Publications by authors named "Lars Fugger"

95Publications

Recovery from COVID-19 in a B-cell-depleted multiple sclerosis patient.

Mult Scler 2020 09 7;26(10):1261-1264. Epub 2020 Aug 7.

Department of Neurology, St. Josef-Hospital Bochum, Ruhr-University Bochum, Bochum, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1352458520943791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502978PMC
September 2020

Inflammation-related plasma and CSF biomarkers for multiple sclerosis.

Proc Natl Acad Sci U S A 2020 06 26;117(23):12952-12960. Epub 2020 May 26.

Neuroimmunology Unit, Center of Molecular Medicine, Department of Clinical Neuroscience, Karolinska University Hospital, Karolinska Institutet, SE-171 77 Stockholm, Sweden;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1912839117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293699PMC
June 2020

A novel neurodegenerative spectrum disorder in patients with MLKL deficiency.

Cell Death Dis 2020 May 1;11(5):303. Epub 2020 May 1.

Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41419-020-2494-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195448PMC
May 2020

Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases.

Cell 2020 04;181(1):63-80

Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia; Institute of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, Cardiff CF14 4XN, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2020.03.007DOI Listing
April 2020

Identifying cross-disease components of genetic risk across hospital data in the UK Biobank.

Nat Genet 2020 01 23;52(1):126-134. Epub 2019 Dec 23.

Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41588-019-0550-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974401PMC
January 2020

HLA variation and disease.

Nat Rev Immunol 2018 05 2;18(5):325-339. Epub 2018 Jan 2.

Danish National Research Foundation Centre PERSIMUNE, Rigshospitalet, University of Copenhagen, Copenhagen DK-2100, Denmark.

View Article

Download full-text PDF

Source
http://www.nature.com/doifinder/10.1038/nri.2017.143
Publisher Site
http://dx.doi.org/10.1038/nri.2017.143DOI Listing
May 2018

Immunomodulation in multiple sclerosis: promises and pitfalls.

Curr Opin Immunol 2017 Dec 18;49:37-43. Epub 2017 Sep 18.

Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology and MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coi.2017.08.013DOI Listing
December 2017

Structural and regulatory diversity shape HLA-C protein expression levels.

Nat Commun 2017 06 26;8:15924. Epub 2017 Jun 26.

MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms15924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490200PMC
June 2017

Severe B-cell-mediated CNS disease secondary to alemtuzumab therapy.

Lancet Neurol 2017 02;16(2):104-106

Department of Neurology of the Ruhr-University Bochum at St Josef-Hospital, Gudrunstrasse 56, 44791 Bochum, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1474-4422(16)30382-9DOI Listing
February 2017

Neuroinflammation - using big data to inform clinical practice.

Nat Rev Neurol 2016 12 18;12(12):685-698. Epub 2016 Nov 18.

Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, and MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrneurol.2016.171DOI Listing
December 2016

Antigen Targeting to Human HLA Class II Molecules Increases Efficacy of DNA Vaccination.

J Immunol 2016 11 26;197(9):3575-3585. Epub 2016 Sep 26.

K.G. Jebsen Center for Influenza Vaccine Research, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, 0027 Oslo, Norway;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1600893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073356PMC
November 2016

Inhibitory Interplay between Orexin Neurons and Eating.

Curr Biol 2016 09 18;26(18):2486-2491. Epub 2016 Aug 18.

Mill Hill Laboratory, The Francis Crick Institute, London NW7 1AA, UK; Institute of Psychiatry, Psychology and Neuroscience, Department of Developmental Neurobiology, King's College London, London WC2R 2LS, UK. Electronic address:

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049542PMC
http://dx.doi.org/10.1016/j.cub.2016.07.013DOI Listing
September 2016

Amiloride Clinical Trial In Optic Neuritis (ACTION) protocol: a randomised, double blind, placebo controlled trial.

BMJ Open 2015 Nov 9;5(11):e009200. Epub 2015 Nov 9.

Division of Clinical Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2015-009200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654308PMC
November 2015

Immunopathology of multiple sclerosis.

Nat Rev Immunol 2015 Sep 7;15(9):545-58. Epub 2015 Aug 7.

Institut für Neuroimmunologie und Multiple Sklerose, Zentrum für Molekulare Neurobiologie Hamburg, Universitätsklinikum Hamburg-Eppendorf, 20246 Hamburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nri3871DOI Listing
September 2015

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.

Authors:
Jenny C Taylor Hilary C Martin Stefano Lise John Broxholme Jean-Baptiste Cazier Andy Rimmer Alexander Kanapin Gerton Lunter Simon Fiddy Chris Allan A Radu Aricescu Moustafa Attar Christian Babbs Jennifer Becq David Beeson Celeste Bento Patricia Bignell Edward Blair Veronica J Buckle Katherine Bull Ondrej Cais Holger Cario Helen Chapel Richard R Copley Richard Cornall Jude Craft Karin Dahan Emma E Davenport Calliope Dendrou Olivier Devuyst Aimée L Fenwick Jonathan Flint Lars Fugger Rodney D Gilbert Anne Goriely Angie Green Ingo H Greger Russell Grocock Anja V Gruszczyk Robert Hastings Edouard Hatton Doug Higgs Adrian Hill Chris Holmes Malcolm Howard Linda Hughes Peter Humburg David Johnson Fredrik Karpe Zoya Kingsbury Usha Kini Julian C Knight Jonathan Krohn Sarah Lamble Craig Langman Lorne Lonie Joshua Luck Davis McCarthy Simon J McGowan Mary Frances McMullin Kerry A Miller Lisa Murray Andrea H Németh M Andrew Nesbit David Nutt Elizabeth Ormondroyd Annette Bang Oturai Alistair Pagnamenta Smita Y Patel Melanie Percy Nayia Petousi Paolo Piazza Sian E Piret Guadalupe Polanco-Echeverry Niko Popitsch Fiona Powrie Chris Pugh Lynn Quek Peter A Robbins Kathryn Robson Alexandra Russo Natasha Sahgal Pauline A van Schouwenburg Anna Schuh Earl Silverman Alison Simmons Per Soelberg Sørensen Elizabeth Sweeney John Taylor Rajesh V Thakker Ian Tomlinson Amy Trebes Stephen Rf Twigg Holm H Uhlig Paresh Vyas Tim Vyse Steven A Wall Hugh Watkins Michael P Whyte Lorna Witty Ben Wright Chris Yau David Buck Sean Humphray Peter J Ratcliffe John I Bell Andrew Om Wilkie David Bentley Peter Donnelly Gilean McVean

Nat Genet 2015 Jul 18;47(7):717-726. Epub 2015 May 18.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601524PMC
July 2015

Please mind the gap: axonal transport deficits in multiple sclerosis neurodegeneration.

Neuron 2014 Dec;84(6):1105-7

Nuffield Department of Clinical Neurosciences, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK; Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK; Clinical Institute, Aarhus University Hospital, Skejby Sygehus, DK-8000 Aarhus, Denmark. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2014.12.012DOI Listing
December 2014

Multiple sclerosis: insights into pathophysiology and novel therapeutic avenues.

Exp Neurol 2014 Dec 18;262 Pt A. Epub 2014 Apr 18.

Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2014.04.012DOI Listing
December 2014

HIV-1 adaptation to antigen processing results in population-level immune evasion and affects subtype diversification.

Cell Rep 2014 Apr 13;7(2):448-463. Epub 2014 Apr 13.

Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital, Headley Way, Oxford OX3 9DS, UK; Division of Clinical Neurology, Nuffield Department of Clinical Neurosciences, Weatherall Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital, Headley Way, Oxford OX3 9DS, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2014.03.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005910PMC
April 2014

Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis.

Nat Rev Neurol 2014 Apr 18;10(4):225-38. Epub 2014 Mar 18.

Nuffield Department of Clinical Neurosciences and Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nrneurol.2014.37
Publisher Site
http://dx.doi.org/10.1038/nrneurol.2014.37DOI Listing
April 2014

A clinical conundrum: the detrimental effect of TNF antagonists in multiple sclerosis.

Pharmacogenomics 2013 Sep;14(12):1397-404

Nuffield Department of Clinical Neurosciences, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs.13.140DOI Listing
September 2013

Therapies for multiple sclerosis: translational achievements and outstanding needs.

Trends Mol Med 2013 May 10;19(5):309-19. Epub 2013 Apr 10.

Nuffield Department of Clinical Neurosciences and MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmed.2013.03.004DOI Listing
May 2013

TCR transgenic mice that shed light on immune and environmental regulators in multiple sclerosis.

J Immunol 2013 Apr;190(7):3015-7

Nuffield Department of Clinical Neurosciences, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1300427DOI Listing
April 2013

The HLA-DRB1*15:01-restricted Goodpasture's T cell epitope induces GN.

J Am Soc Nephrol 2013 Feb 14;24(3):419-31. Epub 2013 Feb 14.

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, 246 Clayton Road, Clayton, VIC 3168, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2012070705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582203PMC
February 2013

Weighing in on autoimmune disease: Big data tip the scale.

Nat Med 2013 Feb;19(2):138-9

Nuffield Department of Clinical Neurosciences, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm.3087DOI Listing
February 2013

Genomewide association studies and common disease--realizing clinical utility.

N Engl J Med 2012 Dec;367(25):2370-1

Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://www.nejm.org/doi/abs/10.1056/NEJMp1212285
Publisher Site
http://dx.doi.org/10.1056/NEJMp1212285DOI Listing
December 2012

The immunodominant myeloperoxidase T-cell epitope induces local cell-mediated injury in antimyeloperoxidase glomerulonephritis.

Proc Natl Acad Sci U S A 2012 Sep 5;109(39):E2615-24. Epub 2012 Sep 5.

Center for Inflammatory Diseases, Department of Medicine, Monash University, Clayton 3168, Victoria, Australia.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.1210147109
Publisher Site
http://dx.doi.org/10.1073/pnas.1210147109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465432PMC
September 2012

Natural killer cells and their receptors in multiple sclerosis.

Brain 2013 Sep 25;136(Pt 9):2657-76. Epub 2012 Jun 25.

MRC Human Immunology Unit, Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.

View Article

Download full-text PDF

Source
https://academic.oup.com/brain/article-lookup/doi/10.1093/br
Publisher Site
http://dx.doi.org/10.1093/brain/aws159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754456PMC
September 2013

Bridging the gap from genetic association to functional understanding: the next generation of mouse models of multiple sclerosis.

Immunol Rev 2012 Jul;248(1):10-22

Division of Clinical Neurology, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1600-065X.2012.01132.xDOI Listing
July 2012

Convergent inputs from electrically and topographically distinct orexin cells to locus coeruleus and ventral tegmental area.

Eur J Neurosci 2012 May 16;35(9):1426-32. Epub 2012 Apr 16.

Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1460-9568.2012.08057.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767120PMC
May 2012

Use of calcium channel blockers and Parkinson's disease.

Am J Epidemiol 2012 Apr 1;175(7):627-35. Epub 2012 Mar 1.

Department of Epidemiology Research, Statens Serum Institut, Copenhagen S, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/aje/kwr362DOI Listing
April 2012

Autoimmunity's next top models.

Nat Med 2012 Jan 6;18(1):66-70. Epub 2012 Jan 6.

Department of Neuroimmunology, Max Planck Institute of Neurobiology, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm.2635DOI Listing
January 2012

Activation of central orexin/hypocretin neurons by dietary amino acids.

Neuron 2011 Nov;72(4):616-29

Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2011.08.027DOI Listing
November 2011

Orexin neurons as conditional glucosensors: paradoxical regulation of sugar sensing by intracellular fuels.

J Physiol 2011 Dec 17;589(Pt 23):5701-8. Epub 2011 Oct 17.

Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1113/jphysiol.2011.217000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249044PMC
December 2011

Tolerance to ingested deamidated gliadin in mice is maintained by splenic, type 1 regulatory T cells.

Gastroenterology 2011 Aug 28;141(2):610-20, 620.e1-2. Epub 2011 Apr 28.

Department of Pediatrics, Erasmus Medical Center - Sophia Children's Hospital, Rotterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2011.04.048DOI Listing
August 2011

Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis.

Acta Crystallogr D Biol Crystallogr 2011 May 13;67(Pt 5):447-54. Epub 2011 Apr 13.

Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX39DS, England.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S0907444911007888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087623PMC
May 2011

Axonal injury in reverse.

Nat Med 2011 Apr;17(4):423-6

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nm0411-423
Publisher Site
http://dx.doi.org/10.1038/nm0411-423DOI Listing
April 2011

IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain.

Am J Pathol 2011 Feb;178(2):794-802

Department of Neuropathology, Weatherall Institute of Molecular Medicine, Oxford Radcliffe NHS Trust, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajpath.2010.10.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032888PMC
February 2011

Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model.

Brain 2011 Feb 13;134(Pt 2):571-84. Epub 2011 Jan 13.

Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awq337DOI Listing
February 2011

Direct and indirect control of orexin/hypocretin neurons by glycine receptors.

J Physiol 2011 Feb 6;589(Pt 3):639-51. Epub 2010 Dec 6.

University of Cambridge, Department of Pharmacology, Cambridge, UK.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1113/jphysiol.2010.198457
Publisher Site
http://dx.doi.org/10.1113/jphysiol.2010.198457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055548PMC
February 2011

An alternative conformation of the T-cell receptor alpha constant region.

J Mol Biol 2010 Jul 31;400(4):828-37. Epub 2010 May 31.

Division of Structural Biology, Wellcome Trust Centre for Human Genetics, The University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2010.05.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930249PMC
July 2010

Pathogenic CD8(+) T cells in multiple sclerosis.

Ann Neurol 2009 Aug;66(2):132-41

Institut für Neuroimmunologie und Klinische Multiple Sklerose-Forschung, Zentrum für Molekulare Neurobiologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.21744DOI Listing
August 2009

From genes to function: the next challenge to understanding multiple sclerosis.

Nat Rev Immunol 2009 Jun;9(6):408-17

Department of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nri2554DOI Listing
June 2009

Stimulation of orexin/hypocretin neurones by thyrotropin-releasing hormone.

J Physiol 2009 Mar 9;587(Pt 6):1179-86. Epub 2009 Feb 9.

Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1113/jphysiol.2008.167940
Publisher Site
http://dx.doi.org/10.1113/jphysiol.2008.167940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674990PMC
March 2009

Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis.

Nat Med 2008 Nov 26;14(11):1227-35. Epub 2008 Oct 26.

Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm.1881DOI Listing
November 2008

Adaptive sugar sensors in hypothalamic feeding circuits.

Proc Natl Acad Sci U S A 2008 Aug 11;105(33):11975-80. Epub 2008 Aug 11.

Department of Pharmacology, University of Cambridge, Cambridge C82 1PD, United Kingdom.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.0802687105
Publisher Site
http://dx.doi.org/10.1073/pnas.0802687105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575303PMC
August 2008

Metabolism-independent sugar sensing in central orexin neurons.

Diabetes 2008 Oct 30;57(10):2569-76. Epub 2008 Jun 30.

Department of Pharmacology, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db08-0548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2551664PMC
October 2008

Dissection of the multiple sclerosis associated DR2 haplotype.

J Autoimmun 2008 Nov 2;31(3):201-7. Epub 2008 Jun 2.

Department of Clinical Neurology, University of Oxford, Oxford OX3 9DS, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2008.04.016DOI Listing
November 2008

Redirecting therapeutic T cells against myelin-specific T lymphocytes using a humanized myelin basic protein-HLA-DR2-zeta chimeric receptor.

J Immunol 2008 Mar;180(5):3601-11

Department of Pathology, St. Jude Children's Research Hospital, and University of Tennessee Health Sciences Center, Memphis, TN 38105, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.180.5.3601DOI Listing
March 2008

Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system.

Nat Med 2007 Dec 11;13(12):1483-9. Epub 2007 Nov 11.

Medical Research Council Human Immunology Unit and Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nm1668
Publisher Site
http://dx.doi.org/10.1038/nm1668DOI Listing
December 2007

T cells and microglia as drivers of multiple sclerosis pathology.

Brain 2007 Nov;130(Pt 11):2755-7

Department of Clinical Neurology and MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awm246DOI Listing
November 2007

Control of hypothalamic orexin neurons by acid and CO2.

Proc Natl Acad Sci U S A 2007 Jun 11;104(25):10685-90. Epub 2007 Jun 11.

Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, England.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0702676104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1965573PMC
June 2007

Humanized mouse models for organ-specific autoimmune diseases.

Curr Opin Immunol 2006 Dec 27;18(6):704-9. Epub 2006 Sep 27.

MRC Human Immunology Unit and Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coi.2006.09.003DOI Listing
December 2006

Functional epistasis on a common MHC haplotype associated with multiple sclerosis.

Nature 2006 Oct 27;443(7111):574-7. Epub 2006 Sep 27.

Department of Clinical Immunology, Aarhus University Hospital, Skejby Sygehus, 8200 N, Aarhus, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature05133DOI Listing
October 2006

Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose.

Neuron 2006 Jun;50(5):711-22

Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2006.04.032DOI Listing
June 2006

The value of animal models for drug development in multiple sclerosis.

Brain 2006 Aug 24;129(Pt 8):1940-52. Epub 2006 Apr 24.

MRC Human Immunology Unit and Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awl083DOI Listing
August 2006

MHC class II proteins and disease: a structural perspective.

Nat Rev Immunol 2006 Apr;6(4):271-82

Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, The University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nri1805
Publisher Site
http://dx.doi.org/10.1038/nri1805DOI Listing
April 2006

Efficient presentation of myelin oligodendrocyte glycoprotein peptides but not protein by astrocytes from HLA-DR2 and HLA-DR4 transgenic mice.

J Neuroimmunol 2006 Apr 4;173(1-2):23-34. Epub 2006 Jan 4.

Institute of Pathology, School of Medicine, Case Western Reserve University, Cleveland, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S016557280500499
Publisher Site
http://dx.doi.org/10.1016/j.jneuroim.2005.11.014DOI Listing
April 2006

MHC II molecules in inflammatory diseases: interplay of qualities and quantities.

Trends Immunol 2005 Nov 31;26(11):559-61. Epub 2005 Aug 31.

MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.it.2005.08.011DOI Listing
November 2005

Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy?

Brain 2005 Aug 23;128(Pt 8):1747-63. Epub 2005 Jun 23.

MRC Human Immunology Unit and Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awh578DOI Listing
August 2005

Multiple sclerosis: MHC associations and therapeutic implications.

Expert Rev Mol Med 2005 Feb 14;7(3):1-17. Epub 2005 Feb 14.

Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, The University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S1462399405008914DOI Listing
February 2005

Control of autoimmunity by "epitope theft".

Trends Mol Med 2005 Jan;11(1):1-4

MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S147149140400284
Publisher Site
http://dx.doi.org/10.1016/j.molmed.2004.11.002DOI Listing
January 2005

Tracking of proinflammatory collagen-specific T cells in early and late collagen-induced arthritis in humanized mice.

J Immunol 2004 Dec;173(11):7037-45

Department of Clinical Immunology, Aarhus University Hospital, Skejby Sygehus, Aarhus, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.173.11.7037DOI Listing
December 2004

Longitudinal and cross-sectional studies of HIV-1 RNA and DNA loads in blood and the female genital tract.

Eur J Obstet Gynecol Reprod Biol 2004 Dec;117(2):227-35

Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9AD, UK.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S030121150400313
Publisher Site
http://dx.doi.org/10.1016/j.ejogrb.2004.05.016DOI Listing
December 2004

Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy.

Proc Natl Acad Sci U S A 2004 Feb 9;101(7):1999-2004. Epub 2004 Feb 9.

Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom.

View Article

Download full-text PDF

Source
http://www.pnas.org/lookup/doi/10.1073/pnas.0308458100
Publisher Site
http://dx.doi.org/10.1073/pnas.0308458100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC357041PMC
February 2004

Efficient purification of unique antibodies using peptide affinity-matrix columns.

J Immunol Methods 2004 Jan;284(1-2):45-54

Department of Pharmacology, The Danish University of Pharmaceutical Sciences, Jagtvej 160, DK 2100 Copenhagen, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jim.2003.10.001DOI Listing
January 2004

Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 transgenic mice.

J Immunol 2003 Jul;171(1):127-33

Neuroimmunology Research and Tykeson Multiple Sclerosis Research Laboratory, Veterans Affairs Medical Center and Oregon Health & Science University, Portland, OR 97239, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.171.1.127DOI Listing
July 2003

The nature of molecular recognition by T cells.

Nat Immunol 2003 Mar;4(3):217-24

Nuffield Department of Clinical Medicine, Weatherall Institute of Molecular Medicine, The University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ni0303-217DOI Listing
March 2003

A functional and structural basis for TCR cross-reactivity in multiple sclerosis.

Nat Immunol 2002 Oct 3;3(10):940-3. Epub 2002 Sep 3.

Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/ni835
Publisher Site
http://dx.doi.org/10.1038/ni835DOI Listing
October 2002

Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP.

Nat Immunol 2002 Feb 14;3(2):169-74. Epub 2002 Jan 14.

Division of Cell Biology and Immunology, Wellcome Trust Biocentre, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ni754DOI Listing
February 2002