Publications by authors named "Laura Orellana"

17Publications

Structure and elevator mechanism of the mammalian sodium/proton exchanger NHE9.

EMBO J 2020 Oct 29:e105908. Epub 2020 Oct 29.

Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.

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http://dx.doi.org/10.15252/embj.2020105908DOI Listing
October 2020

The molecular basis for sugar import in malaria parasites.

Nature 2020 02 29;578(7794):321-325. Epub 2020 Jan 29.

Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41586-020-1963-zDOI Listing
February 2020

Large-Scale Conformational Changes and Protein Function: Breaking the Barrier.

Authors:
Laura Orellana

Front Mol Biosci 2019 5;6:117. Epub 2019 Nov 5.

Institutionen för Biokemi och Biofysik, Stockholms Universitet, Stockholm, Sweden.

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http://dx.doi.org/10.3389/fmolb.2019.00117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848229PMC
November 2019

Convergence of glioblastoma mutations: evolution and allostery rationalizing targeted therapy.

Authors:
Laura Orellana

Mol Cell Oncol 2019 4;6(5):e1630798. Epub 2019 Jul 4.

Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.

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http://dx.doi.org/10.1080/23723556.2019.1630798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736128PMC
July 2019

Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope.

Proc Natl Acad Sci U S A 2019 05 26;116(20):10009-10018. Epub 2019 Apr 26.

Institute for Research in Biomedicine (IRB Barcelona), the Barcelona Institute of Science and Technology, 08028 Barcelona, Catalonia, Spain;

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http://dx.doi.org/10.1073/pnas.1821442116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525488PMC
May 2019

eBDIMS server: protein transition pathways with ensemble analysis in 2D-motion spaces.

Bioinformatics 2019 09;35(18):3505-3507

Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Stockholm, Sweden.

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http://dx.doi.org/10.1093/bioinformatics/btz104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748756PMC
September 2019

Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair.

Cancer Cell 2019 03 28;35(3):504-518.e7. Epub 2019 Feb 28.

Ludwig Institute for Cancer Research, San Diego Branch, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0660, USA; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA; Department of Pathology, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.01.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424615PMC
March 2019

Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development.

Cancer Cell 2018 07;34(1):163-177.e7

Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424337PMC
July 2018

Prediction and validation of protein intermediate states from structurally rich ensembles and coarse-grained simulations.

Nat Commun 2016 08 31;7:12575. Epub 2016 Aug 31.

Department of Theoretical Physics, KTH Royal Institute of Technology, Box 1031, 171 21 Solna, Sweden.

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http://dx.doi.org/10.1038/ncomms12575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013691PMC
August 2016

Cell dipole behaviour revealed by ECM sub-cellular geometry.

Nat Commun 2014 Dec 10;5:5749. Epub 2014 Dec 10.

1] Univ. Grenoble Alpes, LIPhy, F-38000 Grenoble, France [2] CNRS, LIPhy, F-38000 Grenoble, France.

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http://www.nature.com/articles/ncomms6749
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http://dx.doi.org/10.1038/ncomms6749DOI Listing
December 2014

Correlated motions are a fundamental property of β-sheets.

Nat Commun 2014 Jun 11;5:4070. Epub 2014 Jun 11.

1] Joint BSC-CRG-IRB Research Programme in Computational Biology, Institute for Research in Biomedicine (IRB Barcelona), Baldiri Reixac 10, 08028 Barcelona, Spain [2] Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.

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http://dx.doi.org/10.1038/ncomms5070DOI Listing
June 2014

Finding Conformational Transition Pathways from Discrete Molecular Dynamics Simulations.

J Chem Theory Comput 2012 Nov 6;8(11):4707-18. Epub 2012 Sep 6.

Joint IRB-BSC Program in Computational Biology, Institute of Research in Biomedicine, Josep Samitier 1-5, Barcelona, 08028, Spain.

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http://dx.doi.org/10.1021/ct300494qDOI Listing
November 2012

Coarse-grained representation of protein flexibility. Foundations, successes, and shortcomings.

Adv Protein Chem Struct Biol 2011 ;85:183-215

Joint IRB-BSC Program on Computational Biology, Barcelona Supercomputing Center and Institute of Research in Biomedicine, Parc Científic de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1016/B978-0-12-386485-7.00005-3DOI Listing
February 2012

Approaching Elastic Network Models to Molecular Dynamics Flexibility.

J Chem Theory Comput 2010 Sep;6(9):2910-23

Joint Research Program in Computational Biology from the Institute for Research in Biomedicine Barcelona (IRBB) and Barcelona Supercomputing Center (BSC), Barcelona, Spain, Chemical and Physical Biology, Centro de Investigaciones Biológicas, Madrid, Spain, Departament de Bioquímica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain, and Skaggs School of Pharmacy, University of California-San Diego, La Jolla, California 92093.

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http://dx.doi.org/10.1021/ct100208eDOI Listing
September 2010

FlexServ: an integrated tool for the analysis of protein flexibility.

Bioinformatics 2009 Jul 7;25(13):1709-10. Epub 2009 May 7.

Joint IRB-BSC Program on Computational Biology, Institute of Research in Biomedicine, Barcelona Science Park, Josep Samitier 1-5, Barcelona, Spain.

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http://dx.doi.org/10.1093/bioinformatics/btp304DOI Listing
July 2009