Laura Colombo

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Laura Colombo

Publications by authors named "Laura Colombo"

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60Publications

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NMR-driven identification of anti-amyloidogenic compounds in green and roasted coffee extracts.

Food Chem 2018 Jun 12;252:171-180. Epub 2018 Jan 12.

Department of Biotechnologies and Biosciences, University of Milano-Bicocca, P.zza della Scienza 2, 20126 Milan, Italy; Milan Center of Neuroscience (NeuroMI), 20126 Milano Italy. Electronic address:

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June 2018

Alpha-synuclein oligomers impair memory through glial cell activation and via Toll-like receptor 2.

Brain Behav Immun 2018 Mar 16;69:591-602. Epub 2018 Feb 16.

Department of Neuroscience, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. Electronic address:

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March 2018

Pathogenic Aβ A2V versus protective Aβ A2T mutation: Early stage aggregation and membrane interaction.

Biophys Chem 2017 10 6;229:11-18. Epub 2017 May 6.

Department of Medical Biotechnology and Translational Medicine, University of Milan, V.le F.lli Cervi 93, 20090 Segrate, Italy.

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October 2017

[Effect of the cellular and humoral immune response in infertile couples and its relationship with infections.]

Arch Esp Urol 2017 Sep;70(7):662-668

Facultad de Ciencias Bioquímicas y Farmacéuticas. Universidad Nacional de Rosario (UNR).Departamento de Bioquímica Clínica UNR.

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September 2017

The A2V mutation as a new tool for hindering Aβ aggregation: A neutron and x-ray diffraction study.

Sci Rep 2017 Jul 14;7(1):5510. Epub 2017 Jul 14.

Department of Molecular Biochemistry and Pharmacology, IRCCS Istituto di Ricerche Farmacologiche "Mario Negri", Milano, 20156, Italy.

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July 2017

Flavonoids and Their Glycosides as Anti-amyloidogenic Compounds: Aβ1-42 Interaction Studies to Gain New Insights into Their Potential for Alzheimer's Disease Prevention and Therapy.

Chem Asian J 2017 Jan 5;12(1):67-75. Epub 2016 Dec 5.

Department of Biotecnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, I-20126, Milan, Italy.

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January 2017

Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein.

Aging Cell 2016 10 12;15(5):914-23. Epub 2016 Jul 12.

Unit of Geriatric Medicine, Department of Internal Medicine and Medical Specialties (DIMI), University of Genova, Viale Benedetto XV, 6, 16132, Genova, Italy.

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October 2016

The cell-permeable Aβ1-6A2VTAT(D) peptide reverts synaptopathy induced by Aβ1-42wt.

Neurobiol Dis 2016 May 22;89:101-11. Epub 2015 Dec 22.

IRCCS Istituto di Ricerche Farmacologiche "Mario Negri", Via La Masa 19, 20156 Milan, Italy; Department of Pharmacological and Biomolecular Sciences, Milan University, Via Balzaretti 9, 20133 Milan, Italy. Electronic address:

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May 2016

Amyloid-β peptides in interaction with raft-mime model membranes: a neutron reflectivity insight.

Sci Rep 2016 Feb 16;6:20997. Epub 2016 Feb 16.

Dept. of Medical Biotechnologies and Traslational Medicine, University of Milano, LITA, Via F.lli Cervi, 93. 20090 Segrate (Milano), Italy.

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February 2016

Structural Modifications of cis-Glycofused Benzopyran Compounds and Their Influence on the Binding to Amyloid-β Peptide.

Chem Asian J 2016 Jan 20;11(2):299-309. Epub 2015 Nov 20.

Department of Biotecnology and Bioscience (Btbs), University of Milano-Bicocca, Piazza della Scienza 2, I-20126, Milan, Italy.

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January 2016

Organ Distribution and Bone Tropism of Cellulose Nanocrystals in Living Mice.

Biomacromolecules 2015 Sep 7;16(9):2862-71. Epub 2015 Aug 7.

Department of Biotechnology and Biosciences, University of Milano-Bicocca , Piazza della Scienza 2, 20126 Milano, Italy.

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September 2015

Role of lipid rafts and GM1 in the segregation and processing of prion protein.

PLoS One 2014 23;9(5):e98344. Epub 2014 May 23.

Department of Health Science - Medical School, University of Milano-Bicocca, Monza, Italy.

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June 2015

Natural compounds against neurodegenerative diseases: molecular characterization of the interaction of catechins from green tea with Aβ1-42, PrP106-126, and ataxin-3 oligomers.

Chemistry 2014 Oct 1;20(42):13793-800. Epub 2014 Sep 1.

Department of Biotechnology and Biosciences University of Milano-Bicocca, P.zza della Scienza, 2, 20126, Milano (Italy), Fax: (+39) 02-6448-3565.

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October 2014

The peculiar role of the A2V mutation in amyloid-β (Aβ) 1-42 molecular assembly.

J Biol Chem 2014 Aug 18;289(35):24143-52. Epub 2014 Jul 18.

From the Department of Molecular Biochemistry and Pharmacology, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156, Milan, Italy,

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August 2014

Monomeric Aβ1-42 and RAGE: key players in neuronal differentiation.

Neurobiol Aging 2014 Jun 10;35(6):1301-8. Epub 2014 Jan 10.

Department of Experimental Medicine, University of Genoa, Genoa, Italy. Electronic address:

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June 2014

A new face for old antibiotics: tetracyclines in treatment of amyloidoses.

J Med Chem 2013 Aug 8;56(15):5987-6006. Epub 2013 May 8.

IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Via Giuseppe La Masa 19, 20156 Milano, Italy.

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August 2013

Good gene, bad gene: new APP variant may be both.

Prog Neurobiol 2012 Dec 19;99(3):281-92. Epub 2012 Jun 19.

Neurology V & Neuropathology, IRCCS Foundation Carlo Besta Neurological Institute, Via Celoria 11, 20133 Milan, Italy.

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December 2012

The molecular assembly of amyloid aβ controls its neurotoxicity and binding to cellular proteins.

PLoS One 2011 23;6(9):e24909. Epub 2011 Sep 23.

Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy.

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March 2012

Curcumin derivatives as new ligands of Aβ peptides.

J Biotechnol 2011 Dec 22;156(4):317-24. Epub 2011 Jul 22.

Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, Milan, Italy.

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December 2011

cis-Glyco-fused benzopyran compounds as new amyloid-β peptide ligands.

Chem Commun (Camb) 2011 Oct 22;47(37):10266-8. Epub 2011 Aug 22.

Dept. of Biotechnology and Biosciences, University of Milano-Bicocca, P.zza della Scienza 2, 20126, Milan, Italy.

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October 2011

Oxygen-glucose deprivation increases the enzymatic activity and the microvesicle-mediated release of ectonucleotidases in the cells composing the blood-brain barrier.

Neurochem Int 2011 Aug 6;59(2):259-71. Epub 2011 Jun 6.

Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Department of Pharmacological Sciences, Università degli Studi di Milano, Via Balzaretti, 9, 20133 Milan, Italy.

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August 2011

Tetracycline prevents Aβ oligomer toxicity through an atypical supramolecular interaction.

Org Biomol Chem 2011 Jan 10;9(2):463-72. Epub 2010 Nov 10.

Department of Biotechnology and Biosciences, University of Milano-Bicocca, P.zza della Scienza 2, 20126, Milan, Italy.

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January 2011

Overcoming synthetic Abeta peptide aging: a new approach to an age-old problem.

Amyloid 2009 ;16(2):71-80

Department of Biochemistry and Molecular Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy.

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September 2010

Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein.

Proc Natl Acad Sci U S A 2010 Feb 19;107(5):2295-300. Epub 2010 Jan 19.

Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan 20156, Italy.

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February 2010

ST1859 reduces prion infectivity and increase survival in experimental scrapie.

Arch Virol 2009 15;154(9):1539-44. Epub 2009 Aug 15.

Istituto di Ricerche Farmacologiche Mario Negri, Via G. La Masa 19, Milan, Italy.

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November 2009

The anti-fibrillogenic activity of tetracyclines on PrP 106-126: a 3D-QSAR study.

J Mol Model 2008 Oct 16;14(10):987-94. Epub 2008 Jul 16.

Dipartimento di Scienze dell'Ambiente e del Territorio, Università degli Studi di Milano-Bicocca, Milan, Italy.

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October 2008

Conformational plasticity of the Gerstmann-Sträussler-Scheinker disease peptide as indicated by its multiple aggregation pathways.

J Mol Biol 2008 Sep 28;381(5):1349-61. Epub 2008 Jun 28.

Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy.

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September 2008

Docosahexaenoic and eicosapentaenoic acids increase neuronal death in response to HuPrP82-146 and Abeta 1-42.

Neuropharmacology 2008 May 10;54(6):934-43. Epub 2008 Feb 10.

Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, AL9 7TA North Mymms, Herts, UK.

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May 2008

The efficacy of tetracyclines in peripheral and intracerebral prion infection.

PLoS One 2008 Mar 26;3(3):e1888. Epub 2008 Mar 26.

Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.

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March 2008

In vitro evaluation of the anti-prionic activity of newly synthesized congo red derivatives.

Arzneimittelforschung 2003 ;53(12):875-88

Dipartimento di Patologia Animale, Igiene e Sanità Pubblica Veterinaria, Sezione di Microbiologia e Immunologia, Milan, Italy.

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February 2004

Synthetic miniprion PrP106.

J Biol Chem 2002 Aug 10;277(35):31327-34. Epub 2002 Jun 10.

Dulbecco Telethon Institute, Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, via Eritrea 62, Milan 20157, Italy.

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August 2002

Tetracyclines affect prion infectivity.

Proc Natl Acad Sci U S A 2002 Aug 29;99(16):10849-54. Epub 2002 Jul 29.

Istituto di Ricerche Farmacologiche Mario Negri, Istituto Nazionale Neurologico Carlo Besta, and Istituto di Microbiologia e Immunologia Veterinaria, Università degli Studi, 20100 Milano, Italy.

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August 2002