Publications by authors named "Laszlo Urban"

58Publications

Major Clinical Response to Afatinib Monotherapy in Lung Adenocarcinoma Harboring EGFR Exon 20 Insertion Mutation.

Clin Lung Cancer 2021 Jan 18;22(1):e112-e115. Epub 2020 Sep 18.

Oncompass Medicine Hungary Ltd, Budapest, Hungary; Department of Pharmacology, Semmelweis University, Budapest, Hungary; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL. Electronic address:

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January 2021

Lung Cancer in Hungary.

J Thorac Oncol 2020 05;15(5):692-699

Department of Tumor Biology, National Korányi Institute of Pulmonology, Semmelweis University, Budapest, Hungary; MTA-SE NAP, Brain Metastasis Research Group, Hungarian Academy of Sciences, 2nd Department of Pathology, Semmelweis University, Budapest, Hungary.

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May 2020

Safety differentiation: emerging competitive edge in drug development.

Drug Discov Today 2019 01 19;24(1):285-292. Epub 2018 Sep 19.

Novartis Institutes for Biomedical Research, Translational Medicine, Pre-Clinical Safety, Basel, Switzerland.

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January 2019

REPLY TO THORNELOE ET AL.

Physiol Rev 2017 10;97(4):1233-1234

Department of Surgery and Cancer, Anaesthetics, Pain Medicine and Intensive Care Section, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom; Department of Anaesthetics, The Queen Elizabeth Hospital, Birmingham, United Kingdom; Preclinical Compound Profiling, Secondary Pharmacology, Preclinical Safety, NIBR, Cambridge, Massachusetts; Department of Molecular Cell Biology, Campus Gasthuisberg, Leuven, Belgium; School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.

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October 2017

Spatial Distribution of the Cannabinoid Type 1 and Capsaicin Receptors May Contribute to the Complexity of Their Crosstalk.

Sci Rep 2016 Sep 22;6:33307. Epub 2016 Sep 22.

Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK.

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September 2016

Rolapitant improves quality of life of patients receiving highly or moderately emetogenic chemotherapy.

Support Care Cancer 2017 01 24;25(1):85-92. Epub 2016 Aug 24.

Division of Medical Oncology, San Giuseppe Moscati Hospital, Condtrada Amoretta, 8, Avellino, 83100, Italy.

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January 2017

TRPV4: Molecular Conductor of a Diverse Orchestra.

Physiol Rev 2016 07;96(3):911-73

Anaesthetics, Pain Medicine and Intensive Care Section, Department of Surgery and Cancer, Imperial College London, London, United Kingdom; Department of Anaesthetics, The Queen Elizabeth Hospital, Birmingham, United Kingdom; Academic Department of Anaesthesia and Intensive Care Medicine, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, United Kingdom; Preclinical Secondary Pharmacology, Preclinical Safety, Novartis Institute for Biomedical Research, Cambridge, Massachusetts; Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, KU Leuven, Campus Gasthuisberg, Leuven, Belgium; and School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, United Kingdom.

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July 2016

Secondary pharmacology: screening and interpretation of off-target activities - focus on translation.

Drug Discov Today 2016 08 29;21(8):1232-42. Epub 2016 Apr 29.

Preclinical Safety, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA. Electronic address:

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August 2016

A screening pattern recognition method finds new and divergent targets for drugs and natural products.

ACS Chem Biol 2014 Jul 2;9(7):1622-31. Epub 2014 Jun 2.

Novartis Institutes for Biomedical Research Inc. , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.

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July 2014

Computational methods for early predictive safety assessment from biological and chemical data.

Expert Opin Drug Metab Toxicol 2011 Dec 4;7(12):1497-511. Epub 2011 Nov 4.

Novartis Institutes for BioMedical Research, Inc., Chemical Biology Informatics, Quantitative Biology, Developmental and Molecular Pathways, 220 Massachusetts Avenue, 02139 Cambridge, MA, USA.

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December 2011

IonFlux: a microfluidic patch clamp system evaluated with human Ether-à-go-go related gene channel physiology and pharmacology.

Assay Drug Dev Technol 2011 Dec 11;9(6):608-19. Epub 2011 May 11.

Preclinical Safety Profiling, Center for Proteomic Chemistry, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, USA.

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December 2011

Cardiac ion channel safety profiling on the IonWorks Quattro automated patch clamp system.

Assay Drug Dev Technol 2010 Dec 6;8(6):766-80. Epub 2010 Dec 6.

Center for Proteomic Chemistry, Novartis Institutes for BioMedical Sciences Inc., Cambridge, Massachusetts 02139, USA.

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December 2010

TRPV1 function in health and disease.

Curr Pharm Biotechnol 2011 Jan;12(1):130-44

Anaesthetics, Pain Medicine and Intensive Care Section, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, UK.

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January 2011

Molecular structure of transient receptor potential vanilloid type 1 ion channel (TRPV1).

Curr Pharm Biotechnol 2011 Jan;12(1):115-21

Preclinical Compound Profiling, Lead Discovery Center, Discovery Technologies, NIBRI, Cambridge, MA 01932, USA.

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January 2011

Role of transient receptor potential and acid-sensing ion channels in peripheral inflammatory pain.

Anesthesiology 2010 Mar;112(3):729-41

Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom.

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March 2010

Phenotypic screening: Fishing for neuroactive compounds.

Nat Chem Biol 2010 Mar;6(3):172-173

Jeremy L. Jenkins and Laszlo Urban are in the Center for Proteomic Chemistry, Lead Finding Platform, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.

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March 2010

The accuracy of EGSnrc, Geant4 and PENELOPE Monte Carlo systems for the simulation of electron scatter in external beam radiotherapy.

Phys Med Biol 2009 Oct 24;54(20):6151-63. Epub 2009 Sep 24.

UCSF Helen Diller Family Comprehensive Cancer Center, 1600 Divisadero Street, San Francisco, CA 94143-1708, USA.

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October 2009

In vitro safety pharmacology profiling: what else beyond hERG?

Future Med Chem 2009 Jul;1(4):645-65

Center for Proteomic Chemistry, Novartis Pharma AG, Forum 1, 4002 Basel, Switzerland.

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July 2009

Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis.

J Chem Inf Model 2009 Feb;49(2):308-17

Lead Discovery Informatics and Preclinical Safety Profiling, CPC, Novartis Institutes for Biomedical Research, 250 Massachussetts Avenue, Cambridge, Massachusetts 02139, USA.

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February 2009

Mapping adverse drug reactions in chemical space.

J Med Chem 2009 May;52(9):3103-7

Lead Discovery Informatics, CPC, Novartis Institutes for Biomedical Research, 250 Massachussetts Avenue, Cambridge, Massachusetts 02139, USA.

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May 2009

Evaluation of fluorescence- and mass spectrometry-based CYP inhibition assays for use in drug discovery.

J Biomol Screen 2008 Jun 12;13(5):343-53. Epub 2008 May 12.

ADME Profiling Cambridge, Metabolism and Pharmacokinetics, Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, USA.

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June 2008

[Fixed-dose combinations in the first line of antihypertensive therapy].

Acta Pharm Hung 2007 ;77(3):180-4

Semmelweis Egyetem, Egyetemi Gyógyszertár Gyógyszerügyi Szervezési Intézet, Budapest.

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December 2007

Maximising use of in vitro ADMET tools to predict in vivo bioavailability and safety.

Expert Opin Drug Metab Toxicol 2007 Oct;3(5):641-65

Novartis Institutes for Biomedical Research, Metabolism and Pharmacokinetics, 250 Massachusetts Avenue, Cambridge, MA 02139, USA.

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October 2007

Detection of a rare oligo(A) repeat tract mutation (8As-->7As) in the sequence encoding the La/SS-B autoantigen.

Anal Biochem 2007 Nov 5;370(1):47-53. Epub 2007 Jul 5.

Molecular Biology Research Laboratory, 3rd Department of Medicine, Medical and Health Science Center, University of Debrecen, H-4004 Debrecen, Hungary.

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November 2007

Modeling promiscuity based on in vitro safety pharmacology profiling data.

ChemMedChem 2007 Jun;2(6):874-80

CPC/LFP/MLI, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Postfach, 4002 Basel, Switzerland.

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June 2007

Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure.

ChemMedChem 2007 Jun;2(6):861-73

Lead Finding Platform, Novartis Institutes for BioMedical Research Inc. 250 Massachusetts Ave., Cambridge, Massachusetts 02139, USA.

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June 2007

Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development.

Drug Discov Today 2005 Nov;10(21):1421-33

PreClinical Profiling, Lead Discovery Center, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.

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November 2005

The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology.

Eur J Pharmacol 2004 Oct;500(1-3):351-69

Department of Anaesthetics and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom.

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October 2004

Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 in vitro.

Eur J Neurosci 2003 Jun;17(12):2611-8

Department of Academic Anaesthetics, Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK.

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June 2003

Activation of capsaicin-sensitive primary sensory neurones induces anandamide production and release.

J Neurochem 2003 Feb;84(3):585-91

Department of Anaesthetics and Intensive Care, Imperial College, Faculty of Medicine, Chelsea and Westminster Hospital, London, UK.

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February 2003

Responses to sympathomimetics in rat sensory neurones after nerve transection.

Neuroreport 2003 Jan;14(1):9-13

Prince of Wales Medical Research Institute and the University of New South Wales, Randwick, Australia.

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January 2003

Disease modifying and anti-nociceptive effects of the bisphosphonate, zoledronic acid in a model of bone cancer pain.

Pain 2002 Dec;100(3):219-229

Purdue Biopharma LP, 201 College Road East, Princeton, NJ 08540, USA Novartis Institute for Medical Sciences, 5 Gower Place, London WC1E 6BN, UK W. Harvey Research Institute, St Bartholomew's and Royal London School of Medicine, Charterhouse Square, London, UK Novartis Pharma AG, Basel, Switzerland.

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December 2002

On the role of aging in the etiology of autoimmunity.

Gerontology 2002 May-Jun;48(3):179-84

Molecular Biology Research Laboratory, 3rd Department of Medicine, Medical and Health Science Center, University of Debrecen, Moricz Zs. Krt. 22 (POB 3), H-4004 Debrecen, Hungary.

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July 2002

Oral anti-hyperalgesic and anti-inflammatory activity of NK(1) receptor antagonists in models of inflammatory hyperalgesia of the guinea-pig.

Pain 2000 Sep;87(3):253-263

Novartis Institute for Medical Sciences, 5 Gower Place, London WC1E 6BN, UK St. Bartholomew's School of Medicine, London, UK.

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September 2000

Critical evaluation of the streptozotocin model of painful diabetic neuropathy in the rat.

Pain 1999 Jun;81(3):307-316

Novartis Institute for Medical Sciences, 5 Gower Place, London WC1E 6BN, UK Novartis Pharma Corporation, East Hannover, NJ, USA.

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June 1999