Lasse Ebdrup Pedersen

Lasse Ebdrup Pedersen

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Lasse Ebdrup Pedersen

Lasse Ebdrup Pedersen

Publications by authors named "Lasse Ebdrup Pedersen"

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14Publications

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Reprogramming AA catabolism in CHO cells with CRISPR/Cas9 genome editing improves cell growth and reduces byproduct secretion.

Metab Eng 2019 Sep 14;56:120-129. Epub 2019 Sep 14.

Department of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.ymben.2019.09.005DOI Listing
September 2019

Genome-wide systematic identification of methyltransferase recognition and modification patterns.

Nat Commun 2019 Aug 19;10(1):3311. Epub 2019 Aug 19.

The Novo Nordisk Foundation Center for Biosustainability (CfB), Technical University of Denmark (DTU), DK-2800, Lyngby, Denmark.

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http://dx.doi.org/10.1038/s41467-019-11179-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700114PMC
August 2019

Network reconstruction of the mouse secretory pathway applied on CHO cell transcriptome data.

BMC Syst Biol 2017 03 15;11(1):37. Epub 2017 Mar 15.

Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads 223, DK-2800, Kgs. Lyngby, Denmark.

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http://dx.doi.org/10.1186/s12918-017-0414-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353859PMC
March 2017

Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion.

Sci Rep 2017 01 16;7:40388. Epub 2017 Jan 16.

Novo Nordisk Foundation Center for Biosustainability at the University of California, San Diego, School of Medicine, La Jolla, CA 92093, United States.

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http://dx.doi.org/10.1038/srep40388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238448PMC
January 2017

Accelerated homology-directed targeted integration of transgenes in Chinese hamster ovary cells via CRISPR/Cas9 and fluorescent enrichment.

Biotechnol Bioeng 2016 11 3;113(11):2518-23. Epub 2016 Jun 3.

The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Hørsholm, 2970, Denmark.

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http://dx.doi.org/10.1002/bit.26002DOI Listing
November 2016

CRISPy-web: An online resource to design sgRNAs for CRISPR applications.

Synth Syst Biotechnol 2016 Jun 12;1(2):118-121. Epub 2016 Feb 12.

The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Alle 6, 2970 Hørsholm, Denmark.

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http://dx.doi.org/10.1016/j.synbio.2016.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640694PMC
June 2016

CRMAGE: CRISPR Optimized MAGE Recombineering.

Sci Rep 2016 Jan 22;6:19452. Epub 2016 Jan 22.

The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Allé 6, 2970 Hørsholm, Denmark.

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http://dx.doi.org/10.1038/srep19452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726160PMC
January 2016

Elucidation of the CHO Super-Ome (CHO-SO) by Proteoinformatics.

J Proteome Res 2015 Nov 13;14(11):4687-703. Epub 2015 Oct 13.

Department of Chemical and Biomolecular Engineering, Johns Hopkins University , Baltimore, Maryland 21218, United States.

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http://dx.doi.org/10.1021/acs.jproteome.5b00588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721571PMC
November 2015

One-step generation of triple knockout CHO cell lines using CRISPR/Cas9 and fluorescent enrichment.

Biotechnol J 2015 Sep 30;10(9):1446-56. Epub 2015 Apr 30.

The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Hørsholm, Denmark.

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http://dx.doi.org/10.1002/biot.201500027DOI Listing
September 2015

Site-specific integration in CHO cells mediated by CRISPR/Cas9 and homology-directed DNA repair pathway.

Sci Rep 2015 Feb 25;5:8572. Epub 2015 Feb 25.

The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2970 Hørsholm, Denmark.

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http://dx.doi.org/10.1038/srep08572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339809PMC
February 2015

Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web-based target finding tool.

Biotechnol Bioeng 2014 Aug 22;111(8):1604-16. Epub 2014 May 22.

The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Hørsholm, Denmark.

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http://doi.wiley.com/10.1002/bit.25233
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http://dx.doi.org/10.1002/bit.25233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312910PMC
August 2014

High levels of the type III inorganic phosphate transporter PiT1 (SLC20A1) can confer faster cell adhesion.

Exp Cell Res 2014 Aug 29;326(1):57-67. Epub 2014 May 29.

Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Hematology, Aarhus University Hospital, Aarhus, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2014.05.014DOI Listing
August 2014

Regulation of cell proliferation and cell density by the inorganic phosphate transporter PiT1.

Cell Div 2012 Mar 6;7(1). Epub 2012 Mar 6.

Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1186/1747-1028-7-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325893PMC
March 2012