Lars Tharun

Lars Tharun

UNVERIFIED PROFILE

Are you Lars Tharun?   Register this Author

Register author
Lars Tharun

Lars Tharun

Publications by authors named "Lars Tharun"

Are you Lars Tharun?   Register this Author

20Publications

703Reads

13Profile Views

TRIM24 as an independent prognostic biomarker for prostate cancer.

Authors:
Anne Offermann Doris Roth Marie Christine Hupe Silke Hohensteiner Finn Becker Vincent Joerg Jessica Carlsson Christiane Kuempers Julika Ribbat-Idel Lars Tharun Verena Sailer Jutta Kirfel Maria Svensson Ove Andren Verena Lubczyk Rainer Kuefer Axel S Merseburger Sven Perner

Urol Oncol 2019 Sep 7;37(9):576.e1-576.e10. Epub 2019 Jun 7.

Institute of Pathology, University Hospital Schleswig-Holstein, Luebeck, Germany; Pathology of the Research Center Borstel, Leibniz Lung Center, Borstel, Germany. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.urolonc.2019.05.006DOI Listing
September 2019

Surgical Implications for Diagnosis and Treatment of Intestinal Aspergillosis in Pediatric Patients with ALL.

Authors:
Janina Fischer Thorsten Simon Axel Hamprecht Nina Hos Anja Möricke Grigore Cernaianu Lars Tharun Bernd Gruhn Georg Plum Martin Dübbers

Eur J Pediatr Surg 2018 Dec 25;28(6):477-483. Epub 2017 Sep 25.

Division of Pediatric Surgery, University Hospital of Cologne, Cologne, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1055/s-0037-1607194DOI Listing
December 2018

Synergistic anti-angiogenic treatment effects by dual FGFR1 and VEGFR1 inhibition in FGFR1-amplified breast cancer.

Authors:
Kristina Golfmann Lydia Meder Mirjam Koker Caroline Volz Sven Borchmann Lars Tharun Felix Dietlein Florian Malchers Alexandra Florin Reinhard Büttner Neal Rosen Vanessa Rodrik-Outmezguine Michael Hallek Roland T Ullrich

Oncogene 2018 10 3;37(42):5682-5693. Epub 2018 Jul 3.

Department I of Internal Medicine, University Hospital Cologne, Kerpener Straße 62, 50937, Cologne, Germany.

View Article

Download full-text PDF

 Source
http://www.nature.com/articles/s41388-018-0380-3
Publisher Site
http://dx.doi.org/10.1038/s41388-018-0380-3DOI Listing
October 2018

The Cdkn1a Mouse as a Tool to Study p53-Mediated Tumor Suppression.

Authors:
Alessandro Torgovnick Jan Michel Heger Vasiliki Liaki Jörg Isensee Anna Schmitt Gero Knittel Arina Riabinska Filippo Beleggia Lucie Laurien Uschi Leeser Christian Jüngst Florian Siedek Wenzel Vogel Niklas Klümper Hendrik Nolte Maike Wittersheim Lars Tharun Roberta Castiglione Marcus Krüger Astrid Schauss Sven Perner Manolis Pasparakis Reinhard Büttner Thorsten Persigehl Tim Hucho Grit Sophie Herter-Sprie Björn Schumacher Hans Christian Reinhardt

Cell Rep 2018 10;25(4):1027-1039.e6

Department I of Internal Medicine, University Hospital Cologne, Weyertal 115b, 50931 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Joseph Stelzmann Straße 26, 50931 Cologne, Germany; Center for Molecular Medicine, University Hospital Cologne, Robert Koch Straße 21, 50931 Cologne. Electronic address:

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S22111247183153
Publisher Site
http://dx.doi.org/10.1016/j.celrep.2018.09.079DOI Listing
October 2018

The Endosomal Protein CEMIP Links WNT Signaling to MEK1-ERK1/2 Activation in Selumetinib-Resistant Intestinal Organoids.

Authors:
Hong Quan Duong Ivan Nemazanyy Florian Rambow Seng Chuan Tang Sylvain Delaunay Lars Tharun Alexandra Florin Reinhard Büttner Daniel Vandaele Pierre Close Jean-Christophe Marine Kateryna Shostak Alain Chariot

Cancer Res 2018 08 18;78(16):4533-4548. Epub 2018 Jun 18.

Interdisciplinary Cluster for Applied Genoproteomics (GIGA), GIGA-Molecular Biology of Diseases, University of Liege, CHU, Sart-Tilman, Liège, Belgium.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/0008-5472.CAN-17-3149DOI Listing
August 2018

Codon-specific translation reprogramming promotes resistance to targeted therapy.

Authors:
Francesca Rapino Sylvain Delaunay Florian Rambow Zhaoli Zhou Lars Tharun Pascal De Tullio Olga Sin Kateryna Shostak Sebastian Schmitz Jolanda Piepers Bart Ghesquière Latifa Karim Benoit Charloteaux Diane Jamart Alexandra Florin Charles Lambert Andrée Rorive Guy Jerusalem Eleonora Leucci Michael Dewaele Marc Vooijs Sebastian A Leidel Michel Georges Marianne Voz Bernard Peers Reinhard Büttner Jean-Christophe Marine Alain Chariot Pierre Close

Nature 2018 06 20;558(7711):605-609. Epub 2018 Jun 20.

Laboratory of Cancer Signaling, University of Liège, Liège, Belgium.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41586-018-0243-7DOI Listing
June 2018

High protein and mRNA expression levels of TUBB3 (class III ß-tubulin) are associated with aggressive tumor features in esophageal adenocarcinomas.

Authors:
Heike Loeser Simon Schallenberg Moritz von Winterfeld Lars Tharun Hakan Alakus Arnulf Hölscher Elfriede Bollschweiler Reinhard Buettner Thomas Zander Alexander Quaas

Oncotarget 2017 Dec 11;8(70):115179-115189. Epub 2017 Dec 11.

Institute of Pathology, University of Cologne, Cologne, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.18632/oncotarget.23112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777763PMC
December 2017

Characterization of tumor-associated T-lymphocyte subsets and immune checkpoint molecules in head and neck squamous cell carcinoma.

Authors:
Axel Lechner Hans Schlößer Sacha I Rothschild Martin Thelen Sabrina Reuter Peter Zentis Alexander Shimabukuro-Vornhagen Sebastian Theurich Kerstin Wennhold Maria Garcia-Marquez Lars Tharun Alexander Quaas Astrid Schauss Jörg Isensee Tim Hucho Christian Huebbers Michael von Bergwelt-Baildon Dirk Beutner

Oncotarget 2017 07;8(27):44418-44433

Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.18632/oncotarget.17901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546490PMC
July 2017

Histone 3.3 hotspot mutations in conventional osteosarcomas: a comprehensive clinical and molecular characterization of six H3F3A mutated cases.

Authors:
Christian Koelsche Daniel Schrimpf Lars Tharun Eva Roth Dominik Sturm David T W Jones Eva-Kristin Renker Martin Sill Annika Baude Felix Sahm David Capper Melanie Bewerunge-Hudler Wolfgang Hartmann Andreas E Kulozik Iver Petersen Uta Flucke Hendrik W B Schreuder Reinhard Büttner Marc-André Weber Peter Schirmacher Christoph Plass Stefan M Pfister Andreas von Deimling Gunhild Mechtersheimer

Clin Sarcoma Res 2017 4;7. Epub 2017 May 4.

Department of General Pathology, Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s13569-017-0075-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418758PMC
May 2017

Correction: Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine.

Authors:
Aurélie Ladang Francesca Rapino Lukas C Heukamp Lars Tharun Kateryna Shostak Damien Hermand Sylvain Delaunay Iva Klevernic Zheshen Jiang Nicolas Jacques Diane Jamart Valérie Migeot Alexandra Florin Serkan Göktuna Brigitte Malgrange Owen J Sansom Laurent Nguyen Reinhard Büttner Pierre Close Alain Chariot

J Exp Med 2017 04 10;214(4):1199. Epub 2017 Mar 10.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1084/jem.2014228803082017cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379966PMC
April 2017

Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer.

Authors:
Sylvain Delaunay Francesca Rapino Lars Tharun Zhaoli Zhou Lukas Heukamp Martin Termathe Kateryna Shostak Iva Klevernic Alexandra Florin Hadrien Desmecht Christophe J Desmet Laurent Nguyen Sebastian A Leidel Anne E Willis Reinhard Büttner Alain Chariot Pierre Close

J Exp Med 2016 10 10;213(11):2503-2523. Epub 2016 Oct 10.

Laboratory of Cancer Signaling, University of Liège, 4000 Liège, Belgium

View Article

Download full-text PDF

 Source
http://jem.rupress.org/content/jem/early/2016/10/05/jem.2016
Web Search
http://dx.doi.org/10.1084/jem.20160397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068235PMC
October 2016

STAT3/IRF1 Pathway Activation Sensitizes Cervical Cancer Cells to Chemotherapeutic Drugs.

Authors:
Barbara Walch-Rückheim Jennifer Pahne-Zeppenfeld Jil Fischbach Claudia Wickenhauser Lars Christian Horn Lars Tharun Reinhard Büttner Peter Mallmann Peter Stern Yoo-Jin Kim Rainer Maria Bohle Christian Rübe Russalina Ströder Ingolf Juhasz-Böss Erich-Franz Solomayer Sigrun Smola

Cancer Res 2016 07 23;76(13):3872-83. Epub 2016 May 23.

Institute of Virology, Saarland University, Homburg/Saar, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1158/0008-5472.CAN-14-1306DOI Listing
July 2016

Criteria Used in Clinical Practice to Guide Immunosuppressive Treatment in Patients with Primary Sclerosing Cholangitis.

Authors:
Kornelius Schulze Tobias J Weismüller Michael Bubenheim Peter Huebener Roman Zenouzi Henrike Lenzen Christian Rupp Daniel Gotthardt Philipp de Leuw Andreas Teufel Vincent Zimmer Florian P Reiter Christian Rust Lars Tharun Alexander Quaas Sören A Weidemann Frank Lammert Christoph Sarrazin Michael P Manns Ansgar W Lohse Christoph Schramm

PLoS One 2015 21;10(10):e0140525. Epub 2015 Oct 21.

I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

View Article

Download full-text PDF

 Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140525PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619354PMC
June 2016

Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine.

Authors:
Aurélie Ladang Francesca Rapino Lukas C Heukamp Lars Tharun Kateryna Shostak Damien Hermand Sylvain Delaunay Iva Klevernic Zheshen Jiang Nicolas Jacques Diane Jamart Valérie Migeot Alexandra Florin Serkan Göktuna Brigitte Malgrange Owen J Sansom Laurent Nguyen Reinhard Büttner Pierre Close Alain Chariot

J Exp Med 2015 Nov 2;212(12):2057-75. Epub 2015 Nov 2.

Interdisciplinary Cluster for Applied Genoproteomics, University of Liège, 4000 Liège, Belgium Laboratory of Medical Chemistry, University of Liège, 4000 Liège, Belgium GIGA-Signal Transduction, University of Liège, 4000 Liège, Belgium Walloon Excellence in Life Sciences and Biotechnology, 1300 Wavre, Belgium

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1084/jem.20142288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647259PMC
November 2015

A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer.

Authors:
Felix Dietlein Bastian Kalb Mladen Jokic Elisa M Noll Alexander Strong Lars Tharun Luka Ozretić Helen Künstlinger Kato Kambartel Winfried J Randerath Christian Jüngst Anna Schmitt Alessandro Torgovnick André Richters Daniel Rauh Florian Siedek Thorsten Persigehl Cornelia Mauch Jirina Bartkova Allan Bradley Martin R Sprick Andreas Trumpp Roland Rad Dieter Saur Jiri Bartek Jürgen Wolf Reinhard Büttner Roman K Thomas H Christian Reinhardt

Cell 2015 Jul;162(1):146-59

Department I of Internal Medicine, University Hospital Cologne, Weyertal 115B, 50931 Cologne, Germany; CECAD, University of Cologne, Weyertal 115B, 50931 Cologne, Germany. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.cell.2015.05.053DOI Listing
July 2015

Frequency of TERT promoter mutations in primary tumors of the liver.

Authors:
Alexander Quaas Theresa Oldopp Lars Tharun Catina Klingenfeld Till Krech Guido Sauter Tobias J Grob

Virchows Arch 2014 Dec 30;465(6):673-7. Epub 2014 Sep 30.

Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s00428-014-1658-7DOI Listing
December 2014

Prognostic impact of perineural, blood and lymph vessel invasion for esophageal cancer.

Authors:
Michael Tachezy Anne-Kathrin Tiebel Florian Gebauer Asad Kutup Lars Tharun Klaus Pantel Jakob Robert Izbicki Yogesh Kumar Vashist

Histol Histopathol 2014 Nov 12;29(11):1467-75. Epub 2014 May 12.

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.14670/HH-29.1467DOI Listing
November 2014

Morphological study of synovial changes in two-stage reconstructions of the infected hip and knee arthroplasties.

Authors:
Arthur Gontarewicz Oliver Niggemeyer Lars Tharun Livia Grancicova Wolfgang Rüther Jozef Zustin

BMJ Open 2012 13;2(4). Epub 2012 Aug 13.

Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1136/bmjopen-2012-001467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425892PMC
October 2012

Overexpression of cell division cycle 7 homolog is associated with gene amplification frequency in breast cancer.

Authors:
Matthias Choschzick Annette Lebeau Andreas H Marx Lars Tharun Luigi Terracciano Uwe Heilenkötter Fritz Jaenicke Carsten Bokemeyer Ronald Simon Guido Sauter Jörg Schwarz

Hum Pathol 2010 Mar 6;41(3):358-65. Epub 2009 Nov 6.

Institute of Pathology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.humpath.2009.08.008DOI Listing
March 2010

HER-2 amplification is highly homogenous in gastric cancer.

Authors:
Andreas H Marx Lars Tharun Johanna Muth Ana-Maria Dancau Ronald Simon Emre Yekebas Jussuf T Kaifi Martina Mirlacher Tim H Brümmendorf Carsten Bokemeyer Jakob R Izbicki Guido Sauter

Hum Pathol 2009 Jun 9;40(6):769-77. Epub 2009 Mar 9.

Institute of Pathology, University Medical Center Hamburg-Eppendorf, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.humpath.2008.11.014DOI Listing
June 2009