Lars Bullinger

Lars Bullinger

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Lars Bullinger

Lars Bullinger

Publications by authors named "Lars Bullinger"

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Retroperitoneal Hematoma after Bone Marrow Biopsy: The First Cut Should Not Be the Deepest.

Oncol Res Treat 2019 17;42(5):283-288. Epub 2019 Apr 17.

Department of Internal Medicine II, Asklepios Clinic Uckermark, Schwedt, Germany,

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https://www.karger.com/Article/FullText/499743
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http://dx.doi.org/10.1159/000499743DOI Listing
September 2019

getITD for FLT3-ITD-based MRD monitoring in AML.

Leukemia 2019 May 14. Epub 2019 May 14.

Department of Hematology, Oncology and Tumor Immunology, Charité University Medicine, Berlin, Germany.

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http://dx.doi.org/10.1038/s41375-019-0483-zDOI Listing
May 2019

Cytotoxic Effects of Rabbit Anti-Thymocyte Globulin preparations on Primary Human Thymic Epithelial Cells.

Transplantation 2019 May 20. Epub 2019 May 20.

Department of Hematology, Oncology and Tumor Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

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http://dx.doi.org/10.1097/TP.0000000000002799DOI Listing
May 2019

New Targeted Agents in Acute Myeloid Leukemia: New Hope on the Rise.

Int J Mol Sci 2019 Apr 23;20(8). Epub 2019 Apr 23.

Department of Internal Medicine III, University Hospital Ulm, 89081 Ulm, Germany.

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http://dx.doi.org/10.3390/ijms20081983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515298PMC
April 2019

Circular RNAs in Cancer.

Adv Exp Med Biol 2018;1087:215-230

Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1007/978-981-13-1426-1_17DOI Listing
February 2019

IDH2 inhibition: another piece to the puzzle.

Authors:
Lars Bullinger

Blood 2019 Feb;133(7):625-626

Charité University Medicine.

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http://dx.doi.org/10.1182/blood-2018-12-891481DOI Listing
February 2019

Expression of CD274 (PD-L1) is associated with unfavourable recurrent mutations in AML.

Br J Haematol 2018 12 19;183(5):822-825. Epub 2017 Dec 19.

Department of Experimental Haemato-oncology, Medical University of Lublin, Lublin, Poland.

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http://dx.doi.org/10.1111/bjh.15040DOI Listing
December 2018

Nuclear FOXO1 promotes lymphomagenesis in germinal center B cells.

Blood 2018 12 17;132(25):2670-2683. Epub 2018 Oct 17.

Immune Regulation and Cancer, Max Delbrück Center for Molecular Medicine in the Helmholtz Alliance, Berlin-Buch, Germany.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-06
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http://dx.doi.org/10.1182/blood-2018-06-856203DOI Listing
December 2018

Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis.

Leukemia 2018 09 1;32(9):1908-1919. Epub 2018 Mar 1.

Department of Hematology, Oncology, and Tumor Immunology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

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http://dx.doi.org/10.1038/s41375-018-0047-7DOI Listing
September 2018

FACS single cell index sorting is highly reliable and determines immune phenotypes of clonally expanded T cells.

Eur J Immunol 2018 07 3;48(7):1248-1250. Epub 2018 Apr 3.

Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1002/eji.201847507DOI Listing
July 2018

Epigenetic therapy: azacytidine and decitabine in acute myeloid leukemia.

Expert Rev Hematol 2018 05 27;11(5):361-371. Epub 2018 Mar 27.

a Department of Internal Medicine III , University Hospital Ulm , Ulm , Germany.

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http://dx.doi.org/10.1080/17474086.2018.1453802DOI Listing
May 2018

MYB induces the expression of the oncogenic corepressor SKI in acute myeloid leukemia.

Oncotarget 2018 Apr 27;9(32):22423-22435. Epub 2018 Apr 27.

Department of Internal Medicine and Hematology, Oncology and Immunology, Philipps University Marburg, Marburg 35033, Germany.

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http://dx.doi.org/10.18632/oncotarget.25051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976475PMC
April 2018

Novel Treatment Options in Head and Neck Cancer.

Oncol Res Treat 2017 17;40(6):342-346. Epub 2017 May 17.

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http://dx.doi.org/10.1159/000477254DOI Listing
March 2018

Bevacizumab in temozolomide refractory high-grade gliomas: single-centre experience and review of the literature.

Ther Adv Neurol Disord 2018 21;11:1756285617753597. Epub 2018 Jan 21.

Department of Internal Medicine III, Ulm University Medical Centre, Ulm, Germany; Medical Department, Division of Hematology, Oncology and Tumour Immunology, Charité Universitätsmedizin Berlin, Germany.

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http://dx.doi.org/10.1177/1756285617753597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791550PMC
January 2018

The oligodendrocyte lineage transcription factor 2 (OLIG2) is epigenetically regulated in acute myeloid leukemia.

Exp Hematol 2017 11 28;55:76-85.e3. Epub 2017 Jul 28.

Department of Hematology/Oncology and Stem Cell Transplantation, University Medical Center, Freiburg, Germany; Department of Hematology/Oncology, Medical Center Augsburg, Augsburg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0301472X173070
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http://dx.doi.org/10.1016/j.exphem.2017.07.009DOI Listing
November 2017

Partitioned learning of deep Boltzmann machines for SNP data.

Bioinformatics 2017 Oct;33(20):3173-3180

Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, 55131 Mainz, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btx408DOI Listing
October 2017

Identifying Prognostic SNPs in Clinical Cohorts: Complementing Univariate Analyses by Resampling and Multivariable Modeling.

PLoS One 2016 9;11(5):e0155226. Epub 2016 May 9.

Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Johannes Gutenberg University Mainz, Mainz, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0155226PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861340PMC
July 2017

Evaluating the impact of genetic and epigenetic aberrations on survival and response in acute myeloid leukemia patients receiving epigenetic therapy.

Ann Hematol 2017 Apr 5;96(4):559-565. Epub 2017 Jan 5.

Department of Hematology/Oncology and Stem Cell Transplantation, University Medical Center, Hugstetterstr. 55, 79106, Freiburg, Germany.

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http://dx.doi.org/10.1007/s00277-016-2912-7DOI Listing
April 2017

Identifying ischemic stroke associated with cancer: a multiple model derived from a case-control analysis.

J Neurol 2017 Apr 28;264(4):781-791. Epub 2017 Feb 28.

Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.

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http://dx.doi.org/10.1007/s00415-017-8432-0DOI Listing
April 2017

Genomics of Acute Myeloid Leukemia Diagnosis and Pathways.

J Clin Oncol 2017 Mar 13;35(9):934-946. Epub 2017 Feb 13.

All authors: Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1200/JCO.2016.71.2208DOI Listing
March 2017

Cancer-specific changes in DNA methylation reveal aberrant silencing and activation of enhancers in leukemia.

Blood 2017 02 21;129(7):e13-e25. Epub 2016 Dec 21.

Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1182/blood-2016-07-726877DOI Listing
February 2017

Prospective identification of resistance mechanisms to HSP90 inhibition in KRAS mutant cancer cells.

Oncotarget 2017 Jan;8(5):7678-7690

Department of Translational Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.18632/oncotarget.13841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352352PMC
January 2017

MicroRNA-155 is upregulated in MLL-rearranged AML but its absence does not affect leukemia development.

Exp Hematol 2016 Dec 13;44(12):1166-1171. Epub 2016 Sep 13.

Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.08.012DOI Listing
December 2016

T-lymphoid progenitors - we know what they are, but know not what they may be.

Authors:
Lars Bullinger

EMBO J 2016 11 26;35(22):2383-2385. Epub 2016 Sep 26.

Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany.

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http://dx.doi.org/10.15252/embj.201695613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109240PMC
November 2016

Integrating multiple molecular sources into a clinical risk prediction signature by extracting complementary information.

BMC Bioinformatics 2016 Aug 30;17(1):327. Epub 2016 Aug 30.

Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Johannes Gutenberg University Mainz, Obere Zahlbacher Str. 69, Mainz, 55131, Germany.

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http://dx.doi.org/10.1186/s12859-016-1183-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004308PMC
August 2016

Low-grade Glioma Surgery in Intraoperative Magnetic Resonance Imaging: Results of a Multicenter Retrospective Assessment of the German Study Group for Intraoperative Magnetic Resonance Imaging.

Neurosurgery 2016 Jun;78(6):775-86

‡Department of Neurosurgery, University of Ulm, Günzburg, Germany; §Department of Neurosurgery, University of Erlangen, Erlangen, Germany; ¶Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany; ‖Department of Neurosurgery, University of Schleswig-Holstein, Kiel, Germany; #Department of Neurosurgery, University of Frankfurt, Frankfurt, Germany; **Department of Neurosurgery, University of Tübingen, Tübingen, Germany; ‡‡Department of Internal Medicine III, University of Ulm, Ulm, Germany; §§Institute for Epidemiology and Medical Biometrics, University of Ulm, Ulm, Germany; ¶¶Department of Neuroradiology, University of Tübingen, Tübingen, Germany; ‖‖Department of Neurosurgery, International Neuroscience Institute Hannover, Hannover, Germany; ##Department of Neurosurgery, Klinikum Stuttgart, Stuttgart, Germany.

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http://dx.doi.org/10.1227/NEU.0000000000001081DOI Listing
June 2016

GiANT: gene set uncertainty in enrichment analysis.

Bioinformatics 2016 06 1;32(12):1891-4. Epub 2016 Feb 1.

Institute of Medical Systems Biology, Ulm University, Ulm 89069, Germany, Leibniz Institute on Ageing - Fritz Lipmann Institute and FSU Jena, Jena 07745, Germany.

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http://bioinformatics.oxfordjournals.org/content/early/2016/
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http://bioinformatics.oxfordjournals.org/content/early/2016/
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http://bioinformatics.oxfordjournals.org/lookup/doi/10.1093/
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http://dx.doi.org/10.1093/bioinformatics/btw030DOI Listing
June 2016

Genomic Classification and Prognosis in Acute Myeloid Leukemia.

N Engl J Med 2016 Jun;374(23):2209-2221

Cancer Genome Project, Wellcome Trust Sanger Institute (E.P., M.G., N.D.R., N.B., G.G., P.V.L., I.M., L.M., S.M., S.O., K.R., D.R.J., J.W.T., A.P.B., P.J.C.), and the European Bioinformatics Institute, European Molecular Biology Laboratory (EMBL-EBI) (M.G.), Hinxton, the Centre for Evolution and Cancer, Institute of Cancer Research, London (N.E.P., M.F.G.), and the Department of Haematology, University of Cambridge, Cambridge (N.B.) - all in the United Kingdom; the Departments of Epidemiology and Biostatistics and Cancer Biology, the Center for Molecular Oncology and the Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York (E.P.); the Department of Internal Medicine III, Ulm University, Ulm (L.B., V.I.G., P.P., K.D., R.F.S., H.D.), and the Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover (M.H., F.T., A.G.) - both in Germany; the Division of Hematology, Fondazione IRCCS, Istituto Nazionale dei Tumori, and Department of Oncology and Onco-Hematology, University of Milan, Milan (N.B.); the Department of Human Genetics, University of Leuven, Leuven, Belgium (P.V.L.); and the Department of Pathology, University of Otago, Christchurch, New Zealand (P.G., P.J.C.).

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http://dx.doi.org/10.1056/NEJMoa1516192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979995PMC
June 2016

Targeting inhibitor of apoptosis proteins by Smac mimetic elicits cell death in poor prognostic subgroups of chronic lymphocytic leukemia.

Int J Cancer 2015 Dec 31;137(12):2959-70. Epub 2015 Jul 31.

Institute for Experimental Cancer Research in Pediatrics, , Goethe University, Frankfurt, Germany.

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http://dx.doi.org/10.1002/ijc.29650DOI Listing
December 2015

Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy.

Cell Stem Cell 2014 Dec;15(6):775-90

Division of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia; Department of Haematology, Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia; University of Queensland, Brisbane, QLD 4072, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317339PMC
December 2014

A robust estimation of exon expression to identify alternative spliced genes applied to human tissues and cancer samples.

BMC Genomics 2014 Oct 8;15:879. Epub 2014 Oct 8.

Bioinformatics and Functional Genomics Research Group, Cancer Research Center (CiC-IBMCC, CSIC/USAL/IBSAL), Salamanca 37007, Spain.

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http://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2
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http://dx.doi.org/10.1186/1471-2164-15-879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298068PMC
October 2014

Expression profiling of leukemia patients: key lessons and future directions.

Exp Hematol 2014 Aug 15;42(8):651-60. Epub 2014 Apr 15.

Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2014.04.006DOI Listing
August 2014

Differential methylation in CN-AML preferentially targets non-CGI regions and is dictated by DNMT3A mutational status and associated with predominant hypomethylation of HOX genes.

Epigenetics 2014 Aug 27;9(8):1108-19. Epub 2014 May 27.

Center for Hematology and Regenerative Medicine (HERM); Department of Medicine Huddinge; Karolinska Institute; Stockholm, Sweden; Hematology Centre, M54; Karolinska University Hospital and Karolinska Institute; Stockholm, Sweden.

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http://dx.doi.org/10.4161/epi.29315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164496PMC
August 2014

SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia.

Blood 2014 Jul 22;124(1):121-33. Epub 2014 May 22.

Third Department of Medicine, University Medical Center, Johannes Gutenberg University of Mainz, Mainz, Germany;

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http://dx.doi.org/10.1182/blood-2013-11-538819DOI Listing
July 2014

Transitory dasatinib-resistant states in KIT(mut) t(8;21) acute myeloid leukemia cells correlate with altered KIT expression.

Exp Hematol 2014 Feb 6;42(2):90-100. Epub 2013 Nov 6.

Department of Pediatrics and Adolescent Medicine, University Medical Center, Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2013.10.006DOI Listing
February 2014

Identification of gene expression-based prognostic markers in the hematopoietic stem cells of patients with myelodysplastic syndromes.

J Clin Oncol 2013 Oct 3;31(28):3557-64. Epub 2013 Sep 3.

Andrea Pellagatti, Janet Perry, James S. Wainscoat, and Jacqueline Boultwood, University of Oxford, Oxford; Ken I. Mills, Queen's University Belfast, Belfast; Emma-Jane McDonald and Sally Killick, Royal Bournemouth Hospital, Bournemouth, United Kingdom; Axel Benner, German Cancer Research Center, Heidelberg; Aristoteles Giagounidis, St Johannes Hospital, Duisburg; Lars Bullinger, University Hospital of Ulm, Ulm, Germany; Mario Cazzola, Luca Malcovati, and Matteo G. Della Porta, Fondazione Istituto di Ricovera e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy; Martin Jädersten and Eva Hellström-Lindberg, Karolinska Institutet, Stockholm, Sweden; and Amit Verma, Albert Einstein College of Medicine, New York, NY.

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http://dx.doi.org/10.1200/JCO.2012.45.5626DOI Listing
October 2013