Publications by authors named "Lars Tharun"

24Publications

Recurrent HNSCC Harbor an Immunosuppressive Tumor Immune Microenvironment Suggesting Successful Tumor Immune Evasion.

Authors:
Christian Watermann Helen Pasternack Christian Idel Julika Ribbat-Idel Johannes Brägelmann Patrick Kuppler Anne Offermann Danny Jonigk Mark Philipp Kühnel Andreas Schröck Eva Dreyer Christian Rosero Jacqueline Nathansen Anna Dubrovska Lars Tharun Jutta Kirfel Barbara Wollenberg Sven Perner Rosemarie Krupar

Clin Cancer Res 2021 Jan 27;27(2):632-644. Epub 2020 Oct 27.

Institute of Pathology, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.

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January 2021

The X-linked trichothiodystrophy-causing gene RNF113A links the spliceosome to cell survival upon DNA damage.

Authors:
Kateryna Shostak Zheshen Jiang Benoit Charloteaux Alice Mayer Yvette Habraken Lars Tharun Sebastian Klein Xinyi Xu Hong Quan Duong Andrii Vislovukh Pierre Close Alexandra Florin Florian Rambow Jean-Christophe Marine Reinhard Büttner Alain Chariot

Nat Commun 2020 03 9;11(1):1270. Epub 2020 Mar 9.

Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liege, CHU, Sart-Tilman, Liège, Belgium.

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March 2020

Histomorphological analysis of false positive PI-RADS 4 and 5 lesions.

Authors:
Marie Christine Hupe Anne Offermann Lars Tharun Alexander Fürschke Alex Frydrychowicz Nathalie Garstka Shahrokh F Shariat Jörg Barkhausen Axel S Merseburger Mario W Kramer Sven Perner

Urol Oncol 2020 07 27;38(7):636.e7-636.e12. Epub 2020 Feb 27.

Institute of Pathology, University Hospital Schleswig-Holstein, Luebeck, Germany; Pathology, Research Center Borstel, Leibniz Lung Center, Borstel, Germany. Electronic address:

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July 2020

Dickkopf-2 (DKK2) as Context Dependent Factor in Patients with Esophageal Adenocarcinoma.

Authors:
Lars M Schiffmann Heike Loeser Anne Sophie Jacob Martin Maus Hans Fuchs Yue Zhao Lars Tharun Ahlem Essakly Alexander Iannos Damanakis Thomas Zander Reinhard Büttner Wolfgang Schröder Christiane Bruns Alexander Quaas Florian Gebauer

Cancers (Basel) 2020 Feb 14;12(2). Epub 2020 Feb 14.

Department of General, Visceral and Cancer Surgery, University of Cologne, Kerpener Strasse 62, 50937 Cologne, Germany.

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February 2020

TRIM24 as an independent prognostic biomarker for prostate cancer.

Authors:
Anne Offermann Doris Roth Marie Christine Hupe Silke Hohensteiner Finn Becker Vincent Joerg Jessica Carlsson Christiane Kuempers Julika Ribbat-Idel Lars Tharun Verena Sailer Jutta Kirfel Maria Svensson Ove Andren Verena Lubczyk Rainer Kuefer Axel S Merseburger Sven Perner

Urol Oncol 2019 09 7;37(9):576.e1-576.e10. Epub 2019 Jun 7.

Institute of Pathology, University Hospital Schleswig-Holstein, Luebeck, Germany; Pathology of the Research Center Borstel, Leibniz Lung Center, Borstel, Germany. Electronic address:

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September 2019

The Cdkn1a Mouse as a Tool to Study p53-Mediated Tumor Suppression.

Authors:
Alessandro Torgovnick Jan Michel Heger Vasiliki Liaki Jörg Isensee Anna Schmitt Gero Knittel Arina Riabinska Filippo Beleggia Lucie Laurien Uschi Leeser Christian Jüngst Florian Siedek Wenzel Vogel Niklas Klümper Hendrik Nolte Maike Wittersheim Lars Tharun Roberta Castiglione Marcus Krüger Astrid Schauss Sven Perner Manolis Pasparakis Reinhard Büttner Thorsten Persigehl Tim Hucho Grit Sophie Herter-Sprie Björn Schumacher Hans Christian Reinhardt

Cell Rep 2018 10;25(4):1027-1039.e6

Department I of Internal Medicine, University Hospital Cologne, Weyertal 115b, 50931 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Joseph Stelzmann Straße 26, 50931 Cologne, Germany; Center for Molecular Medicine, University Hospital Cologne, Robert Koch Straße 21, 50931 Cologne. Electronic address:

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October 2018

Synergistic anti-angiogenic treatment effects by dual FGFR1 and VEGFR1 inhibition in FGFR1-amplified breast cancer.

Authors:
Kristina Golfmann Lydia Meder Mirjam Koker Caroline Volz Sven Borchmann Lars Tharun Felix Dietlein Florian Malchers Alexandra Florin Reinhard Büttner Neal Rosen Vanessa Rodrik-Outmezguine Michael Hallek Roland T Ullrich

Oncogene 2018 10 3;37(42):5682-5693. Epub 2018 Jul 3.

Department I of Internal Medicine, University Hospital Cologne, Kerpener Straße 62, 50937, Cologne, Germany.

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October 2018

Codon-specific translation reprogramming promotes resistance to targeted therapy.

Authors:
Francesca Rapino Sylvain Delaunay Florian Rambow Zhaoli Zhou Lars Tharun Pascal De Tullio Olga Sin Kateryna Shostak Sebastian Schmitz Jolanda Piepers Bart Ghesquière Latifa Karim Benoit Charloteaux Diane Jamart Alexandra Florin Charles Lambert Andrée Rorive Guy Jerusalem Eleonora Leucci Michael Dewaele Marc Vooijs Sebastian A Leidel Michel Georges Marianne Voz Bernard Peers Reinhard Büttner Jean-Christophe Marine Alain Chariot Pierre Close

Nature 2018 06 20;558(7711):605-609. Epub 2018 Jun 20.

Laboratory of Cancer Signaling, University of Liège, Liège, Belgium.

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June 2018

The Endosomal Protein CEMIP Links WNT Signaling to MEK1-ERK1/2 Activation in Selumetinib-Resistant Intestinal Organoids.

Authors:
Hong Quan Duong Ivan Nemazanyy Florian Rambow Seng Chuan Tang Sylvain Delaunay Lars Tharun Alexandra Florin Reinhard Büttner Daniel Vandaele Pierre Close Jean-Christophe Marine Kateryna Shostak Alain Chariot

Cancer Res 2018 08 18;78(16):4533-4548. Epub 2018 Jun 18.

Interdisciplinary Cluster for Applied Genoproteomics (GIGA), GIGA-Molecular Biology of Diseases, University of Liege, CHU, Sart-Tilman, Liège, Belgium.

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August 2018

High protein and mRNA expression levels of TUBB3 (class III ß-tubulin) are associated with aggressive tumor features in esophageal adenocarcinomas.

Authors:
Heike Loeser Simon Schallenberg Moritz von Winterfeld Lars Tharun Hakan Alakus Arnulf Hölscher Elfriede Bollschweiler Reinhard Buettner Thomas Zander Alexander Quaas

Oncotarget 2017 Dec 11;8(70):115179-115189. Epub 2017 Dec 11.

Institute of Pathology, University of Cologne, Cologne, Germany.

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December 2017

Surgical Implications for Diagnosis and Treatment of Intestinal Aspergillosis in Pediatric Patients with ALL.

Authors:
Janina Fischer Thorsten Simon Axel Hamprecht Nina Hos Anja Möricke Grigore Cernaianu Lars Tharun Bernd Gruhn Georg Plum Martin Dübbers

Eur J Pediatr Surg 2018 Dec 25;28(6):477-483. Epub 2017 Sep 25.

Division of Pediatric Surgery, University Hospital of Cologne, Cologne, Germany.

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December 2018

Characterization of tumor-associated T-lymphocyte subsets and immune checkpoint molecules in head and neck squamous cell carcinoma.

Authors:
Axel Lechner Hans Schlößer Sacha I Rothschild Martin Thelen Sabrina Reuter Peter Zentis Alexander Shimabukuro-Vornhagen Sebastian Theurich Kerstin Wennhold Maria Garcia-Marquez Lars Tharun Alexander Quaas Astrid Schauss Jörg Isensee Tim Hucho Christian Huebbers Michael von Bergwelt-Baildon Dirk Beutner

Oncotarget 2017 07;8(27):44418-44433

Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany.

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July 2017

Histone 3.3 hotspot mutations in conventional osteosarcomas: a comprehensive clinical and molecular characterization of six H3F3A mutated cases.

Authors:
Christian Koelsche Daniel Schrimpf Lars Tharun Eva Roth Dominik Sturm David T W Jones Eva-Kristin Renker Martin Sill Annika Baude Felix Sahm David Capper Melanie Bewerunge-Hudler Wolfgang Hartmann Andreas E Kulozik Iver Petersen Uta Flucke Hendrik W B Schreuder Reinhard Büttner Marc-André Weber Peter Schirmacher Christoph Plass Stefan M Pfister Andreas von Deimling Gunhild Mechtersheimer

Clin Sarcoma Res 2017 4;7. Epub 2017 May 4.

Department of General Pathology, Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany.

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May 2017

Correction: Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine.

Authors:
Aurélie Ladang Francesca Rapino Lukas C Heukamp Lars Tharun Kateryna Shostak Damien Hermand Sylvain Delaunay Iva Klevernic Zheshen Jiang Nicolas Jacques Diane Jamart Valérie Migeot Alexandra Florin Serkan Göktuna Brigitte Malgrange Owen J Sansom Laurent Nguyen Reinhard Büttner Pierre Close Alain Chariot

J Exp Med 2017 04 10;214(4):1199. Epub 2017 Mar 10.

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April 2017

Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer.

Authors:
Sylvain Delaunay Francesca Rapino Lars Tharun Zhaoli Zhou Lukas Heukamp Martin Termathe Kateryna Shostak Iva Klevernic Alexandra Florin Hadrien Desmecht Christophe J Desmet Laurent Nguyen Sebastian A Leidel Anne E Willis Reinhard Büttner Alain Chariot Pierre Close

J Exp Med 2016 10 10;213(11):2503-2523. Epub 2016 Oct 10.

Laboratory of Cancer Signaling, University of Liège, 4000 Liège, Belgium

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October 2016

STAT3/IRF1 Pathway Activation Sensitizes Cervical Cancer Cells to Chemotherapeutic Drugs.

Authors:
Barbara Walch-Rückheim Jennifer Pahne-Zeppenfeld Jil Fischbach Claudia Wickenhauser Lars Christian Horn Lars Tharun Reinhard Büttner Peter Mallmann Peter Stern Yoo-Jin Kim Rainer Maria Bohle Christian Rübe Russalina Ströder Ingolf Juhasz-Böss Erich-Franz Solomayer Sigrun Smola

Cancer Res 2016 07 23;76(13):3872-83. Epub 2016 May 23.

Institute of Virology, Saarland University, Homburg/Saar, Germany.

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July 2016

Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine.

Authors:
Aurélie Ladang Francesca Rapino Lukas C Heukamp Lars Tharun Kateryna Shostak Damien Hermand Sylvain Delaunay Iva Klevernic Zheshen Jiang Nicolas Jacques Diane Jamart Valérie Migeot Alexandra Florin Serkan Göktuna Brigitte Malgrange Owen J Sansom Laurent Nguyen Reinhard Büttner Pierre Close Alain Chariot

J Exp Med 2015 Nov 2;212(12):2057-75. Epub 2015 Nov 2.

Interdisciplinary Cluster for Applied Genoproteomics, University of Liège, 4000 Liège, Belgium Laboratory of Medical Chemistry, University of Liège, 4000 Liège, Belgium GIGA-Signal Transduction, University of Liège, 4000 Liège, Belgium Walloon Excellence in Life Sciences and Biotechnology, 1300 Wavre, Belgium

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November 2015

Criteria Used in Clinical Practice to Guide Immunosuppressive Treatment in Patients with Primary Sclerosing Cholangitis.

Authors:
Kornelius Schulze Tobias J Weismüller Michael Bubenheim Peter Huebener Roman Zenouzi Henrike Lenzen Christian Rupp Daniel Gotthardt Philipp de Leuw Andreas Teufel Vincent Zimmer Florian P Reiter Christian Rust Lars Tharun Alexander Quaas Sören A Weidemann Frank Lammert Christoph Sarrazin Michael P Manns Ansgar W Lohse Christoph Schramm

PLoS One 2015 21;10(10):e0140525. Epub 2015 Oct 21.

I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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June 2016

A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer.

Authors:
Felix Dietlein Bastian Kalb Mladen Jokic Elisa M Noll Alexander Strong Lars Tharun Luka Ozretić Helen Künstlinger Kato Kambartel Winfried J Randerath Christian Jüngst Anna Schmitt Alessandro Torgovnick André Richters Daniel Rauh Florian Siedek Thorsten Persigehl Cornelia Mauch Jirina Bartkova Allan Bradley Martin R Sprick Andreas Trumpp Roland Rad Dieter Saur Jiri Bartek Jürgen Wolf Reinhard Büttner Roman K Thomas H Christian Reinhardt

Cell 2015 Jul;162(1):146-59

Department I of Internal Medicine, University Hospital Cologne, Weyertal 115B, 50931 Cologne, Germany; CECAD, University of Cologne, Weyertal 115B, 50931 Cologne, Germany. Electronic address:

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July 2015

Frequency of TERT promoter mutations in primary tumors of the liver.

Authors:
Alexander Quaas Theresa Oldopp Lars Tharun Catina Klingenfeld Till Krech Guido Sauter Tobias J Grob

Virchows Arch 2014 Dec 30;465(6):673-7. Epub 2014 Sep 30.

Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.

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December 2014