Lars Klimaschewski

Lars Klimaschewski

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Lars Klimaschewski

Lars Klimaschewski

Publications by authors named "Lars Klimaschewski"

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57Publications

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Simultaneous Knockdown of Sprouty2 and PTEN Promotes Axon Elongation of Adult Sensory Neurons.

Front Cell Neurosci 2019 21;13:583. Epub 2020 Jan 21.

Institute of Neuroanatomy, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.3389/fncel.2019.00583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985068PMC
January 2020

Endocytosis and Transport of Growth Factor Receptors in Peripheral Axon Regeneration: Novel Lessons from Neurons Expressing Lysine-Deficient FGF Receptor Type 1 in vitro.

Anat Rec (Hoboken) 2019 08 22;302(8):1268-1275. Epub 2019 Apr 22.

Department of Anatomy, Histology and Embryology, Division of Neuroanatomy, Medical University Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1002/ar.24120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767123PMC
August 2019

Promotion of Peripheral Nerve Regeneration by Stimulation of the Extracellular Signal-Regulated Kinase (ERK) Pathway.

Anat Rec (Hoboken) 2019 08 22;302(8):1261-1267. Epub 2019 Apr 22.

Department of Anatomy, Histology and Embryology, Division of Neuroanatomy, Medical University Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1002/ar.24126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767477PMC
August 2019

Imaging axon regeneration within synthetic nerve conduits.

Sci Rep 2019 Jul 12;9(1):10095. Epub 2019 Jul 12.

Innsbruck Medical University, Biocenter, Division of Neurobiochemistry, 6020, Innsbruck, Austria.

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http://dx.doi.org/10.1038/s41598-019-46579-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626049PMC
July 2019

Sprouty2-a Novel Therapeutic Target in the Nervous System?

Mol Neurobiol 2019 Jun 17;56(6):3897-3903. Epub 2018 Sep 17.

Department of Anatomy, Histology and Embyrology, Division of Neuroanatomy, Medical University Innsbruck, Müllerstrasse 59, 6020, Innsbruck, Austria.

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http://dx.doi.org/10.1007/s12035-018-1338-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505497PMC
June 2019

Membrane-Associated, Not Cytoplasmic or Nuclear, FGFR1 Induces Neuronal Differentiation.

Cells 2019 03 14;8(3). Epub 2019 Mar 14.

Division of Neuroanatomy, Medical University of Innsbruck, 6020 Innsbruck, Austria.

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https://www.mdpi.com/2073-4409/8/3/243
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http://dx.doi.org/10.3390/cells8030243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468866PMC
March 2019

Subcellular Localization of Sprouty2 in Human Glioma Cells.

Front Mol Neurosci 2019 29;12:73. Epub 2019 Mar 29.

Department of Anatomy, Histology and Embryology, Division of Neuroanatomy, Medical University Innsbruck, Innsbruck, Austria.

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https://www.frontiersin.org/article/10.3389/fnmol.2019.00073
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http://dx.doi.org/10.3389/fnmol.2019.00073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449699PMC
March 2019

Nanodiamonds as "artificial proteins": Regulation of a cell signalling system using low nanomolar solutions of inorganic nanocrystals.

Biomaterials 2018 09 21;176:106-121. Epub 2018 May 21.

Department of Biology, Faculty of Medicine, Masaryk University, 62500, Brno, Czech Republic; Institute of Animal Physiology and Genetics of the CAS, 60200, Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital, 65691, Brno, Czech Republic. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2018.05.030DOI Listing
September 2018

Sprouty2 enhances the tumorigenic potential of glioblastoma cells.

Neuro Oncol 2018 07;20(8):1044-1054

Division of Neuroanatomy, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1093/neuonc/noy028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280149PMC
July 2018

Membrane turnover and receptor trafficking in regenerating axons.

Eur J Neurosci 2016 Feb 19;43(3):309-17. Epub 2015 Aug 19.

Division of Neuroanatomy, Department of Anatomy, Histology and Embryology, Medical University Innsbruck, 6020, Innsbruck, Austria.

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http://dx.doi.org/10.1111/ejn.13025DOI Listing
February 2016

siRNA mediated down-regulation of Sprouty2/4 diminishes ischemic brain injury.

Neurosci Lett 2016 Jan 3;612:48-51. Epub 2015 Dec 3.

Department of Neurosciences, Faculty of Medicine, University of the Basque Country, 48940 Leioa, Vizcaya, Spain.

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http://dx.doi.org/10.1016/j.neulet.2015.11.050DOI Listing
January 2016

Enhanced axon outgrowth and improved long-distance axon regeneration in sprouty2 deficient mice.

Dev Neurobiol 2015 Mar 14;75(3):217-31. Epub 2014 Aug 14.

Division of Neuroanatomy, Department of Anatomy and Histology, Medical University Innsbruck, 6020, Innsbruck, Austria.

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http://dx.doi.org/10.1002/dneu.22224DOI Listing
March 2015

Pea3 transcription factor promotes neurite outgrowth.

Front Mol Neurosci 2014 26;7:59. Epub 2014 Jun 26.

Molecular Neurobiology Laboratory, Department of Genetics and Bioengineering, Yeditepe University Istanbul, Turkey.

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http://dx.doi.org/10.3389/fnmol.2014.00059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072091PMC
July 2014

The pros and cons of growth factors and cytokines in peripheral axon regeneration.

Int Rev Neurobiol 2013 ;108:137-71

Division of Neuroanatomy, Department of Anatomy and Histology, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1016/B978-0-12-410499-0.00006-XDOI Listing
May 2014

Inhibition of calpains fails to improve regeneration through a peripheral nerve conduit.

Neurosci Lett 2014 Apr 13;566:280-5. Epub 2014 Mar 13.

Division of Neuroanatomy, Department of Anatomy, Histology and Embryology, Innsbruck Medical University, Muellerstrasse 59, 6020 Innsbruck, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2014.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000267PMC
April 2014

A novel DRAK inhibitor, SC82510, promotes axon branching of adult sensory neurons in vitro.

Neurochem Res 2014 Feb 10;39(2):403-7. Epub 2014 Jan 10.

Division of Neuroanatomy, Department of Anatomy, Histology and Embryology, Medical University of Innsbruck, Muellerstrasse 59, 6020, Innsbruck, Austria.

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http://link.springer.com/10.1007/s11064-014-1238-x
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http://dx.doi.org/10.1007/s11064-014-1238-xDOI Listing
February 2014

Identification of voltage-gated K(+) channel beta 2 (Kvβ2) subunit as a novel interaction partner of the pain transducer Transient Receptor Potential Vanilloid 1 channel (TRPV1).

Biochim Biophys Acta 2013 Dec 11;1833(12):3166-3175. Epub 2013 Sep 11.

Division of Cellular and Molecular Pharmacology, Medical University Innsbruck, Peter-Mayr strasse 1, 6020 Innsbruck, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2013.09.001DOI Listing
December 2013

Axotomy-induced changes in the chemical coding pattern of colon projecting calbindin-positive neurons in the inferior mesenteric ganglia of the pig.

J Mol Neurosci 2013 Sep 2;51(1):99-108. Epub 2013 Apr 2.

Department of Neurology and Neurosurgery, Stem Cell Research Laboratory, Faculty of Medical Sciences, University of Warmia and Mazury, Warszawska 30, 10-082, Olsztyn, Poland.

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http://dx.doi.org/10.1007/s12031-013-0007-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739864PMC
September 2013

C3 exoenzyme lacks effects on peripheral axon regeneration in vivo.

J Peripher Nerv Syst 2013 Mar;18(1):30-6

Division of Neuroanatomy, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1111/jns5.12004DOI Listing
March 2013

Sorting of the FGF receptor 1 in a human glioma cell line.

Histochem Cell Biol 2013 Jan 18;139(1):135-48. Epub 2012 Aug 18.

Division of Neuroanatomy, Medical University Innsbruck, Muellerstrasse 59, 6020 Innsbruck, Austria.

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http://dx.doi.org/10.1007/s00418-012-1009-1DOI Listing
January 2013

Sprouty2 and -4 regulate axon outgrowth by hippocampal neurons.

Hippocampus 2012 Mar 14;22(3):434-41. Epub 2011 Jan 14.

Division of Neuroanatomy, Innsbruck Medical University, Muellerstrasse 59, A-6020 Innsbruck, Austria.

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http://dx.doi.org/10.1002/hipo.20910DOI Listing
March 2012

Leupeptin enhances cell surface localization of fibroblast growth factor receptor 1 in adult sensory neurons by increased recycling.

Eur J Cell Biol 2012 Feb 9;91(2):129-38. Epub 2011 Dec 9.

Division of Neuroanatomy, Innsbruck Medical University, Muellerstrasse 59, 6020 Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.ejcb.2011.09.009DOI Listing
February 2012

Genetically modified stem cells for the treatment of neurological diseases.

Front Biosci (Elite Ed) 2012 Jan 1;4:1170-81. Epub 2012 Jan 1.

Laboratory for Neurogenetics and Developmental Genetics, Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Salata 12, HR-10000 Zagreb, Croatia.

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http://dx.doi.org/10.2741/449DOI Listing
January 2012

Rho GTPases as regulators of morphological neuroplasticity.

Ann Anat 2011 Jul 12;193(4):259-66. Epub 2011 Mar 12.

Division of Neuroanatomy, Medical University of Innsbruck, Muellerstrasse 59, Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.aanat.2011.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143277PMC
July 2011

C3 peptide enhances recovery from spinal cord injury by improved regenerative growth of descending fiber tracts.

J Cell Sci 2010 May 20;123(Pt 10):1652-62. Epub 2010 Apr 20.

Center for Anatomy, Institute of Cell Biology and Neurobiology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany.

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http://dx.doi.org/10.1242/jcs.066050DOI Listing
May 2010

Sprouty2 down-regulation promotes axon growth by adult sensory neurons.

Mol Cell Neurosci 2009 Dec 14;42(4):328-40. Epub 2009 Aug 14.

Division of Neuroanatomy, Innsbruck Medical University, Muellerstrasse 59, A-6020 Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.mcn.2009.08.005DOI Listing
December 2009

From birth till death: neurogenesis, cell cycle, and neurodegeneration.

Anat Rec (Hoboken) 2009 Dec;292(12):1953-61

Department of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey.

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http://dx.doi.org/10.1002/ar.20980DOI Listing
December 2009

Signaling by neuronal tyrosine kinase receptors: relevance for development and regeneration.

Anat Rec (Hoboken) 2009 Dec;292(12):1976-85

Division of Neuroanatomy, Medical University Innsbruck, Muellerstrasse 59, Innsbruck, Austria.

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http://dx.doi.org/10.1002/ar.20964DOI Listing
December 2009

In vitro, inhibition of mitogen-activated protein kinase pathways protects against bupivacaine- and ropivacaine-induced neurotoxicity.

Anesth Analg 2008 May;106(5):1456-64, table of contents

Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Anichstr. 35, 6020 Innsbruck, Austria.

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https://insights.ovid.com/crossref?an=00000539-200805000-000
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http://dx.doi.org/10.1213/ane.0b013e318168514bDOI Listing
May 2008

In vitro, lidocaine-induced axonal injury is prevented by peripheral inhibition of the p38 mitogen-activated protein kinase, but not by inhibiting caspase activity.

Anesth Analg 2007 Dec;105(6):1657-64, table of contents

Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1213/01.ane.0000286171.78182.e2DOI Listing
December 2007

The transcriptional corepressor TPA-inducible sequence 7 regulates adult axon growth through cellular retinoic acid binding protein II expression.

Eur J Neurosci 2007 Dec 4;26(12):3358-67. Epub 2007 Dec 4.

Biocenter, Division of Cell Biology, Innsbruck Medical University, Fritz-Pregl-Strasse 3, A-6020 Innsbruck, Austria.

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http://doi.wiley.com/10.1111/j.1460-9568.2007.05951.x
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http://dx.doi.org/10.1111/j.1460-9568.2007.05951.xDOI Listing
December 2007

Phosphorylation-regulated cleavage of the reticulon protein Nogo-B by caspase-7 at a noncanonical recognition site.

Proteomics 2007 Dec;7(24):4457-67

Division of Neurobiochemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1002/pmic.200700499DOI Listing
December 2007

The neurotoxic effects of amitriptyline are mediated by apoptosis and are effectively blocked by inhibition of caspase activity.

Anesth Analg 2006 Jun;102(6):1728-33

Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Austria.

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http://dx.doi.org/10.1213/01.ane.0000216018.62549.bbDOI Listing
June 2006

Mitigation of direct neurotoxic effects of lidocaine and amitriptyline by inhibition of p38 mitogen-activated protein kinase in vitro and in vivo.

Anesthesiology 2006 Jun;104(6):1266-73

Department of Anesthesiology and Critical Care Medicine, Medical University of Innsbruck, Austria.

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http://dx.doi.org/10.1097/00000542-200606000-00023DOI Listing
June 2006

The N-end rule ubiquitin-conjugating enzyme, HR6B, is up-regulated by nerve growth factor and required for neurite outgrowth.

Mol Cell Neurosci 2005 Aug;29(4):559-68

Department of Anatomy, Histology and Embryology (Division of Neuroanatomy), Innsbruck Medical University, Muellerstrasse 59, 6020 Innsbruck, Austria.

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http://linkinghub.elsevier.com/retrieve/pii/S104474310500095
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http://dx.doi.org/10.1016/j.mcn.2005.04.008DOI Listing
August 2005

Tissue distribution of the "N-end rule" ubiquitin-conjugating enzyme, HR6, in the rat.

Histochem Cell Biol 2005 Jun 3;123(4-5):483-9. Epub 2005 May 3.

Department of Anatomy, Histology and Embryology - Division of Neuroanatomy, Innsbruck Medical University, Muellerstrasse 59, Innsbruck, Austria.

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http://dx.doi.org/10.1007/s00418-005-0774-5DOI Listing
June 2005

Secretion and molecular forms of NESP55, a novel genomically imprinted neuroendocrine-specific protein from AtT-20 cells.

Neurosignals 2004 Nov-Dec;13(6):298-307

Department of Pharmacology, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1159/000081965DOI Listing
February 2005

Secretoneurin in the peripheral ocular innervation.

Invest Ophthalmol Vis Sci 2005 Feb;46(2):647-54

Department of Ophthalmology, Medical University of Innsbruck, 6020 Innsbruck, Austria.

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http://dx.doi.org/10.1167/iovs.04-0425DOI Listing
February 2005

Cisatracurium, but not mivacurium, inhibits survival and axonal growth of neonatal and adult rat peripheral neurons in vitro.

Neurosci Lett 2004 Jul;365(2):153-5

Department of Anesthesiology and Critical Care Medicine, Medical University Innsbruck, Anichstrasse 35, 6020, Austria.

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http://linkinghub.elsevier.com/retrieve/pii/S030439400400528
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http://dx.doi.org/10.1016/j.neulet.2004.04.073DOI Listing
July 2004

Tumor necrosis factor-alpha-induced cell death in U373 cells overexpressing alpha-synuclein.

J Neurosci Res 2003 Aug;73(3):334-40

Department of Neurology, University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1002/jnr.10662DOI Listing
August 2003

Ubiquitin-dependent proteolysis in neurons.

News Physiol Sci 2003 Feb;18:29-33

Institute of Anatomy and Histology, Deptartment of Neuroanatomy, University of Innsbruck, A-6010 Innsbruck, Austria.

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http://dx.doi.org/10.1152/nips.01408.2002DOI Listing
February 2003

Characterization of afferent and efferent galanin-containing nerve fibres in the porcine ovary.

Folia Histochem Cytobiol 2002 ;40(3):261-8

Department of Clinical Physiology, University of Warmia and Mazury, Olsztyn, Poland.

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October 2002

Biolistic transfection and morphological analysis of cultured sympathetic neurons.

J Neurosci Methods 2002 Jan;113(1):63-71

Institute of Anatomy and Histology, University of Innsbruck, Muellerstrasse 59, A-6010 Innsbruck, Austria.

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http://dx.doi.org/10.1016/s0165-0270(01)00473-3DOI Listing
January 2002