Laura Parkkinen

Laura Parkkinen

UNVERIFIED PROFILE

Are you Laura Parkkinen?   Register this Author

Register author
Laura Parkkinen

Laura Parkkinen

Publications by authors named "Laura Parkkinen"

Are you Laura Parkkinen?   Register this Author

36Publications

1296Reads

42Profile Views

Heritability and genetic variance of dementia with Lewy bodies.

Neurobiol Dis 2019 07 3;127:492-501. Epub 2019 Apr 3.

Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, UK; UK Dementia Research Institute (UK DRI) at UCL, London, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2019.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588425PMC
July 2019

A comprehensive screening of copy number variability in dementia with Lewy bodies.

Neurobiol Aging 2019 03 24;75:223.e1-223.e10. Epub 2018 Oct 24.

Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; UK Dementia Research Institute (UK DRI) at UCL, London, UK; Department of Medical Sciences and Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01974580183038
Publisher Site
http://dx.doi.org/10.1016/j.neurobiolaging.2018.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541211PMC
March 2019

Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study.

Lancet Neurol 2018 01 16;17(1):64-74. Epub 2017 Dec 16.

UK Dementia Research Institute, University College London, London, UK; Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, UK; Department of Medical Sciences and Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1474-4422(17)30400-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805394PMC
January 2018

MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons.

Stem Cell Reports 2017 08 6;9(2):587-599. Epub 2017 Jul 6.

Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stemcr.2017.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549835PMC
August 2017

Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies.

Neurobiol Aging 2017 01 2;49:214.e13-214.e15. Epub 2016 Sep 2.

Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK; Department of Medical Sciences and Institute of Biomedicine-iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2016.08.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154872PMC
January 2017

Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies.

Ann Clin Transl Neurol 2016 10 28;3(10):812-818. Epub 2016 Aug 28.

The National CJD Research & Surveillance Unit Western General Hospital University of Edinburgh Edinburgh EH4 2XU United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/acn3.338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048391PMC
October 2016

α-synuclein genetic variability: A biomarker for dementia in Parkinson disease.

Ann Neurol 2016 Jun 5;79(6):991-9. Epub 2016 May 5.

Centre for Applied Neurogenetics, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/ana.24664
Publisher Site
http://dx.doi.org/10.1002/ana.24664DOI Listing
June 2016

Gut Feelings About α-Synuclein in Gastrointestinal Biopsies: Biomarker in the Making?

Mov Disord 2016 Feb 22;31(2):193-202. Epub 2016 Jan 22.

Oxford Parkinson's Disease Centre, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mds.26480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755164PMC
February 2016

Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology.

Neurobiol Dis 2015 Jul 30;79:81-99. Epub 2015 Apr 30.

Department of Biochemistry, College of Medicine and Health Science, United Arab Emirates University, Al Ain, United Arab Emirates; College of Science, Engineering and Technology, HBKU, Education City, Qatar Foundation, Doha, Qatar. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2015.04.009DOI Listing
July 2015

The significance of α-synuclein, amyloid-β and tau pathologies in Parkinson's disease progression and related dementia.

Neurodegener Dis 2014 11;13(2-3):154-6. Epub 2013 Sep 11.

Parkinson Disease and Movement Disorders Unit, Neurology Service, IDIBAPS, CIBERNED, Hospital Clínic, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000354670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194631PMC
September 2014

Staged pathology in Parkinson's disease.

Parkinsonism Relat Disord 2014 Jan;20 Suppl 1:S57-61

Department of Pathology and Cytology, Uppsala University Hospital, Uppsala, Sweden; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1353-8020(13)70016-6DOI Listing
January 2014

Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model.

Proc Natl Acad Sci U S A 2013 Oct 30;110(42):E4016-25. Epub 2013 Sep 30.

Oxford Parkinson's Disease Centre Department of Physiology, Anatomy and Genetics, Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, Nuffield Department of Clinical Neuroscience, John Radcliffe Hospital, and Department of Experimental Psychology, University of Oxford, Oxford OX1 3QX, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1309143110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801069PMC
October 2013

Glucocerebrosidase mutations do not cause increased Lewy body pathology in Parkinson's disease.

Mol Genet Metab 2011 Aug 5;103(4):410-2. Epub 2011 May 5.

Queen Square Brain Bank for Neurological Disorders, Institute of Neurology, University College London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymgme.2011.04.015DOI Listing
August 2011

Cardiovascular diseases and hippocampal infarcts.

Hippocampus 2011 Mar;21(3):281-7

Department of Pathology, Kuopio University Hospital, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hipo.20747DOI Listing
March 2011

Concomitant progressive supranuclear palsy and multiple system atrophy: more than a simple twist of fate?

Neurosci Lett 2009 Dec 14;467(3):208-11. Epub 2009 Oct 14.

Reta Lila Weston Institute for Neurological Studies, UCL Institute of Neurology, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2009.10.036DOI Listing
December 2009

Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain.

Arch Neurol 2009 Mar;66(3):382-9

Department of Neuroscience and Neurology, Clinical Research Center/Mediteknia, Kuopio University Hospital, University of Kuopio, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/archneurol.2008.596DOI Listing
March 2009

Can olfactory bulb biopsy be justified for the diagnosis of Parkinson's disease? Comments on "olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders".

Acta Neuropathol 2009 Feb 25;117(2):213-4; author reply 217-8. Epub 2008 Nov 25.

Queen Square Brain Bank for Neurological Disorders, Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-008-0462-3DOI Listing
February 2009

Systematic appraisal using immunohistochemistry of brain pathology in aged and demented subjects.

Dement Geriatr Cogn Disord 2008 3;25(5):423-32. Epub 2008 Apr 3.

Department of Clinical Medicine, Unit of Neurology, Section of Neuropathology, Kuopio University, Kuopio, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000122963DOI Listing
June 2008

Applicability of current staging/categorization of alpha-synuclein pathology and their clinical relevance.

Acta Neuropathol 2008 Apr 23;115(4):399-407. Epub 2008 Feb 23.

Department of Clinical Medicine, Unit of Neurology, Section of Neuropathology, Kuopio University, Yliopistonranta 1 C, P.O. Box 1627, 70211, Kuopio, Finland.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00401-008-0346-6
Publisher Site
http://dx.doi.org/10.1007/s00401-008-0346-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270355PMC
April 2008

Widespread and abundant alpha-synuclein pathology in a neurologically unimpaired subject.

Neuropathology 2005 Dec;25(4):304-14

Department of Neuroscience and Neurology, Kuopio University, Kuopio, Finland.

View Article

Download full-text PDF

Source
December 2005

Alpha-synuclein pathology does not predict extrapyramidal symptoms or dementia.

Ann Neurol 2005 Jan;57(1):82-91

Department of Neuroscience and Neurology, Kuopio University, 70211 Kuopio, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.20321DOI Listing
January 2005

Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62.

J Neuropathol Exp Neurol 2003 Dec;62(12):1241-53

Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland.

View Article

Download full-text PDF

Source
https://academic.oup.com/jnen/article-lookup/doi/10.1093/jne
Publisher Site
http://dx.doi.org/10.1093/jnen/62.12.1241DOI Listing
December 2003

Regional distribution of alpha-synuclein pathology in unimpaired aging and Alzheimer disease.

J Neuropathol Exp Neurol 2003 Apr;62(4):363-7

Department of Neuroscience, Kuopio University, P.O. Box 1627, FIN-70211 Kuopio, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jnen/62.4.363DOI Listing
April 2003