Lars M Ittner

Lars M Ittner

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Lars M Ittner

Publications by authors named "Lars M Ittner"

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Adeno-associated virus-based Alzheimer's disease mouse models and potential new therapeutic avenues.

Br J Pharmacol 2019 Sep 23;176(18):3649-3665. Epub 2019 Apr 23.

Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia.

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http://dx.doi.org/10.1111/bph.14637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715621PMC
September 2019

Neuroinflammation in frontotemporal dementia.

Nat Rev Neurol 2019 Sep 19;15(9):540-555. Epub 2019 Jul 19.

School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.

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http://dx.doi.org/10.1038/s41582-019-0231-zDOI Listing
September 2019

First Nondiscriminating Translocator Protein Ligands Produced from a Carbazole Scaffold.

J Med Chem 2019 Sep 28;62(17):8235-8248. Epub 2019 Aug 28.

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences , Macquarie University , 2 Technology Place , North Ryde , New South Wales 2109 , Australia.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00980DOI Listing
September 2019

Generation of a New Tau Knockout (tauΔex1) Line Using CRISPR/Cas9 Genome Editing in Mice.

J Alzheimers Dis 2018 ;62(2):571-578

Transgenic Animal Unit, Mark Wainwright Analytical Centre, University of New South Wales, Sydney, NSW, Australia.

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http://dx.doi.org/10.3233/JAD-171058DOI Listing
February 2019

Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice.

Neurobiol Dis 2018 12 5;120:76-87. Epub 2018 Sep 5.

Central Clinical School, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW 2050, Australia; School of Medical Sciences, Faculty of Medicine, University of New South Wales, Kensington, NSW 2033, Australia; Neuroscience Research Australia, Randwick, NSW 2031, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197399PMC
December 2018

Alzheimer's Disease: Insights from Genetic Mouse Models and Current Advances in Human IPSC-Derived Neurons.

Adv Neurobiol 2017 ;15:3-29

Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, The University of New South Wales, Sydney, NSW, 2052, Australia.

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http://dx.doi.org/10.1007/978-3-319-57193-5_1DOI Listing
November 2018

Neuronal MAP kinase p38α inhibits c-Jun N-terminal kinase to modulate anxiety-related behaviour.

Sci Rep 2018 09 24;8(1):14296. Epub 2018 Sep 24.

Dementia Research Unit, School of Medical Sciences, The University of New South Wales, Sydney, NSW, 2052, Australia.

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http://www.nature.com/articles/s41598-018-32592-y
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http://dx.doi.org/10.1038/s41598-018-32592-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155170PMC
September 2018

Peptide Nanofiber Substrates for Long-Term Culturing of Primary Neurons.

ACS Appl Mater Interfaces 2018 Aug 20;10(30):25127-25134. Epub 2018 Jul 20.

Dementia Research Unit, School of Medical Sciences, Faculty of Medicine , University of New South Wales , Sydney , NSW 2052 , Australia.

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http://dx.doi.org/10.1021/acsami.8b07560DOI Listing
August 2018

Dendritic Tau in Alzheimer's Disease.

Neuron 2018 07;99(1):13-27

Dementia Research Unit, School of Medical Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia; Neuroscience Research Australia, Sydney, New South Wales 2031, Australia; Dementia Research Centre, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.06.003DOI Listing
July 2018

Selective Spatiotemporal Vulnerability of Central Nervous System Neurons to Pathologic TAR DNA-Binding Protein 43 in Aged Transgenic Mice.

Am J Pathol 2018 06 22;188(6):1447-1456. Epub 2018 Mar 22.

Motor Neuron Disease Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2018.03.002DOI Listing
June 2018

Physiological changes in neurodegeneration - mechanistic insights and clinical utility.

Nat Rev Neurol 2018 05 23;14(5):259-271. Epub 2018 Mar 23.

Brain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, Australia.

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http://dx.doi.org/10.1038/nrneurol.2018.23DOI Listing
May 2018

Generation of Genetically Modified Mice through the Microinjection of Oocytes.

J Vis Exp 2017 06 15(124). Epub 2017 Jun 15.

Transgenic Animal Unit, Mark Wainwright Analytical Centre, University of New South Wales.

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http://dx.doi.org/10.3791/55765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608437PMC
June 2017

No Overt Deficits in Aged Tau-Deficient C57Bl/6.Mapttm1(EGFP)Kit GFP Knockin Mice.

PLoS One 2016 13;11(10):e0163236. Epub 2016 Oct 13.

Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0163236PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063411PMC
May 2017

The Polyphenol Altenusin Inhibits in Vitro Fibrillization of Tau and Reduces Induced Tau Pathology in Primary Neurons.

ACS Chem Neurosci 2017 04 12;8(4):743-751. Epub 2017 Jan 12.

Dementia Research Unit, School of Medical Sciences, Faculty of Medicine, UNSW Australia , Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1021/acschemneuro.6b00433DOI Listing
April 2017

Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model.

Aging Cell 2017 04 4;16(2):377-386. Epub 2017 Feb 4.

Clem Jones Centre for Ageing Dementia Research (CJCADR), Queensland Brain Institute (QBI), The University of Queensland, Brisbane, Qld, Australia.

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http://dx.doi.org/10.1111/acel.12565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334525PMC
April 2017

Mouse models of frontotemporal dementia: A comparison of phenotypes with clinical symptomatology.

Neurosci Biobehav Rev 2017 Mar 11;74(Pt A):126-138. Epub 2017 Jan 11.

Neuroscience Research Australia, Sydney, Australia; Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.neubiorev.2017.01.004DOI Listing
March 2017

ALS/FTLD: experimental models and reality.

Acta Neuropathol 2017 02 5;133(2):177-196. Epub 2017 Jan 5.

Neuroscience Research Australia, Randwick, NSW, 2031, Australia.

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http://dx.doi.org/10.1007/s00401-016-1666-6DOI Listing
February 2017

In vivocharacterization of the aspartyl-tRNA synthetase DARS: Homing in on the leukodystrophy HBSL.

Neurobiol Dis 2017 01 2;97(Pt A):24-35. Epub 2016 Nov 2.

Translational Neuroscience Facility & Department of Physiology, School of Medical Sciences, UNSW Sydney, NSW 2052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2016.10.008DOI Listing
January 2017

Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination.

Medchemcomm 2017 Jan 15;8(1):202-210. Epub 2016 Nov 15.

School of Chemistry , The University of Sydney , NSW 2006 , Australia . Email:

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http://xlink.rsc.org/?DOI=C6MD00523C
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http://dx.doi.org/10.1039/c6md00523cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071920PMC
January 2017

Tau downregulates BDNF expression in animal and cellular models of Alzheimer's disease.

Neurobiol Aging 2016 12 31;48:135-142. Epub 2016 Aug 31.

Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.08.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159317PMC
December 2016

Neuronal network disintegration: common pathways linking neurodegenerative diseases.

J Neurol Neurosurg Psychiatry 2016 Nov 12;87(11):1234-1241. Epub 2016 May 12.

Sydney Medical School Brain & Mind Centre, University of Sydney, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1136/jnnp-2014-308350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099318PMC
November 2016

Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia.

Neurosci Lett 2016 Sep 10;631:24-9. Epub 2016 Aug 10.

Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.

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http://dx.doi.org/10.1016/j.neulet.2016.08.007DOI Listing
September 2016

The frontotemporal dementia-motor neuron disease continuum.

Lancet 2016 Aug 14;388(10047):919-31. Epub 2016 Mar 14.

Neuroscience Research Australia, Sydney, NSW, Australia; Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(16)00737-6DOI Listing
August 2016

Motor cortical function determines prognosis in sporadic ALS.

Neurology 2016 Aug 8;87(5):513-20. Epub 2016 Jul 8.

From the Brain and Mind Centre (K.S., S.B.P., J.H., W.H., Y.-i.N., M.C.K.), Westmead Clinical School (N.G., P.M., S.V.), and Discipline of Pathology (J.J.K.), Sydney Medical School, University of Sydney; St. Vincent's Clinical School (N.G.S.), Prince of Wales Clinical School (W.H.), and Dementia Research Unit, School of Medical Sciences (L.M.I.), University of New South Wales (J.H., G.H.), Sydney; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute (J.G.), The University of Queensland; and Neuroscience Research Australia (L.M.I., J.H., G.H.), Sydney, Australia.

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http://dx.doi.org/10.1212/WNL.0000000000002912DOI Listing
August 2016

Early-onset axonal pathology in a novel P301S-Tau transgenic mouse model of frontotemporal lobar degeneration.

Neuropathol Appl Neurobiol 2015 Dec 30;41(7):906-25. Epub 2015 May 30.

Dementia Research Unit, Department of Anatomy, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1111/nan.12233DOI Listing
December 2015

The impact of luteinizing hormone and testosterone on beta amyloid (Aβ) accumulation: Animal and human clinical studies.

Horm Behav 2015 Nov 27;76:81-90. Epub 2015 Jun 27.

Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia 6027, Australia; Sir James McCusker Alzheimer's disease Research Unit, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Western Australia 6009, Australia; School of Biomedical Sciences, CHIRI Biosciences, Curtin University, Bentley, Western Australia 6102, Australia.

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http://dx.doi.org/10.1016/j.yhbeh.2015.05.020DOI Listing
November 2015

First Demonstration of Positive Allosteric-like Modulation at the Human Wild Type Translocator Protein (TSPO).

J Med Chem 2015 Nov 23;58(21):8743-9. Epub 2015 Oct 23.

Dementia Research Unit, School of Medical Sciences, University of New South Wales , Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01288DOI Listing
November 2015

Amyotrophic lateral sclerosis-associated mutant profilin 1 increases dendritic arborisation and spine formation in primary hippocampal neurons.

Neurosci Lett 2015 Nov 21;609:223-8. Epub 2015 Oct 21.

Neurodegeneration and Repair Unit, School of Medical Sciences, University of New South Wales, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2015.09.034DOI Listing
November 2015

Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease.

Nat Commun 2015 Nov 27;6:8836. Epub 2015 Nov 27.

School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia.

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http://dx.doi.org/10.1038/ncomms9836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674770PMC
November 2015

FTD and ALS--translating mouse studies into clinical trials.

Nat Rev Neurol 2015 Jun 5;11(6):360-6. Epub 2015 May 5.

Brain and Mind Research Institute, The University of Sydney, 94 Mallett Street, Camperdown, NSW 2050, Australia.

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http://dx.doi.org/10.1038/nrneurol.2015.65DOI Listing
June 2015

Near infrared light mitigates cerebellar pathology in transgenic mouse models of dementia.

Neurosci Lett 2015 Mar 19;591:155-9. Epub 2015 Feb 19.

Bosch Institute, University of Sydney, NSW 2006, Australia; Discipline of Physiology, University of Sydney, NSW 2006, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S03043940150015
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http://dx.doi.org/10.1016/j.neulet.2015.02.037DOI Listing
March 2015

Tau aggregation and its interplay with amyloid-β.

Acta Neuropathol 2015 Feb 10;129(2):207-20. Epub 2014 Dec 10.

Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Australia,

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http://dx.doi.org/10.1007/s00401-014-1371-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305093PMC
February 2015

Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice.

J Neurochem 2015 Jan 1;132(1):135-45. Epub 2014 Aug 1.

Dementia Research Unit, School of Medical Sciences, The University of New South Wales, Sydney, NSW, Australia; Brain & Mind Research Institute, The University of Sydney, Sydney, NSW, Australia.

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http://dx.doi.org/10.1111/jnc.12821DOI Listing
January 2015

p38 MAP kinase-mediated NMDA receptor-dependent suppression of hippocampal hypersynchronicity in a mouse model of Alzheimer's disease.

Acta Neuropathol Commun 2014 Oct 21;2:149. Epub 2014 Oct 21.

Dementia Research Unit, School of Medical Sciences, Faculty of Medicine, UNSW Australia, Sydney, Australia.

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http://dx.doi.org/10.1186/s40478-014-0149-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212118PMC
October 2014

The nucleotide exchange factor SIL1 is required for glucose-stimulated insulin secretion from mouse pancreatic beta cells in vivo.

Diabetologia 2014 Jul 15;57(7):1410-9. Epub 2014 Apr 15.

School of Medical Sciences, University of New South Wales, Botany Street, Kensington, Sydney, 2052, NSW, Australia,

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http://dx.doi.org/10.1007/s00125-014-3230-zDOI Listing
July 2014

ERK inhibition with PD184161 mitigates brain damage in a mouse model of stroke.

J Neural Transm (Vienna) 2014 May 14;121(5):543-7. Epub 2013 Dec 14.

Dementia Research Unit (DRU), School of Medical Sciences, The University of New South Wales, Sydney, NSW, 2052, Australia.

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http://dx.doi.org/10.1007/s00702-013-1138-2DOI Listing
May 2014

Inducible, tightly regulated and non-leaky neuronal gene expression in mice.

Transgenic Res 2014 Apr 9;23(2):225-33. Epub 2013 Nov 9.

Transgenic Animal Unit, School of Medical Science, University of New South Wales, Sydney, NSW, 2052, Australia.

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http://dx.doi.org/10.1007/s11248-013-9767-7DOI Listing
April 2014

The translocator protein as a drug target in Alzheimer's disease.

Expert Rev Neurother 2014 Apr;14(4):439-48

Dementia Research Unit, School of Medical Sciences, Wallace Wurth Building, University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1586/14737175.2014.896201DOI Listing
April 2014

Slow excitotoxicity in Alzheimer's disease.

J Alzheimers Dis 2013 ;35(4):643-68

Department of Anatomy, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore.

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http://dx.doi.org/10.3233/JAD-121990DOI Listing
December 2013

Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation.

J Cereb Blood Flow Metab 2013 May 23;33(5):684-91. Epub 2013 Jan 23.

Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

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http://dx.doi.org/10.1038/jcbfm.2012.212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652703PMC
May 2013

Alzheimer's disease models and functional genomics-How many needles are there in the haystack?

Front Physiol 2012 8;3:320. Epub 2012 Aug 8.

Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland St Lucia, QLD, Australia.

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http://dx.doi.org/10.3389/fphys.2012.00320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429089PMC
October 2012

Tau-mediated nuclear depletion and cytoplasmic accumulation of SFPQ in Alzheimer's and Pick's disease.

PLoS One 2012 25;7(4):e35678. Epub 2012 Apr 25.

Alzheimer's and Parkinson's Disease Laboratory, Brain & Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035678PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338448PMC
September 2012

Lessons from tau-deficient mice.

Int J Alzheimers Dis 2012 6;2012:873270. Epub 2012 Jun 6.

Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, The University of Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia.

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http://dx.doi.org/10.1155/2012/873270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375147PMC
August 2012

Tau protein: function and pathology.

Int J Alzheimers Dis 2012 15;2012:707482. Epub 2012 Aug 15.

Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Ein Karem, Jerusalem 91120, Israel.

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http://dx.doi.org/10.1155/2012/707482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426215PMC
August 2012

MicroRNA networks surrounding APP and amyloid-β metabolism--implications for Alzheimer's disease.

Exp Neurol 2012 Jun 16;235(2):447-54. Epub 2011 Nov 16.

Stem Cell and Developmental Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia.

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http://dx.doi.org/10.1016/j.expneurol.2011.11.013DOI Listing
June 2012

Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice.

PLoS One 2011 8;6(12):e26860. Epub 2011 Dec 8.

Laboratory for Translational Neurodegeneration, Brain and Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026860PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234245PMC
April 2012

Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol.

PLoS One 2011 12;6(12):e28887. Epub 2011 Dec 12.

Alzheimer's & Parkinson's Disease Laboratory, Brain & Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028887PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236223PMC
April 2012

ENU mutagenesis screen to establish motor phenotypes in wild-type mice and modifiers of a pre-existing motor phenotype in tau mutant mice.

J Biomed Biotechnol 2011 15;2011:130947. Epub 2011 Dec 15.

Alzheimer's and Parkinson's Disease Laboratory, Brain & Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia.

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http://dx.doi.org/10.1155/2011/130947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246812PMC
April 2012

Tau-targeted treatment strategies in Alzheimer's disease.

Br J Pharmacol 2012 Mar;165(5):1246-59

Alzheimer's and Parkinson's Disease Laboratory, Brain & Mind Research Institute, University of Sydney, Camperdown, NSW, Australia.

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http://dx.doi.org/10.1111/j.1476-5381.2011.01713.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372713PMC
March 2012

Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons.

PLoS One 2011 29;6(7):e22850. Epub 2011 Jul 29.

Laboratory for Translational Neurodegeneration, Brain & Mind Research Institute, University of Sydney, Sydney, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022850PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146516PMC
December 2011

Modes of Aβ toxicity in Alzheimer's disease.

Cell Mol Life Sci 2011 Oct 25;68(20):3359-75. Epub 2011 Jun 25.

Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia.

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http://dx.doi.org/10.1007/s00018-011-0750-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181413PMC
October 2011

Brief update on different roles of tau in neurodegeneration.

IUBMB Life 2011 Jul;63(7):495-502

Brain and Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia.

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http://dx.doi.org/10.1002/iub.467DOI Listing
July 2011

Amyloid-β and tau--a toxic pas de deux in Alzheimer's disease.

Nat Rev Neurosci 2011 Feb 31;12(2):65-72. Epub 2010 Dec 31.

Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, The University of Sydney, Camperdown, 100 Mallett Street, NSW 2050, Australia.

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http://dx.doi.org/10.1038/nrn2967DOI Listing
February 2011

Animal models reveal role for tau phosphorylation in human disease.

Biochim Biophys Acta 2010 Oct 12;1802(10):860-71. Epub 2009 Sep 12.

Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, New South Wales 2050, Australia.

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http://dx.doi.org/10.1016/j.bbadis.2009.09.008DOI Listing
October 2010

Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models.

Proc Natl Acad Sci U S A 2010 Aug 19;107(31):13888-93. Epub 2010 Jul 19.

Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, Department of Pathology, University of Sydney, Camperdown, New South Wales 2050, Australia.

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http://www.pnas.org/content/107/31/13888.full.pdf
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http://www.pnas.org/cgi/doi/10.1073/pnas.1009038107
Publisher Site
http://dx.doi.org/10.1073/pnas.1009038107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922247PMC
August 2010

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models.

Cell 2010 Aug 22;142(3):387-97. Epub 2010 Jul 22.

Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney NSW 2050, Australia.

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http://dx.doi.org/10.1016/j.cell.2010.06.036DOI Listing
August 2010

Dissecting toxicity of tau and beta-amyloid.

Neurodegener Dis 2010 13;7(1-3):10-2. Epub 2010 Feb 13.

Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, N.S.W., Australia.

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https://www.karger.com/Article/FullText/283475
Publisher Site
http://dx.doi.org/10.1159/000283475DOI Listing
July 2010

Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta.

PLoS One 2010 Jun 11;5(6):e11070. Epub 2010 Jun 11.

Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011070PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884018PMC
June 2010

Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent fusion proteins.

Plasmid 2010 May 2;63(3):155-60. Epub 2010 Feb 2.

Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, The University of Sydney, 100 Mallett St., Camperdown, NSW 2050, Australia.

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http://dx.doi.org/10.1016/j.plasmid.2010.01.002DOI Listing
May 2010

Abeta and human amylin share a common toxicity pathway via mitochondrial dysfunction.

Proteomics 2010 Apr;10(8):1621-33

Alzheimer's & Parkinson's Disease Laboratory, Brain & Mind Research Institute, University of Sydney, Camperdown, Australia.

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http://doi.wiley.com/10.1002/pmic.200900651
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April 2010

Alzheimer's disease selective vulnerability and modeling in transgenic mice.

J Alzheimers Dis 2009 ;18(2):243-51

Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia.

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http://dx.doi.org/10.3233/JAD-2009-1143DOI Listing
December 2009

Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice.

Proc Natl Acad Sci U S A 2009 Nov 6;106(47):20057-62. Epub 2009 Nov 6.

Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics, University of Basel, 4025 Basel, Switzerland.

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http://dx.doi.org/10.1073/pnas.0905529106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774257PMC
November 2009

Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's disease.

PLoS One 2009 Nov 19;4(11):e7917. Epub 2009 Nov 19.

Alzheimer's and Parkinson's Disease Laboratory, Brain & Mind Research Institute, University of Sydney, Sydney, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007917PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775636PMC
November 2009

Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains.

J Neural Transm (Vienna) 2009 Oct 20;116(10):1243-51. Epub 2009 Aug 20.

Discipline of Pathology, The University of Sydney, Sydney, NSW, 2006, Australia.

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http://dx.doi.org/10.1007/s00702-009-0293-yDOI Listing
October 2009

Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease.

J Biol Chem 2009 Jul 2;284(31):20909-16. Epub 2009 Jun 2.

Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, Camperdown, New South Wales 2050, Australia.

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http://dx.doi.org/10.1074/jbc.M109.014472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742856PMC
July 2009

Primary support cultures of hippocampal and substantia nigra neurons.

Nat Protoc 2009 ;4(1):78-85

Oncology Research Unit, The Children's Hospital at Westmead, Sydney, Westmead, New South Wales 2145, Australia.

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http://dx.doi.org/10.1038/nprot.2008.199DOI Listing
March 2009

Substrate-specific reduction of PP2A activity exaggerates tau pathology.

Biochem Biophys Res Commun 2009 Feb 4;379(2):400-5. Epub 2009 Jan 4.

Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X080247
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http://dx.doi.org/10.1016/j.bbrc.2008.12.140DOI Listing
February 2009

The translocator protein (18 kDa): central nervous system disease and drug design.

J Med Chem 2009 Feb;52(3):581-92

Brain and Mind Research Institute, 100 Mallett Street, Camperdown, NSW 2050, Australia.

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http://dx.doi.org/10.1021/jm8011678DOI Listing
February 2009

An update on the toxicity of Abeta in Alzheimer's disease.

Neuropsychiatr Dis Treat 2008 Dec;4(6):1033-42

Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, 100 Mallett St, Camperdown, NSW 2050, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646638PMC
http://dx.doi.org/10.2147/ndt.s3016DOI Listing
December 2008

Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia.

Proc Natl Acad Sci U S A 2008 Oct 2;105(41):15997-6002. Epub 2008 Oct 2.

Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia.

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http://dx.doi.org/10.1073/pnas.0808084105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572931PMC
October 2008

Is tau aggregation toxic or protective: a sensible question in the absence of sensitive methods?

J Alzheimers Dis 2008 Aug;14(4):423-9

Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia.

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http://dx.doi.org/10.3233/jad-2008-14410DOI Listing
August 2008

Animal models of Alzheimer's disease and frontotemporal dementia.

Nat Rev Neurosci 2008 Jul;9(7):532-44

Alzheimer's & Parkinson's Disease Laboratory, Brain & Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia.

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http://dx.doi.org/10.1038/nrn2420DOI Listing
July 2008

Divergent phosphorylation pattern of tau in P301L tau transgenic mice.

Eur J Neurosci 2008 Jul;28(1):137-47

Alzheimer's and Parkinson's Disease Laboratory, Brain & Mind Research Institute, University of Sydney, 100 Mallett St, Camperdown, NSW 2050, Australia.

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http://dx.doi.org/10.1111/j.1460-9568.2008.06318.xDOI Listing
July 2008

Human but not rat amylin shares neurotoxic properties with Abeta42 in long-term hippocampal and cortical cultures.

FEBS Lett 2008 Jun 16;582(15):2188-94. Epub 2008 May 16.

Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia.

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http://dx.doi.org/10.1016/j.febslet.2008.05.006DOI Listing
June 2008

Functional genomics dissects pathomechanisms in tauopathies: mitosis failure and unfolded protein response.

Neurodegener Dis 2008 6;5(3-4):179-81. Epub 2008 Mar 6.

Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia.

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http://dx.doi.org/10.1159/000113696DOI Listing
May 2008

Pronuclear injection for the production of transgenic mice.

Nat Protoc 2007 ;2(5):1206-15

Alzheimer's & Parkinson's Disease Laboratory, Brain & Mind Research Institute, University of Sydney, 100, Mallett Street, Camperdown, New South Wales 2050, Australia.

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http://dx.doi.org/10.1038/nprot.2007.145DOI Listing
January 2008

Transgenic mice with ocular overexpression of an adrenomedullin receptor reflect human acute angle-closure glaucoma.

Clin Sci (Lond) 2008 Jan;114(1):49-58

Laboratory for Orthopedic Research, Orthopedic University Hospital Balgrist, University of Zurich, CH-8008 Zurich, Switzerland.

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http://clinsci.org/lookup/doi/10.1042/CS20070163
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January 2008

Calcitonin gene-related peptide-evoked sustained tachycardia in calcitonin receptor-like receptor transgenic mice is mediated by sympathetic activity.

Am J Physiol Heart Circ Physiol 2007 Oct 27;293(4):H2155-60. Epub 2007 Jul 27.

Research Laboratory, Orthopedic University Hospital Balgrist, University of Zürich, Zürich, Switzerland.

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http://www.physiology.org/doi/10.1152/ajpheart.00629.2007
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October 2007

Interaction of receptor-activity-modifying protein1 with tubulin.

Biochim Biophys Acta 2007 Aug 11;1770(8):1145-50. Epub 2007 Apr 11.

Research Laboratory for Calcium Metabolism, Orthopedic University Hospital Balgrist, University of Zurich, 8008 Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.bbagen.2007.04.002DOI Listing
August 2007

A decade of tau transgenic animal models and beyond.

Brain Pathol 2007 Jan;17(1):91-103

Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia.

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http://dx.doi.org/10.1111/j.1750-3639.2007.00051.xDOI Listing
January 2007

Beta-amyloid treatment of two complementary P301L tau-expressing Alzheimer's disease models reveals similar deregulated cellular processes.

Proteomics 2006 Dec;6(24):6566-77

Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia.

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http://dx.doi.org/10.1002/pmic.200600634DOI Listing
December 2006

Altered levels of PP2A regulatory B/PR55 isoforms indicate role in neuronal differentiation.

Int J Dev Neurosci 2006 Nov 11;24(7):437-43. Epub 2006 Oct 11.

Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.ijdevneu.2006.08.005DOI Listing
November 2006