019

Bispecific light T-cell engagers for gene-based immunotherapy of epidermal growth factor receptor (EGFR)-positive malignancies.

Cancer Immunol Immunother 2018 08 4;67(8):1251-1260. Epub 2018 Jun 4.

Immunotherapy and Cell Engineering Laboratory, Department of Engineering, Aarhus University, Gustav Wieds Vej 10, 8000 C, Aarhus, Denmark.

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http://dx.doi.org/10.1007/s00262-018-2181-5DOI Listing
August 2018

Immune Regulation by Pericytes: Modulating Innate and Adaptive Immunity.

Front Immunol 2016 4;7:480. Epub 2016 Nov 4.

Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda , Madrid , Spain.

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http://dx.doi.org/10.3389/fimmu.2016.00480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095456PMC
November 2016

Development of a Novel High-Density [3H]Hypoxanthine Scintillation Proximity Assay To Assess Plasmodium falciparum Growth.

Antimicrob Agents Chemother 2016 10 23;60(10):5949-56. Epub 2016 Sep 23.

Platform Technology and Science, Centro de Investigación Básica, GlaxoSmithKline, Tres Cantos, Spain.

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http://dx.doi.org/10.1128/AAC.00433-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038259PMC
October 2016

Static and Dynamic Studies on LiNi1/3 Co1/3 Mn1/3 O2 -Based Suspensions for Semi-Solid Flow Batteries.

ChemSusChem 2016 08 22;9(15):1938-44. Epub 2016 Jun 22.

Catalonia Institute for Energy Research, Jardins de les Dones de Negre 1, 08930, Sant Adrià del Besos, Spain.

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http://dx.doi.org/10.1002/cssc.201600285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094516PMC
August 2016

Role of nucleotide-binding oligomerization domain 1 (NOD1) in pericyte-mediated vascular inflammation.

J Cell Mol Med 2016 May 24;20(5):980-6. Epub 2016 Feb 24.

Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Spain.

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http://dx.doi.org/10.1111/jcmm.12804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831361PMC
May 2016

The coming of age of engineered multivalent antibodies.

Drug Discov Today 2015 May 7;20(5):588-94. Epub 2015 Mar 7.

Department of Engineering, Aarhus University, Aarhus, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2015.02.013DOI Listing
May 2015

Selection strategies for anticancer antibody discovery: searching off the beaten path.

Trends Biotechnol 2015 May 26;33(5):292-301. Epub 2015 Mar 26.

Molecular Immunology Unit, Hospital Universitario Puerta de Hierro, Madrid, Majadahonda, 28222 Spain; Department of Engineering, Aarhus University, 8000C Aarhus, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.tibtech.2015.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362106PMC
May 2015

In vivo secretion of anti-CD3 × anti-tumor bispecific antibodies by gene-modified cells: over a decade of T-cell engagement.

Mol Ther 2015 Apr;23(4):612-3

Immunotherapy and Cell Engineering Laboratory, Department of Engineering, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1038/mt.2015.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395791PMC
April 2015

Microencapsulation of therapeutic bispecific antibodies producing cells: immunotherapeutic organoids for cancer management.

J Drug Target 2015 Feb 22;23(2):170-9. Epub 2014 Oct 22.

NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country UPV/EHU , Vitoria-Gasteiz , Spain .

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http://dx.doi.org/10.3109/1061186X.2014.971327DOI Listing
February 2015

Immunotherapeutic organoids: a new approach to cancer treatment.

Biomatter 2013 Jan-Mar;3(1). Epub 2013 Jan 1.

Molecular Immunology Unit; Hospital Universitario Puerta de Hierro Majadahonda; Madrid, Spain.

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http://dx.doi.org/10.4161/biom.23897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732323PMC
December 2014

Functional comparison of single-chain and two-chain anti-CD3-based bispecific antibodies in gene immunotherapy applications.

Oncoimmunology 2014 23;3:e28810. Epub 2014 May 23.

Molecular Immunology Unit; Hospital Universitario Puerta de Hierro; Madrid, Spain ; BCE Protein Engineering; Department of Engineering; Aarhus University; Aarhus, Denmark.

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http://dx.doi.org/10.4161/onci.28810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091452PMC
May 2014

Magnetic isolation of Plasmodium falciparum schizonts iRBCs to generate a high parasitaemia and synchronized in vitro culture.

Malar J 2014 Mar 21;13:112. Epub 2014 Mar 21.

Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain.

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http://malariajournal.biomedcentral.com/articles/10.1186/147
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http://dx.doi.org/10.1186/1475-2875-13-112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994429PMC
March 2014

Lipopolysaccharide activates Toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway and proinflammatory response in human pericytes.

J Biol Chem 2014 Jan 4;289(4):2457-68. Epub 2013 Dec 4.

From the Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Majadahonda, Madrid, Spain.

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http://dx.doi.org/10.1074/jbc.M113.521161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900988PMC
January 2014

Gene expression profiling identifies EPHB4 as a potential predictive biomarker in colorectal cancer patients treated with bevacizumab.

Med Oncol 2013 12;30(2):572. Epub 2013 Apr 12.

Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda, Joaquin Rodrigo 2, 28222 Madrid, Spain.

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http://dx.doi.org/10.1007/s12032-013-0572-1DOI Listing
October 2013

In vivo selection of tumor-specific antibodies.

Oncotarget 2013 Oct;4(10):1547

Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Majadahonda, Madrid, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858540PMC
http://dx.doi.org/10.18632/oncotarget.1407DOI Listing
October 2013

Antibody gene therapy: getting closer to clinical application?

Curr Gene Ther 2013 Aug;13(4):282-90

Molecular Immunology Unit, Hospital Universitario Puerta de Hierro, Joaquin Rodrigo 2, 28222 Majadahonda, Madrid, Spain..

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http://dx.doi.org/10.2174/15665232113139990025DOI Listing
August 2013

Engineering human cells for in vivo secretion of antibody and non-antibody therapeutic proteins.

Curr Opin Biotechnol 2011 Dec 22;22(6):924-30. Epub 2011 Mar 22.

Molecular Immunology Unit, Hospital Universitario Puerta de Hierro, 28222 Majadahonda, Madrid, Spain.

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http://dx.doi.org/10.1016/j.copbio.2011.03.001DOI Listing
December 2011

Engineered human tumor xenografts with functional human vascular networks.

Microvasc Res 2011 Jan 8;81(1):18-25. Epub 2010 Oct 8.

Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.

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http://dx.doi.org/10.1016/j.mvr.2010.10.002DOI Listing
January 2011

The therapeutic potential of engineered human neovessels for cell-based gene therapy.

Expert Opin Biol Ther 2011 Jan 17;11(1):67-76. Epub 2010 Nov 17.

Molecular Immunology Unit, Hospital Universitario Puerta de Hierro, Madrid, Spain.

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http://dx.doi.org/10.1517/14712598.2011.538378DOI Listing
January 2011

Stathmin and interfacial microtubule inhibitors recognize a naturally curved conformation of tubulin dimers.

J Biol Chem 2010 Oct 30;285(41):31672-81. Epub 2010 Jul 30.

Faculté de Pharmacie, Aix-Marseille Université, INSERM UMR 911, Centre de Recherche en Oncologie Biologique et Oncopharmacologie, 27 bd Jean Moulin, 13385 Marseille Cedex 05, France.

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http://dx.doi.org/10.1074/jbc.M110.141929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951239PMC
October 2010

Lymphocyte display: a novel antibody selection platform based on T cell activation.

PLoS One 2009 Sep 24;4(9):e7174. Epub 2009 Sep 24.

Molecular Immunology Unit, Hospital Universitario Puerta de Hierro, Madrid, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007174PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747005PMC
September 2009

Differential transplantability of human endothelial cells in colorectal cancer and renal cell carcinoma primary xenografts.

Lab Invest 2009 Jan 10;89(1):91-7. Epub 2008 Nov 10.

Molecular Immunology Unit, Hospital Universitario Puerta de Hierro, Madrid, Spain.

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http://dx.doi.org/10.1038/labinvest.2008.108DOI Listing
January 2009

Functionally fused antibodies--a novel adjuvant fusion system.

J Immunol Methods 2008 Dec 12;339(2):220-7. Epub 2008 Oct 12.

Department of Molecular Biology, University of Aarhus, Denmark.

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http://dx.doi.org/10.1016/j.jim.2008.09.015DOI Listing
December 2008

Delivery of CCL21 to metastatic disease improves the efficacy of adoptive T-cell therapy.

Cancer Res 2007 Jan;67(1):300-8

Molecular Medicine Program and Department of Immunology, Mayo Clinic, 200 First Street SW, Rochester, MN 55902, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-1017DOI Listing
January 2007

Antibody-based antiangiogenic cancer therapy.

Expert Opin Ther Targets 2005 Dec;9(6):1235-45

Department of Immunology, Hospital Universitario Clínica Puerta de Hierro, San Martín de Porres 4, 28035 Madrid, Spain.

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http://dx.doi.org/10.1517/14728222.9.6.1235DOI Listing
December 2005

Tumor cell surface display of immunoglobulin heavy chain Fc by gene transfer as a means to mimic antibody therapy.

Hum Gene Ther 2005 Jul;16(7):830-44

Molecular Medicine Program and Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.

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http://www.liebertpub.com/doi/10.1089/hum.2005.16.830
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http://dx.doi.org/10.1089/hum.2005.16.830DOI Listing
July 2005

Antibody engineering: facing new challenges in cancer therapy.

Acta Pharmacol Sin 2005 Jun;26(6):641-8

Servicio de Inmunologia, Hospital Universitario Puerta de Hierro, Madrid, Spain.

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http://dx.doi.org/10.1111/j.1745-7254.2005.00135.xDOI Listing
June 2005

Replicating retroviral vectors mediating continuous production and secretion of therapeutic gene products from cancer cells.

Cancer Gene Ther 2005 May;12(5):464-74

Division of Medical Biotechnology, Paul-Ehrlich-Institut, 63225 Langen, Germany.

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http://dx.doi.org/10.1038/sj.cgt.7700805DOI Listing
May 2005

Antibody engineering, virus retargeting and cellular immunotherapy: one ring to rule them all?

Curr Gene Ther 2005 Feb;5(1):63-70

Molecular Medicine Program, Mayo Clinic, Rochester, USA.

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http://dx.doi.org/10.2174/1566523052997479DOI Listing
February 2005

Bcl-2 family gene modulation during spontaneous apoptosis of B-chronic lymphocytic leukemia cells.

Biochem Biophys Res Commun 2004 Mar;315(3):562-7

Departamento de Inmunología, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.

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http://dx.doi.org/10.1016/j.bbrc.2004.01.095DOI Listing
March 2004

Antibodies and gene therapy: teaching old 'magic bullets' new tricks.

Trends Immunol 2004 Feb;25(2):85-91

Molecular Medicine Program, Mayo Clinic, 200 First Street, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.it.2003.12.001DOI Listing
February 2004

Generation of non-permissive basement membranes by anti-laminin antibody fragments produced by matrix-embedded gene-modified cells.

Cancer Immunol Immunother 2003 Oct 19;52(10):643-7. Epub 2003 Jun 19.

Department of Immunology, Hospital Universitario Clínica Puerta de Hierro, San Martín de Porres 4, 28035 Madrid, Spain.

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http://dx.doi.org/10.1007/s00262-003-0400-0DOI Listing
October 2003

The extracellular matrix: a new turn-of-the-screw for anti-angiogenic strategies.

Trends Mol Med 2003 Jun;9(6):256-62

Molecular Medicine Program, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/s1471-4914(03)00070-4DOI Listing
June 2003

Development of a computer-assisted high-throughput screening platform for anti-angiogenic testing.

Microvasc Res 2002 May;63(3):335-9

Department of Immunology, Hospital Universitario Clínica Puerta de Hierro, Madrid, Spain.

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http://dx.doi.org/10.1006/mvre.2001.2389DOI Listing
May 2002

Engagement of alpha4beta1 integrin by fibronectin induces in vitro resistance of B chronic lymphocytic leukemia cells to fludarabine.

J Leukoc Biol 2002 Mar;71(3):495-502

Departamento de Inmunología, Centro de Investigaciones Biológicas, CSIC, Velázquez 144, 28006 Madrid, Spain.

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March 2002