Publications

Alpha-synuclein oligomers impair memory through glial cell activation and via Toll-like receptor 2.
Brain Behav Immun 2018 Feb 16. Epub 2018 Feb 16.
Department of Neuroscience, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.. Electronic address:


The A2V mutation as a new tool for hindering Aβ aggregation: A neutron and x-ray diffraction study.
Sci Rep 2017 Jul 14;7(1):5510. Epub 2017 Jul 14.
Department of Molecular Biochemistry and Pharmacology, IRCCS Istituto di Ricerche Farmacologiche "Mario Negri", Milano, 20156, Italy.


Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein.
Aging Cell 2016 Oct 12;15(5):914-23. Epub 2016 Jul 12.
Unit of Geriatric Medicine, Department of Internal Medicine and Medical Specialties (DIMI), University of Genova, Viale Benedetto XV, 6, 16132, Genova, Italy.

The cell-permeable Aβ1-6A2VTAT(D) peptide reverts synaptopathy induced by Aβ1-42wt.
Neurobiol Dis 2016 May 22;89:101-11. Epub 2015 Dec 22.
IRCCS Istituto di Ricerche Farmacologiche "Mario Negri", Via La Masa 19, 20156 Milan, Italy; Department of Pharmacological and Biomolecular Sciences, Milan University, Via Balzaretti 9, 20133 Milan, Italy. Electronic address:



Structural Modifications of cis-Glycofused Benzopyran Compounds and Their Influence on the Binding to Amyloid-β Peptide.
Chem Asian J 2016 Jan 20;11(2):299-309. Epub 2015 Nov 20.
Department of Biotecnology and Bioscience (Btbs), University of Milano-Bicocca, Piazza della Scienza 2, I-20126, Milan, Italy.


Natural compounds against neurodegenerative diseases: molecular characterization of the interaction of catechins from green tea with Aβ1-42, PrP106-126, and ataxin-3 oligomers.
Chemistry 2014 Oct 1;20(42):13793-800. Epub 2014 Sep 1.
Department of Biotechnology and Biosciences University of Milano-Bicocca, P.zza della Scienza, 2, 20126, Milano (Italy), Fax: (+39) 02-6448-3565.


The peculiar role of the A2V mutation in amyloid-β (Aβ) 1-42 molecular assembly.
J Biol Chem 2014 Aug 18;289(35):24143-52. Epub 2014 Jul 18.
From the Department of Molecular Biochemistry and Pharmacology, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156, Milan, Italy,




Good gene, bad gene: new APP variant may be both.
Prog Neurobiol 2012 Dec 19;99(3):281-92. Epub 2012 Jun 19.
Neurology V & Neuropathology, IRCCS Foundation Carlo Besta Neurological Institute, Via Celoria 11, 20133 Milan, Italy.

β-amyloid 1-42 induces physiological transcriptional regulation of BACE1.
J Neurochem 2012 Sep 11;122(5):1023-31. Epub 2012 Jul 11.
Department of Internal Medicine and Medical Specialities, University of Genova, Genova, Italy.


Oxygen-glucose deprivation increases the enzymatic activity and the microvesicle-mediated release of ectonucleotidases in the cells composing the blood-brain barrier.
Neurochem Int 2011 Aug 6;59(2):259-71. Epub 2011 Jun 6.
Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Department of Pharmacological Sciences, Università degli Studi di Milano, Via Balzaretti, 9, 20133 Milan, Italy.

Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils.
Org Biomol Chem 2011 Jul 1;9(14):5137-48. Epub 2011 Jun 1.
European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, via Aldo Moro, 53100, Siena, Italy.


Tetracycline prevents Aβ oligomer toxicity through an atypical supramolecular interaction.
Org Biomol Chem 2011 Jan 10;9(2):463-72. Epub 2010 Nov 10.
Department of Biotechnology and Biosciences, University of Milano-Bicocca, P.zza della Scienza 2, 20126, Milan, Italy.

Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein.
Proc Natl Acad Sci U S A 2010 Feb 19;107(5):2295-300. Epub 2010 Jan 19.
Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan 20156, Italy.



Conformational plasticity of the Gerstmann-Sträussler-Scheinker disease peptide as indicated by its multiple aggregation pathways.
J Mol Biol 2008 Sep 28;381(5):1349-61. Epub 2008 Jun 28.
Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy.






Tetracyclines affect prion infectivity.
Proc Natl Acad Sci U S A 2002 Aug 29;99(16):10849-54. Epub 2002 Jul 29.
Istituto di Ricerche Farmacologiche Mario Negri, Istituto Nazionale Neurologico Carlo Besta, and Istituto di Microbiologia e Immunologia Veterinaria, Università degli Studi, 20100 Milano, Italy.

The molecular assembly of amyloid aβ controls its neurotoxicity and binding to cellular proteins.
PLoS One 2011 23;6(9):e24909. Epub 2011 Sep 23.
Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy.


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