Laura C Greaves

Laura C Greaves

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Laura C Greaves

Laura C Greaves

Publications by authors named "Laura C Greaves"

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Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations.

J Pathol 2018 12 5;246(4):427-432. Epub 2018 Nov 5.

Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1002/path.5156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282723PMC
December 2018

A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency.

J Pathol 2018 07 14;245(3):311-323. Epub 2018 May 14.

Max Planck Institute for Biology of Ageing, Cologne, Germany.

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http://dx.doi.org/10.1002/path.5084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032845PMC
July 2018

Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts.

EBioMedicine 2018 May 25;31:166-173. Epub 2018 Apr 25.

LLHW Centre for Ageing and Vitality, Newcastle University Institute for Ageing, The Medical School, Newcastle upon Tyne NE2 4HH, UK; Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013780PMC
May 2018

Impact of Age-Related Mitochondrial Dysfunction and Exercise on Intestinal Microbiota Composition.

J Gerontol A Biol Sci Med Sci 2018 04;73(5):571-578

Wellcome Trust Centre for Mitochondrial Research, Institute for Cell and Molecular Biosciences and Institute of Neuroscience, Medical School, Newcastle University, Newcastle upon Tyne.

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http://dx.doi.org/10.1093/gerona/glx197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905657PMC
April 2018

Roles of Mitochondrial DNA Mutations in Stem Cell Ageing.

Genes (Basel) 2018 Mar 27;9(4). Epub 2018 Mar 27.

Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.3390/genes9040182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924524PMC
March 2018

The presence of highly disruptive 16S rRNA mutations in clinical samples indicates a wider role for mutations of the mitochondrial ribosome in human disease.

Mitochondrion 2015 Nov 5;25:17-27. Epub 2015 Sep 5.

Grupo GIBE, Bioloxía Celular e Molecular, Facultade de Ciencias, Universidade da Coruña (UDC), Campus Zapateira s/n, 15071 A Coruña, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2015.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665369PMC
November 2015

SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts.

Cell Stem Cell 2015 Jan 20;16(1):33-8. Epub 2014 Nov 20.

TSI Laboratory, University Heart Center Hamburg, Martinistrasse 52, 20246 Hamburg, Germany; Cardiovascular Research Center Hamburg (CVRC) and DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Luebeck, Martinistrasse 52, 20246 Hamburg, Germany; Stanford Cardiovascular Institute and Department of Cardiothoracic Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.11.003DOI Listing
January 2015

Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing.

PLoS Genet 2014 Sep 18;10(9):e1004620. Epub 2014 Sep 18.

Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom; Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1004620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169240PMC
September 2014

Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans.

Mech Ageing Dev 2014 Jul 7;139:22-30. Epub 2014 Jun 7.

Centre for Brain Ageing and Vitality, Institute for Ageing and Health, The Medical School, Newcastle upon Tyne NE2 4HH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.mad.2014.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141908PMC
July 2014

Human stem cell aging: do mitochondrial DNA mutations have a causal role?

Aging Cell 2014 Apr 28;13(2):201-5. Epub 2014 Jan 28.

Centre for Brain Ageing and Vitality, Institute for Ageing and Health, The Medical School, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1111/acel.12199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331785PMC
April 2014

Differences in the accumulation of mitochondrial defects with age in mice and humans.

Mech Ageing Dev 2011 Nov-Dec;132(11-12):588-91. Epub 2011 Oct 12.

Mitochondrial Research Group, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1016/j.mad.2011.10.004DOI Listing
April 2012

Mitochondrial DNA and disease.

J Pathol 2012 Jan 21;226(2):274-86. Epub 2011 Nov 21.

Mitochondrial Research Group, Institute for Ageing and Health, Newcastle University, UK.

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http://doi.wiley.com/10.1002/path.3028
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http://dx.doi.org/10.1002/path.3028DOI Listing
January 2012

Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts.

Exp Gerontol 2010 Aug 22;45(7-8):573-9. Epub 2010 Jan 22.

Mitochondrial Research Group, Institute for Ageing and Health, Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1016/j.exger.2010.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887930PMC
August 2010

Somatic mitochondrial DNA deletions accumulate to high levels in aging human extraocular muscles.

Invest Ophthalmol Vis Sci 2010 Jul 17;51(7):3347-53. Epub 2010 Feb 17.

Mitochondrial Research Group, Institute for Ageing and Health, The Medical School, Newcastle University, Newcastle-upon-Tyne, United Kingdom.

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http://dx.doi.org/10.1167/iovs.09-4660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904001PMC
July 2010

Mitochondrial DNA defects and selective extraocular muscle involvement in CPEO.

Invest Ophthalmol Vis Sci 2010 Jul 17;51(7):3340-6. Epub 2010 Feb 17.

Mitochondrial Research Group, Institute for Ageing and Health, Newcastle University, Newcastle-upon-Tyne, United Kingdom.

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http://dx.doi.org/10.1167/iovs.09-4659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904000PMC
July 2010

Mitochondrial DNA mutations and ageing.

Biochim Biophys Acta 2009 Oct 4;1790(10):1015-20. Epub 2009 May 4.

Mitochondrial Research Group, Institute for Ageing and Health, The Medical School, Newcastle University, Newcastle Upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1016/j.bbagen.2009.04.018DOI Listing
October 2009

Quantification of mitochondrial DNA mutation load.

Aging Cell 2009 Sep 18;8(5):566-72. Epub 2009 Jul 18.

Mitochondrial Research Group, Institute for Ageing and Health, Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1111/j.1474-9726.2009.00505.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752485PMC
September 2009

Locating the stem cell niche and tracing hepatocyte lineages in human liver.

Hepatology 2009 May;49(5):1655-63

Centre for Diabetes and Metabolic Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

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http://dx.doi.org/10.1002/hep.22791DOI Listing
May 2009

The ageing mitochondrial genome.

Nucleic Acids Res 2007 2;35(22):7399-405. Epub 2007 Oct 2.

School of Neurology, Neurobiology and Psychiatry and Institute for Ageing and Health, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1093/nar/gkm635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190723PMC
January 2008

Mitochondrial DNA mutations and aging.

Ann N Y Acad Sci 2007 Apr;1100:227-40

Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, Newcastle University, Framlington Place, NE2 4HH, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1196/annals.1395.024DOI Listing
April 2007

Interactions of skin thickness and physicochemical properties of test compounds in percutaneous penetration studies.

Int Arch Occup Environ Health 2006 May 25;79(5):405-13. Epub 2006 Jan 25.

School of Clinical and Laboratory Sciences, University of Newcastle, Newcastle upon Tyne, NE2 4HH, UK.

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http://link.springer.com/10.1007/s00420-005-0056-5
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http://dx.doi.org/10.1007/s00420-005-0056-5DOI Listing
May 2006

Clonal expansion in the human gut: mitochondrial DNA mutations show us the way.

Cell Cycle 2006 Apr 17;5(8):808-11. Epub 2006 Apr 17.

Histopathology Unit, London Research Institute, Cancer Research UK, London, UK.

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http://dx.doi.org/10.4161/cc.5.8.2641DOI Listing
April 2006

Mitochondrial DNA mutations in human disease.

IUBMB Life 2006 Mar;58(3):143-51

Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1080/15216540600686888DOI Listing
March 2006

Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission.

Proc Natl Acad Sci U S A 2006 Jan 6;103(3):714-9. Epub 2006 Jan 6.

Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0505903103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1325106PMC
January 2006