Laura M Heiser

Laura M Heiser

UNVERIFIED PROFILE

Are you Laura M Heiser?   Register this Author

Register author
Laura M Heiser

Laura M Heiser

Publications by authors named "Laura M Heiser"

Are you Laura M Heiser?   Register this Author

51Publications

1599Reads

12Profile Views

The tracking of lipopolysaccharide through the feto-maternal compartment and the involvement of maternal TLR4 in inflammation-induced fetal brain injury.

Am J Reprod Immunol 2019 Dec 30;82(6):e13189. Epub 2019 Sep 30.

Department of Obstetrics and Gynecology, Maternal and Child Health Research Center, Center for Research on Reproduction and Women's Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/aji.13189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899932PMC
December 2019

Individual Cells Can Resolve Variations in Stimulus Intensity along the IGF-PI3K-AKT Signaling Axis.

Cell Syst 2019 Dec 11;9(6):580-588.e4. Epub 2019 Dec 11.

Department of Biomedical Engineering, OHSU Center for Spatial Systems Biomedicine, Knight Cancer Institute, Oregon Health & Sciences University, Portland OR, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cels.2019.11.005DOI Listing
December 2019

Annot: a Django-based sample, reagent, and experiment metadata tracking system.

BMC Bioinformatics 2019 Nov 1;20(1):542. Epub 2019 Nov 1.

Department of Biomedical Engineering and OHSU Center for Spatial Systems Biomedicine, OHSU, Portland, OR, 97201, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12859-019-3147-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824123PMC
November 2019

Therapeutic Clues from an Integrated Omic Assessment of East Asian Triple Negative Breast Cancers.

Cancer Cell 2019 03;35(3):341-343

Center for Spatial Systems Biomedicine, Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97201, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2019.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499473PMC
March 2019

Variational Autoencoding Tissue Response to Microenvironment Perturbation.

Proc SPIE Int Soc Opt Eng 2019 Feb 15;10949. Epub 2019 Mar 15.

Dept. of Biomedical Engineering, Center for Spatial Systems Biomedicine, Oregon Health & Science University, Portland, OR, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1117/12.2512660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677277PMC
February 2019

Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes.

Cell Syst 2018 Mar 14;6(3):329-342.e6. Epub 2018 Mar 14.

Department of Biomedical Engineering, Knight Cancer Institute, OHSU Center for Spatial Systems Biomedicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S24054712183005
Publisher Site
http://dx.doi.org/10.1016/j.cels.2018.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927625PMC
March 2018

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.

Authors:
Alexandra B Keenan Sherry L Jenkins Kathleen M Jagodnik Simon Koplev Edward He Denis Torre Zichen Wang Anders B Dohlman Moshe C Silverstein Alexander Lachmann Maxim V Kuleshov Avi Ma'ayan Vasileios Stathias Raymond Terryn Daniel Cooper Michele Forlin Amar Koleti Dusica Vidovic Caty Chung Stephan C Schürer Jouzas Vasiliauskas Marcin Pilarczyk Behrouz Shamsaei Mehdi Fazel Yan Ren Wen Niu Nicholas A Clark Shana White Naim Mahi Lixia Zhang Michal Kouril John F Reichard Siva Sivaganesan Mario Medvedovic Jaroslaw Meller Rick J Koch Marc R Birtwistle Ravi Iyengar Eric A Sobie Evren U Azeloglu Julia Kaye Jeannette Osterloh Kelly Haston Jaslin Kalra Steve Finkbiener Jonathan Li Pamela Milani Miriam Adam Renan Escalante-Chong Karen Sachs Alex Lenail Divya Ramamoorthy Ernest Fraenkel Gavin Daigle Uzma Hussain Alyssa Coye Jeffrey Rothstein Dhruv Sareen Loren Ornelas Maria Banuelos Berhan Mandefro Ritchie Ho Clive N Svendsen Ryan G Lim Jennifer Stocksdale Malcolm S Casale Terri G Thompson Jie Wu Leslie M Thompson Victoria Dardov Vidya Venkatraman Andrea Matlock Jennifer E Van Eyk Jacob D Jaffe Malvina Papanastasiou Aravind Subramanian Todd R Golub Sean D Erickson Mohammad Fallahi-Sichani Marc Hafner Nathanael S Gray Jia-Ren Lin Caitlin E Mills Jeremy L Muhlich Mario Niepel Caroline E Shamu Elizabeth H Williams David Wrobel Peter K Sorger Laura M Heiser Joe W Gray James E Korkola Gordon B Mills Mark LaBarge Heidi S Feiler Mark A Dane Elmar Bucher Michel Nederlof Damir Sudar Sean Gross David F Kilburn Rebecca Smith Kaylyn Devlin Ron Margolis Leslie Derr Albert Lee Ajay Pillai

Cell Syst 2018 01 29;6(1):13-24. Epub 2017 Nov 29.

NIH, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cels.2017.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799026PMC
January 2018

Pathway-Enriched Gene Signature Associated with 53BP1 Response to PARP Inhibition in Triple-Negative Breast Cancer.

Mol Cancer Ther 2017 Dec 27;16(12):2892-2901. Epub 2017 Sep 27.

Department of Biomedical Engineering, OHSU Center for Spatial Systems Biomedicine, Oregon Health and Science University, Portland, Oregon.

View Article

Download full-text PDF

Source
http://mct.aacrjournals.org/lookup/doi/10.1158/1535-7163.MCT
Publisher Site
http://dx.doi.org/10.1158/1535-7163.MCT-17-0170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765867PMC
December 2017

Quantification of sensitivity and resistance of breast cancer cell lines to anti-cancer drugs using GR metrics.

Sci Data 2017 11 7;4:170166. Epub 2017 Nov 7.

HMS LINCS Center, Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115 USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sdata.2017.166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674849PMC
November 2017

FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer.

Proc Natl Acad Sci U S A 2016 10 6;113(43):E6600-E6609. Epub 2016 Oct 6.

Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030; Department of Medicine, Baylor College of Medicine, Houston, TX 77030;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1612835113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087040PMC
October 2016

PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder.

Sci Rep 2016 08 30;6:31750. Epub 2016 Aug 30.

Department of Pharmaceutical Sciences, College of Pharmacy, Collaborative Life Science Building, Oregon State University, Portland OR, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep31750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004151PMC
August 2016

Tumor-Derived Cell Lines as Molecular Models of Cancer Pharmacogenomics.

Mol Cancer Res 2016 Jan 6;14(1):3-13. Epub 2015 Aug 6.

Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado. University of Colorado Comprehensive Cancer Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1541-7786.MCR-15-0189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828339PMC
January 2016

A Network-Based Model of Oncogenic Collaboration for Prediction of Drug Sensitivity.

Front Genet 2015 23;6:341. Epub 2015 Dec 23.

Department of Biomedical Engineering, Knight Cancer Institute, Oregon Health & Science University, Portland OR, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fgene.2015.00341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688377PMC
January 2016

A community computational challenge to predict the activity of pairs of compounds.

Nat Biotechnol 2014 Dec 17;32(12):1213-22. Epub 2014 Nov 17.

1] Department of Systems Biology, Columbia University, New York, New York, USA. [2] Center for Computational Biology and Bioinformatics, Columbia University, New York, New York, USA. [3] Department of Biomedical Informatics, Columbia University, New York, New York, USA. [4] Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, USA. [5] Institute for Cancer Genetics, Columbia University, New York, New York, USA. [6] Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nbt.3052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399794PMC
December 2014

A robust prognostic signature for hormone-positive node-negative breast cancer.

Genome Med 2013 11;5(10):92. Epub 2013 Oct 11.

Department of Cancer and DNA Damage Responses, Life Sciences Division, Lawrence Berkeley National Laboratory, One Cyclotron Rd, Berkeley 94720, CA, USA ; Department of Biomedical Engineering, Center for Spatial Systems Biomedicine, Knight Cancer Institute, Oregon Health and Science University, 3303 SW Bond Ave, Portland, 97239, OR, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/gm496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961800PMC
May 2014

Metrics other than potency reveal systematic variation in responses to cancer drugs.

Nat Chem Biol 2013 Nov 8;9(11):708-14. Epub 2013 Sep 8.

Harvard Medical School Library of Integrated Network-based Cellular Signatures Center, Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchembio.1337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947796PMC
November 2013

Biomarkers and cervical length to predict spontaneous preterm birth in asymptomatic high-risk women.

Obstet Gynecol 2013 Aug;122(2 Pt 1):283-9

Maternal and Child Health Research Program, Department of Obstetrics & Gynecology, Center for Research on Reproduction and Women's Health, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/AOG.0b013e31829ab714DOI Listing
August 2013

Bayesian inference of signaling network topology in a cancer cell line.

Bioinformatics 2012 Nov 24;28(21):2804-10. Epub 2012 Aug 24.

Department of Biochemistry, The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/bts514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476330PMC
November 2012

Corollary discharge and spatial updating: when the brain is split, is space still unified?

Prog Brain Res 2005 ;149:187-205

Department of Neuroscience, University of Pittsburgh, Center for the Neural Basis of Cognition, Mellon Institute, Pittsburgh, PA 15213-2683, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0079-6123(05)49014-7DOI Listing
December 2008

Dynamic circuitry for updating spatial representations. III. From neurons to behavior.

J Neurophysiol 2007 Jul 9;98(1):105-21. Epub 2007 May 9.

Department of Neuroscience and Center for the Neural Basis of Cognition, University of Pittsbirgh, Pittsburgh, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/jn.00330.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2383318PMC
July 2007

Spatial updating in area LIP is independent of saccade direction.

J Neurophysiol 2006 May 16;95(5):2751-67. Epub 2005 Nov 16.

Department of Neuroscience and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/jn.00054.2005DOI Listing
May 2006

Dynamic circuitry for updating spatial representations. II. Physiological evidence for interhemispheric transfer in area LIP of the split-brain macaque.

J Neurophysiol 2005 Nov 11;94(5):3249-58. Epub 2005 May 11.

Department of Neuroscience and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/jn.00029.2005DOI Listing
November 2005

Dynamic circuitry for updating spatial representations. I. Behavioral evidence for interhemispheric transfer in the split-brain macaque.

J Neurophysiol 2005 Nov 11;94(5):3228-48. Epub 2005 May 11.

Department of Neuroscience and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA 15213, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/jn.00028.2005DOI Listing
November 2005