Lars S Maier

Lars S Maier

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Lars S Maier

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Inhibition of Na1.8 prevents atrial arrhythmogenesis in human and mice.

Basic Res Cardiol 2020 Feb 20;115(2):20. Epub 2020 Feb 20.

Department of Internal Medicine II, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.

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http://dx.doi.org/10.1007/s00395-020-0780-8DOI Listing
February 2020

Ca/calmodulin-dependent protein kinase II is essential in hyperacute pressure overload.

J Mol Cell Cardiol 2020 Jan 10;138:212-221. Epub 2019 Dec 10.

Dept. of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1016/j.yjmcc.2019.12.002DOI Listing
January 2020

Prediction of short- and long-term mortality in takotsubo syndrome: the InterTAK Prognostic Score.

Authors:
Manfred B Wischnewsky Alessandro Candreva Beatrice Bacchi Victoria L Cammann Ken Kato Konrad A Szawan Sebastiano Gili Fabrizio D'Ascenzo Wolfgang Dichtl Rodolfo Citro Eduardo Bossone Michael Neuhaus Jennifer Franke Ioana Sorici-Barb Milosz Jaguszewski Michel Noutsias Maike Knorr Susanne Heiner Christof Burgdorf Behrouz Kherad Carsten Tschöpe Annahita Sarcon Jerold Shinbane Lawrence Rajan Guido Michels Roman Pfister Alessandro Cuneo Claudius Jacobshagen Mahir Karakas Wolfgang Koenig Alexander Pott Philippe Meyer Jose David Arroja Adrian Banning Florim Cuculi Richard Kobza Thomas A Fischer Tuija Vasankari K E Juhani Airaksinen L Christian Napp Monika Budnik Rafal Dworakowski Philip MacCarthy Christoph Kaiser Stefan Osswald Leonarda Galiuto Christina Chan Paul Bridgman Daniel Beug Clément Delmas Olivier Lairez Ibrahim El-Battrawy Ibrahim Akin Ekaterina Gilyarova Alexandra Shilova Mikhail Gilyarov Martin Kozel Petr Tousek David E Winchester Jan Galuszka Christian Ukena Gregor Poglajen Pedro Carrilho-Ferreira Christian Hauck Carla Paolini Claudio Bilato Abhiram Prasad Charanjit S Rihal Kan Liu P Christian Schulze Matteo Bianco Lucas Jörg Hans Rickli Thanh H Nguyen Yoshio Kobayashi Michael Böhm Lars S Maier Fausto J Pinto Petr Widimský Martin Borggrefe Stephan B Felix Grzegorz Opolski Ruediger C Braun-Dullaeus Wolfgang Rottbauer Gerd Hasenfuß Burkert M Pieske Heribert Schunkert Holger Thiele Johann Bauersachs Hugo A Katus John Horowitz Carlo Di Mario Thomas Münzel Filippo Crea Jeroen J Bax Thomas F Lüscher Frank Ruschitzka Jelena R Ghadri Christian Templin

Eur J Heart Fail 2019 Nov 27;21(11):1469-1472. Epub 2019 Aug 27.

Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1002/ejhf.1561DOI Listing
November 2019

Mechanisms of cardiac ethanol toxicity and novel treatment options.

Pharmacol Ther 2019 05 14;197:1-10. Epub 2018 Dec 14.

Department of Internal Medicine II, University Medical Center Regensburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2018.12.006DOI Listing
May 2019

Achieving Guideline-Directed Heart Rate ControlEarly Posthospitalization.

Am J Cardiol 2019 04 4;123(7):1096-1100. Epub 2019 Jan 4.

Parkview Health, Fort Wayne, Indiana; Indiana University School of Medicine, Indianapolis, Indiana.

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http://dx.doi.org/10.1016/j.amjcard.2018.12.032DOI Listing
April 2019

Empagliflozin enhances human and murine cardiomyocyte glucose uptake by increased expression of GLUT1.

Diabetologia 2019 04;62(4):726-729

Department of Internal Medicine II, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.

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http://dx.doi.org/10.1007/s00125-019-4819-zDOI Listing
April 2019

Impact of Body Mass Index on Outcomes in the Edoxaban Versus Warfarin Therapy Groups in Patients Underwent Cardioversion of Atrial Fibrillation (from ENSURE-AF).

Am J Cardiol 2019 02 24;123(4):592-597. Epub 2018 Nov 24.

St. Vincenz-Hospital, Paderborn, Germany; Working Group: Molecular Electrophysiology, University Hospital Magdeburg, Magdeburg, Germany.

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http://dx.doi.org/10.1016/j.amjcard.2018.11.019DOI Listing
February 2019

Bail-Out Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy in a Patient With Takotsubo Cardiomyopathy-Induced Cardiogenic Shock.

Circ Cardiovasc Interv 2019 02;12(2):e007425

Department of Internal Medicine II, University Medical Center Regensburg, Germany.

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.118.007425DOI Listing
February 2019

Postoperative complications after elective coronary artery bypass grafting surgery in patients with sleep-disordered breathing.

Clin Res Cardiol 2018 Dec 12;107(12):1148-1159. Epub 2018 Jun 12.

Department of Internal Medicine II (Cardiology, Pneumology, and Intensive Care), University Medical Centre Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.

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http://dx.doi.org/10.1007/s00392-018-1289-0DOI Listing
December 2018

Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart.

Cardiovasc Res 2018 11;114(13):1728-1737

Clinic for Cardiology & Pneumology, Georg-August University Goettingen, DZHK (German Centre for Cardiovascular Research), partner site Goettingen, Germany.

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http://dx.doi.org/10.1093/cvr/cvy152DOI Listing
November 2018

One-Year Outcomes after PCI Strategies in Cardiogenic Shock.

N Engl J Med 2018 11 25;379(18):1699-1710. Epub 2018 Aug 25.

From Heart Center Leipzig at University of Leipzig and Leipzig Heart Institute, Leipzig (H.T., M.S., A.J., S.D.), Universitätsmedizin Mannheim, Mannheim (I.A.), University Heart Center Lübeck, Lübeck (S.W.-T., R.M.-S., G.F., I.E.), German Center for Cardiovascular Research (I.A., S.W.-T., R.M.-S., G.F., I.E., U.L., C.S., A.J., S.B.F., S.D.) and Universitätsklinikum Charité, Campus Benjamin Franklin (U.L., C.S.), Berlin, Universitätsklinikum Würzburg, Würzburg (P.N.), Klinikum der Eberhard-Karls-Universität Tübingen, Tübingen (T. Geisler), Klinikum Links der Weser, Bremen (A.F.), Helios Klinik Erfurt, Erfurt (H.L.), Ernst-Moritz-Arndt-Universität, Greifswald (S.B.F.), Universitäres Herzzentrum Regensburg, Regensburg (L.S.M.), and Institut für Herzinfarktforschung (S. Schneider, U.Z.) and Klinikum Ludwigshafen (U.Z.), Ludwigshafen - all in Germany; Academic Medical Center, Amsterdam (J.J.P.); University Medical Center Ljubljana, Ljubljana, Slovenia (M.N., T. Goslar); Institute of Cardiology, Warsaw, Poland (J.S.); Golden Jubilee National Hospital, Glasgow, United Kingdom (K.O.); Vilnius University Hospital Santaros Klinikos and Faculty of Medicine, Vilnius University, Vilnius, Lithuania (P.S.); Sorbonne Université Paris 6, ACTION Study Group, Centre Hospitalier Universitaire Pitié-Salpêtrière (G.M., O.B.), and Applied Research, Technology Transfer, Industrial Collaboration, Société par Actions Simplifiée (P.T.), Paris; Wilhelminenpital, Department of Cardiology, and Sigmund Freud University, Medical School, Vienna (K.H.); the Department of Cardiology, Inselspital Bern, University of Bern, Bern, Switzerland (S.W., L.H.); Manzoni Hospital, Lecco, Italy (S. Savonitto); and Universitair Ziekenhuis Antwerp, Antwerp, Belgium (C.V.).

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http://www.nejm.org/doi/10.1056/NEJMoa1808788
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http://dx.doi.org/10.1056/NEJMoa1808788DOI Listing
November 2018

The detrimental potential of arrhythmia-induced cardiomyopathy.

ESC Heart Fail 2018 10 6;5(5):960-964. Epub 2018 Aug 6.

Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.

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http://dx.doi.org/10.1002/ehf2.12343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165941PMC
October 2018

Nocturnal hypoxemic burden is associated with epicardial fat volume in patients with acute myocardial infarction.

Sleep Breath 2018 09 11;22(3):703-711. Epub 2018 Jan 11.

Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1007/s11325-017-1616-0DOI Listing
September 2018

Cardiac unloading by LVAD support differentially influences components of the cGMP-PKG signaling pathway in ischemic and dilated cardiomyopathy.

Heart Vessels 2018 Aug 15;33(8):948-957. Epub 2018 Mar 15.

Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1007/s00380-018-1149-xDOI Listing
August 2018

Clinical care for patients with recurrent myocardial ischemia in Germany-the VOICES trial.

J Thorac Dis 2018 Jun;10(Suppl 15):S1777-S1784

Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.21037/jtd.2017.10.123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035955PMC
June 2018

Erratum to: Resolution of ST deviation after myocardial infarction in patients with and without sleep-disordered breathing.

Somnologie (Berl) 2018 23;22(2):130. Epub 2018 May 23.

1Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1007/s11818-018-0165-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992229PMC
May 2018

Adaptive servo-ventilation and sleep quality in treatment emergent central sleep apnea and central sleep apnea in patients with heart disease and preserved ejection fraction.

Clin Res Cardiol 2018 May 25;107(5):421-429. Epub 2018 Jan 25.

Department of Internal Medicine II, Cardiology and Pneumology, Center for Sleep Medicine, University Medical Center Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1007/s00392-018-1203-9DOI Listing
May 2018

SCN10A-Dependent Late I Current: Never Too Late for Cardiac Conduction?

Circ Genom Precis Med 2018 05;11(5):e002167

Institute for Genetics of Heart Diseases, University Hospital Münster, Germany (E.S.-B.).

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http://dx.doi.org/10.1161/CIRCGEN.118.002167DOI Listing
May 2018

Identification of optimal reference genes for transcriptomic analyses in normal and diseased human heart.

Cardiovasc Res 2018 02;114(2):247-258

Inserm, UMR-S 1180, University of Paris-Sud, Université Paris-Saclay, Châtenay-Malabry, France.

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http://dx.doi.org/10.1093/cvr/cvx182DOI Listing
February 2018

Improvement of cardiomyocyte function by a novel pyrimidine-based CaMKII-inhibitor.

J Mol Cell Cardiol 2018 02 30;115:73-81. Epub 2017 Dec 30.

Dept. of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2017.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820112PMC
February 2018

3D vena contracta area after MitraClip© procedure: precise quantification of residual mitral regurgitation and identification of prognostic information.

Cardiovasc Ultrasound 2018 Jan 9;16(1). Epub 2018 Jan 9.

Department of Internal Medicine II, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, D-93053, Regensburg, Germany.

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http://dx.doi.org/10.1186/s12947-017-0120-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759791PMC
January 2018

Efficacy of Ranolazine in Patients With Symptomatic Hypertrophic Cardiomyopathy: The RESTYLE-HCM Randomized, Double-Blind, Placebo-Controlled Study.

Circ Heart Fail 2018 01;11(1):e004124

>From the Cardiomyopathy Unit, Careggi University Hospital, Florence, Italy (I.O., B.T., A.F.); Vita Salute University and Scientific Institute San Raffaele, Milan, Italy (P.G.C.); Dipartimento Cardiotoracovascolare, Ospedale Niguarda, Milan, Italy (P.A.M.); Ospedale S. Orsola Malpighi, Bologna, Italy (C.R.); Clinic of General and Interventional Cardiology, University Heart Center, Hamburg, Germany (M.P.); Cardiology Department, Hospital General Universitario de Alicante, ISABIAL - FISABIO, Alicante, Spain (V.C.); Cardiovascular Department, Ospedale di Cattinara, Trieste, Italy (G.S.); Hospital Universitario Virgen de la Arrixaca, IMIB-Arrixaca, Murcia, Spain (F.M.); University Hospital, Heidelberg, Germany (P.E.); University Hospital Regensburg, Germany (L.S.M.); Herz zentrum Georg-August-Universitaet, Göttingen, Germany (C.J.); Department of Clinical and Experimental Medicine, Cardiology, Sassari Hospital, Sassari, Italy (A.G.); Ospedale Mazzoni, Ascoli Piceno, Italy (L.M.); Hospital Ramòn y Cajal, Alcalá University, Madrid, Spain (A.H.M.); Department Neurofarba, University of Florence, Italy (R.C., A.M.); Medi Service, Genoa, Italy (G.R.); Department of Experimental and Clinical Medicine, University of Florence, Italy (C.P., F.F.); Gilead Sciences, Foster City, CA (L.B.); and CESMAV, Florence, Italy (G.G.).

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https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.117
Publisher Site
http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004124DOI Listing
January 2018

PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock.

N Engl J Med 2017 12 30;377(25):2419-2432. Epub 2017 Oct 30.

From Heart Center Leipzig, University Hospital, Leipzig (H.T., M.S., S.D.), Universitätsmedizin Mannheim, Mannheim (I.A.), University Heart Center Lübeck, Lübeck (G.F., S. de Waha, R.M.-S.), German Center for Cardiovascular Research (DZHK) (G.F., S. de Waha, R.M.-S., U.L., C.S., S.B.F., S.D.) and Universitätsklinikum Charité, Campus Benjamin Franklin (U.L., C.S.), Berlin, Universitätsklinikum Würzburg, Würzburg (P.N.), Klinikum der Eberhard-Karls-Universität Tübingen, Tübingen (T. Geisler), Klinikum Links der Weser, Bremen (A.F.), Helios Klinik Erfurt, Erfurt (H.L.), Ernst-Moritz-Arndt-Universität, Greifswald (S.B.F.), Universitäres Herzzentrum Regensburg, Regensburg (L.S.M.), and Institut für Herzinfarktforschung (S. Schneider, U.Z.) and Klinikum Ludwigshafen (U.Z.), Ludwigshafen - all in Germany; Academic Medical Center, Amsterdam (J.J.P.); University Medical Center Ljubljana, Ljubljana, Slovenia (M.N., T. Goslar); Institute of Cardiology, Warsaw, Poland (J.S.); Golden Jubilee National Hospital, Glasgow, United Kingdom (K.O.); Vilnius University Hospital Santaros Klinikos and Faculty of Medicine, Vilnius University, Vilnius, Lithuania (P.S.); Sorbonne Université Paris 6, ACTION Study Group, Centre Hospitalier Universitaire Pitié-Salpêtrière (G.M., O.B.), and Applied Research, Technology Transfer, Industrial Collaboration, Société Par Actions Simplifiée (P.T.), Paris; Wilhelminenspital, Department of Cardiology, and Sigmund Freud University, Medical School, Vienna (K.H.); University of Bern, Inselspital, Bern, Switzerland (S. Windecker); Manzoni Hospital, Lecco, Italy (S. Savonitto); and Universitair Ziekenhuis Antwerp, Antwerp, Belgium (C.V.).

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http://dx.doi.org/10.1056/NEJMoa1710261DOI Listing
December 2017

CaMKII as a target for arrhythmia suppression.

Pharmacol Ther 2017 Aug 11;176:22-31. Epub 2016 Oct 11.

Universitäres Herzzentrum Regensburg, Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2016.10.006DOI Listing
August 2017

Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity.

Naunyn Schmiedebergs Arch Pharmacol 2017 Aug 27;390(8):857-862. Epub 2017 Apr 27.

Department of Pharmacology and Toxicology, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.

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http://dx.doi.org/10.1007/s00210-017-1376-1DOI Listing
August 2017

Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress.

Free Radic Biol Med 2017 07 8;108:452-464. Epub 2017 Apr 8.

Dept. Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.04.003DOI Listing
July 2017

Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation.

Basic Res Cardiol 2017 07 9;112(4):43. Epub 2017 Jun 9.

Department of Pharmacology and Toxicology, Medical Faculty, Technische Universität Dresden, Fetscherstraße 74, Dresden, 01307, Germany.

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http://dx.doi.org/10.1007/s00395-017-0635-0DOI Listing
July 2017

Reduction of SR Ca leak and arrhythmogenic cellular correlates by SMP-114, a novel CaMKII inhibitor with oral bioavailability.

Basic Res Cardiol 2017 07 13;112(4):45. Epub 2017 Jun 13.

Klinik für Innere Medizin II, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.

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http://dx.doi.org/10.1007/s00395-017-0637-yDOI Listing
July 2017

[Acute Coronary Syndrome - What should the general practitioner do?]

Dtsch Med Wochenschr 2017 Jul 3;142(13):994-999. Epub 2017 Jul 3.

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http://dx.doi.org/10.1055/s-0042-124042DOI Listing
July 2017

Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure.

Circulation 2017 May 15;135(22):2163-2177. Epub 2017 Mar 15.

From King's College London British Heart Foundation Centre of Excellence, Cardiovascular Division, United Kingdom (C.M.S., M.S., J.Z., C.E.M., A.P., C.X.C.S., G.S., X.Z., H.M.-D., D.A.R., A.C.B., A.P., P.J.E., A.M.S.); Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Regensburg, Germany (C.M.S., L.S.M.); Department of Cardiology and Pneumology, Medical Center Goettingen, Germany (M.S.); and Center for Cardiology and Center for Thrombosis and Hemostasis, University Medical Center Mainz, Germany (S.K., P.W.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.023877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444427PMC
May 2017

Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure.

Circ Heart Fail 2017 May;10(5):e003840

From the Institute of Pharmacology (M.D., C.B., L.C.Z.) and Department of Cardiology and Pneumology (S.S.), University Medical Center Göttingen (UMG) Heart Center, Georg August University Medical School Göttingen, Germany; Department Molecular Cardiology and Epigenetics, Heidelberg University, Germany (M.D., S.K., A.v.d.L., J.B.); DZHK (German Centre for Cardiovascular Research), Partner Sites Heidelberg/Mannheim and Göttingen, Germany (M.D., C.V., C.B., L.C.Z., S.K., A.v.d.L., T.W., S.S., J.B.); Department of Internal Medicine II, University Hospital Regensburg, Germany (S.N., S.S., L.S.M.); Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, Heidelberg University, Germany (C.V., T.W.); Institute of Pharmacology and Toxicology, University of Technology Dresden, Germany (S.L., S.M.-R., S.W., A.E.-A.); and Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla (J.H.B.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.003840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479434PMC
May 2017

Improvement in Risk Stratification in Transcatheter Aortic Valve Implantation Using a Combination of the Tumor Marker CA125 and the Logistic EuroSCORE.

Rev Esp Cardiol (Engl Ed) 2017 Mar 9;70(3):186-193. Epub 2016 Sep 9.

Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Munich, Germany; Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Regensburg, Germany; Deutsches Zentrum für Herz-Kreislauf-Forschung e.V., Partner Site Munich Heart Alliance, Munich, Germany.

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http://dx.doi.org/10.1016/j.rec.2016.08.004DOI Listing
March 2017

Antiarrhythmic effects of dantrolene in human diseased cardiomyocytes.

Heart Rhythm 2017 03 17;14(3):412-419. Epub 2016 Sep 17.

Department of Cardiology and Pneumology, Georg-August-University Göttingen, Göttingen, Germany; Department of Internal Medicine III: Cardiology and Angiology, University of Kiel, Kiel, Germany; DZHK (German Center for Cardiovascular Research), partner site Göttingen, Göttingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2016.09.014DOI Listing
March 2017

Dysferlin mediates membrane tubulation and links T-tubule biogenesis to muscular dystrophy.

J Cell Sci 2017 03 19;130(5):841-852. Epub 2017 Jan 19.

Department of Child and Adolescent Health, University Medical Centre Göttingen, Göttingen 37075, Germany

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http://dx.doi.org/10.1242/jcs.198861DOI Listing
March 2017

Sex-dependent alterations of Ca2+ cycling in human cardiac hypertrophy and heart failure.

Europace 2016 Sep 22;18(9):1440-8. Epub 2015 Oct 22.

Klinik für Kardiologie und Pneumologie/Herzzentrum, Georg-August-Universität Göttingen, Göttingen, Germany Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Standort Göttingen, Germany

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http://dx.doi.org/10.1093/europace/euv313DOI Listing
September 2016

The combined effects of ranolazine and dronedarone on human atrial and ventricular electrophysiology.

J Mol Cell Cardiol 2016 05 4;94:95-106. Epub 2016 Apr 4.

Department of Cardiology and Pneumology, Georg August University Göttingen, Göttingen, Germany; Department of Internal Medicine III: Cardiology and Angiology, University of Kiel, Germany; DZHK (German Centre for Cardiovascular Research), partner site Göttingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2016.03.012DOI Listing
May 2016

Adaptive servo-ventilation therapy of central sleep apnoea and its effect on sleep quality.

Clin Res Cardiol 2016 Mar 5;105(3):189-95. Epub 2015 Sep 5.

Department of Internal Medicine II, Cardiology and Pneumology, Centre for Sleep Medicine, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.

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http://dx.doi.org/10.1007/s00392-015-0904-6DOI Listing
March 2016

Ranolazine antagonizes catecholamine-induced dysfunction in isolated cardiomyocytes, but lacks long-term therapeutic effects in vivo in a mouse model of hypertrophic cardiomyopathy.

Cardiovasc Res 2016 Jan 3;109(1):90-102. Epub 2015 Nov 3.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Martinistraße 52, D-20246 Hamburg, Germany DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany

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http://cardiovascres.oxfordjournals.org/content/cardiovascre
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http://dx.doi.org/10.1093/cvr/cvv247DOI Listing
January 2016

Sensing Cardiac Electrical Activity With a Cardiac Myocyte--Targeted Optogenetic Voltage Indicator.

Circ Res 2015 Aug 15;117(5):401-12. Epub 2015 Jun 15.

From the Institute of Pharmacology (M.-L.C.L., S.D., E. Wettwer, W.-H.Z.), Clinic for Cardiology and Pulmonology (N.R., E. Wagner, B.U., K.S.-B., K.G., S.W., S.E.L., L.S.M.), and Microarray and Deep-Sequencing Facility (B.R.D.), University Medical Center Göttingen, Göttingen, Germany; DZHK (German Center for Cardiovascular Research), partner site Göttingen, Göttingen, Germany (M.-L.C.L., N.R., E. Wagner, K.S.-B., S.L., K.G., S.E.L., W.S., W.-H.Z.); Institute of Biomechanics, Technical University Hamburg-Harburg, Hamburg, Germany (M.-L.C.L., M.M.M.); Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands (T.P.d.B., I.A., T.v.V.); Laboratory of Neuronal Circuit Dynamics, RIKEN Brain Science Institute, Saitama, Japan (H.M., T.K.); Max-Planck-Institutes for Dynamics and Self Organization (N.R., C.R., S.L.) and Experimental Medicine (W.S.), Göttingen, Germany; Department of Internal Medicine II, University Hospital of Regensburg, Regensburg, Germany (B.U., S.W., L.S.M.); Department of Medicine and Centre for Neurotechnology, Imperial College London, United Kingdom (T.K.).

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http://circres.ahajournals.org/content/suppl/2015/06/15/CIRC
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http://circres.ahajournals.org/lookup/doi/10.1161/CIRCRESAHA
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http://dx.doi.org/10.1161/CIRCRESAHA.117.306143DOI Listing
August 2015

Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII.

Cardiovasc Res 2015 Jul 18;107(1):184-96. Epub 2015 May 18.

Klinik für Kardiologie und Pneumologie/Herzzentrum, Georg-August-Universität Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany DZHK (German Center for Cardiovascular Research), partner site Göttingen, Göttingen, Germany

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http://dx.doi.org/10.1093/cvr/cvv153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476413PMC
July 2015

Prevalence of Sleep-Disordered Breathing-Related Symptoms in Patients with Chronic Heart Failure and Reduced Ejection Fraction.

Can J Cardiol 2015 Jul 25;31(7):839-45. Epub 2015 Feb 25.

Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2015.02.025DOI Listing
July 2015

Role of sodium and calcium dysregulation in tachyarrhythmias in sudden cardiac death.

Circ Res 2015 Jun;116(12):1956-70

From the Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany (S.W., L.S.M.); and Department of Pharmacology, University of California, Davis, CA (D.M.B.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.304678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458704PMC
June 2015

Single Institution Experience With Transcatheter Valve-in-Valve Implantation Emphasizing Strategies for Coronary Protection.

Ann Thorac Surg 2015 May 7;99(5):1532-8. Epub 2015 Feb 7.

Department of Cardiothoracic Surgery, University Medical Center Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1016/j.athoracsur.2014.11.047DOI Listing
May 2015

Targets for therapy in sarcomeric cardiomyopathies.

Cardiovasc Res 2015 Apr 29;105(4):457-70. Epub 2015 Jan 29.

Department of Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands ICIN-Netherlands Heart Institute, Utrecht, the Netherlands

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http://dx.doi.org/10.1093/cvr/cvv023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402369PMC
April 2015

Some 'brain' in the heart: a novel microdomain with neuronal Na channels responsible for arrhythmias?

Authors:
Lars S Maier

Cardiovasc Res 2015 Apr 13;106(1):4-5. Epub 2015 Feb 13.

Department for Internal Medicine II, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, Regensburg 93053, Germany

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http://dx.doi.org/10.1093/cvr/cvv036DOI Listing
April 2015

In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease.

Nat Commun 2015 Apr 28;6:6965. Epub 2015 Apr 28.

1] Emmy Noether Group of the DFG, European Heart Research Institute Göttingen, University Medical Center Göttingen, D-37075 Göttingen, Germany [2] Department of Cardiology and Pulmonology, Heart Research Center Göttingen, University Medical Center Göttingen, Georg August University, D-37075 Göttingen, Germany [3] Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany [4] German Center for Cardiovascular Research (DZHK), D-93053 Regensburg, Germany.

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http://dx.doi.org/10.1038/ncomms7965DOI Listing
April 2015

Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis.

Cardiovasc Res 2015 Mar 23;105(3):279-91. Epub 2015 Jan 23.

Department of Cardiology and Pneumology, University Medical Center of Göttingen, Georg-August University, Robert-Koch-Str. 40, 37075 Göttingen, Germany German Center for Cardiovascular Research (DZHK), Partner Site Göttingen, Göttingen, Germany

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http://dx.doi.org/10.1093/cvr/cvv015DOI Listing
March 2015

Enhanced late INa induces proarrhythmogenic SR Ca leak in a CaMKII-dependent manner.

J Mol Cell Cardiol 2014 Nov 27;76:94-105. Epub 2014 Aug 27.

Department of Internal Medicine II, University of Regensburg, Germany.

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http://dx.doi.org/10.1016/j.yjmcc.2014.08.016DOI Listing
November 2014

NADPH oxidase 2 mediates angiotensin II-dependent cellular arrhythmias via PKA and CaMKII.

J Mol Cell Cardiol 2014 Oct 27;75:206-15. Epub 2014 Jul 27.

Dept. Internal Medicine II, University Hospital Regensburg, Regensburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2014.07.011DOI Listing
October 2014

Cardiac CaM Kinase II genes δ and γ contribute to adverse remodeling but redundantly inhibit calcineurin-induced myocardial hypertrophy.

Circulation 2014 Oct 14;130(15):1262-73. Epub 2014 Aug 14.

From the Research Unit Cardiac Epigenetics, Department of Cardiology, University of Heidelberg, and DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Germany (M.M.K., L.H.L., S.K., M.-O.H., U.O., J.B.); Department of Cardiology, Saarland University, Homburg, Germany (M.K., J.-C.R., C.M.); Department of Internal Medicine II, University of Regensburg, Germany (K.N., L.S.M.); British Heart Foundation Centre of Research Excellence, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom (M.D.S.); Department of Internal Medicine, University of Southwestern Texas Medical Center, Dallas (J.A.H.); Institute of Pharmacology, University of Duisburg-Essen, Germany (D.D.); Department of Molecular Pathology, German Cancer Research Center, Heidelberg, Germany (H.-J.G.); Department of Cardiology, University of Heidelberg, and DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Germany (H.A.K.); and the Department of Molecular Biology, University of Southwestern Texas Medical Center, Dallas (E.N.O.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.006185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316667PMC
October 2014

Reactive oxygen species and excitation-contraction coupling in the context of cardiac pathology.

J Mol Cell Cardiol 2014 Aug 11;73:92-102. Epub 2014 Mar 11.

Department of Internal Medicine II, University Hospital Regensburg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00222828140007
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http://dx.doi.org/10.1016/j.yjmcc.2014.03.001DOI Listing
August 2014

Effects of ranolazine on torsades de pointes tachycardias in a healthy isolated rabbit heart model.

Cardiovasc Ther 2014 Aug;32(4):170-7

Klinik für Kardiologie und Pneumologie/Herzzentrum, Georg-August-Universität Göttingen, Göttingen, Germany; DZHK (German Center for Cardiovascular Research), Göttingen, Germany.

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http://dx.doi.org/10.1111/1755-5922.12078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285941PMC
August 2014

Tubulin polymerization disrupts cardiac β-adrenergic regulation of late INa.

Cardiovasc Res 2014 Jul 8;103(1):168-77. Epub 2014 May 8.

Department of Internal Medicine II, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, Regensburg 93053, Germany

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https://academic.oup.com/cardiovascres/article-lookup/doi/10
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http://dx.doi.org/10.1093/cvr/cvu120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133594PMC
July 2014

CaMKII regulation of cardiac K channels.

Front Pharmacol 2014 21;5:20. Epub 2014 Feb 21.

Department of Cardiology, University Medical Center Göttingen Göttingen, Germany.

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http://dx.doi.org/10.3389/fphar.2014.00020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930912PMC
June 2014

Ionizing radiation regulates cardiac Ca handling via increased ROS and activated CaMKII.

Basic Res Cardiol 2013 Nov 26;108(6):385. Epub 2013 Sep 26.

Department of Cardiology and Pneumology/Heart Center, Georg-August-University Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.

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http://dx.doi.org/10.1007/s00395-013-0385-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898380PMC
November 2013

Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation.

Circulation 2013 Oct 12;128(16):1748-57. Epub 2013 Sep 12.

Department of Internal Medicine, Division of Cardiovascular Medicine and Cardiovascular Research Center, Carver College of Medicine (A.P., A.G.R., X.G., B.C., O.M.K., Z.G., E.D.L., H.S., A.C.B., R.N.E.-A., P.D.S., R.M.W., L.-S.S., M.E.A.), Department of Obstetrics and Gynecology (B.Y.), and Department of Molecular Physiology and Biophysics (M.E.A.), University of Iowa, Iowa City; Institute of Pharmacology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany, and Division of Experimental Cardiology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany (N.V., D.D.); Cardiology and Pneumology, German Heart Center, University Hospital Goettingen, Goettingen, Germany (S.N., T.S., L.S.M.); and Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX (N.L., X.H.T.W.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.003313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876034PMC
October 2013