Publications by authors named "Laura Andreoli"

100Publications

Coagulation dysfunction in COVID-19: The interplay between inflammation, viral infection and the coagulation system.

Blood Rev 2020 Aug 24:100745. Epub 2020 Aug 24.

Rheumatology and Clinical Immunology Unit, ASST Spedali Civili of Brescia, Brescia, Italy; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.blre.2020.100745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444609PMC
August 2020

COVID-19 in patients with rheumatic diseases in northern Italy: a single-centre observational and case-control study.

Lancet Rheumatol 2020 Sep 18;2(9):e549-e556. Epub 2020 Jun 18.

Rheumatology and Clinical Immunology Unit, ASST Spedali Civili of Brescia, Brescia, Italy.

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http://dx.doi.org/10.1016/S2665-9913(20)30169-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302769PMC
September 2020

Effectiveness of reproductive health counseling of women with systemic lupus erythematosus: observational cross-sectional study at an academic lupus clinic.

Rheumatol Int 2020 Aug 7. Epub 2020 Aug 7.

Rheumatology Department, Centro Hospitalar Universitário de Coimbra, Praceta Professor Mota Pinto, 3000-075, Coimbra, Portugal.

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http://dx.doi.org/10.1007/s00296-020-04671-9DOI Listing
August 2020

"APS pregnancy - The offspring".

Lupus 2020 Aug 4:961203320947154. Epub 2020 Aug 4.

Department of Obstetrics and Gynecology, I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.

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http://dx.doi.org/10.1177/0961203320947154DOI Listing
August 2020

Impact of the new 2019 EULAR/ACR classification criteria for Systemic Lupus Erythematosus in a multicenter cohort study of 133 women with undifferentiated connective tissue disease.

Arthritis Care Res (Hoboken) 2020 Jul 23. Epub 2020 Jul 23.

Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d'Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, and SCDU Nephrology and Dialysis, S. Giovanni Bosco Hospital, Turin, Italy.

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http://dx.doi.org/10.1002/acr.24391DOI Listing
July 2020

Beyond current concepts in anti-phospholipid syndrome: The 16th International Congress on Anti-phospholipid Antibodies (ICAPA) in Manchester.

Autoimmun Rev 2020 Sep 11;19(9):102615. Epub 2020 Jul 11.

Experimental Laboratory of Immunological and Rheumatologic Researches, IRCCS Istituto Auxologico Italiano, Cusano Milanino, Milan, Italy; Unit of Allergology, Immunology and Rheumatology, IRCCS Istituto Auxologico Italiano, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.autrev.2020.102615DOI Listing
September 2020

The immunologic etiology of psychiatric manifestations in systemic lupus erythematosus: A narrative review on the role of the blood brain barrier, antibodies, cytokines and chemokines.

Autoimmun Rev 2020 Aug 17;19(8):102592. Epub 2020 Jun 17.

Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht University, Utrecht 3584 CX, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.autrev.2020.102592DOI Listing
August 2020

Covid-19 and autoimmunity.

Autoimmun Rev 2020 08 11;19(8):102597. Epub 2020 Jun 11.

The Zabludowicz Center for autoimmune diseases, Sheba Medical Center, Israel; The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Sechenov University, Russia.

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http://dx.doi.org/10.1016/j.autrev.2020.102597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289100PMC
August 2020

A guide to managing reproductive health in rheumatology.

Nat Rev Rheumatol 2020 Aug;16(8):411-412

Unit of Rheumatology and Clinical Immunology, ASST Spedali Civili; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

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http://dx.doi.org/10.1038/s41584-020-0443-zDOI Listing
August 2020

Tocilizumab for the treatment of severe COVID-19 pneumonia with hyperinflammatory syndrome and acute respiratory failure: A single center study of 100 patients in Brescia, Italy.

Autoimmun Rev 2020 Jul 3;19(7):102568. Epub 2020 May 3.

University Division of Anesthesiology and Critical Care Medicine, ASST Spedali Civili, Brescia, Italy; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.autrev.2020.102568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252115PMC
July 2020

A multicentre study of 244 pregnancies in undifferentiated connective tissue disease: maternal/fetal outcomes and disease evolution.

Rheumatology (Oxford) 2020 Sep;59(9):2412-2418

Center of Research of Immunopathology and Rare Diseases - Coordinating Center of Piemonte and Valle d'Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, and SCDU Nephrology and Dialysis, S. Giovanni Bosco Hospital, Turin, Italy.

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http://dx.doi.org/10.1093/rheumatology/kez620DOI Listing
September 2020

Improved pregnancy outcome in patients with Rheumatoid Arthritis who followed an ideal clinical pathway.

Arthritis Care Res (Hoboken) 2020 Jan 7. Epub 2020 Jan 7.

Department of Medical Sciences, Rheumatology Unit, University of Ferrara, Cona (Ferrara), Italy.

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http://dx.doi.org/10.1002/acr.24116DOI Listing
January 2020

Targeting CD20 in the treatment of interstitial lung diseases related to connective tissue diseases: A systematic review.

Autoimmun Rev 2020 Feb 12;19(2):102453. Epub 2019 Dec 12.

Department of Translational Medicine, Università del Piemonte Orientale UPO, Novara, Italy; CAAD, Centre for Autoimmune and Allergic Diseases, Novara, Italy; Division of Internal Medicine, Immunorheumatology Unit "AOU Maggiore della Carità", Novara, Italy.

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http://dx.doi.org/10.1016/j.autrev.2019.102453DOI Listing
February 2020

Infertility in women with systemic autoimmune diseases.

Best Pract Res Clin Endocrinol Metab 2019 12 2;33(6):101369. Epub 2019 Dec 2.

Department of Obstetrics and Gynecology of I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.

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http://dx.doi.org/10.1016/j.beem.2019.101369DOI Listing
December 2019

Cardiovascular target organ damage in premenopausal systemic lupus erythematosus patients and in controls: Are there any differences?

Eur J Intern Med 2020 Mar 9;73:76-82. Epub 2019 Dec 9.

Department of Clinical and Experimental Sciences, University of Brescia, Italy; UOC 2° Medicina, ASST Spedali Civili Brescia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejim.2019.12.001DOI Listing
March 2020

Long-term outcome of children born from mothers with autoimmune diseases.

Best Pract Res Clin Obstet Gynaecol 2020 Apr 13;64:107-116. Epub 2019 Nov 13.

Rheumatology and Immunology Unit, Department of Clinical and Experimental Sciences, University of Brescia and ASST Spedali Civili of Brescia, Piazzale Spedali Civili 1, 25123, Brescia, Italy.

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http://dx.doi.org/10.1016/j.bpobgyn.2019.11.003DOI Listing
April 2020

Does seronegative obstetric APS exist? "pro" and "cons".

Autoimmun Rev 2019 Dec 19;18(12):102407. Epub 2019 Oct 19.

Head of Rheumatology Unit, First Department of Propaedeutic Internal Medicine, School of Medicine, National University of Athens, Greece.

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http://dx.doi.org/10.1016/j.autrev.2019.102407DOI Listing
December 2019

Is cholecalciferol a potential disease-modifying anti-rheumatic drug for the management of rheumatoid arthritis?

Clin Exp Rheumatol 2020 Mar-Apr;38(2):343-349. Epub 2019 Sep 17.

Department of Translational Medicine, Università del Piemonte Orientale UPO, Novara; Division of Internal Medicine, Immuno-Rheumatology Unit, CAAD (Center for Translational Research on Autoimmune and Allergic Disease) "Maggiore della Carità" Hospital, Novara; and IRCAD, Interdisciplinary Research Center of Autoimmune Diseases, Novara, Italy.

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April 2020

Autoimmune diseases and pregnancy.

Best Pract Res Clin Endocrinol Metab 2019 12 11;33(6):101322. Epub 2019 Sep 11.

Department of Obstetrics and Gynecology of I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.

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http://dx.doi.org/10.1016/j.beem.2019.101322DOI Listing
December 2019

The Course of Rheumatic Diseases During Pregnancy.

Isr Med Assoc J 2019 Jul;21(7):464-470

Unit of Rheumatology and Clinical Immunology, Spedali Civili, Brescia, Italy.

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July 2019

Management of maternal antiphospholipid syndrome.

Clin Exp Rheumatol 2020 Jan-Feb;38(1):149-156. Epub 2019 Jun 28.

Rheumatology and Clinical Immunology Unit and Department of Clinical and Experimental Sciences, Spedali Civili and University of Brescia, Italy, and Sechenov Medical University, Moscow, Russia.

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March 2020

Gender equity in clinical practice, research and training: Where do we stand in rheumatology?

Joint Bone Spine 2019 Nov 17;86(6):669-672. Epub 2019 Jun 17.

NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jbspin.2019.05.005DOI Listing
November 2019

Pregnancy outcomes in mixed connective tissue disease: a multicentre study.

Rheumatology (Oxford) 2019 11;58(11):2000-2008

Center of Research of Immunopathology and Rare Diseases, Coordinating Center of Piemonte and Valle d'Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences and SCDU Nephrology and Dialysis, S. Giovanni Bosco Hospital and University of Turin, Turin, Italy.

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http://dx.doi.org/10.1093/rheumatology/kez141DOI Listing
November 2019

"Disease knowledge index" and perspectives on reproductive issues: A nationwide study on 398 women with autoimmune rheumatic diseases.

Joint Bone Spine 2019 07 21;86(4):475-481. Epub 2018 Dec 21.

Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123 Brescia, Italy; Rheumatology and Clinical Immunology Unit, ASST Spedali Civili, Piazzale Spedali Civili, 1, 25123 Brescia, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S1297319X183025
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http://dx.doi.org/10.1016/j.jbspin.2018.12.002DOI Listing
July 2019

HIBISCUS: Hydroxychloroquine for the secondary prevention of thrombotic and obstetrical events in primary antiphospholipid syndrome.

Autoimmun Rev 2018 Dec 12;17(12):1153-1168. Epub 2018 Oct 12.

Istituto Auxologico Italiano, IRCCS, Laboratory of Immunorheumatology, Milan, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S15689972183022
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http://dx.doi.org/10.1016/j.autrev.2018.05.012DOI Listing
December 2018

Obstetric Anti-phospholipid Syndrome: State of the Art.

Curr Rheumatol Rep 2018 08 13;20(10):59. Epub 2018 Aug 13.

Rheumatology and Clinical Immunology Unit and Department of Clinical and Experimental Sciences, Spedali Civili and University of Brescia, Brescia, Italy.

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http://link.springer.com/10.1007/s11926-018-0772-y
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http://dx.doi.org/10.1007/s11926-018-0772-yDOI Listing
August 2018

Update on Antiphospholipid Syndrome: Ten Topics in 2017.

Curr Rheumatol Rep 2018 03 15;20(3):15. Epub 2018 Mar 15.

Rheumatology and Clinical Immunology, Spedali Civili, piazzale Spedali Civili 1, 25100, Brescia, Italy.

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http://link.springer.com/10.1007/s11926-018-0718-4
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http://dx.doi.org/10.1007/s11926-018-0718-4DOI Listing
March 2018

Beyond thrombosis: Anti-β2GPI domain 1 antibodies identify late pregnancy morbidity in anti-phospholipid syndrome.

J Autoimmun 2018 06 14;90:76-83. Epub 2018 Feb 14.

Department of Clinical Sciences and Community Health, University of Milan, Via Festa del Perdono 7, 20122 Milan, Italy; Experimental Laboratory of Immunological and Rheumatologic Researches, IRCCS Istituto Auxologico Italiano, Via Zucchi 18, 20095 Cusano Milanino, Milan, Italy; Department of Rheumatology, ASST Istituto Gaetano Pini & CTO, Piazza Cardinal Ferrari, 1 20122 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2018.02.002DOI Listing
June 2018

The treatment of anti-phospholipid syndrome: A comprehensive clinical approach.

J Autoimmun 2018 06 13;90:1-27. Epub 2018 Feb 13.

Experimental Laboratory of Immunological and Rheumatologic Researches, IRCCS Istituto Auxologico Italiano, Via Zucchi 18, 20095 Cusano Milanino, Milan, Italy.

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http://dx.doi.org/10.1016/j.jaut.2018.02.003DOI Listing
June 2018

Vitamin D and systemic lupus erythematous: a review of immunological and clinical aspects.

Clin Exp Rheumatol 2018 Jan-Feb;36(1):153-162. Epub 2017 Nov 14.

Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS AOU San Martino Hospital, Genova, Italy.

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April 2018

Pregnancy and reproductive aspects of systemic lupus erythematosus.

Curr Opin Rheumatol 2017 Sep;29(5):473-479

Department of Clinical and Experimental Sciences, University of Brescia, and Rheumatology and Clinical Immunology Unit, Spedali Civili of Brescia, Brescia, Italy.

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http://dx.doi.org/10.1097/BOR.0000000000000415DOI Listing
September 2017

Longterm Outcome of Patients with Primary Antiphospholipid Syndrome: A Retrospective Multicenter Study.

J Rheumatol 2017 08 1;44(8):1165-1172. Epub 2017 Jun 1.

From the Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia, Brescia; Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan, Milan; Rheumatology Unit, Department of Medicine - DIMED, University of Padua, Padua; Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome, Rome, Italy; AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University, Paris, France; University of the West Indies, Kingston, Jamaica.

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http://dx.doi.org/10.3899/jrheum.161364DOI Listing
August 2017

Undifferentiated connective tissue disease, fibromyalgia and the environmental factors.

Curr Opin Rheumatol 2017 07;29(4):355-360

Department of Clinical and Experimental Sciences, University of Brescia, and Rheumatology and Clinical Immunology Unit, Spedali Civili of Brescia, Brescia, Italy.

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http://dx.doi.org/10.1097/BOR.0000000000000392DOI Listing
July 2017

The 2016 classification criteria for primary Sjogren's syndrome: what's new?

BMC Med 2017 03 31;15(1):69. Epub 2017 Mar 31.

Rheumatology and Clinical Immunology Unit, ASST Spedali Civili, Brescia, Italy.

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http://dx.doi.org/10.1186/s12916-017-0837-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374666PMC
March 2017

The antiphospholipid syndrome in patients with systemic lupus erythematosus.

J Autoimmun 2017 01 21;76:10-20. Epub 2016 Oct 21.

Department of Clinical and Experimental Sciences, University of Brescia, Rheumatology and Clinical Immunology, Spedali Civili, Brescia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2016.10.004DOI Listing
January 2017

A comprehensive review of the clinical approach to pregnancy and systemic lupus erythematosus.

J Autoimmun 2016 11 2;74:106-117. Epub 2016 Jul 2.

Rheumatology and Clinical Immunology, Spedali Civili of Brescia, Italy; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2016.06.016DOI Listing
November 2016

Exploring Autoimmunity in a Cohort of Children with Genetically Confirmed Aicardi-Goutières Syndrome.

J Clin Immunol 2016 10 18;36(7):693-9. Epub 2016 Aug 18.

Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

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http://dx.doi.org/10.1007/s10875-016-0325-yDOI Listing
October 2016

Long-term use of hydroxychloroquine reduces antiphospholipid antibodies levels in patients with primary antiphospholipid syndrome.

Immunol Res 2017 02;65(1):17-24

Rheumatology and Clinical Immunology Unit, ASST Spedali Civili, University of Brescia, Piazzale Spedali Civili 1, 25123, Brescia, Italy.

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http://dx.doi.org/10.1007/s12026-016-8812-zDOI Listing
February 2017

Management of Gender-Related Problems in Women with Autoimmune Rheumatic Diseases.

Isr Med Assoc J 2016 Mar-Apr;18(3-4):183-7

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June 2016

The Efficacy and Safety of Cyclosporin A in Pregnant Patients with Systemic Autoimmune Diseases.

Am J Reprod Immunol 2016 06 5;75(6):654-60. Epub 2016 May 5.

Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy.

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http://dx.doi.org/10.1111/aji.12514DOI Listing
June 2016

Antirheumatic drugs and reproduction in women and men with chronic arthritis.

RMD Open 2015 15;1(Suppl 1):e000048. Epub 2015 Aug 15.

Rheumatology and Clinical Immunology Unit , Spedali Civili di Brescia , Brescia , Italy ; Department of Clinical and Experimental Sciences , University of Brescia , Brescia , Italy.

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http://dx.doi.org/10.1136/rmdopen-2015-000048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632146PMC
November 2015

The Pathogenicity of Anti-β2GP1-IgG Autoantibodies Depends on Fc Glycosylation.

J Immunol Res 2015 22;2015:638129. Epub 2015 Jun 22.

Department for Internal Medicine 3, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Ulmenweg 18, 91054 Erlangen, Germany.

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http://www.hindawi.com/journals/jir/2015/638129/
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http://dx.doi.org/10.1155/2015/638129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491572PMC
March 2016

The prevalence and incidence of systemic lupus erythematosus in children and adults: a population-based study in a mountain community in northern Italy.

Clin Exp Rheumatol 2015 Sep-Oct;33(5):681-7. Epub 2015 Jun 19.

Rheumatology and Clinical Immunology, Spedali Civili, and Department of Clinical and Experimental Sciences, University of Brescia, Italy.

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December 2015

Winter lupus flares are associated with low vitamin D levels in a retrospective longitudinal study of Italian adult patients.

Clin Exp Rheumatol 2015 Mar-Apr;33(2):153-8. Epub 2015 Jan 29.

Rheumatology and Clinical Immunology, Department of Clinical and Experimental Sciences, Spedali Civili and University of Brescia, Italy.

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May 2015

The efficacy of hydroxychloroquine for obstetrical outcome in anti-phospholipid syndrome: Data from a European multicenter retrospective study.

Autoimmun Rev 2015 Jun 21;14(6):498-502. Epub 2015 Jan 21.

AP-HP, Hôpital Saint-Antoine, Service de Médecine Interne, Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Sorbonne Universités, UPMC Univ Paris 06, F-75012 Paris, France.

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http://dx.doi.org/10.1016/j.autrev.2015.01.012DOI Listing
June 2015

The role of second trimester uterine artery Doppler in pregnancies with systemic lupus erythematosus.

Prenat Diagn 2015 May;35(5):447-52

Maternal Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Spedali Civili and University of Brescia, Brescia, Italy.

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http://doi.wiley.com/10.1002/pd.4517
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http://dx.doi.org/10.1002/pd.4517DOI Listing
May 2015

The estimated frequency of antiphospholipid antibodies in young adults with cerebrovascular events: a systematic review.

Ann Rheum Dis 2015 Nov 18;74(11):2028-33. Epub 2014 Jun 18.

Graham Hughes Lupus Research Laboratory, Lupus Research Unit, The Rayne Institute, Division of Women's Health, King's College London, London, UK.

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http://ard.bmj.com/content/74/11/2028.full.pdf
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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2014-20566
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http://dx.doi.org/10.1136/annrheumdis-2014-205663DOI Listing
November 2015

14th International Congress on Antiphospholipid Antibodies Task Force report on obstetric antiphospholipid syndrome.

Autoimmun Rev 2014 Aug 17;13(8):795-813. Epub 2014 Mar 17.

Department of Obstetrics and Gynecology, University of UT, Salt Lake City, USA; Intermountain Healthcare, Salt Lake City, USA.

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http://dx.doi.org/10.1016/j.autrev.2014.02.003DOI Listing
August 2014

Management of recurrent thrombosis in antiphospholipid syndrome.

Curr Rheumatol Rep 2014 Mar;16(3):405

Rheumatology and Clinical Immunology, Department of Clinical and Experimental Sciences, Spedali Civili and University of Brescia, Brescia, Italy,

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http://dx.doi.org/10.1007/s11926-013-0405-4DOI Listing
March 2014

Reply: To PMID 23861221.

Arthritis Care Res (Hoboken) 2014 Jun;66(6):966-7

Istituto Auxologico Italiano and University of Milan, Milan, Italy.

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http://dx.doi.org/10.1002/acr.22272DOI Listing
June 2014

Anti-phospholipid antibodies.

Rheumatology (Oxford) 2014 Feb 27;53(2):201-2. Epub 2013 Nov 27.

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer 52621, Israel.

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http://dx.doi.org/10.1093/rheumatology/ket394DOI Listing
February 2014

Clinical significance of IgA anti-cardiolipin and IgA anti-β2glycoprotein I antibodies.

Curr Rheumatol Rep 2013 Jul;15(7):343

Rheumatology and Clinical Immunology, Department of Clinical and Experimental Sciences, Spedali Civili and University of Brescia, Piazzale Spedali Civili 1, 25123, Brescia, Italy.

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http://dx.doi.org/10.1007/s11926-013-0343-1DOI Listing
July 2013

Antiphospholipid antibodies mediate autoimmunity against dying cells.

Autoimmunity 2013 Aug 29;46(5):302-6. Epub 2013 May 29.

Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Italy.

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http://dx.doi.org/10.3109/08916934.2013.783025DOI Listing
August 2013