Publications by authors named "Laura S Schmidt"

72Publications

A germline 1;3 translocation disrupting the gene: a novel genetic cause for von Hippel-Lindau.

J Med Genet 2020 Oct 16. Epub 2020 Oct 16.

Urologic Oncology Branch, National Cancer Institue, Bethesda, Maryland, USA

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http://dx.doi.org/10.1136/jmedgenet-2020-107308DOI Listing
October 2020

A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity.

Cell Rep 2020 02;30(6):1823-1834.e5

Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, Singapore 117599, Singapore; International Research Center for Medical Sciences (IRCMS), Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.01.042DOI Listing
February 2020

The Metabolic Basis of Kidney Cancer.

Cancer Discov 2019 08 14;9(8):1006-1021. Epub 2019 May 14.

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1158/2159-8290.CD-18-1354DOI Listing
August 2019

Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90.

Cell Rep 2019 01;26(5):1344-1356.e5

Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY 13210, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193002
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http://dx.doi.org/10.1016/j.celrep.2019.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370319PMC
January 2019

CDC73 Germline Mutation in a Family With Mixed Epithelial and Stromal Tumors.

Urology 2019 02 16;124:91-97. Epub 2018 Nov 16.

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00904295183120
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http://dx.doi.org/10.1016/j.urology.2018.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382532PMC
February 2019

FLCN: The causative gene for Birt-Hogg-Dubé syndrome.

Gene 2018 Jan 29;640:28-42. Epub 2017 Sep 29.

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, United States. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2017.09.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682220PMC
January 2018

A mouse model of renal cell carcinoma.

Nat Med 2017 07;23(7):802-803

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/nm.4366DOI Listing
July 2017

Genetic predisposition to kidney cancer.

Semin Oncol 2016 Oct 22;43(5):566-574. Epub 2016 Sep 22.

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD. Electronic address:

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http://dx.doi.org/10.1053/j.seminoncol.2016.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137802PMC
October 2016

SnapShot: Renal Cell Carcinoma.

Cancer Cell 2016 Apr;29(4):610-610.e1

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.ccell.2016.03.021DOI Listing
April 2016

Clinical Features, Genetics and Potential Therapeutic Approaches for Birt-Hogg-Dubé Syndrome.

Expert Opin Orphan Drugs 2015;3(1):15-29. Epub 2014 Nov 29.

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892.

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http://www.tandfonline.com/doi/full/10.1517/21678707.2014.98
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http://dx.doi.org/10.1517/21678707.2014.987124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646088PMC
November 2014

Mitochondrial DNA mutations distinguish bilateral multifocal renal oncocytomas from familial Birt-Hogg-Dubé tumors.

Mod Pathol 2015 Nov 2;28(11):1458-69. Epub 2015 Oct 2.

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/modpathol.2015.101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628590PMC
November 2015

Molecular genetics and clinical features of Birt-Hogg-Dubé syndrome.

Nat Rev Urol 2015 Oct 1;12(10):558-69. Epub 2015 Sep 1.

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, CRC Room 15940, Bethesda, MD 20892-1107, USA.

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http://dx.doi.org/10.1038/nrurol.2015.206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119524PMC
October 2015

Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn.

Proc Natl Acad Sci U S A 2015 Mar 16;112(13):E1624-31. Epub 2015 Mar 16.

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702

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http://dx.doi.org/10.1073/pnas.1419502112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386336PMC
March 2015

Hereditary leiomyomatosis and renal cell carcinoma.

Int J Nephrol Renovasc Dis 2014 20;7:253-60. Epub 2014 Jun 20.

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://ukgtn.nhs.uk/uploads/tx_ukgtn/Leiomyomatosis_Leiomyom
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http://link.springer.com/content/pdf/10.1007%2Fs10689-014-97
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http://link.springer.com/content/pdf/10.1007/s10689-011-9491
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http://www.dovepress.com/hereditary-leiomyomatosis-and-renal
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http://dx.doi.org/10.2147/IJNRD.S42097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074185PMC
July 2014

Folliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulation.

Hum Mol Genet 2014 Nov 6;23(21):5706-19. Epub 2014 Jun 6.

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA,

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http://dx.doi.org/10.1093/hmg/ddu286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189904PMC
November 2014

Folliculin controls lung alveolar enlargement and epithelial cell survival through E-cadherin, LKB1, and AMPK.

Cell Rep 2014 Apr 13;7(2):412-423. Epub 2014 Apr 13.

Pulmonary, Allergy and Critical Care Division, Airways Biology Initiative, Department of Medicine, Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.03.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034569PMC
April 2014

Editorial comment.

Urology 2014 Mar;83(3):675.e5; discussion 675.e5-6

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD.

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http://dx.doi.org/10.1016/j.urology.2013.09.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154619PMC
March 2014

Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN.

J Natl Cancer Inst 2012 Nov 12;104(22):1750-64. Epub 2012 Nov 12.

Urologic Oncology Branch, National Cancer Institute, 10 Center Dr, MSC 1107, CRC Rm 1-5940W, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1093/jnci/djs418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502196PMC
November 2012

Birt-Hogg-Dubé syndrome: from gene discovery to molecularly targeted therapies.

Authors:
Laura S Schmidt

Fam Cancer 2013 Sep;12(3):357-64

Basic Science Program, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA,

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http://dx.doi.org/10.1007/s10689-012-9574-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637987PMC
September 2013

Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization.

PLoS One 2010 Dec 29;5(12):e15793. Epub 2010 Dec 29.

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015793PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012117PMC
December 2010

Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling.

Mol Cancer 2010 Jun 23;9:160. Epub 2010 Jun 23.

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, 10 Center Drive MSC1107, 10/CRC/1W-5940, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1186/1476-4598-9-160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907329PMC
June 2010

Proteomic analysis of ethene-enriched groundwater microcosms from a vinyl chloride-contaminated site.

Environ Sci Technol 2010 Mar;44(5):1594-601

Department of Civil and Environmental Engineering, University of Iowa, Iowa City, IA, USA.

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http://dx.doi.org/10.1021/es903033rDOI Listing
March 2010

Molecular diagnosis and therapy of kidney cancer.

Annu Rev Med 2010 ;61:329-43

Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1146/annurev.med.042808.171650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921612PMC
May 2010

Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2.

Proc Natl Acad Sci U S A 2009 Nov 22;106(44):18722-7. Epub 2009 Oct 22.

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0908853106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765925PMC
November 2009

Hereditary kidney cancer: unique opportunity for disease-based therapy.

Cancer 2009 May;115(10 Suppl):2252-61

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Building 10 CRC, Room 1-5940, Bethesda, MD 20892-1107, USA.

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http://dx.doi.org/10.1002/cncr.24230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720093PMC
May 2009

Identification and characterization of a novel folliculin-interacting protein FNIP2.

Gene 2008 May 4;415(1-2):60-7. Epub 2008 Mar 4.

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20894, United States.

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http://dx.doi.org/10.1016/j.gene.2008.02.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727720PMC
May 2008

Identification of the genes for kidney cancer: opportunity for disease-specific targeted therapeutics.

Clin Cancer Res 2007 Jan;13(2 Pt 2):671s-679s

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-1870DOI Listing
January 2007

Familial renal carcinoma: clinical evaluation, clinical subtypes and risk of renal carcinoma development.

J Urol 2007 Feb;177(2):461-5; discussion 465

Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892-1107, USA.

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http://dx.doi.org/10.1016/j.juro.2006.09.037DOI Listing
February 2007

Vascular defects and liver damage by the acute inactivation of the VHL gene during mouse embryogenesis.

Lab Invest 2006 Jul 1;86(7):664-75. Epub 2006 May 1.

Laboratory of Immunobiology, Center for Cancer Research, NCI-Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1038/labinvest.3700431DOI Listing
July 2006

Evaluation and management of renal tumors in the Birt-Hogg-Dubé syndrome.

J Urol 2005 May;173(5):1482-6

Urologic Oncology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute and Basic Research Program, SAIC-Frederick, Inc., Frederick, Maryland, USA.

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http://dx.doi.org/10.1097/01.ju.0000154629.45832.30DOI Listing
May 2005

Birt-Hogg-Dubé syndrome, a genodermatosis that increases risk for renal carcinoma.

Authors:
Laura S Schmidt

Curr Mol Med 2004 Dec;4(8):877-85

Basic Research Program, SAIC Frederick, Inc., Laboratory of Immunobiology, National Cancer Institute-Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.2174/1566524043359773DOI Listing
December 2004

Expression of Birt-Hogg-Dubé gene mRNA in normal and neoplastic human tissues.

Mod Pathol 2004 Aug;17(8):998-1011

Laboratory of Immunobiology, Center for Cancer Research, NCI Frederick, Frederick, MD, USA.

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http://dx.doi.org/10.1038/modpathol.3800152DOI Listing
August 2004

Searching for the hereditary causes of renal-cell carcinoma.

Nat Rev Cancer 2004 May;4(5):381-93

Johns Hopkins Bayview Medical Center, Brady Urological Institute, A-345, 4940 Eastern Ave., Baltimore, Maryland 21224, USA.

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http://dx.doi.org/10.1038/nrc1364DOI Listing
May 2004

A germ-line insertion in the Birt-Hogg-Dubé (BHD) gene gives rise to the Nihon rat model of inherited renal cancer.

Proc Natl Acad Sci U S A 2004 Feb 9;101(7):2023-7. Epub 2004 Feb 9.

Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 1-37-1 Kami-ikebukuro, Toshima-ku, Tokyo 170-8455, Japan.

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http://dx.doi.org/10.1073/pnas.0308071100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC357045PMC
February 2004

Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene.

Cancer Res 2003 Sep;63(17):5320-8

Laboratory of Immunobiology, Center for Cancer Research, Science Applications International Corporation-Frederick, Inc., National Cancer Institute Frederick, Frederick, Maryland 21702, USA.

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September 2003

The genetic basis of renal cell carcinoma.

Urol Clin North Am 2003 Aug;30(3):437-54, vii

James Buchanan Brady Urological Institute, A-345 Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/s0094-0143(03)00023-5DOI Listing
August 2003

Mutations in the fumarate hydratase gene cause hereditary leiomyomatosis and renal cell cancer in families in North America.

Am J Hum Genet 2003 Jul 22;73(1):95-106. Epub 2003 May 22.

Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Executive Plaza South, Rockville, MD 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180594PMC
http://dx.doi.org/10.1086/376435DOI Listing
July 2003