Laura De Luca

Laura De Luca

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Laura De Luca

Laura De Luca

Publications by authors named "Laura De Luca"

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Exploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile.

Eur J Med Chem 2019 Sep 6;178:380-389. Epub 2019 Jun 6.

Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, Polo Universitario SS. Annunziata, University of Messina, Viale Palatucci 13, I-98168, Messina, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.06.019DOI Listing
September 2019

A Combination of Pharmacophore and Docking-based Virtual Screening to Discover new Tyrosinase Inhibitors.

Mol Inform 2019 Sep 11. Epub 2019 Sep 11.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Palatucci, 98168, Messina, Italy.

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http://dx.doi.org/10.1002/minf.201900054DOI Listing
September 2019

Cardiovascular morbidity and mortality is increased post-liver transplantation even in recipients with no pre-existing risk factors.

Liver Int 2019 Aug 10;39(8):1557-1565. Epub 2019 Jul 10.

UCL Institute for Liver and Digestive Health and Sheila Sherlock Liver Unit, Royal Free Hospital and UCL, London, UK.

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http://dx.doi.org/10.1111/liv.14185DOI Listing
August 2019

Hepatocellular metastasis recurrence in liver transplant after treatment with direct antiviral agents.

Clin J Gastroenterol 2019 Aug 13. Epub 2019 Aug 13.

Liver Unit, Internal Medicine, Department of Medicine (DAME), University School of Medicine of Udine, Piazzale S. M. Misericordia 1, 33100, Udine, Italy.

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http://dx.doi.org/10.1007/s12328-019-01031-4DOI Listing
August 2019

The link between the AMPK/SIRT1 axis and a flavonoid-rich extract of Citrus bergamia juice: A cell-free, in silico, and in vitro study.

Phytother Res 2019 Jul 15;33(7):1805-1814. Epub 2019 May 15.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.

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http://dx.doi.org/10.1002/ptr.6368DOI Listing
July 2019

Microvascular obstruction extent predicts major adverse cardiovascular events in patients with acute myocardial infarction and preserved ejection fraction.

Eur Radiol 2019 May 14;29(5):2369-2377. Epub 2018 Dec 14.

Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome "Sapienza", Viale Regina Elena 324, 00161, Rome, Italy.

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http://dx.doi.org/10.1007/s00330-018-5895-zDOI Listing
May 2019

Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety.

Eur J Med Chem 2019 Feb 1;163:443-452. Epub 2018 Dec 1.

Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali (CHIBIOFARAM), Università degli Studi di Messina, Viale Palatucci, Polo didattico SS, Annunziata, 98168, Messina, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.11.073DOI Listing
February 2019

Discovery of benzimidazole-based Leishmania mexicana cysteine protease CPB2.8ΔCTE inhibitors as potential therapeutics for leishmaniasis.

Chem Biol Drug Des 2018 09 31;92(3):1585-1596. Epub 2018 May 31.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.

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http://doi.wiley.com/10.1111/cbdd.13326
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http://dx.doi.org/10.1111/cbdd.13326DOI Listing
September 2018

Graphene Quantum Dots Based Systems As HIV Inhibitors.

Bioconjug Chem 2018 09 22;29(9):3084-3093. Epub 2018 Aug 22.

Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research , KU Leuven , Herestraat 49 , B-3000 Leuven , Belgium.

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http://dx.doi.org/10.1021/acs.bioconjchem.8b00448DOI Listing
September 2018

Identification of influenza PA-Nter endonuclease inhibitors using pharmacophore- and docking-based virtual screening.

Bioorg Med Chem 2018 08 27;26(15):4544-4550. Epub 2018 Jul 27.

Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche e Ambientali (CHIBIOFARAM), Polo Universitario SS. Annunziata, Università di Messina, Viale Annunziata, I-98168 Messina, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2018.07.046DOI Listing
August 2018

Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments.

J Med Chem 2018 05 20;61(9):3908-3917. Epub 2018 Apr 20.

Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche e Ambientali (CHIBIOFARAM) , Polo Universitario SS. Annunziata, Università di Messina , Viale Annunziata , I-98168 Messina , Italy.

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http://dx.doi.org/10.1021/acs.jmedchem.7b01745DOI Listing
May 2018

Structural optimization of N-aryl-benzimidazoles for the discovery of new non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains.

Bioorg Med Chem 2018 02 24;26(3):661-674. Epub 2017 Dec 24.

Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali (CHIBIOFARAM), Università degli Studi di Messina, Viale Annunziata, 98168 Messina, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.12.033DOI Listing
February 2018

Inhibitory effects and structural insights for a novel series of coumarin-based compounds that selectively target human CA IX and CA XII carbonic anhydrases.

Eur J Med Chem 2018 Jan 23;143:276-282. Epub 2017 Nov 23.

Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali (CHIBIOFARAM), Università degli Studi di Messina, Viale Annunziata, I-98168 Messina, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.11.061DOI Listing
January 2018

An objective definition for clinical suspicion of T-cell-mediated rejection after liver transplantation.

Clin Transplant 2017 07 10;31(7). Epub 2017 Jun 10.

Department of Hepatology and Liver Transplantation, Reina Sofía University Hospital, IMIBIC, CIBERehd, Córdoba, Spain.

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http://dx.doi.org/10.1111/ctr.13005DOI Listing
July 2017

Searching for novel N-substituted benzimidazol-2-ones as non-nucleoside HIV-1 RT inhibitors.

Bioorg Med Chem 2017 07 19;25(14):3861-3870. Epub 2017 May 19.

Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali (CHIBIOFARAM), Università degli Studi di Messina, Viale Annunziata, 98168 Messina, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.05.040DOI Listing
July 2017

Probing Molecular Interactions between Human Carbonic Anhydrases (hCAs) and a Novel Class of Benzenesulfonamides.

J Med Chem 2017 05 9;60(10):4316-4326. Epub 2017 May 9.

Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali (CHIBIOFARAM), Università degli Studi di Messina , Viale Annunziata, I-98168 Messina, Italy.

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http://dx.doi.org/10.1021/acs.jmedchem.7b00264DOI Listing
May 2017

Chemical exploration of 4-(4-fluorobenzyl)piperidine fragment for the development of new tyrosinase inhibitors.

Eur J Med Chem 2017 Jan 18;125:992-1001. Epub 2016 Oct 18.

Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche e Ambientali (CHIBIOFARAM) Polo Universitario SS. Annunziata, Università di Messina, Viale Annunziata I-98168 Messina, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2016.10.030DOI Listing
January 2017

Searching for indole derivatives as potential mushroom tyrosinase inhibitors.

J Enzyme Inhib Med Chem 2016 31;31(3):398-403. Epub 2015 Mar 31.

a Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute , Università di Messina , Messina , Italy and.

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http://dx.doi.org/10.3109/14756366.2015.1029470DOI Listing
November 2016

Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase.

Eur J Med Chem 2016 Nov 3;123:673-683. Epub 2016 Aug 3.

Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche e Ambientali (CHIBIOFARAM), Polo Universitario SS. Annunziata, Università di Messina, Viale Annunziata, I-98168, Messina, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.07.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283093PMC
November 2016

Influence of metals on rhinosinusal polyposis in Sardinian population (Italy).

Environ Sci Pollut Res Int 2016 Nov 13;23(21):21726-21732. Epub 2016 Aug 13.

Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43B, 07100, Sassari, Italy.

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http://dx.doi.org/10.1007/s11356-016-7406-6DOI Listing
November 2016

Rational Design, Synthesis and Evaluation of Coumarin Derivatives as Protein-protein Interaction Inhibitors.

Mol Inform 2016 09 25;35(8-9):460-73. Epub 2016 Jul 25.

Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università degli Studi di Messina, Viale Annunziata, I-98168, Messina, Italy.

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http://dx.doi.org/10.1002/minf.201501034DOI Listing
September 2016

In Vivo Evaluation of Selective Carbonic Anhydrase Inhibitors as Potential Anticonvulsant Agents.

ChemMedChem 2016 08 24;11(16):1812-8. Epub 2016 Feb 24.

Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences (CHIBIOFARAM), University of Messina, Viale Annunziata, 98168, Messina, Italy.

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http://dx.doi.org/10.1002/cmdc.201500596DOI Listing
August 2016

N-acylhydrazone inhibitors of influenza virus PA endonuclease with versatile metal binding modes.

Sci Rep 2016 08 11;6:31500. Epub 2016 Aug 11.

Rega Institute for Medical Research, KU Leuven - University of Leuven, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1038/srep31500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980666PMC
August 2016

Long-term patient-reported functional and cosmetic outcomes following severe traumatic foot and ankle wound reconstruction with acellular dermal matrix.

J Cosmet Laser Ther 2015 1;17(6):321-9. Epub 2015 May 1.

a Plastic Surgery and Burns Unit, Centre FX Michelet, Bordeaux University Hospital , Bordeaux , France.

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http://dx.doi.org/10.3109/14764172.2015.1027231DOI Listing
July 2016

Structure-guided design of new indoles as negative allosteric modulators (NAMs) of N-methyl-D-aspartate receptor (NMDAR) containing GluN2B subunit.

Bioorg Med Chem 2016 Apr 15;24(7):1513-9. Epub 2016 Feb 15.

Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali (CHIBIOFARAM) Università degli Studi di Messina, Viale Annunziata, I-98168 Messina, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.02.021DOI Listing
April 2016

Angioleiomyoma of the External Auditory Canal.

Otol Neurotol 2016 Mar;37(3):e171-2

*Division of Otorhinolaryngology, Department of Surgical, Microsurgical and Medical Sciences †Unit of Pathology, Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy.

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http://dx.doi.org/10.1097/MAO.0000000000000917DOI Listing
March 2016

Investigation of the salicylaldehyde thiosemicarbazone scaffold for inhibition of influenza virus PA endonuclease.

J Biol Inorg Chem 2015 Oct 1;20(7):1109-21. Epub 2015 Sep 1.

Dipartimento di Chimica, Università di Parma, Parco Area delle Scienze 17/A, 43124, Parma, Italy.

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http://dx.doi.org/10.1007/s00775-015-1292-0DOI Listing
October 2015

Long-term renal function in unilateral non-syndromic renal tumor survivors treated according to International Society of Pediatric Oncology protocols.

Pediatr Blood Cancer 2015 Sep 20;62(9):1637-44. Epub 2015 Apr 20.

Department of Pediatrics, "Sapienza" University, Rome, Italy.

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http://dx.doi.org/10.1002/pbc.25558DOI Listing
September 2015

Carbonic anhydrase inhibitors: Design, synthesis and structural characterization of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms.

Eur J Med Chem 2015 Sep 31;102:223-32. Epub 2015 Jul 31.

Dipartimento Scienze del Farmaco e dei Prodotti per la salute, Università degli Studi di Messina, Viale Annunziata, I-98168 Messina, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.07.049DOI Listing
September 2015

Optimization of rhodanine scaffold for the development of protein-protein interaction inhibitors.

Bioorg Med Chem 2015 Jul 2;23(13):3208-14. Epub 2015 May 2.

Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute, Università di Messina, Viale Annunziata, I-98168 Messina, Italy.

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http://dx.doi.org/10.1016/j.bmc.2015.04.072DOI Listing
July 2015

Noninvasive Assessment of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease.

Int J Endocrinol 2015 30;2015:343828. Epub 2015 Apr 30.

UCL Institute for Liver and Digestive Health, Royal Free Hospital and UCL, London NW3 2QG, UK.

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http://dx.doi.org/10.1155/2015/343828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430647PMC
June 2015

Metabolic and cardiovascular complications in the liver transplant recipient.

Ann Gastroenterol 2015 Apr-Jun;28(2):183-192

Sheila Sherlock Liver Unit and UCL Institute for Liver and Digestive Health, Royal Free Hospital, London, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367207PMC
September 2014

Targeting GluN2B-containing N-Methyl-D-aspartate receptors: design, synthesis, and binding affinity evaluation of novel 3-substituted indoles.

Arch Pharm (Weinheim) 2014 Aug 23;347(8):533-9. Epub 2014 May 23.

Dipartimento di Scienze del Farmaco e Prodotti per la Salute, Università di Messina, Messina, Italy.

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http://dx.doi.org/10.1002/ardp.201400061DOI Listing
August 2014

Diketoacid chelating ligands as dual inhibitors of HIV-1 integration process.

Eur J Med Chem 2014 May 25;78:425-30. Epub 2014 Mar 25.

Dipartimento di Scienze del Farmaco e Prodotti per la Salute, Università di Messina, Viale Annunziata, I-98168 Messina, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.03.070DOI Listing
May 2014

Synthesis and biological evaluation of novel antiviral agents as protein-protein interaction inhibitors.

J Enzyme Inhib Med Chem 2014 Apr 16;29(2):237-42. Epub 2013 Jul 16.

Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute, Università di Messina , Messina , Italy and.

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http://dx.doi.org/10.3109/14756366.2013.766609DOI Listing
April 2014

A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition.

Bioorg Med Chem 2014 Apr 20;22(7):2269-79. Epub 2014 Feb 20.

Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute, Università di Messina, Viale Annunziata, I-98168 Messina, Italy.

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http://dx.doi.org/10.1016/j.bmc.2014.02.012DOI Listing
April 2014

Synthesis, modelling and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-d-aspartate receptors.

Bioorg Med Chem 2014 Feb 30;22(3):1040-8. Epub 2013 Dec 30.

Dipartimento di Scienze del Farmaco e Prodotti per la Salute, Università di Messina, Viale Annunziata, I-98168 Messina, Italy.

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http://dx.doi.org/10.1016/j.bmc.2013.12.040DOI Listing
February 2014

Design and synthesis of N₁-aryl-benzimidazoles 2-substituted as novel HIV-1 non-nucleoside reverse transcriptase inhibitors.

Bioorg Med Chem 2014 Feb 30;22(4):1459-67. Epub 2013 Dec 30.

Dipartimento di Scienze del Farmaco e Prodotti per la Salute, Università di Messina, Viale Annunziata, I-98168 Messina, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S09680896130105
Publisher Site
http://dx.doi.org/10.1016/j.bmc.2013.12.045DOI Listing
February 2014

Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors.

Eur J Med Chem 2014 Jan 8;71:105-11. Epub 2013 Nov 8.

Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute, Università di Messina, Viale Annunziata, I-98168 Messina, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2013.10.071DOI Listing
January 2014

From NMDA receptor antagonists to discovery of selective σ₂ receptor ligands.

Bioorg Med Chem 2014 Jan 15;22(1):393-7. Epub 2013 Nov 15.

Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute, Università di Messina, Viale Annunziata, I-98168 Messina, Italy.

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http://dx.doi.org/10.1016/j.bmc.2013.11.014DOI Listing
January 2014

Prodromal angina is associated with myocardial salvage in acute ST-segment elevation myocardial infarction.

Eur Heart J Cardiovasc Imaging 2013 Nov 21;14(11):1041-8. Epub 2013 Jun 21.

Fondazione CNR/Regione Toscana 'G. Monasterio', Via Moruzzi 1, 56124 Pisa, Italy.

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http://dx.doi.org/10.1093/ehjci/jet063DOI Listing
November 2013

Fragment hopping approach directed at design of HIV IN-LEDGF/p75 interaction inhibitors.

J Enzyme Inhib Med Chem 2013 Oct 18;28(5):1002-9. Epub 2012 Jul 18.

Dipartimento Farmaco-Chimico, Università di Messina , Messina , Italy.

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http://dx.doi.org/10.3109/14756366.2012.703184DOI Listing
October 2013

New scaffolds of natural origin as Integrase-LEDGF/p75 interaction inhibitors: virtual screening and activity assays.

Eur J Med Chem 2013 Oct 9;68:405-11. Epub 2013 Aug 9.

Dipartimento di Scienze del Farmaco e Prodotti per la Salute, Università di Messina, Viale Annunziata, I-98168 Messina, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2013.07.025DOI Listing
October 2013

Indole derivatives as dual-effective agents for the treatment of neurodegenerative diseases: synthesis, biological evaluation, and molecular modeling studies.

Bioorg Med Chem 2013 Aug 2;21(15):4575-80. Epub 2013 Jun 2.

Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute, Università di Messina, Viale Annunziata, Messina I-98168, Italy.

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http://dx.doi.org/10.1016/j.bmc.2013.05.044DOI Listing
August 2013

Synthesis and biological characterization of 3-substituted 1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors. Part 2.

J Med Chem 2012 Dec 19;55(23):10532-9. Epub 2012 Nov 19.

Dipartimento di Scienze del Farmaco e Prodotti per la Salute, Università di Messina, Viale Annunziata, I-98168 Messina, Italy.

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http://dx.doi.org/10.1021/jm301508dDOI Listing
December 2012

Insight into the fundamental interactions between LEDGF binding site inhibitors and integrase combining docking and molecular dynamics simulations.

J Chem Inf Model 2012 Dec 11;52(12):3245-54. Epub 2012 Dec 11.

Dipartimento di Scienze del Farmaco e Prodotti per la Salute, Università di Messina, Viale Annunziata, I-98168 Messina, Italy.

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http://dx.doi.org/10.1021/ci300361eDOI Listing
December 2012

Glutamatergic neurotransmission as molecular target of new anticonvulsants.

Curr Top Med Chem 2012 ;12(9):971-93

Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, 98168 Messina, Italy.

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http://dx.doi.org/10.2174/156802612800229242DOI Listing
October 2012

Circulating vascular endothelial growth factor in childhood solid tumors: plasma and serum measurements.

Anticancer Res 2012 Aug;32(8):3565-9

Department of Pediatrics,Viale Regina Elena 324, 00161 Roma, Italy.

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August 2012

Synthesis and biological profile of new 1,2,3,4-tetrahydroisoquinolines as selective carbonic anhydrase inhibitors.

Bioorg Med Chem 2011 Dec 12;19(23):7003-7. Epub 2011 Oct 12.

Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, I-98168 Messina, Italy.

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http://dx.doi.org/10.1016/j.bmc.2011.10.015DOI Listing
December 2011

4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration process.

Antiviral Res 2011 Oct 13;92(1):102-7. Epub 2011 Jul 13.

Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, I-98168 Messina, Italy.

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http://dx.doi.org/10.1016/j.antiviral.2011.07.005DOI Listing
October 2011

Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping.

Bioorg Med Chem 2011 Aug 16;19(15):4544-51. Epub 2011 Jun 16.

Dipartimento di Scienze Farmaceutiche 'Pietro Pratesi', Facoltà di Farmacia, Università degli Studi di Milano, Via Mangiagalli, 25, I-20133 Milano, Italy.

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http://dx.doi.org/10.1016/j.bmc.2011.06.027DOI Listing
August 2011

Microwave assisted organic synthesis (MAOS) of small molecules as potential HIV-1 integrase inhibitors.

Molecules 2011 Aug 11;16(8):6858-70. Epub 2011 Aug 11.

Department of Medicinal Chemistry, University of Messina, Viale Annunziata, I-98168 Messina, Italy.

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http://dx.doi.org/10.3390/molecules16086858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264142PMC
August 2011

Inhibitors of the interactions between HIV-1 IN and the cofactor LEDGF/p75.

ChemMedChem 2011 Jul 19;6(7):1184-91. Epub 2011 Apr 19.

Dipartimento Farmaco-Chimico, Università degli Studi di Messina, Viale Annunziata, 98168 Messina, Italy.

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http://dx.doi.org/10.1002/cmdc.201100071DOI Listing
July 2011

HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation.

Eur J Med Chem 2011 Feb 21;46(2):756-64. Epub 2010 Dec 21.

Dipartimento Farmco-Chimico, University of Messina, Viale Annunziata, I-98168 Messina, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2010.12.012DOI Listing
February 2011

Synthesis and structure-active relationship of 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline anticonvulsants.

Chem Pharm Bull (Tokyo) 2010 Dec;58(12):1602-5

Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, 98168 Messina, Italy.

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http://dx.doi.org/10.1248/cpb.58.1602DOI Listing
December 2010

Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor.

Bioorg Med Chem 2010 Nov 17;18(21):7515-21. Epub 2010 Sep 17.

Dipartimento Farmaco-Chimico, Università di Messina Viale Annunziata, I-98168 Messina, Italy.

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http://dx.doi.org/10.1016/j.bmc.2010.08.051DOI Listing
November 2010

New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action.

Bioorg Med Chem 2010 Aug 22;18(15):5510-8. Epub 2010 Jun 22.

Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, I-98168 Messina, Italy.

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http://dx.doi.org/10.1016/j.bmc.2010.06.063DOI Listing
August 2010

Novel 1,3-dihydro-benzimidazol-2-ones and their analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Bioorg Med Chem 2010 Feb 4;18(4):1702-10. Epub 2010 Jan 4.

Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, 98168 Messina, Italy.

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http://dx.doi.org/10.1016/j.bmc.2009.12.059DOI Listing
February 2010

Induced-fit docking approach provides insight into the binding mode and mechanism of action of HIV-1 integrase inhibitors.

ChemMedChem 2009 Sep;4(9):1446-56

Dipartimento di Chimica e Tecnologia del Farmaco, Facoltà di Farmacia, Università di Perugia, Via del Liceo 1, 06123 Perugia, Italy.

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http://dx.doi.org/10.1002/cmdc.200900166DOI Listing
September 2009

Combined strategies for the discovery of ionotropic glutamate receptor antagonists.

ChemMedChem 2009 Jun;4(6):917-22

Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, 98168 Messina, Italy.

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http://dx.doi.org/10.1002/cmdc.200900109DOI Listing
June 2009

Development of 3-substituted-1H-indole derivatives as NR2B/NMDA receptor antagonists.

Bioorg Med Chem 2009 Feb 31;17(4):1640-7. Epub 2008 Dec 31.

Dipartimento Farmaco-Chimico, Università di Messina, Messina, Italy.

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http://dx.doi.org/10.1016/j.bmc.2008.12.058DOI Listing
February 2009

Modeling of the intestinal peptide transporter hPepT1 and analysis of its transport capacities by docking and pharmacophore mapping.

ChemMedChem 2008 Dec;3(12):1913-21

Istituto di Chimica Farmaceutica e Tossicologica "Pietro Pratesi", Facoltà di Farmacia, Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy.

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http://dx.doi.org/10.1002/cmdc.200800184DOI Listing
December 2008

Computational studies to discover a new NR2B/NMDA receptor antagonist and evaluation of pharmacological profile.

ChemMedChem 2008 Oct;3(10):1539-48

Dipartimento Farmaco-Chimico, Facoltà di Farmacia, Università di Messina, Viale Annunziata, 98168 Messina, Italy.

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http://dx.doi.org/10.1002/cmdc.200800124DOI Listing
October 2008

Improvement of water solubility of non-competitive AMPA receptor antagonists by complexation with beta-cyclodextrin.

Bioorg Med Chem 2008 Sep 5;16(18):8706-12. Epub 2008 Aug 5.

Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, 98168 Messina, Italy.

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http://dx.doi.org/10.1016/j.bmc.2008.07.085DOI Listing
September 2008

A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series.

Bioorg Med Chem Lett 2008 May 8;18(9):2891-5. Epub 2008 Apr 8.

Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, 98168 Messina, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2008.03.089DOI Listing
May 2008

Synthesis and anticonvulsant evaluation of N-substituted isoquinoline AMPA receptor antagonists.

Bioorg Med Chem 2008 Mar 29;16(5):2379-84. Epub 2007 Nov 29.

Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, 98168 Messina, Italy.

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http://dx.doi.org/10.1016/j.bmc.2007.11.071DOI Listing
March 2008

Fragmental modeling of human glutamate transporter EAAT1 and analysis of its binding modes by docking and pharmacophore mapping.

ChemMedChem 2008 Jan;3(1):79-90

Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Facoltà di Farmacia, Università degli Studi di Milano, Via Mangiagalli, 25, I-20133 Milano, Italia.

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http://dx.doi.org/10.1002/cmdc.200700197DOI Listing
January 2008

Tn5 transposase as a useful platform to simulate HIV-1 integrase inhibitor binding mode.

Biochem Biophys Res Commun 2007 Nov 14;363(3):554-60. Epub 2007 Sep 14.

Dipartimento Farmaco-Chimico, Università di Messina,Viale Annunziata, I-98168 Messina, Italy.

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http://dx.doi.org/10.1016/j.bbrc.2007.08.199DOI Listing
November 2007

Structure-based pharmacophore identification of new chemical scaffolds as non-nucleoside reverse transcriptase inhibitors.

J Chem Inf Model 2007 Mar-Apr;47(2):557-62. Epub 2007 Feb 3.

Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, 98168 Messina, Italy.

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http://dx.doi.org/10.1021/ci600320qDOI Listing
May 2007

Novel potent anticonvulsant agent containing a tetrahydroisoquinoline skeleton.

J Med Chem 2006 Sep;49(18):5618-22

Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, 98168 Messina, Italy.

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http://dx.doi.org/10.1021/jm060411bDOI Listing
September 2006

Binding mode prediction of strand transfer HIV-1 integrase inhibitors using Tn5 transposase as a plausible surrogate model for HIV-1 integrase.

J Med Chem 2006 Jun;49(13):3994-7

Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, 98168 Messina, Italy.

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http://dx.doi.org/10.1021/jm060323rDOI Listing
June 2006

Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors.

J Med Chem 2005 Nov;48(22):7084-8

Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, 98168 Messina, Italy.

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http://dx.doi.org/10.1021/jm050549eDOI Listing
November 2005