Publications by authors named "Laura Lazzeri"

8 Publications

  • Page 1 of 1

New-Onset Psoriasis Developing in Atopic Patient With Prurigo Nodularis After Treatment With Dupilumab.

Dermatitis 2021 Feb 27. Epub 2021 Feb 27.

Department of Medical, Surgical and Neurological Science Dermatology Section, University of Siena, Italy.

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http://dx.doi.org/10.1097/DER.0000000000000740DOI Listing
February 2021

Reticular erythematous mucinosis: a clinical challenge.

Ital J Dermatol Venerol 2021 May 13. Epub 2021 May 13.

Dermatology Section, Department of Clinical Medicine and Immunological Science, University of Siena, Siena, Italy.

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http://dx.doi.org/10.23736/S2784-8671.21.06946-7DOI Listing
May 2021

Teledermatology in 2020: past, present and future perspectives.

Ital J Dermatol Venerol 2021 Apr;156(2):198-212

Unit of Dermatology, Department of Medical, Surgical and Neurosciences, University of Siena, Siena, Italy.

Born in 1995, teledermatology (TD) turns 25 years old today. Since then, TD evolved according to patients and physicians needs. The present review aimed to summarize all the efforts and experiences carried out in the field of TD and its subspecialties, the evolution and the future perspectives. A literature search was conducted in PubMed and Google Scholar. The state of the art of the "tele-dermo research" included TD and clinical trials, TD/TDS web platforms, TDS and artificial intelligence studies. Finally, the future perspective of TD/TDS in the era of social distancing was discussed. Using TD in specific situations adds several benefits including time-effectiveness of intervention and reduction in the waiting time for the first visit, reduced travel-costs, reduced sanitary costs, equalization of access from patient to specialistic consult. The communication technologies devices currently available can adequately support the growing needs of tele-assistance. A main limit is the current lack of a common clear European regulation for practicing TD, encompassing privacy issues and data management. The pandemic lockdown of 2020 has highlighted the importance of performing TD for all those patient, elderly and/or fragile, where the alternative would be no care at all. Many efforts are needed to develop efficient workflows and TD programs to facilitate the interplay among the different TD actors, along with practice guidelines or position statements.
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http://dx.doi.org/10.23736/S2784-8671.21.06731-6DOI Listing
April 2021

Usefulness of in vivo reflectance confocal microscopy in Morbihan syndrome.

Skin Res Technol 2021 Jan 17. Epub 2021 Jan 17.

Department of Medical, Surgical and Neurological Science, Dermatology Section, S. Maria alle Scotte Hospital, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1111/srt.13002DOI Listing
January 2021

Dupilumab in Elderly Patients With Severe Atopic Dermatitis.

Dermatitis 2020 Dec 15;Publish Ahead of Print. Epub 2020 Dec 15.

From the Dermatology Section, Department of Medical, Surgical and Neurological Science, University of Siena, S. Maria alle Scotte Hospital, Siena Allergological and Pediatric Dermatology Unit, Department of Health Sciences, University of Florence, Florence Department of Medical Biotechnology, University of Siena, Siena Unit of Dermatology, Livorno Hospital, Livorno, Italy.

Background: Atopic dermatitis (AD) in the elderly has been poorly investigated, although its incidence is gradually increasing mainly in industrialized countries. Age-specific factors in older patients must be considered when selecting treatment options.

Objectives: To evaluate the efficacy and tolerability of dupilumab in treating elderly patients with severe AD.

Methods: This was a retrospective, multicenter study involving 26 elderly patients (age, ≥65 years) with severe AD who were treated with dupilumab for at least 16 weeks. Absolute and percentage frequencies were used to evaluate qualitative variables and mean and SD for quantitative ones. For Eczema Area and Severity Index (EASI), Pruritus Numeric Rating Scale (NRS), and Dermatology Life Quality Index (DLQI), the median was also calculated. Wilcoxon test was used to evaluate the variations in EASI, Pruritus NRS, and DLQI observed between the 2 examinations.

Results: After 4 months of therapy, the majority of patients showed a significant improvement in EASI (64.4%), Pruritus NRS (58.2%), and DLQI (44.9%). Only 11% of patients reported mild or moderate conjunctivitis.

Conclusions: To the best of our knowledge, this is the first study concerning the use of dupilumab in the elderly with severe AD. Our data show the effectiveness of dupilumab in this particular population with a lower percentage of conjunctivitis than observed in studies on adults and also excellent control of itching. Only larger, controlled case studies will be able to clarify whether the dosage or frequency of administration of dupilumab in these patients should be different from the protocol used for adults.
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http://dx.doi.org/10.1097/DER.0000000000000686DOI Listing
December 2020

Amenorrhea secondary to vismodegib: An adverse event to consider especially in female patients with Gorlin-Goltz syndrome.

Dermatol Ther 2020 07 26;33(4):e13527. Epub 2020 May 26.

Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, Siena, Italy.

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http://dx.doi.org/10.1111/dth.13527DOI Listing
July 2020

Efficacy of Dupilumab in two patients with severe and recalcitrant atopic dermatitis previously treated with extracorporeal photopheresis.

Dermatol Ther 2020 05 2;33(3):e13284. Epub 2020 Mar 2.

Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, Siena, Italy.

Atopic dermatitis (AD) is a complex disease and can often be a clinical challenge for dermatologists. When standard immunosuppressive therapies fail, extracorporeal phototherapy (ECP) can be considered as a therapeutic option. In recent years, better understanding of the pathogenesis of AD allowed to improve treatment strategies with many emerging therapeutic options. Currently, Dupilumab, a monoclonal antibody that selectively inhibits IL-4 and IL-13, is the only biological drug authorized for the treatment of severe adult atopic dermatitis, refractory to traditional firstline and secondline therapies. ECP, compared to biological therapy, is associated with some disadvantages: it is costly and time-consuming for patients and personnel to administer. Moreover, it should be noted that the completion of the entire procedure takes about 3 hr and must be done in a hospital, while the administration of Dupilumab can be carried out by patients themselves at home. For these reasons and on the basis of our experience, it would be necessary to evaluate whether all patients with refractory atopic dermatitis in treatment with ECP with unsatisfactory clinical response should be switched to recent available target therapies.
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http://dx.doi.org/10.1111/dth.13284DOI Listing
May 2020

Cutaneous colorimetric evaluation of serum concentrations of bilirubin in healthy term neonates: a new methodological approach.

Skin Res Technol 2005 Feb;11(1):70-5

Department of Dermatology, University of Siena, Siena, Italy.

Background: In recent years, many non-invasive instruments have been used to examine the correlation between transcutaneous bilirubin (TcB) measurements and serum concentrations of bilirubin (SB) in newborns with a view to reducing the need for blood samples. However, their exact role has not been univocal. The aim of the present study was to determine whether non-invasive measurement of skin colour combined with appropriate clinico-statistical methodology can be used to better quantify SB in the first days of life.

Methods: The study group consisted of 49 healthy term breast-fed newborns. Skin colour was measured with a Minolta CR-300 colorimeter and measurements were made in the first 12 h of life, at 48 h and in 13 babies at 96 h. To determine changes in SB from variations in skin colour between birth and 48 h (and also 96 h in 13 cases), a multivariate linear regression model was designed. To test the generalisation power of the regression model, we examined its predictive power for SB a third time (96 h; 13/49 cases) with respect to the previous two times.

Results: The model made it possible to recognise increases in SB accurately with a mean absolute error 0.99 mg/dL with a good generalisation power.

Conclusions: The methodological model proposed here made it possible to accurately recognise increases in SB with respect to an initial value. Provided the methodological protocol is observed, TcB can therefore be used in the screening and follow-up of neonatal jaundice.
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http://dx.doi.org/10.1111/j.1600-0846.2005.00102.xDOI Listing
February 2005
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