Laura Pasqualucci

Laura Pasqualucci

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Laura Pasqualucci

Laura Pasqualucci

Publications by authors named "Laura Pasqualucci"

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73Publications

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Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma.

Immunity 2019 Sep 10;51(3):535-547.e9. Epub 2019 Sep 10.

Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.08.006DOI Listing
September 2019

Emerging epigenetic-modulating therapies in lymphoma.

Nat Rev Clin Oncol 2019 Aug;16(8):494-507

Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1038/s41571-019-0190-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650343PMC
August 2019

Repurposing dasatinib for diffuse large B cell lymphoma.

Proc Natl Acad Sci U S A 2019 Aug 5;116(34):16981-16986. Epub 2019 Aug 5.

Institute for Cancer Genetics, Columbia University, New York, NY 10032;

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http://dx.doi.org/10.1073/pnas.1905239116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708382PMC
August 2019

Molecular pathogenesis of germinal center-derived B cell lymphomas.

Immunol Rev 2019 03;288(1):240-261

Pathology and Cell Biology, Institute for Cancer Genetics, Columbia University, New York City, New York.

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http://dx.doi.org/10.1111/imr.12745DOI Listing
March 2019

MEF2B Instructs Germinal Center Development and Acts as an Oncogene in B Cell Lymphomagenesis.

Cancer Cell 2018 09;34(3):453-465.e9

Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA; Department of Microbiology and Immunology, Columbia University, New York, NY 10032, USA; Department of Genetics and Development, Columbia University, New York, NY 10032, USA; The Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223119PMC
September 2018

On statistical modeling of sequencing noise in high depth data to assess tumor evolution.

J Stat Phys 2018 Jul 21;172(1):143-155. Epub 2017 Dec 21.

Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ.

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http://dx.doi.org/10.1007/s10955-017-1945-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051708PMC
July 2018

Genetics of diffuse large B-cell lymphoma.

Blood 2018 05 17;131(21):2307-2319. Epub 2018 Apr 17.

Institute for Cancer Genetics.

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http://dx.doi.org/10.1182/blood-2017-11-764332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969374PMC
May 2018

Follicular lymphoma: State-of-the-art ICML workshop in Lugano 2015.

Hematol Oncol 2017 Dec 4;35(4):397-407. Epub 2017 Apr 4.

Oncology Institute of Southern Switzerland, Ospedale San Giovanni, Bellinzona, Switzerland.

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http://dx.doi.org/10.1002/hon.2411DOI Listing
December 2017

Genetic drivers of NF-κB deregulation in diffuse large B-cell lymphoma.

Semin Cancer Biol 2016 08 18;39:26-31. Epub 2016 Aug 18.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, United States.

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http://dx.doi.org/10.1016/j.semcancer.2016.08.001DOI Listing
August 2016

An oncogenic role for alternative NF-κB signaling in DLBCL revealed upon deregulated BCL6 expression.

Cell Rep 2015 May 23;11(5):715-26. Epub 2015 Apr 23.

Program of Cellular and Molecular Medicine, Children's Hospital, and Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA; Max Delbrück Center for Molecular Medicine, Robert-Rössle-Str 10, Berlin 13125, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.03.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426003PMC
May 2015

The genetic landscape of diffuse large B-cell lymphoma.

Semin Hematol 2015 Apr 17;52(2):67-76. Epub 2015 Jan 17.

Professor and Director, Institute for Cancer Genetics, Columbia University, New York, NY.

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http://dx.doi.org/10.1053/j.seminhematol.2015.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646421PMC
April 2015

BCL2 mutation spectrum in B-cell non-Hodgkin lymphomas and patterns associated with evolution of follicular lymphoma.

Hematol Oncol 2015 Mar 4;33(1):23-30. Epub 2014 Feb 4.

Experimental Oncology/Hematology, Department of Clinical Research, University of Bern, Bern, Switzerland; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1002/hon.2132DOI Listing
March 2015

Lack of the ubiquitin-editing enzyme A20 results in loss of hematopoietic stem cell quiescence.

J Exp Med 2015 Feb 26;212(2):203-16. Epub 2015 Jan 26.

Department of Genetics and Development, Institute for Cancer Genetics, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032 Department of Genetics and Development, Institute for Cancer Genetics, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032

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http://dx.doi.org/10.1084/jem.20132544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322050PMC
February 2015

Genetics of follicular lymphoma transformation.

Cell Rep 2014 Jan 2;6(1):130-40. Epub 2014 Jan 2.

Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA; Department of Genetics & Development, Columbia University, New York, NY 10032, USA; Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2013.12.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100800PMC
January 2014

SnapShot: diffuse large B cell lymphoma.

Cancer Cell 2014 Jan;25(1):132-132.e1

Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA; Department of Genetics, Columbia University, New York, NY 10032, USA; Department of Microbiology and Immunology, Columbia University, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.ccr.2013.12.012DOI Listing
January 2014

Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome.

J Exp Med 2013 Oct 14;210(11):2273-88. Epub 2013 Oct 14.

Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, 2 Department of Pathology and Cell Biology, 3 Departments of Genetics and Development and of Microbiology and Immunology and 4 Department of Biomedical Informatics and Center for Computational Biology and Bioinformatics, Columbia University, New York, NY 10032.

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http://dx.doi.org/10.1084/jem.20131448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804949PMC
October 2013

Fractal-like distributions over the rational numbers in high-throughput biological and clinical data.

Sci Rep 2011 13;1:191. Epub 2011 Dec 13.

Department of Biomedical Informatics, Center for Computational Biology and Bioinformatics, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1038/srep00191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240948PMC
September 2013

The genetic basis of diffuse large B-cell lymphoma.

Curr Opin Hematol 2013 Jul;20(4):336-44

Institute for Cancer Genetics and the Department of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1097/MOH.0b013e3283623d7fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060531PMC
July 2013

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.

Nat Genet 2012 Oct 2;44(10):1104-10. Epub 2012 Sep 2.

Department of Translational Genomics, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1038/ng.2396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915822PMC
October 2012

Genomic analysis of non-splenic marginal zone lymphomas (MZL) indicates similarities between nodal and extranodal MZL and supports their derivation from memory B-cells.

Br J Haematol 2011 Nov 25;155(3):362-5. Epub 2011 Aug 25.

Departments of Pathology and Cell Biology Genetics and Development Herbert Irving Comprehensive Cancer Center Institute for Cancer Genetics, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2011.08841.xDOI Listing
November 2011

Molecular pathogenesis of diffuse large B-cell lymphoma.

Semin Diagn Pathol 2011 May;28(2):167-77

Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, and Department of Clinical Pathology and Cell Biology, Columbia University, New York, New York 10032, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562715PMC
May 2011

B-cell receptor signaling derailed in lymphomas.

Immunol Cell Biol 2010 May-Jun;88(4):346-7. Epub 2010 Mar 16.

Departments of Pathology & Cell Biology and Microbiology & Immunology, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1038/icb.2010.36DOI Listing
August 2010

Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation.

Cancer Res 2009 Nov 10;69(22):8686-92. Epub 2009 Nov 10.

Institute for Cancer Genetics and the Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-1110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973841PMC
November 2009

BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma.

Proc Natl Acad Sci U S A 2009 Jul 23;106(27):11294-9. Epub 2009 Jun 23.

Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1073/pnas.0903854106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708681PMC
July 2009

The NF-{kappa}B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas.

Blood 2009 May 3;113(20):4918-21. Epub 2009 Mar 3.

Institute for Cancer Genetics, Departments of Pathology and Genetics & Development, and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1182/blood-2008-08-174110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686142PMC
May 2009

AID is required for germinal center-derived lymphomagenesis.

Nat Genet 2008 Jan 9;40(1):108-12. Epub 2007 Dec 9.

Institute for Cancer Genetics, the Departments of Pathology and Genetics & Development, and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1038/ng.2007.35DOI Listing
January 2008

A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma.

Cancer Cell 2007 Sep;12(3):280-92

Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.ccr.2007.08.011DOI Listing
September 2007

Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma.

Haematologica 2006 Oct;91(10):1405-9

Division of Hematology, Department of Clinical and Experimental Medicine & IRCAD, Amedeo Avogadro University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy.

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October 2006

Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma.

J Exp Med 2006 Feb;203(2):311-7

Institute for Cancer Genetics and 2The Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1084/jem.20052204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118216PMC
February 2006

PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells.

Proc Natl Acad Sci U S A 2006 Jan 30;103(2):395-400. Epub 2005 Dec 30.

Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center and Department of Microbiology, Columbia University, 1150 Saint Nicholas Avenue, New York, NY 10032, USA.

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http://dx.doi.org/10.1073/pnas.0509969103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1326186PMC
January 2006

Analysis of aberrant somatic hypermutation (SHM) in non-Hodgkin's lymphomas of patients with chronic HCV infection.

J Pathol 2005 May;206(1):87-91

Experimental Oncology 1, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Istituto di Ricovero e Cura a Carattere Scientifico, Aviano, Italy.

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http://dx.doi.org/10.1002/path.1754DOI Listing
May 2005

Expression of the AID protein in normal and neoplastic B cells.

Blood 2004 Nov 10;104(10):3318-25. Epub 2004 Aug 10.

Institute for Cancer Genetics, Department of Pathology, Columbia University, 1150 St Nicholas Ave, New York, NY 10032, USA.

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http://dx.doi.org/10.1182/blood-2004-04-1558DOI Listing
November 2004

Molecular pathogenesis of non-Hodgkin's lymphoma: the role of Bcl-6.

Leuk Lymphoma 2003 ;44 Suppl 3:S5-12

Institute for Cancer Genetics, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA.

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October 2004

Aberrant somatic hypermutation in multiple subtypes of AIDS-associated non-Hodgkin lymphoma.

Blood 2003 Sep 24;102(5):1833-41. Epub 2003 Apr 24.

Institute for Cancer Genetics, Columbia University, Russ Berrie Science Pavilion, 1150 St Nicholas Ave, Rm 303B, New York, NY 10032, USA.

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http://dx.doi.org/10.1182/blood-2002-11-3606DOI Listing
September 2003

Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma.

Blood 2003 Apr 19;101(8):2914-23. Epub 2002 Dec 19.

Institute for Cancer Genetics and the Department of Pathology, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1182/blood-2002-11-3387DOI Listing
April 2003