Publications by authors named "Laura E MacConaill"

58Publications

ViroPanel: Hybrid Capture and Massively Parallel Sequencing for Simultaneous Detection and Profiling of Oncogenic Virus Infection and Tumor Genome.

J Mol Diagn 2020 04 15;22(4):476-487. Epub 2020 Feb 15.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2019.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193840PMC
April 2020

Endometrial cancer with an rearrangement.

Cold Spring Harb Mol Case Stud 2018 08 1;4(4). Epub 2018 Aug 1.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1101/mcs.a003020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071573PMC
August 2018

Validation of a targeted next-generation sequencing approach to detect mismatch repair deficiency in colorectal adenocarcinoma.

Mod Pathol 2018 12 28;31(12):1882-1890. Epub 2018 Jun 28.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41379-018-0091-xDOI Listing
December 2018

Somatic mutations in and in primary carcinomas at 13 anatomic sites.

Oncotarget 2017 Oct 21;8(49):85680-85691. Epub 2017 Sep 21.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

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http://www.oncotarget.com/fulltext/21115
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http://dx.doi.org/10.18632/oncotarget.21115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689640PMC
October 2017

Validation of OncoPanel: A Targeted Next-Generation Sequencing Assay for the Detection of Somatic Variants in Cancer.

Arch Pathol Lab Med 2017 Jun 3;141(6):751-758. Epub 2017 Mar 3.

From the Center for Advanced Molecular Diagnostics, Brigham and Women's Hospital (Drs Garcia, Minkovsky, Jia, Ligon, Sholl, Kuo, MacConaill, Lindeman, and Dong, Messrs Ducar and Gong, and Ms. Shivdasani), and the Center for Cancer Genome Discovery, Dana Farber Cancer Institute (Mr Ducar and Dr MacConaill), Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.5858/arpa.2016-0527-OADOI Listing
June 2017

Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors.

Neuro Oncol 2017 Jul;19(7):986-996

Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Department of Pathology, Department of Radiology, Department of Neurosurgery, Boston Children's Hospital, Boston, Massachusetts; Department of Medical Oncology, Oncologic Pathology, Department of Pediatric Oncology, Department of Cancer Biology, Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts; Department of Pathology, Department of Neurosurgery, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Pratiti Bandopadhayay, Broad Institute of MIT and Harvard, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1093/neuonc/now294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570190PMC
July 2017

KRAS and NKX2-1 Mutations in Invasive Mucinous Adenocarcinoma of the Lung.

J Thorac Oncol 2016 Apr 30;11(4):496-503. Epub 2016 Jan 30.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2016.01.010DOI Listing
April 2016

Brave-ish New World--What's Needed to Make Precision Oncology a Practical Reality.

JAMA Oncol 2015 Oct;1(7):879-80

Havard Medical School, Boston, Massachusetts3Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamaoncol.2015.1540DOI Listing
October 2015

MAP2K1 and MAP3K1 mutations in Langerhans cell histiocytosis.

Genes Chromosomes Cancer 2015 Jun 31;54(6):361-8. Epub 2015 Mar 31.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.

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http://dx.doi.org/10.1002/gcc.22247DOI Listing
June 2015

BreaKmer: detection of structural variation in targeted massively parallel sequencing data using kmers.

Nucleic Acids Res 2015 Feb 26;43(3):e19. Epub 2014 Nov 26.

Center for Cancer Genome Discovery and Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA Department of Pathology, Brigham and Women's Hospital, Boston, MA 02215, USA

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http://dx.doi.org/10.1093/nar/gku1211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330340PMC
February 2015

Role of BRAFV600E in the first preclinical model of multifocal infiltrating myopericytoma development and microenvironment.

J Natl Cancer Inst 2014 Aug 25;106(8). Epub 2014 Jul 25.

Department of Pathology, Massachusetts General Hospital (PMS) and Department of Medicine, Brigham and Women's Hospital (CP, EPH), Harvard Medical School, Boston, MA; Unit of Endocrinology, Department of Medicine, A. Gemelli, Catholic University, Roma, Italy (SN, AP); Division of Cancer Genetics, Department of Medicine (FAK, JC, PPP) and Laboratory of Human Thyroid Cancers Preclinical and Translational Research, Division of Cancer Biology and Angiogenesis, Department of Pathology, Center for Vascular Biology Research (MD, CN), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Medicine (RM, CVC) and Department of Pathology (AH, HD, JL), Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, MA; Dermatopathologische Gemeinschaftspraxis, Siemensstrasse, Friedri chshafen, Germany (HK, TM); National Research Council (CNR-IBCN) and Department of Experimental Oncology, Regina Elena Cancer Institute, Rome, Italy (AF); Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA (EP, LEM); MIT/Broad Institute, Cambridge, MA (EP, LEM); Department of Plastic and Reconstructive Surgery, National Health Insurance Service Ilsan Hospital, Ilsan, Korea (SC); Department of Pathology (GF) and Department of Surgery (CPL), A. Gemelli, Catholic University, Roma, Italy; Department of Experimental and Clinical Medicine (AMDA) and Unit of Radiotherapy (OD), University of Catanzaro, Italy; Department of Nuclear Medicine, Beth Israel Deaconess Medical Center (JAP); Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (CF).

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http://dx.doi.org/10.1093/jnci/dju182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155429PMC
August 2014

Analysis and comparison of somatic mutations in paired primary and recurrent epithelial ovarian cancer samples.

PLoS One 2014 17;9(6):e99451. Epub 2014 Jun 17.

Department of Pathology, University of Ulsan, ASAN Medical Center, Seoul, Korea; ASAN Center for Cancer Genome Discovery, ASAN Medical Center, Seoul, Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099451PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060993PMC
February 2015

Somatic activating ARAF mutations in Langerhans cell histiocytosis.

Blood 2014 May 20;123(20):3152-5. Epub 2014 Mar 20.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA; Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA;

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http://dx.doi.org/10.1182/blood-2013-06-511139DOI Listing
May 2014

Colorectal cancers from distinct ancestral populations show variations in BRAF mutation frequency.

PLoS One 2013 16;8(9):e74950. Epub 2013 Sep 16.

Center for Cancer Genome Discovery, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, United States of America ; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, United States of America ; The Broad Institute, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074950PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774610PMC
May 2014

Oncogenic mutations in cervical cancer: genomic differences between adenocarcinomas and squamous cell carcinomas of the cervix.

Cancer 2013 Nov 23;119(21):3776-83. Epub 2013 Aug 23.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts; Centers for Outcomes and Policy Research and Psychosocial Epidemiology and Outcomes Research, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cncr.28288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972000PMC
November 2013

Existing and emerging technologies for tumor genomic profiling.

J Clin Oncol 2013 May 15;31(15):1815-24. Epub 2013 Apr 15.

Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, 44 Binney St, Dana 1539, Boston, MA 02115, USA.

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http://dx.doi.org/10.1200/JCO.2012.46.5948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808234PMC
May 2013

Advancing personalized cancer medicine in lung cancer.

Arch Pathol Lab Med 2012 Oct;136(10):1210-6

Department of Pathology, Brigham and Women's Hospital, 450 Brookline Ave., Dana 1539, Boston, MA 02215, USA.

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http://dx.doi.org/10.5858/arpa.2012-0244-SADOI Listing
October 2012

Absence of oncogenic canonical pathway mutations in aggressive pediatric rhabdoid tumors.

Pediatr Blood Cancer 2012 Dec 19;59(7):1155-7. Epub 2012 Sep 19.

Director, Pediatric Medical Neuro-Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Pediatric Hematology/Oncology, Boston, MA 02215, USA.

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http://dx.doi.org/10.1002/pbc.24315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538080PMC
December 2012

High throughput mass spectrometry-based mutation profiling of primary uveal melanoma.

Invest Ophthalmol Vis Sci 2012 Oct 9;53(11):6991-6. Epub 2012 Oct 9.

Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114-3096, USA.

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http://dx.doi.org/10.1167/iovs.12-10427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471553PMC
October 2012

Integrating multiple social statuses in health disparities research: the case of lung cancer.

Health Serv Res 2012 Jun 30;47(3 Pt 2):1255-77. Epub 2012 Mar 30.

Department of Society, Human Development and Health, Harvard University, School of Public Health, 677 Huntington Avenue, 6th Floor, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1111/j.1475-6773.2012.01404.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418828PMC
June 2012

Clinical implementation of comprehensive strategies to characterize cancer genomes: opportunities and challenges.

Cancer Discov 2011 Sep;1(4):297-311

Center for Cancer Genome Discovery, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-11-0110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175123PMC
September 2011

Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma.

BMC Cancer 2011 Feb 8;11:60. Epub 2011 Feb 8.

Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1186/1471-2407-11-60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045359PMC
February 2011

Clinical implications of the cancer genome.

J Clin Oncol 2010 Dec 25;28(35):5219-28. Epub 2010 Oct 25.

Center for Cancer Genome Discovery, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1200/JCO.2009.27.4944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020694PMC
December 2010

Toward accurate high-throughput SNP genotyping in the presence of inherited copy number variation.

BMC Genomics 2007 Jul 3;8:211. Epub 2007 Jul 3.

Dana-Farber Cancer Institute, Boston, Massachusetts 02116, USA.

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http://dx.doi.org/10.1186/1471-2164-8-211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1934372PMC
July 2007

Phosphorylation of the menin tumor suppressor protein on serine 543 and serine 583.

Mol Cancer Res 2006 Oct;4(10):793-801

Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney St., Boston, MA 02115, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-06-0123DOI Listing
October 2006

Investigation of protein export in Bifidobacterium breve UCC2003.

Appl Environ Microbiol 2003 Dec;69(12):6994-7001

Alimentary Pharmabiotic Centre, National University of Ireland, Cork, Cork, Ireland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC309956PMC
http://dx.doi.org/10.1128/aem.69.12.6994-7001.2003DOI Listing
December 2003