Lars Farde

Lars Farde

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Lars Farde

Lars Farde

Publications by authors named "Lars Farde"

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The pro-psychotic metabotropic glutamate receptor compounds fenobam and AZD9272 share binding sites with monoamine oxidase-B inhibitors in humans.

Neuropharmacology 2020 Jan 4;162:107809. Epub 2019 Oct 4.

Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden; PET Science Centre, Precision Medicine, R&D Oncology, AstraZeneca, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neuropharm.2019.107809DOI Listing
January 2020

A [ C]raclopride positron emission tomography study of dopamine-D receptor binding in patients with severe major depressive episodes before and after electroconvulsive therapy and compared to control subjects.

Psychiatry Clin Neurosci 2020 Jan 14. Epub 2020 Jan 14.

Center for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden.

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http://dx.doi.org/10.1111/pcn.12980DOI Listing
January 2020

Validity and reliability of extrastriatal [C]raclopride binding quantification in the living human brain.

Neuroimage 2019 Nov 29;202:116143. Epub 2019 Aug 29.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Karolinska University Hospital, SE-171 76, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neuroimage.2019.116143DOI Listing
November 2019

Potential for imaging the high-affinity state of the 5-HT receptor: a comparison of three PET radioligands with differing intrinsic activity.

EJNMMI Res 2019 Nov 21;9(1):100. Epub 2019 Nov 21.

Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, SE-17176, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13550-019-0570-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872687PMC
November 2019

In response to the letter "[C]raclopride and extrastriatal binding to D2/3 receptors".

Neuroimage 2019 Nov 20:116371. Epub 2019 Nov 20.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Karolinska University Hospital, SE-171 76, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.neuroimage.2019.116371DOI Listing
November 2019

Effect of clinically relevant doses of vortioxetine and citalopram on serotonergic PET markers in the nonhuman primate brain.

Neuropsychopharmacology 2019 09 19;44(10):1706-1713. Epub 2019 Jun 19.

Department of Clinical Neuroscience, Center for Psychiatric Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41386-019-0442-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784989PMC
September 2019

D1-Dopamine Receptor Availability in First-Episode Neuroleptic Naive Psychosis Patients.

Int J Neuropsychopharmacol 2019 07;22(7):415-425

Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden.

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http://dx.doi.org/10.1093/ijnp/pyz017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600463PMC
July 2019

A PET study in healthy subjects of brain exposure of C-labelled osimertinib - A drug intended for treatment of brain metastases in non-small cell lung cancer.

J Cereb Blood Flow Metab 2019 Apr 20:271678X19843776. Epub 2019 Apr 20.

1 Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden.

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http://dx.doi.org/10.1177/0271678X19843776DOI Listing
April 2019

PET imaging of [C]PBR28 in Parkinson's disease patients does not indicate increased binding to TSPO despite reduced dopamine transporter binding.

Eur J Nucl Med Mol Imaging 2019 02 1;46(2):367-375. Epub 2018 Oct 1.

Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, R5:02 Karolinska University Hospital, SE-17176, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00259-018-4161-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333720PMC
February 2019

Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator.

EJNMMI Res 2019 Jan 29;9(1). Epub 2019 Jan 29.

PET Science Centre, Precision Medicine and Genomics, IMED Biotech Unit, AstraZeneca, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13550-019-0479-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890867PMC
January 2019

Serotonin 5-HT receptor binding and self-transcendence in healthy control subjects-a replication study using Bayesian hypothesis testing.

PeerJ 2018 16;6:e5790. Epub 2018 Nov 16.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden.

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https://peerj.com/articles/5790
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http://dx.doi.org/10.7717/peerj.5790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241390PMC
November 2018

Test-retest reliability and convergent validity of (R)-[C]PK11195 outcome measures without arterial input function.

EJNMMI Res 2018 Nov 29;8(1):102. Epub 2018 Nov 29.

Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, SE-171 76, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13550-018-0455-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265355PMC
November 2018

[C]SCH23390 binding to the D-dopamine receptor in the human brain-a comparison of manual and automated methods for image analysis.

EJNMMI Res 2018 Aug 2;8(1):74. Epub 2018 Aug 2.

PET Science Centre, Precision Medicine and Genomics, IMED Biotech Unit, AstraZeneca, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13550-018-0416-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070454PMC
August 2018

Serotonin concentration enhancers at clinically relevant doses reduce [C]AZ10419369 binding to the 5-HT receptors in the nonhuman primate brain.

Transl Psychiatry 2018 07 16;8(1):132. Epub 2018 Jul 16.

Department of Clinical Neuroscience, Center for Psychiatric Research, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41398-018-0178-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048172PMC
July 2018

Is dopamine D1 receptor availability related to social behavior? A positron emission tomography replication study.

PLoS One 2018 15;13(3):e0193770. Epub 2018 Mar 15.

Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, SE, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193770PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854259PMC
June 2018

The metabotropic glutamate receptor 5 radioligand [C]AZD9272 identifies unique binding sites in primate brain.

Neuropharmacology 2018 06 30;135:455-463. Epub 2018 Mar 30.

Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden; PET Science Centre, Precision Medicine and Genomics, IMED Biotech Unit, AstraZeneca, Karolinska Institutet, Sweden.

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http://dx.doi.org/10.1016/j.neuropharm.2018.03.039DOI Listing
June 2018

Potential Effect of Prolonged Sevoflurane Anesthesia on the Kinetics of [C]Raclopride in Non-human Primates.

Mol Imaging Biol 2018 04;20(2):183-187

Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s11307-017-1120-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862918PMC
April 2018

Nigrostriatal dopamine transporter availability in early Parkinson's disease.

Mov Disord 2018 04 13;33(4):592-599. Epub 2018 Feb 13.

Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden.

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http://dx.doi.org/10.1002/mds.27316DOI Listing
April 2018

Brain neuroreceptor density and personality traits: towards dimensional biomarkers for psychiatric disorders.

Philos Trans R Soc Lond B Biol Sci 2018 04;373(1744)

Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, 17176 Stockholm, Sweden.

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http://dx.doi.org/10.1098/rstb.2017.0156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832682PMC
April 2018

Assessment of simplified ratio-based approaches for quantification of PET [C]PBR28 data.

EJNMMI Res 2017 Dec 21;7(1):58. Epub 2017 Jul 21.

Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13550-017-0304-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520824PMC
December 2017

[C]AZ10419096 - a full antagonist PET radioligand for imaging brain 5-HT receptors.

Nucl Med Biol 2017 Nov 21;54:34-40. Epub 2017 Jul 21.

Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.nucmedbio.2017.07.007DOI Listing
November 2017

Differential Effect of APOE Alleles on Brain Glucose Metabolism in Targeted Replacement Mice: An [F]FDG-μPET Study.

J Alzheimers Dis Rep 2017 Nov 16;1(1):169-180. Epub 2017 Nov 16.

Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/ADR-170006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159693PMC
November 2017

Fenfluramine Reduces [11C]Cimbi-36 Binding to the 5-HT2A Receptor in the Nonhuman Primate Brain.

Int J Neuropsychopharmacol 2017 09;20(9):683-691

Karolinska Institutet and Stockholm County Council, Department of Clinical Neuroscience, Center for Psychiatric Research, Stockholm, Sweden; Rigshospitalet, Center for Integrated Molecular Brain Imaging, Copenhagen, Denmark and University of Copenhagen, Faculty of Health and Medicine Sciences, Copenhagen, Denmark; AstraZeneca, PET Science Center at Karolinska Institutet, Personalized Health Care and Biomarkers, Stockholm, Sweden.

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http://dx.doi.org/10.1093/ijnp/pyx051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581490PMC
September 2017

Reliability of volumetric and surface-based normalisation and smoothing techniques for PET analysis of the cortex: A test-retest analysis using [C]SCH-23390.

Neuroimage 2017 07 15;155:344-353. Epub 2017 Apr 15.

Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neuroimage.2017.04.031DOI Listing
July 2017

The immune response of the human brain to abdominal surgery.

Ann Neurol 2017 Apr 11;81(4):572-582. Epub 2017 Apr 11.

Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/ana.24909DOI Listing
April 2017

Characterization of [C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain.

Eur J Nucl Med Mol Imaging 2017 Feb 5;44(2):308-320. Epub 2016 Nov 5.

Department of Clinical Neuroscience, Center for Psychiatric Research, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00259-016-3544-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215309PMC
February 2017

GABA receptor occupancy by subtype selective GABA modulators: PET studies in humans.

Psychopharmacology (Berl) 2017 Feb 24;234(4):707-716. Epub 2016 Dec 24.

Department of Clinical Neuroscience, AstraZeneca PET Center, Karolinska Institutet, R5:02, SE-17176, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00213-016-4506-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5263201PMC
February 2017

Optimal Acquisition Time Window and Simplified Quantification of Dopamine Transporter Availability Using 18F-FE-PE2I in Healthy Controls and Parkinson Disease Patients.

J Nucl Med 2016 Oct 26;57(10):1529-1534. Epub 2016 May 26.

Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden.

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http://dx.doi.org/10.2967/jnumed.115.171231DOI Listing
October 2016

Integrated Strategy for Use of Positron Emission Tomography in Nonhuman Primates to Confirm Multitarget Occupancy of Novel Psychotropic Drugs: An Example with AZD3676.

J Pharmacol Exp Ther 2016 09 11;358(3):464-71. Epub 2016 Jul 11.

Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm (K.V., P.J., M.S., C.H., L.F.); AstraZeneca Translational Science Centre at Karolinska Institutet, PET CoE, Stockholm (P.J., M.S., L.F.); AstraZeneca R&D, Södertälje (A.J., C.A., P.S., S.G., E.J., J.M., L.A.), Sweden.

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http://dx.doi.org/10.1124/jpet.116.234146DOI Listing
September 2016

Neurokinin-3 Receptor Binding in Guinea Pig, Monkey, and Human Brain: In Vitro and in Vivo Imaging Using the Novel Radioligand, [18F]Lu AF10628.

Int J Neuropsychopharmacol 2016 08 12;19(8). Epub 2016 Aug 12.

Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden (Drs Varnäs, Finnema, Stepanov, Takano, Tóth, Svedberg, Halldin, and Farde); Lundbeck Research, H. Lundbeck A/S, 9 Ottiliavej, DK-2500 Copenhagen-Valby, Denmark (Drs Møller Nielsen, Khanzhin, Juhl, and Bang-Andersen); AstraZeneca Translational Science Centre at Karolinska Institutet, PET CoE, Stockholm, Sweden (Dr Farde).Present address: Glycom A/S, Diplomvej 373, 1, DK-2800 Kgs. Lyngby, Denmark (N.A.K.).

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http://dx.doi.org/10.1093/ijnp/pyw023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006196PMC
August 2016

Low serotonin1B receptor binding potential in the anterior cingulate cortex in drug-free patients with recurrent major depressive disorder.

Psychiatry Res Neuroimaging 2016 07 27;253:36-42. Epub 2016 Apr 27.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, R5:0, Karolinska Universitetssjukhuset i Solna, 171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.pscychresns.2016.04.016DOI Listing
July 2016

In vivo evidence of a functional association between immune cells in blood and brain in healthy human subjects.

Brain Behav Immun 2016 May 25;54:149-157. Epub 2016 Jan 25.

Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2016.01.019DOI Listing
May 2016

Discovery and Preclinical Validation of [(11)C]AZ13153556, a Novel Probe for the Histamine Type 3 Receptor.

ACS Chem Neurosci 2016 Feb 30;7(2):177-84. Epub 2015 Nov 30.

AstraZeneca Translational Science Centre at Karolinska Institutet, PET Centre of Excellence, Department of Clinical Neuroscience, S-17176 Stockholm, Sweden.

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http://dx.doi.org/10.1021/acschemneuro.5b00268DOI Listing
February 2016

Serotonin transporter occupancy by escitalopram and citalopram in the non-human primate brain: a [(11)C]MADAM PET study.

Psychopharmacology (Berl) 2015 Nov 17;232(21-22):4159-67. Epub 2015 May 17.

Department of Clinical Neuroscience, Center for Psychiatric Research, Karolinska Institutet, Karolinska University Hospital, Building R5:02, SE-17176, Stockholm, Sweden.

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http://link.springer.com/10.1007/s00213-015-3961-7
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http://dx.doi.org/10.1007/s00213-015-3961-7DOI Listing
November 2015

Synthesis of ([(11)C]carbonyl)raclopride and a comparison with ([(11)C]methyl)raclopride in a monkey PET study.

Nucl Med Biol 2015 Nov 15;42(11):893-8. Epub 2015 Jul 15.

Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska University Hospital, R5:U1, 17176 Stockholm, Sweden; Department of Chemistry-BMC, Uppsala University, Husargatan 3, 75237 Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.nucmedbio.2015.07.003DOI Listing
November 2015

Quantification of blood flow-dependent component in estimates of beta-amyloid load obtained using quasi-steady-state standardized uptake value ratio.

J Cereb Blood Flow Metab 2015 Sep 15;35(9):1485-93. Epub 2015 Apr 15.

Department of Clinical Neuroscience, PET Centre, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/jcbfm.2015.66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640337PMC
September 2015

β-Amyloid binding in elderly subjects with declining or stable episodic memory function measured with PET and [¹¹C]AZD2184.

Eur J Nucl Med Mol Imaging 2015 Sep 27;42(10):1507-11. Epub 2015 Jun 27.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden,

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http://dx.doi.org/10.1007/s00259-015-3103-9DOI Listing
September 2015

Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease.

Brain 2015 Sep 1;138(Pt 9):2687-700. Epub 2015 Jul 1.

1 AstraZeneca Translational Science Centre at Karolinska Institutet, PET CoE, Stockholm, Sweden 2 Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1093/brain/awv184DOI Listing
September 2015

5-HT1B receptor imaging and cognition: a positron emission tomography study in control subjects and Parkinson's disease patients.

Synapse 2015 Jul 25;69(7):365-74. Epub 2015 May 25.

Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden.

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http://dx.doi.org/10.1002/syn.21823DOI Listing
July 2015

Development of rapid multistep carbon-11 radiosynthesis of the myeloperoxidase inhibitor AZD3241 to assess brain exposure by PET microdosing.

Nucl Med Biol 2015 Jun 8;42(6):555-60. Epub 2015 Feb 8.

AstraZeneca Translational Science Centre at Karolinska Institutet, Stockholm, Sweden; Karolinska Institutet, Department of Clinical Neuroscience, Center for Psychiatric Research and Education, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.nucmedbio.2015.02.001DOI Listing
June 2015

Diurnal and seasonal variation of the brain serotonin system in healthy male subjects.

Neuroimage 2015 May 12;112:225-231. Epub 2015 Mar 12.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Stockholm Brain Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neuroimage.2015.03.007DOI Listing
May 2015

Large Variation in Brain Exposure of Reference CNS Drugs: a PET Study in Nonhuman Primates.

Int J Neuropsychopharmacol 2015 Mar 26;18(10):pyv036. Epub 2015 Mar 26.

AstraZeneca Translational Science Centre at Karolinska Institutet, Stockholm, Sweden (Drs Schou and Farde); Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden (Drs Varnäs, Lundquist, Nakao, Amini, Takano, Finnema, and Halldin); AstraZeneca, Innovative Medicines, CNS & Pain, Södertälje, Sweden (Dr Lundquist).

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http://dx.doi.org/10.1093/ijnp/pyv036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648157PMC
March 2015

Distinct regional age effects on [11C]AZ10419369 binding to 5-HT1B receptors in the human brain.

Neuroimage 2014 Dec 23;103:303-308. Epub 2014 Sep 23.

Karolinska Institutet, Department of Clinical Neuroscience, Center for Psychiatric Research, Karolinska University Hospital, SE-17176 Stockholm, Sweden; AstraZeneca Translational Science Center, Department of Clinical Neuroscience, Karolinska Institutet, SE-17176 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neuroimage.2014.09.040DOI Listing
December 2014

Amphetamine decreases α2C-adrenoceptor binding of [11C]ORM-13070: a PET study in the primate brain.

Int J Neuropsychopharmacol 2014 Dec 13;18(3). Epub 2014 Dec 13.

Karolinska Institutet, Department of Clinical Neuroscience, Center for Psychiatric Research, Stockholm, Sweden (Drs Finnema, Stepanov, Nakao, Varnäs, Varrone, Farde, and Halldin); Pfizer, Neuroscience Research Unit, Cambridge, MA (Drs Hughes, Babalola, and Grimwood); University of Turku, Turku PET Centre, Turku, Finland (Drs Haaparanta-Solin, Arponen, Marjamäki, and Solin); University of Turku, Department of Pharmacology, Drug Development and Therapeutics, and Turku University Hospital, Unit of Clinical Pharmacology, Turku, Finland (Drs Pohjanoksa, Vuorilehto, and Scheinin); Orion Corporation, Orion Pharma, Research and Development, Turku, Finland (Dr Sallinen); AstraZeneca, Translational Science Center at Karolinska Institutet, Stockholm, Sweden (Dr Farde).

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http://dx.doi.org/10.1093/ijnp/pyu081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360244PMC
December 2014

Identification of positron emission tomography (PET) tracer candidates by prediction of the target-bound fraction in the brain.

EJNMMI Res 2014 Dec 23;4(1):50. Epub 2014 Sep 23.

Respiratory Inflammation and Autoimmunity Innovative Medicines, AstraZeneca R&D, Mölndal, Sweden,

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http://dx.doi.org/10.1186/s13550-014-0050-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452637PMC
December 2014

Dopamine D1 receptor availability is related to social behavior: a positron emission tomography study.

Neuroimage 2014 Nov 16;102 Pt 2:590-5. Epub 2014 Aug 16.

Center for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neuroimage.2014.08.018DOI Listing
November 2014

Evaluation of two automated methods for PET region of interest analysis.

Neuroinformatics 2014 Oct;12(4):551-62

Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden,

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http://dx.doi.org/10.1007/s12021-014-9233-6DOI Listing
October 2014

Meta-analysis of cognitive performance in drug-naïve patients with schizophrenia.

Schizophr Res 2014 Sep 30;158(1-3):156-62. Epub 2014 Jul 30.

Karolinska Institutet, Dept. of Clinical Neurosciences, Centre for Psychiatric Research, R5, Karolinska University Hospital, 171 76 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2014.06.034DOI Listing
September 2014

Reduced 5-HT(1B) receptor binding in the dorsal brain stem after cognitive behavioural therapy of major depressive disorder.

Psychiatry Res 2014 Aug 27;223(2):164-70. Epub 2014 May 27.

Department of Clinical Neuroscience, Karolinska Institutet, Centrum för psykiatriforskning, R5:0, Karolinska Universitetssjukhuset i Solna, 171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.pscychresns.2014.05.011DOI Listing
August 2014

Synthesis, radiolabeling, and in vivo pharmacokinetic evaluation of the amyloid beta radioligand [11C]AZD4694 in nonhuman primates.

Mol Imaging Biol 2014 Apr;16(2):173-9

AstraZeneca Translational Science Centre, PET Centre of Excellence, Department of Clinical Neuroscience, Karolinska University Hospital, Karolinska Institutet, 171 76, Stockholm, Sweden,

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http://link.springer.com/content/pdf/10.1007/s11307-013-0666
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http://link.springer.com/10.1007/s11307-013-0666-3
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http://dx.doi.org/10.1007/s11307-013-0666-3DOI Listing
April 2014

Positron emission tomography imaging of 5-hydroxytryptamine1B receptors in Parkinson's disease.

Neurobiol Aging 2014 Apr 12;35(4):867-75. Epub 2013 Oct 12.

Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden; Stockholm Brain Institute, Stockholm, Sweden; AstraZeneca Translational Science Centre at Karolinska Institutet, Stockholm, Sweden.

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April 2014

Test-retest reliability of [11C]AZ10419369 binding to 5-HT(1B) receptors in human brain.

Eur J Nucl Med Mol Imaging 2014 Feb 5;41(2):301-7. Epub 2013 Sep 5.

Department of Clinical Neuroscience, Karolinska Institutet, Center for Psychiatric Research, R5:00, Karolinska University Hospital, SE-17176, Stockholm, Sweden,

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http://dx.doi.org/10.1007/s00259-013-2529-1DOI Listing
February 2014

Norepinephrine transporter occupancy in the human brain after oral administration of quetiapine XR.

Int J Neuropsychopharmacol 2013 Nov 1;16(10):2235-44. Epub 2013 Jul 1.

AstraZeneca R&D, Södertälje, Sweden.

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http://dx.doi.org/10.1017/S1461145713000680DOI Listing
November 2013

Performance evaluation of the small-animal nanoScan PET/MRI system.

J Nucl Med 2013 Oct 29;54(10):1825-32. Epub 2013 Aug 29.

Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; and.

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http://www.medisousa.com/literature/nanoScanPETMRI_Performan
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http://jnm.snmjournals.org/cgi/doi/10.2967/jnumed.112.119065
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http://dx.doi.org/10.2967/jnumed.112.119065DOI Listing
October 2013

Effect of a single dose of escitalopram on serotonin concentration in the non-human and human primate brain.

Int J Neuropsychopharmacol 2013 Aug 25;16(7):1577-86. Epub 2013 Jan 25.

Department of Clinical Neuroscience, Karolinska Institutet, Center for Psychiatric Research, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1017/S1461145712001617DOI Listing
August 2013

Radiosynthesis and evaluation of new α1-adrenoceptor antagonists as PET radioligands for brain imaging.

Nucl Med Biol 2013 Aug 27;40(6):747-54. Epub 2013 Jun 27.

Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Karolinska Hospital, S-17176 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.nucmedbio.2013.05.007DOI Listing
August 2013

A PET study with [11C]AZ10419369 to determine brain 5-HT1B receptor occupancy of zolmitriptan in healthy male volunteers.

Cephalalgia 2013 Jul 19;33(10):853-60. Epub 2013 Feb 19.

Karolinska Institutet, Department of Clinical Neuroscience, SE-17176 Stockholm, Sweden.

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http://dx.doi.org/10.1177/0333102413476372DOI Listing
July 2013

Arterial input function derived from pairwise correlations between PET-image voxels.

J Cereb Blood Flow Metab 2013 Jul 10;33(7):1058-65. Epub 2013 Apr 10.

Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/jcbfm.2013.47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705432PMC
July 2013

Modeling of PET data in CNS drug discovery and development.

J Pharmacokinet Pharmacodyn 2013 Jun 10;40(3):267-79. Epub 2013 May 10.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s10928-013-9320-6DOI Listing
June 2013

Effects of amphetamine on the human brain opioid system--a positron emission tomography study.

Int J Neuropsychopharmacol 2013 May 29;16(4):763-9. Epub 2012 Aug 29.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1017/S1461145712000818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622172PMC
May 2013

Radiolabeling of the cannabinoid receptor agonist AZD1940 with carbon-11 and PET microdosing in non-human primate.

Nucl Med Biol 2013 Apr 22;40(3):410-4. Epub 2013 Jan 22.

AstraZeneca Translational Sciences Centre, PET CoE, Dept of Clinical Neuroscience, Karolinska Institutet, Karolinska Hospital, SE-17176 Stockholm, Sweden.

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https://linkinghub.elsevier.com/retrieve/pii/S09698051120027
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http://dx.doi.org/10.1016/j.nucmedbio.2012.10.011DOI Listing
April 2013

SERT and NET occupancy by venlafaxine and milnacipran in nonhuman primates: a PET study.

Psychopharmacology (Berl) 2013 Mar 23;226(1):147-53. Epub 2012 Oct 23.

Karolinska Institutet, Department of Clinical Neuroscience, Center for Psychiatric Research, Karolinska University Hospital Solna. R5:02, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00213-012-2901-zDOI Listing
March 2013

Individual differences in the proneness to have flow experiences are linked to dopamine D2-receptor availability in the dorsal striatum.

Neuroimage 2013 Feb 2;67:1-6. Epub 2012 Nov 2.

Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neuroimage.2012.10.072DOI Listing
February 2013

Improved mapping and quantification of serotonin transporter availability in the human brainstem with the HRRT.

Eur J Nucl Med Mol Imaging 2013 Jan 18;40(2):228-37. Epub 2012 Oct 18.

Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Karolinska Hospital, R5:02, SE-171 76, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00259-012-2260-3DOI Listing
January 2013

Serotonin transporter occupancy with TCAs and SSRIs: a PET study in patients with major depressive disorder.

Int J Neuropsychopharmacol 2012 Sep 16;15(8):1167-72. Epub 2012 Jan 16.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1017/S1461145711001945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409583PMC
September 2012

Confirmation of fenfluramine effect on 5-HT(1B) receptor binding of [(11)C]AZ10419369 using an equilibrium approach.

J Cereb Blood Flow Metab 2012 Apr 14;32(4):685-95. Epub 2011 Dec 14.

Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://journals.sagepub.com/doi/10.1038/jcbfm.2011.172
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http://dx.doi.org/10.1038/jcbfm.2011.172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318146PMC
April 2012

Quantification of serotonin transporter availability with [11C]MADAM--a comparison between the ECAT HRRT and HR systems.

Neuroimage 2012 Mar 28;60(1):800-7. Epub 2011 Dec 28.

Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden.

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http://linkinghub.elsevier.com/retrieve/pii/S105381191101449
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http://dx.doi.org/10.1016/j.neuroimage.2011.12.047DOI Listing
March 2012

Clinical validation of 18F-AZD4694, an amyloid-β-specific PET radioligand.

J Nucl Med 2012 Mar 9;53(3):415-24. Epub 2012 Feb 9.

Neuroscience Research and Therapy Area, AstraZeneca Research and Development, Södertälje, Sweden.

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http://dx.doi.org/10.2967/jnumed.111.094029DOI Listing
March 2012

Quantitative PET analyses of regional [11C]PE2I binding to the dopamine transporter--application to juvenile myoclonic epilepsy.

Neuroimage 2012 Feb 28;59(4):3582-93. Epub 2011 Oct 28.

Psychiatric Section, Department of Clinical Neuroscience Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neuroimage.2011.10.067DOI Listing
February 2012

Comparison of D₂ dopamine receptor occupancy after oral administration of quetiapine fumarate immediate-release and extended-release formulations in healthy subjects.

Int J Neuropsychopharmacol 2011 Nov 11;14(10):1357-66. Epub 2011 Apr 11.

Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1017/S1461145711000514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198174PMC
November 2011

Extrastriatal dopamine D(2) receptor binding in Huntington's disease.

Hum Brain Mapp 2011 Oct 30;32(10):1626-36. Epub 2010 Sep 30.

PET Centre, Stockholm Brain Institute, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/hbm.21134DOI Listing
October 2011

Dopamine D1 receptor associations within and between dopaminergic pathways in younger and elderly adults: links to cognitive performance.

Cereb Cortex 2011 Sep 21;21(9):2023-32. Epub 2011 Jan 21.

Aging Research Center, Department of Neurobiology, Care Sciences & Society, Karolinska Institute, SE-113 30 Stockholm, Sweden.

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https://academic.oup.com/cercor/article-lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/cercor/bhq266DOI Listing
September 2011

NET occupancy by clomipramine and its active metabolite, desmethylclomipramine, in non-human primates in vivo.

Psychopharmacology (Berl) 2011 Jul 19;216(2):279-86. Epub 2011 Feb 19.

Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, 171 76, Stockholm, Sweden.

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http://link.springer.com/10.1007/s00213-011-2212-9
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July 2011

Antipsychotic occupancy of dopamine receptors in schizophrenia.

CNS Neurosci Ther 2011 Apr 8;17(2):97-103. Epub 2010 Dec 8.

Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Karolinska University Hospital, Stockholm, Sweden.

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http://doi.wiley.com/10.1111/j.1755-5949.2010.00222.x
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http://dx.doi.org/10.1111/j.1755-5949.2010.00222.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493889PMC
April 2011

Effect of risperidone on high-affinity state of dopamine D2 receptors: a PET study with agonist ligand [11C](R)-2-CH3O-N-n-propylnorapomorphine.

Int J Neuropsychopharmacol 2011 Feb 22;14(1):83-9. Epub 2010 Sep 22.

Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan.

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http://dx.doi.org/10.1017/S1461145710001148DOI Listing
February 2011

Dose-dependent binding of AZD3783 to brain 5-HT1B receptors in non-human primates and human subjects: a positron emission tomography study with [11C]AZ10419369.

Psychopharmacology (Berl) 2011 Feb 15;213(2-3):533-45. Epub 2011 Jan 15.

Karolinska Institutet, Department of Clinical Neuroscience, Karolinska University Hospital, Stockholm, Sweden.

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http://link.springer.com/10.1007/s00213-011-2165-z
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February 2011

Development of a PET radioligand for the central 5-HT1B receptor: radiosynthesis and characterization in cynomolgus monkeys of eight radiolabeled compounds.

Nucl Med Biol 2011 Feb 3;38(2):261-72. Epub 2010 Dec 3.

Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, SE-17176 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.nucmedbio.2010.08.006DOI Listing
February 2011

Quantitative analysis of [11C]AZ10419369 binding to 5-HT1B receptors in human brain.

J Cereb Blood Flow Metab 2011 Jan 28;31(1):113-23. Epub 2010 Apr 28.

Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1038/jcbfm.2010.55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049476PMC
January 2011

Characterization of AZD4694, a novel fluorinated Abeta plaque neuroimaging PET radioligand.

J Neurochem 2010 Aug 13;114(3):784-94. Epub 2010 May 13.

Department of Neuroscience, AstraZeneca R&D Södertälje, Södertälje, Sweden.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06812.xDOI Listing
August 2010

Thinking outside a less intact box: thalamic dopamine D2 receptor densities are negatively related to psychometric creativity in healthy individuals.

PLoS One 2010 May 17;5(5):e10670. Epub 2010 May 17.

Neuropediatric Research Unit, Department of Women's and Children's Health and Stockholm Brain Institute, Karolinska Institutet, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010670PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871784PMC
May 2010

Dopamine D2 receptor density in the limbic striatum is related to implicit but not explicit movement sequence learning.

Proc Natl Acad Sci U S A 2010 Apr 5;107(16):7574-9. Epub 2010 Apr 5.

Neuropediatric Research Unit Q2:07, Department of Women's and Children's Health and Stockholm Brain Institute, Karolinska Institutet, SE-171 76 Stockholm, Sweden.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0911805107
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867711PMC
April 2010