Lars Jansen

Lars Jansen

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Lars Jansen

Lars Jansen

Publications by authors named "Lars Jansen"

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Quantitative Microscopy Reveals Centromeric Chromatin Stability, Size, and Cell Cycle Mechanisms to Maintain Centromere Homeostasis.

Prog Mol Subcell Biol 2017;56:139-162

Instituto Gulbenkian de Ciência, 2780-156, Oeiras, Portugal.

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http://dx.doi.org/10.1007/978-3-319-58592-5_6DOI Listing
May 2019

time-ChIP: A Method to Determine Long-Term Locus-Specific Nucleosome Inheritance.

Methods Mol Biol 2018 ;1832:131-158

Instituto Gulbenkian de Ciência, Oeiras, Portugal.

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http://dx.doi.org/10.1007/978-1-4939-8663-7_7DOI Listing
April 2019

Epigenetic gene silencing alters the mechanisms and rate of evolutionary adaptation.

Nat Ecol Evol 2019 03 4;3(3):491-498. Epub 2019 Feb 4.

Instituto Gulbenkian de Ciência, Oeiras, Portugal.

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http://www.nature.com/articles/s41559-018-0781-2
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http://dx.doi.org/10.1038/s41559-018-0781-2DOI Listing
March 2019

Detection of HPV16 in Esophageal Cancer in a High-Incidence Region of Malawi.

Int J Mol Sci 2018 Feb 12;19(2). Epub 2018 Feb 12.

Department of Gynecology, Jena University Hospital-Friedrich-Schiller-University, 07747 Jena, Germany.

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http://dx.doi.org/10.3390/ijms19020557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855779PMC
February 2018

Tribbles 2 mediates cisplatin sensitivity and DNA damage response in epithelial ovarian cancer.

Int J Cancer 2017 10 12;141(8):1600-1614. Epub 2017 Jul 12.

Department of Gynecology and Reproductive Medicine, Jena University Hospital, Friedrich-Schiller University, Jena, Germany.

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http://dx.doi.org/10.1002/ijc.30860DOI Listing
October 2017

Gene expression analysis combined with functional genomics approach identifies ITIH5 as tumor suppressor gene in cervical carcinogenesis.

Mol Carcinog 2017 06 6;56(6):1578-1589. Epub 2017 Mar 6.

Department of Gynecology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.

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http://dx.doi.org/10.1002/mc.22613DOI Listing
June 2017

Induction of dormancy in hypoxic human papillomavirus-positive cancer cells.

Proc Natl Acad Sci U S A 2017 02 23;114(6):E990-E998. Epub 2017 Jan 23.

Molecular Therapy of Virus-Associated Cancers (F065), German Cancer Research Center, D-69120 Heidelberg, Germany;

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http://dx.doi.org/10.1073/pnas.1615758114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307428PMC
February 2017

An HL7-FHIR-based Object Model for a Home-Centered Data Warehouse for Ambient Assisted Living Environments.

Stud Health Technol Inform 2015 ;216:1060

Peter L. Reichertz Institute for Medical Informatics, University of Braunschweig and Hannover Medical School, Germany.

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December 2016

RUNX3 and CAMK2N1 hypermethylation as prognostic marker for epithelial ovarian cancer.

Int J Cancer 2016 Jan 28;138(1):217-28. Epub 2015 Jul 28.

Department of Gynecology, Jena University Hospital-Friedrich Schiller University, Jena, Germany.

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http://dx.doi.org/10.1002/ijc.29690DOI Listing
January 2016

Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere.

Science 2015 May;348(6235):699-703

Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Graduate Program in Cell and Molecular Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Graduate Program in Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/science.1259308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610723PMC
May 2015

Frictional dissipation in a polymer bilayer system.

Langmuir 2014 Feb 3;30(6):1557-65. Epub 2014 Feb 3.

Physikalisches Institut, Westfälische Wilhelms-Universität Münster , Wilhelm-Klemm-Str. 10, 48149 Münster, Germany.

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http://dx.doi.org/10.1021/la404537uDOI Listing
February 2014

SORBS2 and TLR3 induce premature senescence in primary human fibroblasts and keratinocytes.

BMC Cancer 2013 Oct 29;13:507. Epub 2013 Oct 29.

Department of Gynecology, Jena University Hospital, Friedrich Schiller University Jena, Bachstr, 18, Jena 07743, Germany.

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http://dx.doi.org/10.1186/1471-2407-13-507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819711PMC
October 2013

A two-step mechanism for epigenetic specification of centromere identity and function.

Nat Cell Biol 2013 Sep 21;15(9):1056-66. Epub 2013 Jul 21.

Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/ncb2805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418506PMC
September 2013

Tetraspanin 1 promotes invasiveness of cervical cancer cells.

Int J Oncol 2013 Aug 10;43(2):503-12. Epub 2013 Jun 10.

Department of Gynecology and Obstretrics, Jena University Hospital, Jena, Germany.

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http://dx.doi.org/10.3892/ijo.2013.1980DOI Listing
August 2013

How two become one: HJURP dimerization drives CENP-A assembly.

EMBO J 2013 Jul 21;32(15):2090-2. Epub 2013 Jun 21.

Instituto Gulbenkian de Ciência, Oeiras, Portugal.

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http://dx.doi.org/10.1038/emboj.2013.150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730231PMC
July 2013

Basic properties of epigenetic systems: lessons from the centromere.

Curr Opin Genet Dev 2013 Apr 5;23(2):219-27. Epub 2012 Dec 5.

Instituto Gulbenkian de Ciência, 2780-156, Oeiras, Portugal.

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http://dx.doi.org/10.1016/j.gde.2012.11.002DOI Listing
April 2013

Assembly in G1 phase and long-term stability are unique intrinsic features of CENP-A nucleosomes.

Mol Biol Cell 2013 Apr 30;24(7):923-32. Epub 2013 Jan 30.

Instituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal.

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http://dx.doi.org/10.1091/mbc.E13-01-0034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608502PMC
April 2013

Non-random integration of the HPV genome in cervical cancer.

PLoS One 2012 27;7(6):e39632. Epub 2012 Jun 27.

Klinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Jena, Jena, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039632PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384597PMC
January 2013

Reductionism at the vertebrate kinetochore.

J Cell Biol 2013 Jan 31;200(1):7-8. Epub 2012 Dec 31.

Instituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal.

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http://dx.doi.org/10.1083/jcb.201212005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542803PMC
January 2013

Loss of gene function as a consequence of human papillomavirus DNA integration.

Int J Cancer 2012 Sep 22;131(5):E593-602. Epub 2012 Feb 22.

Klinik für Geburtshilfe und Frauenheilkunde, Universitätsklinikum Jena, Jena, Germany.

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http://dx.doi.org/10.1002/ijc.27433DOI Listing
September 2012

Temporal control of epigenetic centromere specification.

Chromosome Res 2012 Jul;20(5):481-92

Instituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal.

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http://dx.doi.org/10.1007/s10577-012-9291-2DOI Listing
July 2012

Basic properties of epigenetic systems: lessons from the centromere.

Curr Opin Genet Dev 2013 Apr 5;23(2):219-27. Epub 2012 Dec 5.

Instituto Gulbenkian de Ciência, 2780-156, Oeiras, Portugal.

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http://dx.doi.org/10.1016/j.gde.2012.11.002DOI Listing
April 2013

Cdk activity couples epigenetic centromere inheritance to cell cycle progression.

Dev Cell 2012 Jan 8;22(1):52-63. Epub 2011 Dec 8.

Instituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal.

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http://dx.doi.org/10.1016/j.devcel.2011.10.014DOI Listing
January 2012

Genetics. Sowing the seeds of centromeres.

Authors:
Lars E T Jansen

Science 2012 Jan;335(6066):299-300

Instituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal.

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http://dx.doi.org/10.1126/science.1218162DOI Listing
January 2012

Novel splice variant CAR 4/6 of the coxsackie adenovirus receptor is differentially expressed in cervical carcinogenesis.

J Mol Med (Berl) 2011 Jun 23;89(6):621-30. Epub 2011 Mar 23.

Department of Gynaecology and Obstetrics, Jena University Hospital, Germany.

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http://dx.doi.org/10.1007/s00109-011-0742-6DOI Listing
June 2011

Hypermethylated DAPK in serum DNA of women with uterine leiomyoma is a biomarker not restricted to cancer.

Gynecol Oncol 2011 Apr 14;121(1):224-9. Epub 2010 Dec 14.

Department of Gynecology and Obstetrics, Jena University Hospital, Jena, Germany.

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http://dx.doi.org/10.1016/j.ygyno.2010.11.018DOI Listing
April 2011

The Perceived Stress Reactivity Scale: measurement invariance, stability, and validity in three countries.

Psychol Assess 2011 Mar;23(1):80-94

School of Psychology, University of Southampton, Highfield Campus, Southampton SO17 1BJ, United Kingdom.

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http://doi.apa.org/getdoi.cfm?doi=10.1037/a0021148
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http://dx.doi.org/10.1037/a0021148DOI Listing
March 2011

Temperature dependence of atomic-scale stick-slip friction.

Phys Rev Lett 2010 Jun 25;104(25):256101. Epub 2010 Jun 25.

Physikalisches Institut and Center for Nanotechnology (CeNTech), Westfälische Wilhelms-Universität Münster, Wilhelm-Klemm-Strasse 10, 48149 Münster, Germany.

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http://dx.doi.org/10.1103/PhysRevLett.104.256101DOI Listing
June 2010

Multibond dynamics of nanoscale friction: the role of temperature.

Phys Rev Lett 2010 Feb 12;104(6):066104. Epub 2010 Feb 12.

School of Chemistry, Tel Aviv University, 69978 Tel Aviv, Israel.

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https://link.aps.org/doi/10.1103/PhysRevLett.104.066104
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http://dx.doi.org/10.1103/PhysRevLett.104.066104DOI Listing
February 2010

At the right place at the right time: novel CENP-A binding proteins shed light on centromere assembly.

Chromosoma 2009 Oct 10;118(5):567-74. Epub 2009 Jul 10.

Laboratory for Epigenetic Mechanisms, Instituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal.

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http://dx.doi.org/10.1007/s00412-009-0227-3DOI Listing
October 2009

Human condensin function is essential for centromeric chromatin assembly and proper sister kinetochore orientation.

PLoS One 2009 Aug 28;4(8):e6831. Epub 2009 Aug 28.

Unit on Chromosome Structure and Function, National Institute of Child Health and Human Development (NICHD), Laboratory of Gene Regulation and Development (LGRD), Bethesda, Maryland, United States of America.

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http://sites.igc.gulbenkian.pt/epilab/files/2009Samoshkin.pd
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http://dx.plos.org/10.1371/journal.pone.0006831
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006831PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730017PMC
August 2009

Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N.

Nat Cell Biol 2009 Jul 21;11(7):896-902. Epub 2009 Jun 21.

Department of Biochemistry, Stanford University School of Medicine, Beckman Center, Palo Alto, CA 94503-5307, USA.

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http://dx.doi.org/10.1038/ncb1899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704923PMC
July 2009

Nanoscale frictional dissipation into shear-stressed polymer relaxations.

Phys Rev Lett 2009 Jun 9;102(23):236101. Epub 2009 Jun 9.

Physikalisches Institut, Westfälische Wilhelms-Universität Münster, Wilhelm-Klemm-Strasse 10, 48149 Münster, Germany.

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https://link.aps.org/doi/10.1103/PhysRevLett.102.236101
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http://dx.doi.org/10.1103/PhysRevLett.102.236101DOI Listing
June 2009

Activating NK cell receptor ligands are differentially expressed during progression to cervical cancer.

Int J Cancer 2008 Nov;123(10):2343-53

Division of Innate Immunity, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.23733DOI Listing
November 2008

Propagation of centromeric chromatin requires exit from mitosis.

J Cell Biol 2007 Mar 5;176(6):795-805. Epub 2007 Mar 5.

Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1083/jcb.200701066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064054PMC
March 2007

Centromere identity maintained by nucleosomes assembled with histone H3 containing the CENP-A targeting domain.

Mol Cell 2007 Jan;25(2):309-22

Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.molcel.2006.12.018DOI Listing
January 2007

Force dependence of transition rates in atomic friction.

Phys Rev Lett 2006 Dec 11;97(24):240601. Epub 2006 Dec 11.

Universität Bielefeld, Fakultät für Physik, 33615 Bielefeld, Germany.

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http://dx.doi.org/10.1103/PhysRevLett.97.240601DOI Listing
December 2006

The human CENP-A centromeric nucleosome-associated complex.

Nat Cell Biol 2006 May 16;8(5):458-69. Epub 2006 Apr 16.

Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093-0670, USA.

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http://dx.doi.org/10.1038/ncb1397DOI Listing
May 2006

Characterization of the DNA binding and structural properties of the BRCT region of human replication factor C p140 subunit.

J Biol Chem 2006 Feb 16;281(7):4308-17. Epub 2005 Dec 16.

Leiden Institute of Chemistry, Leiden University, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M511090200DOI Listing
February 2006

A region on human chromosome 4 (q35.1-->qter) induces senescence in cell hybrids and is involved in cervical carcinogenesis.

Genes Chromosomes Cancer 2005 Jul;43(3):260-72

Gynäkologische Molekularbiologie, Abteilung Frauenheilkunde, Frauenklinik der Friedrich-Schiller-Universität Jena, Germany.

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http://dx.doi.org/10.1002/gcc.20192DOI Listing
July 2005

Platinated DNA adducts enhance poisoning of DNA topoisomerase I by camptothecin.

J Biol Chem 2004 Dec 6;279(52):54502-9. Epub 2004 Oct 6.

Department of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M410103200
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http://dx.doi.org/10.1074/jbc.M410103200DOI Listing
December 2004

Detection of cancer-related gene expression profiles in severe cervical neoplasia.

Int J Cancer 2004 Oct;112(1):33-43

Klinik für Frauenheilkunde und Geburtshilfe, Friedrich-Schiller-Universität, Jena, Germany.

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http://dx.doi.org/10.1002/ijc.20351DOI Listing
October 2004

Propofol anesthesia in children does not induce sister chromatid exchanges in lymphocytes.

Mutat Res 2003 Dec;542(1-2):59-64

Department of Anesthesiology, University Hospital Hamburg-Eppendorf, Martinistr 52, 20246 Hamburg, Germany.

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http://dx.doi.org/10.1016/j.mrgentox.2003.08.007DOI Listing
December 2003

Transcription elongation factor Spt4 mediates loss of phosphorylated RNA polymerase II transcription in response to DNA damage.

Nucleic Acids Res 2002 Aug;30(16):3532-9

MGC Department of Molecular Genetics, Leiden Institute of Chemistry, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC134242PMC
http://dx.doi.org/10.1093/nar/gkf475DOI Listing
August 2002

Identification of a new proliferation-associated protein NET-1/C4.8 characteristic for a subset of high-grade cervical intraepithelial neoplasia and cervical carcinomas.

Int J Cancer 2002 Jun;99(6):771-5

Gynäkologische Molekularbiologie, Abteilung Frauenheilkunde, Klinik für Frauenheilkunde und Geburtshilfe der Friedrich-Schiller-Universität Jena, Jena, Germany.

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http://dx.doi.org/10.1002/ijc.10442DOI Listing
June 2002

A Rad26-Def1 complex coordinates repair and RNA pol II proteolysis in response to DNA damage.

Nature 2002 Feb;415(6874):929-33

Mechanisms of Gene Transcription Laboratory, Cancer Research UK, Clare Hall Laboratories, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, UK.

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http://www.nature.com/articles/415929a
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http://dx.doi.org/10.1038/415929aDOI Listing
February 2002