Publications by authors named "Laura L Kiessling"

100Publications

Polysaccharide length affects mycobacterial cell shape and antibiotic susceptibility.

Sci Adv 2020 Sep 16;6(38). Epub 2020 Sep 16.

Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA.

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September 2020

Glycan-Modified Virus-like Particles Evoke T Helper Type 1-like Immune Responses.

ACS Nano 2020 Aug 17. Epub 2020 Aug 17.

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

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August 2020

Scientific Response to the Coronavirus Crisis in Spain: Collaboration and Multidisciplinarity.

ACS Chem Biol 2020 07 25;15(7):1722-1723. Epub 2020 Jun 25.

CIC bioGUNE, Basque Research Technology Alliance, BRTA, Bizkaia Technology Park, Building 800, 48160 Derio, Spain.

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July 2020

Stereoelectronic Effects Impact Glycan Recognition.

J Am Chem Soc 2020 02 24;142(5):2386-2395. Epub 2020 Jan 24.

Department of Chemistry , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.

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February 2020

Antigen structure affects cellular routing through DC-SIGN.

Proc Natl Acad Sci U S A 2019 07 3;116(30):14862-14867. Epub 2019 Jul 3.

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139;

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July 2019

Bacterial Cell Wall Modification with a Glycolipid Substrate.

J Am Chem Soc 2019 06 4;141(23):9262-9272. Epub 2019 Jun 4.

Department of Chemistry , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.

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June 2019

Angiomotin Regulates YAP Localization during Neural Differentiation of Human Pluripotent Stem Cells.

Stem Cell Reports 2019 05 18;12(5):869-877. Epub 2019 Apr 18.

Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address:

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May 2019

Chemoselective, Postpolymerization Modification of Bioactive, Degradable Polymers.

Biomacromolecules 2019 02 22;20(2):1018-1027. Epub 2019 Jan 22.

Department of Chemistry , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.

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February 2019

Chemistry-driven glycoscience.

Bioorg Med Chem 2018 10 22;26(19):5229-5238. Epub 2018 Sep 22.

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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October 2018

Imaging mycobacterial growth and division with a fluorogenic probe.

Proc Natl Acad Sci U S A 2018 05 27;115(20):5271-5276. Epub 2018 Apr 27.

Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706;

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May 2018

Deleterious Consequences of UDP-Galactopyranose Mutase Inhibition for Nematodes.

ACS Chem Biol 2017 09 16;12(9):2354-2361. Epub 2017 Aug 16.

Department of Chemistry, University of Wisconsin-Madison , 1101 University Avenue, Madison, Wisconsin 53706-1322, United States.

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September 2017

Conformational Control of UDP-Galactopyranose Mutase Inhibition.

Biochemistry 2017 08 20;56(30):3983-3992. Epub 2017 Jul 20.

Department of Chemistry, ‡Department of Biochemistry, and §Department of Bacteriology, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.

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August 2017

Recognition of microbial glycans by soluble human lectins.

Curr Opin Struct Biol 2017 06 5;44:168-178. Epub 2017 May 5.

Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, 53706, USA; Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, 53706, USA. Electronic address:

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June 2017

Comparing Galactan Biosynthesis in and .

J Biol Chem 2017 02 30;292(7):2944-2955. Epub 2016 Dec 30.

From the Department of Biochemistry and

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February 2017

Carboxylate Surrogates Enhance the Antimycobacterial Activity of UDP-Galactopyranose Mutase Probes.

ACS Infect Dis 2016 08 29;2(8):538-43. Epub 2016 Jun 29.

Department of Chemistry, University of Wisconsin-Madison , 1101 University Avenue, Madison, Wisconsin 53706-1322, United States.

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August 2016

Fidelity and Promiscuity of a Mycobacterial Glycosyltransferase.

J Am Chem Soc 2016 07 13;138(29):9205-11. Epub 2016 Jul 13.

Department of Chemistry, University of Wisconsin-Madison , 1101 University Avenue, Madison, Wisconsin 53706, United States.

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July 2016

Bioconjugates and Chemical Biology.

Bioconjug Chem 2016 06;27(6):1429

Department of Chemistry, University of Massachusetts Amherst 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.

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June 2016

Focus on Epigenetics.

ACS Chem Biol 2016 Mar;11(3):541-2

ACS Chemical Biology.

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March 2016

Structures of Xenopus Embryonic Epidermal Lectin Reveal a Conserved Mechanism of Microbial Glycan Recognition.

J Biol Chem 2016 Mar 11;291(11):5596-610. Epub 2016 Jan 11.

Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin 53706

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March 2016

Carbohydrate-Aromatic Interactions in Proteins.

J Am Chem Soc 2015 Dec 30;137(48):15152-60. Epub 2015 Nov 30.

School of Chemistry, University of Bristol , Bristol BS8 1TS, United Kingdom.

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December 2015

Recognition of microbial glycans by human intelectin-1.

Nat Struct Mol Biol 2015 Aug 6;22(8):603-10. Epub 2015 Jul 6.

1] Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA. [2] Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.

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August 2015

The non-detergent sulfobetaine-201 acts as a pharmacological chaperone to promote folding and crystallization of the type II TGF-β receptor extracellular domain.

Protein Expr Purif 2015 Nov 11;115:19-25. Epub 2015 Jun 11.

Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706, United States; Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Dr., Madison, WI 53706, United States. Electronic address:

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November 2015

Multivalent Antigens for Promoting B and T Cell Activation.

ACS Chem Biol 2015 Aug 2;10(8):1817-24. Epub 2015 Jun 2.

†Department of Chemistry, ‡Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.

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August 2015

Forces of Change: Mechanics Underlying Formation of Functional 3D Organ Buds.

Cell Stem Cell 2015 May;16(5):453-4

Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53792, USA; Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53792, USA. Electronic address:

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May 2015

Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins.

Proc Natl Acad Sci U S A 2014 Dec 24;111(51):18126-31. Epub 2014 Nov 24.

Departments of Biochemistry and Cell and Molecular Biology Program, University of Wisconsin-Madison, Madison, WI 53706; and Chemistry,

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December 2014

Polyspecific pyrrolysyl-tRNA synthetases from directed evolution.

Proc Natl Acad Sci U S A 2014 Nov 10;111(47):16724-9. Epub 2014 Nov 10.

Departments of Molecular Biophysics & Biochemistry and Chemistry, and

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November 2014

A symposium in honor of Peter B. Dervan, the 2014 ACS Chemical Biology Lectureship Award Winner.

ACS Chem Biol 2014 Jun;9(6):1221-3

Department of Chemistry, University of Wisconsin, Madition , 433 Babcock Drive, Madison, Wisconsin 53706-1544, United States.

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June 2014

Rhamnose glycoconjugates for the recruitment of endogenous anti-carbohydrate antibodies to tumor cells.

Chembiochem 2014 Jul 6;15(10):1393-8. Epub 2014 Jun 6.

Department of Biochemistry, UW-Madison, 433 Babcock Drive, Madison, WI 53706 (USA).

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July 2014

Isoprenoid phosphonophosphates as glycosyltransferase acceptor substrates.

J Am Chem Soc 2014 Jun 10;136(24):8492-5. Epub 2014 Jun 10.

Department of Chemistry and ‡Department of Biochemistry, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.

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June 2014

New insights into bacterial chemoreceptor array structure and assembly from electron cryotomography.

Biochemistry 2014 Mar 6;53(10):1575-85. Epub 2014 Mar 6.

Division of Biology, California Institute of Technology , 1200 East California Boulevard, Pasadena, California 91125, United States.

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March 2014

Synthetic antigens reveal dynamics of BCR endocytosis during inhibitory signaling.

ACS Chem Biol 2014 Jan 14;9(1):202-10. Epub 2013 Nov 14.

Department of Biochemistry, University of Wisconsin-Madison , 433 Babcock Drive, Madison, Wisconsin 53706, United States.

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January 2014

Chemistry. A path to complex carbohydrates.

Science 2013 Jul;341(6144):357-8

Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.

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July 2013

UDP-galactopyranose mutase in nematodes.

Biochemistry 2013 Jun 11;52(25):4391-8. Epub 2013 Jun 11.

Department of Biochemistry, University of Wisconsin-Madison, United States.

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June 2013

Glycopolymer probes of signal transduction.

Chem Soc Rev 2013 May 18;42(10):4476-91. Epub 2013 Apr 18.

Department of Chemistry, University of Wisconsin-Madison, 1101 University Ave, Madison, WI 53706, USA.

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May 2013

Synthesis of functionalizable and degradable polymers by ring-opening metathesis polymerization.

Angew Chem Int Ed Engl 2013 May 8;52(19):5061-4. Epub 2013 Apr 8.

Department of Chemistry, University of Wisconsin-Madison, 1101 University Ave., Madison, WI 53706, USA.

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May 2013

Synthesis of lipid-linked arabinofuranose donors for glycosyltransferases.

J Org Chem 2013 Mar 7;78(5):2128-33. Epub 2013 Feb 7.

Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.

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March 2013

Glycosaminoglycan-binding hydrogels enable mechanical control of human pluripotent stem cell self-renewal.

ACS Nano 2012 Nov 1;6(11):10168-77. Epub 2012 Oct 1.

Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.

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November 2012

Noncarbohydrate glycomimetics and glycoprotein surrogates as DC-SIGN antagonists and agonists.

ACS Chem Biol 2012 Sep 19;7(9):1603-8. Epub 2012 Jul 19.

Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.

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September 2012

Quinoxalinone Inhibitors of the Lectin DC-SIGN.

Chem Sci 2012 Mar 24;3(3):772-777. Epub 2011 Nov 24.

Department of Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.

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March 2012

Fluorosugar chain termination agents as probes of the sequence specificity of a carbohydrate polymerase.

J Am Chem Soc 2012 Apr 10;134(15):6552-5. Epub 2012 Apr 10.

Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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April 2012

An asymmetric synthesis of L-pyrrolysine.

Org Lett 2012 Mar 6;14(6):1378-81. Epub 2012 Mar 6.

Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.

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March 2012

A processive carbohydrate polymerase that mediates bifunctional catalysis using a single active site.

Biochemistry 2012 Feb 3;51(6):1148-59. Epub 2012 Feb 3.

Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706-1544, United States.

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February 2012

Small-molecule-modified surfaces engage cells through the αvβ3 integrin.

ACS Chem Biol 2012 Mar 26;7(3):518-25. Epub 2012 Jan 26.

Cell and Molecular Biology Program, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.

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March 2012

Monitoring processivity and length control of a carbohydrate polymerase.

J Am Chem Soc 2011 Aug 25;133(32):12758-66. Epub 2011 Jul 25.

Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.

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August 2011

Spatial control of cell fate using synthetic surfaces to potentiate TGF-beta signaling.

Proc Natl Acad Sci U S A 2011 Jul 30;108(29):11745-50. Epub 2011 Jun 30.

Department of Chemistry, Graduate University of Wisconsin, Madison, WI 53706, USA.

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July 2011

Glycomimetic building blocks: a divergent synthesis of epimers of shikimic acid.

Org Lett 2011 Aug 28;13(15):3790-3. Epub 2011 Jun 28.

Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, USA.

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August 2011

Protein footprinting in a complex milieu: identifying the interaction surfaces of the chemotaxis adaptor protein CheW.

J Mol Biol 2011 Jun 2;409(4):483-95. Epub 2011 Apr 2.

Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.

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June 2011

A defined glycosaminoglycan-binding substratum for human pluripotent stem cells.

Nat Methods 2010 Dec 14;7(12):989-94. Epub 2010 Nov 14.

Cell and Molecular Biology Program, University of Wisconsin-Madison, Madison, Wisconsin, USA.

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December 2010

Classifying chemoreceptors: quantity versus quality.

EMBO J 2010 Oct;29(20):3435-6

Department of Biochemistry, University of Wisconsin, Madison, WI, USA.

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October 2010

Peptide ligands that use a novel binding site to target both TGF-β receptors.

Mol Biosyst 2010 Dec 4;6(12):2392-402. Epub 2010 Oct 4.

Department of Chemistry and Biochemistry, University of Wisconsin, Madison, WI 53706, USA.

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December 2010

A general glycomimetic strategy yields non-carbohydrate inhibitors of DC-SIGN.

Chem Commun (Camb) 2010 Sep 18;46(36):6747-9. Epub 2010 Aug 18.

Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706, USA.

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September 2010

Unexpected enhancement in biological activity of a GPCR ligand induced by an oligoethylene glycol substituent.

J Am Chem Soc 2010 Jul;132(26):8844-5

Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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July 2010

Synthesis of galactofuranose-based acceptor substrates for the study of the carbohydrate polymerase GlfT2.

Bioorg Med Chem 2010 Jun 28;18(11):3753-9. Epub 2010 Apr 28.

Department of Chemistry, University of Wisconsin, Madison, WI 53706, USA.

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June 2010

Chemical approaches to glycobiology.

Annu Rev Biochem 2010 ;79:619-53

Department of Chemistry, University of Wisconsin-Madison, Wisconsin 53706, USA.

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June 2010

ROMP from ROMP: A New Approach to Graft Copolymer Synthesis.

Macromolecules 2009 Jun;42(12):4023-4027

Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706.

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June 2009

High-throughput discovery of synthetic surfaces that support proliferation of pluripotent cells.

J Am Chem Soc 2010 Feb;132(4):1289-95

Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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February 2010

X-ray crystallography reveals a reduced substrate complex of UDP-galactopyranose mutase poised for covalent catalysis by flavin.

Biochemistry 2009 Oct;48(39):9171-3

Department of Biochemistry, National Magnetic Resonance Facility at Madison, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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October 2009

A tethering mechanism for length control in a processive carbohydrate polymerization.

Proc Natl Acad Sci U S A 2009 Jul 1;106(29):11851-6. Epub 2009 Jul 1.

Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA.

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July 2009

Ligand binding and substrate discrimination by UDP-galactopyranose mutase.

J Mol Biol 2009 Aug 3;391(2):327-40. Epub 2009 Jun 3.

Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706-1544, USA.

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August 2009

General synthetic route to cell-permeable block copolymers via ROMP.

J Am Chem Soc 2009 Jun;131(21):7327-33

Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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June 2009

Structure-based design of a periplasmic binding protein antagonist that prevents domain closure.

ACS Chem Biol 2009 Jun;4(6):447-56

Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.

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June 2009

Sialylated multivalent antigens engage CD22 in trans and inhibit B cell activation.

Proc Natl Acad Sci U S A 2009 Feb 6;106(8):2500-5. Epub 2009 Feb 6.

Departments of Biochemistry and Chemistry, University of Wisconsin, Madison, WI 53706, USA.

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February 2009

Potent ligands for prokaryotic UDP-galactopyranose mutase that exploit an enzyme subsite.

Org Lett 2009 Jan;11(1):193-6

Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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January 2009

Isotope-coded affinity tags with tunable reactivities for protein footprinting.

Angew Chem Int Ed Engl 2008 ;47(50):9677-80

Departments of Chemistry and Biochemistry, University of Wisconsin, Madison, Madison, WI 53706 (USA), Fax: (+1) 608-265-0764.

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December 2008

Synthesis of fluorogenic polymers for visualizing cellular internalization.

Org Lett 2008 Jul 19;10(14):2997-3000. Epub 2008 Jun 19.

Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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July 2008

Inhibitors of UDP-galactopyranose mutase thwart mycobacterial growth.

J Am Chem Soc 2008 May 1;130(21):6706-7. Epub 2008 May 1.

Departments of Chemistry and Biochemistry, University of WisconsinMadison, Madison, Wisconsin 53706, USA.

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May 2008

A polymeric domain that promotes cellular internalization.

J Am Chem Soc 2008 Apr 8;130(17):5626-7. Epub 2008 Apr 8.

Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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April 2008

Chemical probes of bacterial signal transduction reveal that repellents stabilize and attractants destabilize the chemoreceptor array.

ACS Chem Biol 2008 Feb;3(2):101-9

Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.

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February 2008

Non-carbohydrate inhibitors of the lectin DC-SIGN.

J Am Chem Soc 2007 Oct 29;129(42):12780-5. Epub 2007 Sep 29.

Department of Biochemistry and Chemistry, University of Wisconsin, Madison, WI 53706, USA.

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October 2007

Solid-phase synthesis of alkanethiols for the preparation of self-assembled monolayers.

Langmuir 2007 Oct 20;23(22):11164-7. Epub 2007 Sep 20.

Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.

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October 2007

Defined substrates for human embryonic stem cell growth identified from surface arrays.

ACS Chem Biol 2007 May 4;2(5):347-55. Epub 2007 May 4.

Department of Chemistry, 1101 University Avenue, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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May 2007

Conformational changes of glucose/galactose-binding protein illuminated by open, unliganded, and ultra-high-resolution ligand-bound structures.

Protein Sci 2007 Jun 1;16(6):1032-41. Epub 2007 May 1.

Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.

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June 2007

Activating B cell signaling with defined multivalent ligands.

ACS Chem Biol 2007 Apr;2(4):252-62

Department of Biochemistry,University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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April 2007

Selective tumor cell targeting using low-affinity, multivalent interactions.

ACS Chem Biol 2007 Feb 26;2(2):119-27. Epub 2007 Feb 26.

Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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February 2007

Symbiosis: Chemical biology at Wisconsin.

ACS Chem Biol 2006 Sep;1(8):481-4

Department of Biochemistry and Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, USA.

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September 2006

Fostering major breakthroughs.

ACS Chem Biol 2006 Feb;1(1):1-2

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February 2006

Bifunctional ligands that target cells displaying the alpha v beta3 integrin.

Chembiochem 2007 Jan;8(1):68-82

Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.

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January 2007

Phage display affords peptides that modulate beta-amyloid aggregation.

J Am Chem Soc 2006 Sep;128(36):11882-9

Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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September 2006

Chemical probes of UDP-galactopyranose mutase.

Chem Biol 2006 Aug;13(8):825-37

Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.

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August 2006

N-acylsulfonamide linker activation by Pd-catalyzed allylation.

Org Lett 2006 Jun;8(12):2483-5

Departments of Chemistry and Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.

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June 2006

Contrast agents for magnetic resonance imaging synthesized with ring-opening metathesis polymerization.

J Am Chem Soc 2006 May;128(20):6534-5

Department of Chemistry , University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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May 2006

Synthetic multivalent ligands as probes of signal transduction.

Angew Chem Int Ed Engl 2006 Apr;45(15):2348-68

Department of Chemistry, University of Wisconsin--Madison, 1101 University Ave., Madison, WI 53706, USA.

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April 2006

Solid-phase synthesis of polymers using the ring-opening metathesis polymerization.

J Am Chem Soc 2005 Oct;127(42):14536-7

Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.

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October 2005