Publications



Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn.
Proc Natl Acad Sci U S A 2015 Mar 16;112(13):E1624-31. Epub 2015 Mar 16.
Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702

Folliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulation.
Hum Mol Genet 2014 Nov 6;23(21):5706-19. Epub 2014 Jun 6.
Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA,


Folliculin controls lung alveolar enlargement and epithelial cell survival through E-cadherin, LKB1, and AMPK.
Cell Rep 2014 Apr 13;7(2):412-23. Epub 2014 Apr 13.
Pulmonary, Allergy and Critical Care Division, Airways Biology Initiative, Department of Medicine, Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:






Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling.
Mol Cancer 2010 Jun 23;9:160. Epub 2010 Jun 23.
Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, 10 Center Drive MSC1107, 10/CRC/1W-5940, Bethesda, MD 20892, USA.

Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2.
Proc Natl Acad Sci U S A 2009 Nov 22;106(44):18722-7. Epub 2009 Oct 22.
Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.




Lung cysts, spontaneous pneumothorax, and genetic associations in 89 families with Birt-Hogg-Dubé syndrome.
Am J Respir Crit Care Med 2007 May 22;175(10):1044-53. Epub 2007 Feb 22.
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892-7231, USA.




Evaluation and management of renal tumors in the Birt-Hogg-Dubé syndrome.
J Urol 2005 May;173(5):1482-6
Urologic Oncology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute and Basic Research Program, SAIC-Frederick, Inc., Frederick, Maryland, USA.


A germ-line insertion in the Birt-Hogg-Dubé (BHD) gene gives rise to the Nihon rat model of inherited renal cancer.
Proc Natl Acad Sci U S A 2004 Feb 9;101(7):2023-7. Epub 2004 Feb 9.
Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 1-37-1 Kami-ikebukuro, Toshima-ku, Tokyo 170-8455, Japan.


Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene.
Cancer Res 2003 Sep;63(17):5320-8
Laboratory of Immunobiology, Center for Cancer Research, Science Applications International Corporation-Frederick, Inc., National Cancer Institute Frederick, Frederick, Maryland 21702, USA.

Mutations in the fumarate hydratase gene cause hereditary leiomyomatosis and renal cell cancer in families in North America.
Am J Hum Genet 2003 Jul 22;73(1):95-106. Epub 2003 May 22.
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Executive Plaza South, Rockville, MD 20892, USA.


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