Laura J Niedernhofer

Laura J Niedernhofer

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Laura J Niedernhofer

Laura J Niedernhofer

Publications by authors named "Laura J Niedernhofer"

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Creating the Next Generation of Translational Geroscientists.

J Am Geriatr Soc 2019 Sep 9;67(9):1934-1939. Epub 2019 Jul 9.

Robert and Arlene Kogod Center on Aging and the Division of Geriatric Medicine and Gerontology, Department of Medicine, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1111/jgs.16055DOI Listing
September 2019

Mouse Models of Accelerated Cellular Senescence.

Methods Mol Biol 2019 ;1896:203-230

Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.

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http://link.springer.com/10.1007/978-1-4939-8931-7_17
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http://dx.doi.org/10.1007/978-1-4939-8931-7_17DOI Listing
August 2019

Methods to Quantify the NF-κB Pathway During Senescence.

Methods Mol Biol 2019 ;1896:231-250

Department of Molecular Medicine and Center on Aging, The Scripps Research Institute, Jupiter, FL, USA.

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http://link.springer.com/10.1007/978-1-4939-8931-7_18
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http://dx.doi.org/10.1007/978-1-4939-8931-7_18DOI Listing
August 2019

Murine models of accelerated aging and musculoskeletal disease.

Bone 2019 Aug 4;125:122-127. Epub 2019 Mar 4.

Institute on the Biology of Aging and Metabolism, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, United States of America; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2019.03.002DOI Listing
August 2019

Signal Transduction, Ageing and Disease.

Subcell Biochem 2019;91:227-247

Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.1007/978-981-13-3681-2_9DOI Listing
June 2019

Oxidative stress-induced senescence markedly increases disc cell bioenergetics.

Mech Ageing Dev 2019 06 17;180:97-106. Epub 2019 Apr 17.

Department of Orthopedic Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA, 15213, USA; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, 15213, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00476374183019
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http://dx.doi.org/10.1016/j.mad.2019.04.006DOI Listing
June 2019

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs.

J Vis Exp 2019 Jun 28(148). Epub 2019 Jun 28.

Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota; Institute on the Biology of Aging and Metabolism, University of Minnesota;

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http://dx.doi.org/10.3791/58133DOI Listing
June 2019

Measuring biological age in mice using differential mass spectrometry.

Aging (Albany NY) 2019 Feb;11(3):1045-1061

Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.18632/aging.101810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382423PMC
February 2019

Cellular senescence in intervertebral disc aging and degeneration.

Curr Mol Biol Rep 2018 Dec 25;4(4):180-190. Epub 2018 Oct 25.

Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

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http://link.springer.com/10.1007/s40610-018-0108-8
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http://dx.doi.org/10.1007/s40610-018-0108-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248341PMC
December 2018

Modeling Alzheimer's disease in progeria mice. An age-related concept.

Pathobiol Aging Age Relat Dis 2018 4;8(1):1524815. Epub 2018 Oct 4.

Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1080/20010001.2018.1524815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179061PMC
October 2018

Oxidation Products of 5-Methylcytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice.

J Gerontol A Biol Sci Med Sci 2018 07;73(8):1003-1009

Department of Clinical Biochemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.

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http://dx.doi.org/10.1093/gerona/gly012DOI Listing
July 2018

Hsp90 inhibitors as senolytic drugs to extend healthy aging.

Cell Cycle 2018 23;17(9):1048-1055. Epub 2018 Jul 23.

a Department of Molecular Medicine and The Center on Aging , The Scripps Research Institute , Jupiter , FL , USA.

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http://dx.doi.org/10.1080/15384101.2018.1475828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110594PMC
July 2018

Neurodegeneration as the presenting symptom in 2 adults with xeroderma pigmentosum complementation group F.

Neurol Genet 2018 Jun 8;4(3):e240. Epub 2018 Jun 8.

Department of Neurology (N.M.S., M.D.G.), University of California San Francisco, CA; Laboratory of Cancer Biology and Genetics (J.J.D., K.H.K.), Center for Cancer Research, National Cancer Institute, National Institutes of Health; NIH Undiagnosed Diseases Program (C.G., R.G., M.C.V.M., W.A.G., C.T.), National Human Genome Research Institute, National Institutes of Health, Bethesda, MD; and Department of Molecular Medicine (M.J.Y., E.A.W., L.J.N.), Center on Aging, The Scripps Research Institute, Jupiter, FL.

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http://dx.doi.org/10.1212/NXG.0000000000000240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994703PMC
June 2018

Nuclear Genomic Instability and Aging.

Annu Rev Biochem 2018 06;87:295-322

Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute Florida, Jupiter, Florida 33458, USA; email:

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http://dx.doi.org/10.1146/annurev-biochem-062917-012239DOI Listing
June 2018

Senotherapeutics for healthy ageing.

Nat Rev Drug Discov 2018 05 13;17(5):377. Epub 2018 Apr 13.

Department of Molecular Medicine and The Center on Aging, The Scripps Research Institute, Jupiter, FL, USA.

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http://dx.doi.org/10.1038/nrd.2018.44DOI Listing
May 2018

ADAMTS5 Deficiency Protects Mice From Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration.

Spine (Phila Pa 1976) 2017 Oct;42(20):1521-1528

*Department of Orthopedic Surgery, University of Pittsburgh School of Medicine, PA †Department of Medicine, University of Pittsburgh School of Medicine, PA ‡Department of Environmental and Occupational Health, University of Pittsburgh, PA §McGill Scoliosis and Spine Group, Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, Canada ¶Department of Metabolism & Aging, The Scripps Research Institute, FL ||Department of Physical Medicine and Rehabilitation, University of Pittsburgh, PA **Department of Orthopedic Surgery, Harvard Medical School, Brigham and Women's Hospital, MA.

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http://dx.doi.org/10.1097/BRS.0000000000002258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633483PMC
October 2017

The Clinical Potential of Senolytic Drugs.

J Am Geriatr Soc 2017 Oct 4;65(10):2297-2301. Epub 2017 Sep 4.

Department of Molecular Medicine and the Center on Aging, Scripps Research Institute, Jupiter, Florida.

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http://dx.doi.org/10.1111/jgs.14969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641223PMC
October 2017

Inhibition of NF-κB improves the stress resistance and myogenic differentiation of MDSPCs isolated from naturally aged mice.

PLoS One 2017 22;12(6):e0179270. Epub 2017 Jun 22.

Department of Orthopaedic Surgery, Institute of Molecular Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179270PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480862PMC
September 2017

Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype.

Mech Ageing Dev 2017 09 19;166:16-23. Epub 2017 Aug 19.

Department of Orthopaedic Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mad.2017.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632945PMC
September 2017

Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2 Scripps Symposium on the Biology of Aging.

Aging Cell 2017 08 6;16(4):610-614. Epub 2017 Jun 6.

Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL, 33458, USA.

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http://doi.wiley.com/10.1111/acel.12620
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http://dx.doi.org/10.1111/acel.12620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506446PMC
August 2017

Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism.

Aging Cell 2017 06 23;16(3):480-487. Epub 2017 Feb 23.

Department of Metabolism and Aging, The Scripps Research Institute-Florida, Jupiter, FL, 33458, USA.

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http://dx.doi.org/10.1111/acel.12571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418207PMC
June 2017

Quantitative Analysis of Cellular Senescence in Culture and In Vivo.

Curr Protoc Cytom 2017 01 5;79:9.51.1-9.51.25. Epub 2017 Jan 5.

Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, Florida.

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http://dx.doi.org/10.1002/cpcy.16DOI Listing
January 2017

Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage.

Chem Res Toxicol 2016 12 7;29(12):2008-2039. Epub 2016 Nov 7.

Department of Metabolism and Aging, The Scripps Research Institute Florida , Jupiter, Florida 33458, United States.

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http://dx.doi.org/10.1021/acs.chemrestox.6b00265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614522PMC
December 2016

Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms.

J Gerontol A Biol Sci Med Sci 2016 11 16;71(11):1388-1394. Epub 2016 Aug 16.

Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055650PMC
http://dx.doi.org/10.1093/gerona/glw112DOI Listing
November 2016

NF-κB activation with aging: characterization and therapeutic inhibition.

Methods Mol Biol 2015 ;1280:543-57

Department of Metabolism and Aging, The Scripps Research Institute, 130 Scripps Way, #3B3, Jupiter, FL, 33458, USA.

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http://dx.doi.org/10.1007/978-1-4939-2422-6_32DOI Listing
November 2015

In vivo detection and replication studies of α-anomeric lesions of 2'-deoxyribonucleosides.

Nucleic Acids Res 2015 Sep 21;43(17):8314-24. Epub 2015 Jul 21.

Department of Chemistry, University of California, Riverside, CA 92521, USA

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http://dx.doi.org/10.1093/nar/gkv725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787794PMC
September 2015

Comparison of mice with accelerated aging caused by distinct mechanisms.

Exp Gerontol 2015 Aug 21;68:43-50. Epub 2015 Jan 21.

Department of Metabolism and Aging, Scripps Florida, 130 Scripps Way #3B3, Jupiter, FL 33458, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S05315565150004
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http://dx.doi.org/10.1016/j.exger.2015.01.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464936PMC
August 2015

Tet-mediated formation of 5-hydroxymethylcytosine in RNA.

J Am Chem Soc 2014 Aug 7;136(33):11582-5. Epub 2014 Aug 7.

Environmental Toxicology Graduate Program and ‡Department of Chemistry, University of California , Riverside, California 92521, United States.

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http://dx.doi.org/10.1021/ja505305zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140497PMC
August 2014

Choline phosphate cytidylyltransferase-α is a novel antigen detected by the anti-ERCC1 antibody 8F1 with biomarker value in patients with lung and head and neck squamous cell carcinomas.

Cancer 2014 Jun 1;120(12):1898-907. Epub 2014 Apr 1.

Department of Otolaryngology and Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania; Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1002/cncr.28643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047200PMC
June 2014

Investigating the role of DNA damage in tobacco smoking-induced spine degeneration.

Spine J 2014 Mar 6;14(3):416-23. Epub 2013 Nov 6.

Department of Orthopaedic Surgery, Ferguson Laboratory for Orthopaedic Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. Electronic address:

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http://dx.doi.org/10.1016/j.spinee.2013.08.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944725PMC
March 2014

Pharmacologic IKK/NF-κB inhibition causes antigen presenting cells to undergo TNFα dependent ROS-mediated programmed cell death.

Sci Rep 2014 Jan 10;4:3631. Epub 2014 Jan 10.

1] Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219 [2] Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, Florida 33458.

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http://dx.doi.org/10.1038/srep03631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887388PMC
January 2014

Age-related dystrophic changes in corneal endothelium from DNA repair-deficient mice.

Aging Cell 2013 Dec 1;12(6):1122-31. Epub 2013 Sep 1.

Department of Ophthalmology, University of Pittsburgh School of Medicine, 203 Lothrop St., Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1111/acel.12143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116745PMC
December 2013

DNA damage triggers a chronic autoinflammatory response, leading to fat depletion in NER progeria.

Cell Metab 2013 Sep;18(3):403-15

Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 70013 Heraklion, Crete, Greece; Department of Biology, University of Crete, 71409 Heraklion, Crete, Greece.

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http://dx.doi.org/10.1016/j.cmet.2013.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116679PMC
September 2013

Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs.

Mech Ageing Dev 2013 Jan-Feb;134(1-2):35-42. Epub 2012 Dec 19.

Ferguson Laboratory for Orthopaedic Research, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1016/j.mad.2012.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558562PMC
July 2013

Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration.

J Orthop Res 2013 Jul 6;31(7):1150-7. Epub 2013 Feb 6.

Ferguson Laboratory for Orthopaedic Research, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

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http://dx.doi.org/10.1002/jor.22320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668354PMC
July 2013

Isolation of muscle-derived stem/progenitor cells based on adhesion characteristics to collagen-coated surfaces.

Methods Mol Biol 2013 ;976:53-65

Department of Orthopaedic Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1007/978-1-62703-317-6_5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731996PMC
July 2013

An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints.

J Orthop Res 2013 Jun 11;31(6):831-7. Epub 2013 Mar 11.

Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, E1641 Biomedical Science Tower, Pittsburgh, Pennsylvania 15261, USA.

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http://dx.doi.org/10.1002/jor.22204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628921PMC
June 2013

Identification of microRNAs dysregulated in cellular senescence driven by endogenous genotoxic stress.

Aging (Albany NY) 2013 Jun;5(6):460-73

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824412PMC
http://dx.doi.org/10.18632/aging.100571DOI Listing
June 2013

DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism.

J Bone Miner Res 2013 May;28(5):1214-28

Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1002/jbmr.1851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662975PMC
May 2013

Cell autonomous and nonautonomous mechanisms drive hematopoietic stem/progenitor cell loss in the absence of DNA repair.

Stem Cells 2013 Mar;31(3):511-25

University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1002/stem.1261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582850PMC
March 2013

ERCC1 and XRCC1 as biomarkers for lung and head and neck cancer.

Pharmgenomics Pers Med 2011 20;4:47-63. Epub 2011 Jul 20.

Department of Otolaryngology and Head and Neck Surgery, University of Pittsburgh School of Medicine ; University of Pittsburgh Cancer Institute.

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http://dx.doi.org/10.2147/PGPM.S20317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513219PMC
December 2012

A quantitative assay for assessing the effects of DNA lesions on transcription.

Nat Chem Biol 2012 Oct;8(10):817-22

Department of Chemistry, University of California-Riverside, Riverside, CA, USA

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http://dx.doi.org/10.1038/nchembio.1046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509257PMC
October 2012

The oxidative DNA lesions 8,5'-cyclopurines accumulate with aging in a tissue-specific manner.

Aging Cell 2012 Aug 22;11(4):714-6. Epub 2012 May 22.

Department of Chemistry, University of California, Riverside, CA 92521-0403, USA.

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http://dx.doi.org/10.1111/j.1474-9726.2012.00828.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399950PMC
August 2012

Endogenous formation and repair of oxidatively induced G[8-5 m]T intrastrand cross-link lesion.

Nucleic Acids Res 2012 Aug 11;40(15):7368-74. Epub 2012 May 11.

Department of Chemistry, University of California, Riverside, CA 92521-0403, USA.

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http://dx.doi.org/10.1093/nar/gks357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424544PMC
August 2012

Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair.

J Biol Chem 2012 Jun 30;287(26):21846-55. Epub 2012 Apr 30.

Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, USA.

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http://dx.doi.org/10.1074/jbc.M111.337899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381147PMC
June 2012

NF-κB negatively impacts the myogenic potential of muscle-derived stem cells.

Mol Ther 2012 Mar 13;20(3):661-8. Epub 2011 Dec 13.

Stem Cell Research Center, School of Medicine and Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA.

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http://dx.doi.org/10.1038/mt.2011.261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293604PMC
March 2012

Downregulation of cholesterol biosynthesis genes in the forebrain of ERCC1-deficient mice.

Neurobiol Dis 2012 Mar 29;45(3):1136-44. Epub 2011 Dec 29.

Kentucky Spinal Cord Injury Research Center and Department of Neurological Surgery, University of Louisville School of Medicine, 511 S. Floyd St., Louisville, KY 40202, USA.

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http://dx.doi.org/10.1016/j.nbd.2011.12.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345809PMC
March 2012

Xeroderma pigmentosum and other diseases of human premature aging and DNA repair: molecules to patients.

Mech Ageing Dev 2011 Jun-Jul;132(6-7):340-7. Epub 2011 Jun 25.

University of Pittsburgh, Pittsburgh, PA, United States.

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http://dx.doi.org/10.1016/j.mad.2011.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474983PMC
December 2011

NF-κB in Aging and Disease.

Aging Dis 2011 Dec 2;2(6):449-65. Epub 2011 Dec 2.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295063PMC
December 2011

Premature aging-related peripheral neuropathy in a mouse model of progeria.

Mech Ageing Dev 2011 Aug 11;132(8-9):437-42. Epub 2011 May 11.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, PA 15213-1863, USA.

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http://dx.doi.org/10.1016/j.mad.2011.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179831PMC
August 2011

XPF expression correlates with clinical outcome in squamous cell carcinoma of the head and neck.

Clin Cancer Res 2011 Aug 7;17(16):5513-22. Epub 2011 Jul 7.

Departments of Otolaryngology and Head and Neck Surgery, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, PA 15213, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-0086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156890PMC
August 2011

Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease.

DNA Repair (Amst) 2011 Jul 25;10(7):781-91. Epub 2011 May 25.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.

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http://dx.doi.org/10.1016/j.dnarep.2011.04.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139823PMC
July 2011

Dedifferentiation rescues senescence of progeria cells but only while pluripotent.

Stem Cell Res Ther 2011 Jun 1;2(3):28. Epub 2011 Jun 1.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, 523 Bridgeside Point II, 450 Technology Drive, Pittsburgh, PA 15219, USA.

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http://dx.doi.org/10.1186/scrt69DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152996PMC
June 2011

Bupivacaine decreases cell viability and matrix protein synthesis in an intervertebral disc organ model system.

Spine J 2011 Feb;11(2):139-46

Ferguson Laboratory for Orthopaedic Research, Department of Orthopaedic Surgery, University of Pittsburgh, 200 Lothrop St, E1641 Biomedical Science Tower, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1016/j.spinee.2010.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056334PMC
February 2011

Accelerated aging of intervertebral discs in a mouse model of progeria.

J Orthop Res 2010 Dec;28(12):1600-7

Ferguson Laboratory for Orthopaedic Research, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

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http://dx.doi.org/10.1002/jor.21153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477798PMC
December 2010

Hyper telomere recombination accelerates replicative senescence and may promote premature aging.

Proc Natl Acad Sci U S A 2010 Sep 23;107(36):15768-73. Epub 2010 Aug 23.

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, 80523-1618, USA.

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http://dx.doi.org/10.1073/pnas.1006338107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936608PMC
September 2010

Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients.

PLoS Genet 2010 Mar 5;6(3):e1000871. Epub 2010 Mar 5.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832669PMC
March 2010

The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways.

J Biol Chem 2010 Feb 23;285(6):3705-12. Epub 2009 Nov 23.

Department of Pharmacological Sciences and Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, USA.

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http://dx.doi.org/10.1074/jbc.M109.067538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823511PMC
February 2010

XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.

Mol Cell Biol 2009 Dec 5;29(24):6427-37. Epub 2009 Oct 5.

Department of Human Genetics, University of Pittsburgh School of Public Health, A300 Crabtree Hall, 130 Desoto St., Pittsburgh, Pennsylvania 152611, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.00086-09
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http://dx.doi.org/10.1128/MCB.00086-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786876PMC
December 2009

Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue.

Cancer Res 2009 Sep;69(17):6831-8

Department of Human Genetics, University of Pittsburgh School of Public Health, PA, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-1237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739111PMC
September 2009

Mouse models of Fanconi anemia.

Mutat Res 2009 Jul 10;668(1-2):133-40. Epub 2009 Apr 10.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00275107090011
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http://dx.doi.org/10.1016/j.mrfmmm.2009.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778466PMC
July 2009

Tissue-specific accelerated aging in nucleotide excision repair deficiency.

Mech Ageing Dev 2008 Jul-Aug;129(7-8):408-15. Epub 2008 May 1.

Department of Microbiology and Molecular Genetics, UP Cancer Institute, University of Pittsburgh School of Medicine, 5117 Centre Avenue, Pittsburgh, PA 15213, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S004763740800103
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http://dx.doi.org/10.1016/j.mad.2008.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518655PMC
September 2008

ERCC1-XPF endonuclease facilitates DNA double-strand break repair.

Mol Cell Biol 2008 Aug 9;28(16):5082-92. Epub 2008 Jun 9.

University of Pittsburgh Cancer Institute, Hillman Cancer Center, Research Pavilion 2.6, 5117 Centre Avenue, Pittsburgh, Pennsylvania 15213-1863, USA.

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http://dx.doi.org/10.1128/MCB.00293-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519706PMC
August 2008

Nucleotide excision repair deficient mouse models and neurological disease.

DNA Repair (Amst) 2008 Jul 12;7(7):1180-9. Epub 2008 Feb 12.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Hillman Cancer Center, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1016/j.dnarep.2007.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474780PMC
July 2008

Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan.

Int J Biochem Cell Biol 2008 13;40(2):176-80. Epub 2007 Oct 13.

Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, PA 15213, USA.

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http://dx.doi.org/10.1016/j.biocel.2007.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192627PMC
March 2008

DNA repair is crucial for maintaining hematopoietic stem cell function.

DNA Repair (Amst) 2008 Mar 8;7(3):523-9. Epub 2008 Jan 8.

Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1016/j.dnarep.2007.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731414PMC
March 2008

ERCC1 and non-small-cell lung cancer.

N Engl J Med 2007 Jun;356(24):2538-40; author reply 2540-1

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http://dx.doi.org/10.1056/NEJMc070742DOI Listing
June 2007

The Fanconi anemia signalosome anchor.

Mol Cell 2007 Feb;25(4):487-90

Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine and Cancer Institute, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1016/j.molcel.2007.02.002DOI Listing
February 2007