Lars Klareskog

Lars Klareskog

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Lars Klareskog

Publications by authors named "Lars Klareskog"

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Understanding and Prevention of the Evolution Toward Autoimmune Rheumatoid Arthritis: The New Challenge.

Authors:
Lars Klareskog

Clin Ther 2019 Jul 10;41(7):1232-1234. Epub 2019 Jun 10.

Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, 171 76, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.clinthera.2019.04.034DOI Listing
July 2019

Interplay between alcohol, smoking and HLA genes in RA aetiology.

RMD Open 2019 9;5(1):e000893. Epub 2019 May 9.

Instititute of Environmental Medicine, Karolinska Institutet, Stockhom, Sweden.

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http://dx.doi.org/10.1136/rmdopen-2019-000893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525609PMC
May 2019

Interplay between obesity and smoking with regard to RA risk.

RMD Open 2019 16;5(1):e000856. Epub 2019 Apr 16.

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1136/rmdopen-2018-000856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525604PMC
April 2019

Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.

Arthritis Rheumatol 2019 Feb 4;71(2):210-221. Epub 2019 Jan 4.

Karolinska Institutet, Stockholm, Sweden, and Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1002/art.40698DOI Listing
February 2019

Reply.

Arthritis Rheumatol 2019 Feb 9;71(2):325-327. Epub 2019 Jan 9.

Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/art.40757DOI Listing
February 2019

Smoking, HLA-genes and serology in rheumatoid arthritis; complex relationships investigated in the Swedish EIRA case-control study.

Arthritis Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://doi.wiley.com/10.1002/art.40852
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http://dx.doi.org/10.1002/art.40852DOI Listing
February 2019

Translating genomic medicine to the clinic: challenges and opportunities.

Genome Med 2019 02 22;11(1). Epub 2019 Feb 22.

Centre for Personalised Medicine, Linköping University, Linköping, Sweden.

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http://dx.doi.org/10.1186/s13073-019-0622-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385380PMC
February 2019

Reply.

Arthritis Care Res (Hoboken) 2018 08;70(8):1276

Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/acr.23436DOI Listing
August 2018

Memory T cells specific to citrullinated α-enolase are enriched in the rheumatic joint.

J Autoimmun 2018 08 28;92:47-56. Epub 2018 May 28.

Rheumatology Unit, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183012
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http://dx.doi.org/10.1016/j.jaut.2018.04.004DOI Listing
August 2018

Exposure to passive smoking and rheumatoid arthritis risk: results from the Swedish EIRA study.

Ann Rheum Dis 2018 Jul 3;77(7):970-972. Epub 2018 May 3.

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1136/annrheumdis-2018-212973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029632PMC
July 2018

Occupation and Risk of Developing Rheumatoid Arthritis: Results From a Population-Based Case-Control Study.

Arthritis Care Res (Hoboken) 2018 04 7;70(4):499-509. Epub 2018 Mar 7.

Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/acr.23321DOI Listing
April 2018

Smoking and susceptibility to rheumatoid arthritis in a Swedish population-based case-control study.

Eur J Epidemiol 2018 04 31;33(4):415-423. Epub 2018 Jan 31.

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://link.springer.com/10.1007/s10654-018-0360-5
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http://dx.doi.org/10.1007/s10654-018-0360-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945793PMC
April 2018

IgG Fc galactosylation predicts response to methotrexate in early rheumatoid arthritis.

Arthritis Res Ther 2017 08 9;19(1):182. Epub 2017 Aug 9.

Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13075-017-1389-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549282PMC
August 2017

Working in cold environment and risk of developing rheumatoid arthritis: results from the Swedish EIRA case-control study.

RMD Open 2017 16;3(2):e000488. Epub 2017 Aug 16.

Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1136/rmdopen-2017-000488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574417PMC
August 2017

Relationship between shift work and the onset of rheumatoid arthritis.

RMD Open 2017 29;3(2):e000475. Epub 2017 Aug 29.

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1136/rmdopen-2017-000475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706490PMC
August 2017

DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis.

Arthritis Res Ther 2017 03 29;19(1):71. Epub 2017 Mar 29.

Department of Biochemistry and Molecular Biology, The Ministry of Education Key Laboratory of Metabolism and Molecular Medicine, School of Basic Medical Sciences, Fudan University, West Building 13, 130 Dong An Road, Shanghai, China.

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http://dx.doi.org/10.1186/s13075-017-1276-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372280PMC
March 2017

Mechanisms leading from systemic autoimmunity to joint-specific disease in rheumatoid arthritis.

Nat Rev Rheumatol 2017 Feb 15;13(2):79-86. Epub 2016 Dec 15.

Rheumatology Unit, Department of Medicine (Solna), Karolinska Institute and Karolinska University Hospital, 171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1038/nrrheum.2016.200DOI Listing
February 2017

Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis.

Arthritis Res Ther 2017 Feb 2;19(1):19. Epub 2017 Feb 2.

Rheumatology Unit, Department of Medicine Centre of Molecular Medicine, CMM:L8:04, Karolinska Institutet/Karolinska University Hospital Solna, 171 61, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13075-017-1220-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288892PMC
February 2017

The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting.

Nat Rev Immunol 2017 01 5;17(1):60-75. Epub 2016 Dec 5.

Rheumatology Unit, Department of Medicine at Solna, Karolinska University Hospital, Karolinska Institute, 171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1038/nri.2016.124DOI Listing
January 2017

Erratum: Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.

Nat Commun 2016 10 10;7:13205. Epub 2016 Oct 10.

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http://dx.doi.org/10.1038/ncomms13205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062501PMC
October 2016

Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.

Nat Commun 2016 08 23;7:12460. Epub 2016 Aug 23.

Sage Bionetworks, Seattle, Washington 98115, USA.

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http://dx.doi.org/10.1038/ncomms12460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996969PMC
August 2016

High sodium chloride consumption enhances the effects of smoking but does not interact with SGK1 polymorphisms in the development of ACPA-positive status in patients with RA.

Ann Rheum Dis 2016 May 22;75(5):943-6. Epub 2016 Feb 22.

Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1136/annrheumdis-2015-209009DOI Listing
May 2016

TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits.

PLoS One 2015 7;10(4):e0122271. Epub 2015 Apr 7.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122271PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388675PMC
March 2016

Is rheumatoid arthritis an autoimmune disease?

Curr Opin Rheumatol 2016 Mar;28(2):181-8

Rheumatology Unit, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1097/BOR.0000000000000253DOI Listing
March 2016

Familial aggregation of arthritis-related diseases in seropositive and seronegative rheumatoid arthritis: a register-based case-control study in Sweden.

Ann Rheum Dis 2016 Jan 12;75(1):183-9. Epub 2014 Dec 12.

Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Solna, Sweden Rheumatology Unit, Department of Medicine, Karolinska Institutet, Solna, Sweden.

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http://dx.doi.org/10.1136/annrheumdis-2014-206133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465879PMC
January 2016

Predicting and preventing the development of rheumatoid arthritis.

Rheumatology (Oxford) 2016 Jan 29;55(1):1-3. Epub 2015 Jul 29.

Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, USA.

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https://academic.oup.com/rheumatology/article-lookup/doi/10.
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http://dx.doi.org/10.1093/rheumatology/kev261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854029PMC
January 2016

An Immunochip-based interaction study of contrasting interaction effects with smoking in ACPA-positive versus ACPA-negative rheumatoid arthritis.

Rheumatology (Oxford) 2016 Jan 13;55(1):149-55. Epub 2015 Aug 13.

The Institute of Environmental Medicine, Karolinska Institute, Stockholm, Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden.

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http://dx.doi.org/10.1093/rheumatology/kev285DOI Listing
January 2016

Loci associated with N-glycosylation of human IgG are not associated with rheumatoid arthritis: a Mendelian randomisation study.

Ann Rheum Dis 2016 Jan 17;75(1):317-20. Epub 2015 Sep 17.

Faculty of Medical and Human Sciences, Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2014-207210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717396PMC
January 2016

Mechanisms involved in triggering rheumatoid arthritis.

Immunol Rev 2016 Jan;269(1):162-74

Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1111/imr.12379DOI Listing
January 2016

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis.

Authors:
S Hong Lee Enda M Byrne Christina M Hultman Anna Kähler Anna A E Vinkhuyzen Stephan Ripke Ole A Andreassen Thomas Frisell Alexander Gusev Xinli Hu Robert Karlsson Vasilis X Mantzioris John J McGrath Divya Mehta Eli A Stahl Qiongyi Zhao Kenneth S Kendler Patrick F Sullivan Alkes L Price Michael O'Donovan Yukinori Okada Bryan J Mowry Soumya Raychaudhuri Naomi R Wray William Byerley Wiepke Cahn Rita M Cantor Sven Cichon Paul Cormican David Curtis Srdjan Djurovic Valentina Escott-Price Pablo V Gejman Lyudmila Georgieva Ina Giegling Thomas F Hansen Andrés Ingason Yunjung Kim Bettina Konte Phil H Lee Andrew McIntosh Andrew McQuillin Derek W Morris Markus M Nöthen Colm O'Dushlaine Ann Olincy Line Olsen Carlos N Pato Michele T Pato Benjamin S Pickard Danielle Posthuma Henrik B Rasmussen Marcella Rietschel Dan Rujescu Thomas G Schulze Jeremy M Silverman Srinivasa Thirumalai Thomas Werge Ingrid Agartz Farooq Amin Maria H Azevedo Nicholas Bass Donald W Black Douglas H R Blackwood Richard Bruggeman Nancy G Buccola Khalid Choudhury Robert C Cloninger Aiden Corvin Nicholas Craddock Mark J Daly Susmita Datta Gary J Donohoe Jubao Duan Frank Dudbridge Ayman Fanous Robert Freedman Nelson B Freimer Marion Friedl Michael Gill Hugh Gurling Lieuwe De Haan Marian L Hamshere Annette M Hartmann Peter A Holmans René S Kahn Matthew C Keller Elaine Kenny George K Kirov Lydia Krabbendam Robert Krasucki Jacob Lawrence Todd Lencz Douglas F Levinson Jeffrey A Lieberman Dan-Yu Lin Don H Linszen Patrik K E Magnusson Wolfgang Maier Anil K Malhotra Manuel Mattheisen Morten Mattingsdal Steven A McCarroll Helena Medeiros Ingrid Melle Vihra Milanova Inez Myin-Germeys Benjamin M Neale Roel A Ophoff Michael J Owen Jonathan Pimm Shaun M Purcell Vinay Puri Digby J Quested Lizzy Rossin Douglas Ruderfer Alan R Sanders Jianxin Shi Pamela Sklar David St Clair T Scott Stroup Jim Van Os Peter M Visscher Durk Wiersma Stanley Zammit S Louis Bridges Hyon K Choi Marieke J H Coenen Niek de Vries Philippe Dieud Jeffrey D Greenberg Tom W J Huizinga Leonid Padyukov Katherine A Siminovitch Paul P Tak Jane Worthington Philip L De Jager Joshua C Denny Peter K Gregersen Lars Klareskog Xavier Mariette Robert M Plenge Mart van Laar Piet van Riel

Int J Epidemiol 2015 Oct;44(5):1706-21

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http://dx.doi.org/10.1093/ije/dyv136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881824PMC
October 2015

Recent infections are associated with decreased risk of rheumatoid arthritis: a population-based case-control study.

Ann Rheum Dis 2015 May 5;74(5):904-7. Epub 2015 Feb 5.

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Rheumatology Unit, Department of Medicine, Karolinska Institutet/Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1136/annrheumdis-2014-206493DOI Listing
May 2015

Gene-gene interaction and RNA splicing profiles of MAP2K4 gene in rheumatoid arthritis.

Clin Immunol 2015 May 27;158(1):19-28. Epub 2015 Feb 27.

Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.clim.2015.02.011DOI Listing
May 2015

Autoimmunity: lungs and citrullination.

Nat Rev Rheumatol 2015 May 17;11(5):261-2. Epub 2015 Mar 17.

Rheumatology Unit, Department of Medicine, Karolinska Institutet/Karolinska University Hospital, 171 76 Stockholm, Sweden.

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http://www.nature.com/articles/nrrheum.2015.38
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http://dx.doi.org/10.1038/nrrheum.2015.38DOI Listing
May 2015

The genetics of rheumatoid arthritis: new insights and implications.

JAMA 2015 Apr;313(16):1623-4

Rheumatology Unit, Department of Medicine, Karolinska Institutet/Karolinska University Hospital, Stockholm, Sweden.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2015.1710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476922PMC
April 2015

Response to: 'Obesity and comorbidity are independently associated with a failure to achieve remission in patients with established rheumatoid arthritis' by Ellerby et al.

Ann Rheum Dis 2014 Dec 26;73(12):e79. Epub 2014 Sep 26.

Department of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Department of Rheumatology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1136/annrheumdis-2014-206369DOI Listing
December 2014

Overweight decreases the chance of achieving good response and low disease activity in early rheumatoid arthritis.

Ann Rheum Dis 2014 Nov 12;73(11):2029-33. Epub 2014 May 12.

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Rheumatology Unit, Department of Medicine, Karolinska Institutet/Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1136/annrheumdis-2013-205094DOI Listing
November 2014

Lungs, joints and immunity against citrullinated proteins in rheumatoid arthritis.

Nat Rev Rheumatol 2014 Nov 29;10(11):645-53. Epub 2014 Jul 29.

Rheumatology Unit, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm S-17176, Sweden.

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http://dx.doi.org/10.1038/nrrheum.2014.115DOI Listing
November 2014

A role for noncoding variation in schizophrenia.

Cell Rep 2014 Nov 6;9(4):1417-29. Epub 2014 Nov 6.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://www.cell.com/cell-reports/pdf/S2211-1247(14)00869-9.p
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S221112471400869
Publisher Site
http://dx.doi.org/10.1016/j.celrep.2014.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255904PMC
November 2014

Integration of sequence data from a Consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene.

PLoS One 2014 10;9(2):e87645. Epub 2014 Feb 10.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America ; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America ; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087645PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919745PMC
October 2014

Patients with regular physical activity before onset of rheumatoid arthritis present with milder disease.

Ann Rheum Dis 2014 Aug 18;73(8):1541-4. Epub 2014 Mar 18.

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Rheumatology Unit, Department of Medicine, Karolinska Institutet/Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1136/annrheumdis-2014-205180DOI Listing
August 2014

GeMes, clusters of DNA methylation under genetic control, can inform genetic and epigenetic analysis of disease.

Am J Hum Genet 2014 Apr 20;94(4):485-95. Epub 2014 Mar 20.

Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297140006
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http://dx.doi.org/10.1016/j.ajhg.2014.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980524PMC
April 2014

Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity.

Am J Hum Genet 2014 Apr 20;94(4):522-32. Epub 2014 Mar 20.

Division of Genetics, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Partners HealthCare Center for Personalized Genetic Medicine, Boston, MA 02115, USA; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA; Arthritis Research UK Epidemiology Unit, Musculoskeletal Research Group, University of Manchester, Manchester Academic Health Sciences Centre, Manchester M13 9PT, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297140007
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http://dx.doi.org/10.1016/j.ajhg.2014.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980428PMC
April 2014