Publications by authors named "Lars Zender"

100Publications

Therapy-induced senescence - an induced synthetic lethality in liver cancer?

Nat Rev Gastroenterol Hepatol 2020 03;17(3):135-136

Department of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1038/s41575-020-0262-3DOI Listing
March 2020

Novel patient-derived preclinical models of liver cancer.

J Hepatol 2020 02;72(2):239-249

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, USA; Liver Cancer Program, Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, USA; Graduate School of Biomedical Sciences at Icahn School of Medicine at Mount Sinai, New York, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2019.09.028DOI Listing
February 2020

[Nuclear protein in testis (NUT) midline carcinoma].

Rofo 2020 Apr 12;192(4):303-306. Epub 2019 Dec 12.

Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Ulm Germany.

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http://dx.doi.org/10.1055/a-1026-6561DOI Listing
April 2020

The Worst from Both Worlds: cHCC-ICC.

Cancer Cell 2019 06;35(6):823-824

Department of Medical Oncology & Pneumology, University Hospital Tübingen, 72076 Tübingen, Germany; German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg 69120, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.05.008DOI Listing
June 2019

Charting a path from 'bench to bedside'.

Authors:
Lars Zender

Nat Med 2019 Apr;25(4):535

University Hospital Tubingen, Tubingen, Germany.

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http://dx.doi.org/10.1038/s41591-019-0394-6DOI Listing
April 2019

Cellular senescence in gastrointestinal diseases: from pathogenesis to therapeutics.

Nat Rev Gastroenterol Hepatol 2018 02 29;15(2):81-95. Epub 2017 Nov 29.

Department of Internal Medicine I, University of Tuebingen, Otfried-Müller-Strasse 10, 72076 Tuebingen, Germany.

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http://www.nature.com/doifinder/10.1038/nrgastro.2017.146
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http://dx.doi.org/10.1038/nrgastro.2017.146DOI Listing
February 2018

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.

Nat Cell Biol 2017 Sep 31;19(9):1061-1070. Epub 2017 Jul 31.

Global Health Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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http://www.nature.com/doifinder/10.1038/ncb3586
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http://dx.doi.org/10.1038/ncb3586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826565PMC
September 2017

Optimized Target Residence Time: Type I1/2 Inhibitors for p38α MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R-Spine.

Angew Chem Int Ed Engl 2017 05 11;56(19):5363-5367. Epub 2017 Apr 11.

Institute of Pharmaceutical Sciences, Pharmaceutical and Medicinal Chemistry, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany.

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http://dx.doi.org/10.1002/anie.201701185DOI Listing
May 2017

Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice.

Gastroenterology 2017 04 10;152(5):1161-1173.e1. Epub 2016 Dec 10.

RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, Massachusetts; Program in Molecular Medicine and Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204228PMC
April 2017

Proteomic Analysis Reveals GMP Synthetase as p53 Repression Target in Liver Cancer.

Am J Pathol 2017 Feb 7;187(2):228-235. Epub 2016 Dec 7.

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; European Molecular Biology Laboratory, Structural and Computational Biology Unit, Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029440163045
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http://dx.doi.org/10.1016/j.ajpath.2016.09.022DOI Listing
February 2017

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression.

Cancer Cell 2016 10;30(4):533-547

Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.09.003DOI Listing
October 2016

p62 in Liver Disease: Good Guy or Bad Guy?

Authors:
Zexi Hu Lars Zender

Cancer Cell 2016 10;30(4):509-510

Department of Internal Medicine VIII, University Hospital Tübingen, 72076 Tübingen, Germany; Department of Physiology I, Institute of Physiology, Eberhard Karls University Tübingen, Otfried-Müller-Str. 14, 72076 Tübingen, Germany; Translational Gastrointestinal Oncology Group within the German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg 69120, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.09.013DOI Listing
October 2016

IGF2 Is Up-regulated by Epigenetic Mechanisms in Hepatocellular Carcinomas and Is an Actionable Oncogene Product in Experimental Models.

Gastroenterology 2016 12 7;151(6):1192-1205. Epub 2016 Sep 7.

Liver Cancer Translational Research Laboratory, Barcelona Clinic Liver Cancer Group, Liver Unit, IDIBAPS-Hospital Clínic de Barcelona, CIBERehd Universitat de Barcelona, Catalonia, Spain; Liver Cancer Program, Division of Liver Diseases and Pathology Department, Tisch Cancer Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; Institució Catalana de Recerca i Estudis Avançats, Barcelona, Catalonia, Spain. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.09.001DOI Listing
December 2016

C-arm computed tomography parenchymal blood volume measurement in evaluation of hepatocellular carcinoma before transarterial chemoembolization with drug eluting beads.

Cancer Imaging 2015 Dec 29;15:22. Epub 2015 Dec 29.

Department of Radiology, Diagnostic and Interventional Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.

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http://dx.doi.org/10.1186/s40644-015-0057-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696182PMC
December 2015

Parenchymal Blood Volume Assessed by C-Arm-Based Computed Tomography in Immediate Posttreatment Evaluation of Drug-Eluting Bead Transarterial Chemoembolization in Hepatocellular Carcinoma.

Invest Radiol 2016 Feb;51(2):121-6

From the *Diagnostic and Interventional Radiology, Department of Radiology, Eberhard-Karls University; and †Division of Translational Gastrointestinal Oncology, Department of Internal Medicine I, University of Tübingen, Tübingen, Germany.

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http://pdfs.journals.lww.com/investigativeradiology/2016/020
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http://dx.doi.org/10.1097/RLI.0000000000000215DOI Listing
February 2016

Reconstitution of Mice with Modified Liver Stem Cells.

Cold Spring Harb Protoc 2015 Jul 1;2015(7):685-8. Epub 2015 Jul 1.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.

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http://dx.doi.org/10.1101/pdb.prot078006DOI Listing
July 2015

Reciprocal interaction of Wnt and RXR-α pathways in hepatocyte development and hepatocellular carcinoma.

PLoS One 2015 4;10(3):e0118480. Epub 2015 Mar 4.

Cancer Genome Center, Cold Spring Harbor Laboratory, Woodbury, NY 11740, United States of America; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0118480PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349704PMC
December 2015

In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.

Nat Med 2014 Oct 14;20(10):1138-46. Epub 2014 Sep 14.

1] Division of Translational Gastrointestinal Oncology, Department of Internal Medicine I, University of Tuebingen, Tuebingen, Germany. [2] Translational Gastrointestinal Oncology Group within the German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nm.3679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587571PMC
October 2014

p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer.

Cell 2014 Jul;158(3):579-92

Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA; Howard Hughes Medical Institute, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.05.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221237PMC
July 2014

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles.

Nature 2014 Jul 9;511(7510):483-7. Epub 2014 Jul 9.

1] Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany [2] Comprehensive Cancer Center Mainfranken, University of Würzburg, Josef-Schneider-Str. 6, 97080 Würzburg, Germany [3].

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http://dx.doi.org/10.1038/nature13473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879323PMC
July 2014

Cancer: interference identifies immune modulators.

Authors:
Lars Zender

Nature 2014 Feb 29;506(7486):39-40. Epub 2014 Jan 29.

University of Tübingen, 72076 Tübingen, Germany, and at the German Center for Translational Cancer Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature13050DOI Listing
February 2014

α-1-antitrypsin inhibits acute liver failure in mice.

Hepatology 2014 Jun 28;59(6):2299-308. Epub 2014 Apr 28.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; Chronic Infection and Cancer Group, Helmholtz Center for Infection Research, Braunschweig, Germany; Division of Translational Gastrointestinal Oncology, Department of Internal Medicine I, University Hospital Tuebingen, Tübingen, Germany.

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http://doi.wiley.com/10.1002/hep.27024
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http://dx.doi.org/10.1002/hep.27024DOI Listing
June 2014

Microsphere priming facilitates induction of potent therapeutic T-cell immune responses against autochthonous liver cancers.

Eur J Immunol 2014 Apr 16;44(4):1213-24. Epub 2014 Jan 16.

Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Hannover, Germany.

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http://dx.doi.org/10.1002/eji.201343794DOI Listing
April 2014

Changing T-cell enigma: cancer killing or cancer control?

2013 Oct 26;12(19):3146-53. Epub 2013 Aug 26.

Department of Dermatology; Eberhard Karls University; Tübingen, Germany.

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http://dx.doi.org/10.4161/cc.26060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865009PMC
October 2013

RRM1 domain of the splicing oncoprotein SRSF1 is required for MEK1-MAPK-ERK activation and cellular transformation.

Carcinogenesis 2013 Nov 10;34(11):2498-504. Epub 2013 Jul 10.

Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Ein Karem, Jerusalem 91120, Israel and.

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http://dx.doi.org/10.1093/carcin/bgt247DOI Listing
November 2013

Regulation of accumulation and function of myeloid derived suppressor cells in different murine models of hepatocellular carcinoma.

J Hepatol 2013 Nov 22;59(5):1007-13. Epub 2013 Jun 22.

Gastrointestinal Malignancy Section, Medical Oncology Branch, National Cancer Institute, Bethesda, USA; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1016/j.jhep.2013.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805787PMC
November 2013

A critical role for notch signaling in the formation of cholangiocellular carcinomas.

Cancer Cell 2013 Jun 30;23(6):784-95. Epub 2013 May 30.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany.

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http://dx.doi.org/10.1016/j.ccr.2013.04.019DOI Listing
June 2013

Primary liver carcinomas can originate from different cell types: a new level of complexity in hepatocarcinogenesis.

Gastroenterology 2013 Jul 29;145(1):53-55. Epub 2013 May 29.

Division of Translational Gastrointestinal Oncology, Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1053/j.gastro.2013.05.024DOI Listing
July 2013

Immune surveillance of pre-cancerous senescent hepatocytes limits hepatocellular carcinoma development.

Oncoimmunology 2012 May;1(3):398-399

Helmholtz Centre for Infection Research; Braunschweig, Germany ; Hannover Medical School; Department of Gastroenterology, Hepatology and Endocrinology; Hannover, Germany.

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http://dx.doi.org/10.4161/onci.19128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382854PMC
May 2012

Immune surveillance of senescent cells--biological significance in cancer- and non-cancer pathologies.

Carcinogenesis 2012 Jun 2;33(6):1123-6. Epub 2012 Apr 2.

Helmholtz Centre for Infection Research, Braunschweig, Germany.

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http://dx.doi.org/10.1093/carcin/bgs124DOI Listing
June 2012

Deregulated MYC expression induces dependence upon AMPK-related kinase 5.

Nature 2012 Mar 28;483(7391):608-12. Epub 2012 Mar 28.

Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.

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http://dx.doi.org/10.1038/nature10927DOI Listing
March 2012

Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression.

J Exp Med 2012 Feb 23;209(2):275-89. Epub 2012 Jan 23.

Department of Molecular Oncology, Göttingen Center of Molecular Biosciences, University of Göttingen, 37077 Göttingen, Germany.

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http://dx.doi.org/10.1084/jem.20111117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280870PMC
February 2012

DLC1 and liver cancer: the Akt connection.

Gastroenterology 2010 Oct 25;139(4):1093-6. Epub 2010 Aug 25.

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http://dx.doi.org/10.1053/j.gastro.2010.08.016DOI Listing
October 2010

Selectivity of oncolytic viral replication prevents antiviral immune response and toxicity, but does not improve antitumoral immunity.

Mol Ther 2010 Nov 10;18(11):1972-82. Epub 2010 Aug 10.

Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Hannover, Germany.

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http://dx.doi.org/10.1038/mt.2010.163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990511PMC
November 2010

Cancer gene discovery in hepatocellular carcinoma.

J Hepatol 2010 Jun 20;52(6):921-9. Epub 2010 Mar 20.

Helmholtz Centre for Infection Research, Braunschweig 38124, Germany.

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http://dx.doi.org/10.1016/j.jhep.2009.12.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905725PMC
June 2010

Keeping your senescent cells under control.

Aging (Albany NY) 2009 May 6;1(5):438-41. Epub 2009 May 6.

Helmholtz Centre for Infection Research, Braunschweig, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806024PMC
http://dx.doi.org/10.18632/aging.100046DOI Listing
May 2009

Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma.

Cancer 2009 Oct;115(19):4576-85

Department of Surgery and Center for Cancer Research, the University of Hong Kong, Pokfulam, Hong Kong.

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http://dx.doi.org/10.1002/cncr.24495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811690PMC
October 2009

p53-dependent antiviral RNA-interference facilitates tumor-selective viral replication.

Nucleic Acids Res 2009 Jul 14;37(12):e84. Epub 2009 May 14.

Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Carl Neuberg Str. 1, 30625 Hannover, Germany.

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http://dx.doi.org/10.1093/nar/gkp374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709585PMC
July 2009

IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis.

Nat Cell Biol 2008 Nov 19;10(11):1309-17. Epub 2008 Oct 19.

The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1038/ncb1789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818601PMC
November 2008

Molecular pathogenesis and targeted therapy of hepatocellular carcinoma.

Onkologie 2008 Oct 9;31(10):550-5. Epub 2008 Sep 9.

Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hanover, Hanover, Germany.

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http://dx.doi.org/10.1159/000151586DOI Listing
October 2008

Androgen receptor and hepatocarcinogenesis: what do we learn from HCC mouse models?

Gastroenterology 2008 Sep 8;135(3):738-40. Epub 2008 Aug 8.

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http://dx.doi.org/10.1053/j.gastro.2008.07.034DOI Listing
September 2008

Topoisomerase levels determine chemotherapy response in vitro and in vivo.

Proc Natl Acad Sci U S A 2008 Jul 23;105(26):9053-8. Epub 2008 Jun 23.

Cold Spring Harbor Laboratory and Howard Hughes Medical Institute, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

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http://dx.doi.org/10.1073/pnas.0803513105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435590PMC
July 2008

Integrative oncogenomic approaches for accelerated cancer-gene discovery.

Curr Opin Oncol 2008 Jan;20(1):72-6

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

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http://dx.doi.org/10.1097/CCO.0b013e3282f31d5dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285239PMC
January 2008

A microRNA component of the p53 tumour suppressor network.

Nature 2007 Jun 6;447(7148):1130-4. Epub 2007 Jun 6.

Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.

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http://dx.doi.org/10.1038/nature05939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590999PMC
June 2007