Lap-Chee Tsui

Lap-Chee Tsui

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Lap-Chee Tsui

Lap-Chee Tsui

Publications by authors named "Lap-Chee Tsui"

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36Publications

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The cystic fibrosis gene: a molecular genetic perspective.

Cold Spring Harb Perspect Med 2013 Feb 1;3(2):a009472. Epub 2013 Feb 1.

The University of Hong Kong, Hong Kong, Special Administrative Region, China.

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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a009472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552342PMC
February 2013

A second generation human haplotype map of over 3.1 million SNPs.

Authors:
Kelly A Frazer Dennis G Ballinger David R Cox David A Hinds Laura L Stuve Richard A Gibbs John W Belmont Andrew Boudreau Paul Hardenbol Suzanne M Leal Shiran Pasternak David A Wheeler Thomas D Willis Fuli Yu Huanming Yang Changqing Zeng Yang Gao Haoran Hu Weitao Hu Chaohua Li Wei Lin Siqi Liu Hao Pan Xiaoli Tang Jian Wang Wei Wang Jun Yu Bo Zhang Qingrun Zhang Hongbin Zhao Hui Zhao Jun Zhou Stacey B Gabriel Rachel Barry Brendan Blumenstiel Amy Camargo Matthew Defelice Maura Faggart Mary Goyette Supriya Gupta Jamie Moore Huy Nguyen Robert C Onofrio Melissa Parkin Jessica Roy Erich Stahl Ellen Winchester Liuda Ziaugra David Altshuler Yan Shen Zhijian Yao Wei Huang Xun Chu Yungang He Li Jin Yangfan Liu Yayun Shen Weiwei Sun Haifeng Wang Yi Wang Ying Wang Xiaoyan Xiong Liang Xu Mary M Y Waye Stephen K W Tsui Hong Xue J Tze-Fei Wong Luana M Galver Jian-Bing Fan Kevin Gunderson Sarah S Murray Arnold R Oliphant Mark S Chee Alexandre Montpetit Fanny Chagnon Vincent Ferretti Martin Leboeuf Jean-François Olivier Michael S Phillips Stéphanie Roumy Clémentine Sallée Andrei Verner Thomas J Hudson Pui-Yan Kwok Dongmei Cai Daniel C Koboldt Raymond D Miller Ludmila Pawlikowska Patricia Taillon-Miller Ming Xiao Lap-Chee Tsui William Mak You Qiang Song Paul K H Tam Yusuke Nakamura Takahisa Kawaguchi Takuya Kitamoto Takashi Morizono Atsushi Nagashima Yozo Ohnishi Akihiro Sekine Toshihiro Tanaka Tatsuhiko Tsunoda Panos Deloukas Christine P Bird Marcos Delgado Emmanouil T Dermitzakis Rhian Gwilliam Sarah Hunt Jonathan Morrison Don Powell Barbara E Stranger Pamela Whittaker David R Bentley Mark J Daly Paul I W de Bakker Jeff Barrett Yves R Chretien Julian Maller Steve McCarroll Nick Patterson Itsik Pe'er Alkes Price Shaun Purcell Daniel J Richter Pardis Sabeti Richa Saxena Stephen F Schaffner Pak C Sham Patrick Varilly David Altshuler Lincoln D Stein Lalitha Krishnan Albert Vernon Smith Marcela K Tello-Ruiz Gudmundur A Thorisson Aravinda Chakravarti Peter E Chen David J Cutler Carl S Kashuk Shin Lin Gonçalo R Abecasis Weihua Guan Yun Li Heather M Munro Zhaohui Steve Qin Daryl J Thomas Gilean McVean Adam Auton Leonardo Bottolo Niall Cardin Susana Eyheramendy Colin Freeman Jonathan Marchini Simon Myers Chris Spencer Matthew Stephens Peter Donnelly Lon R Cardon Geraldine Clarke David M Evans Andrew P Morris Bruce S Weir Tatsuhiko Tsunoda James C Mullikin Stephen T Sherry Michael Feolo Andrew Skol Houcan Zhang Changqing Zeng Hui Zhao Ichiro Matsuda Yoshimitsu Fukushima Darryl R Macer Eiko Suda Charles N Rotimi Clement A Adebamowo Ike Ajayi Toyin Aniagwu Patricia A Marshall Chibuzor Nkwodimmah Charmaine D M Royal Mark F Leppert Missy Dixon Andy Peiffer Renzong Qiu Alastair Kent Kazuto Kato Norio Niikawa Isaac F Adewole Bartha M Knoppers Morris W Foster Ellen Wright Clayton Jessica Watkin Richard A Gibbs John W Belmont Donna Muzny Lynne Nazareth Erica Sodergren George M Weinstock David A Wheeler Imtaz Yakub Stacey B Gabriel Robert C Onofrio Daniel J Richter Liuda Ziaugra Bruce W Birren Mark J Daly David Altshuler Richard K Wilson Lucinda L Fulton Jane Rogers John Burton Nigel P Carter Christopher M Clee Mark Griffiths Matthew C Jones Kirsten McLay Robert W Plumb Mark T Ross Sarah K Sims David L Willey Zhu Chen Hua Han Le Kang Martin Godbout John C Wallenburg Paul L'Archevêque Guy Bellemare Koji Saeki Hongguang Wang Daochang An Hongbo Fu Qing Li Zhen Wang Renwu Wang Arthur L Holden Lisa D Brooks Jean E McEwen Mark S Guyer Vivian Ota Wang Jane L Peterson Michael Shi Jack Spiegel Lawrence M Sung Lynn F Zacharia Francis S Collins Karen Kennedy Ruth Jamieson John Stewart

Nature 2007 Oct;449(7164):851-61

The Scripps Research Institute, 10550 North Torrey Pines Road MEM275, La Jolla, California 92037, USA.

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https://www.genome.gov/Pages/Newsroom/CurrentNewsReleases/In
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http://www.nature.com/doifinder/10.1038/nature06258
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http://dx.doi.org/10.1038/nature06258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689609PMC
October 2007

Genome-wide detection and characterization of positive selection in human populations.

Authors:
Pardis C Sabeti Patrick Varilly Ben Fry Jason Lohmueller Elizabeth Hostetter Chris Cotsapas Xiaohui Xie Elizabeth H Byrne Steven A McCarroll Rachelle Gaudet Stephen F Schaffner Eric S Lander Kelly A Frazer Dennis G Ballinger David R Cox David A Hinds Laura L Stuve Richard A Gibbs John W Belmont Andrew Boudreau Paul Hardenbol Suzanne M Leal Shiran Pasternak David A Wheeler Thomas D Willis Fuli Yu Huanming Yang Changqing Zeng Yang Gao Haoran Hu Weitao Hu Chaohua Li Wei Lin Siqi Liu Hao Pan Xiaoli Tang Jian Wang Wei Wang Jun Yu Bo Zhang Qingrun Zhang Hongbin Zhao Hui Zhao Jun Zhou Stacey B Gabriel Rachel Barry Brendan Blumenstiel Amy Camargo Matthew Defelice Maura Faggart Mary Goyette Supriya Gupta Jamie Moore Huy Nguyen Robert C Onofrio Melissa Parkin Jessica Roy Erich Stahl Ellen Winchester Liuda Ziaugra David Altshuler Yan Shen Zhijian Yao Wei Huang Xun Chu Yungang He Li Jin Yangfan Liu Yayun Shen Weiwei Sun Haifeng Wang Yi Wang Ying Wang Xiaoyan Xiong Liang Xu Mary M Y Waye Stephen K W Tsui Hong Xue J Tze-Fei Wong Luana M Galver Jian-Bing Fan Kevin Gunderson Sarah S Murray Arnold R Oliphant Mark S Chee Alexandre Montpetit Fanny Chagnon Vincent Ferretti Martin Leboeuf Jean-François Olivier Michael S Phillips Stéphanie Roumy Clémentine Sallée Andrei Verner Thomas J Hudson Pui-Yan Kwok Dongmei Cai Daniel C Koboldt Raymond D Miller Ludmila Pawlikowska Patricia Taillon-Miller Ming Xiao Lap-Chee Tsui William Mak You Qiang Song Paul K H Tam Yusuke Nakamura Takahisa Kawaguchi Takuya Kitamoto Takashi Morizono Atsushi Nagashima Yozo Ohnishi Akihiro Sekine Toshihiro Tanaka Tatsuhiko Tsunoda Panos Deloukas Christine P Bird Marcos Delgado Emmanouil T Dermitzakis Rhian Gwilliam Sarah Hunt Jonathan Morrison Don Powell Barbara E Stranger Pamela Whittaker David R Bentley Mark J Daly Paul I W de Bakker Jeff Barrett Yves R Chretien Julian Maller Steve McCarroll Nick Patterson Itsik Pe'er Alkes Price Shaun Purcell Daniel J Richter Pardis Sabeti Richa Saxena Stephen F Schaffner Pak C Sham Patrick Varilly David Altshuler Lincoln D Stein Lalitha Krishnan Albert Vernon Smith Marcela K Tello-Ruiz Gudmundur A Thorisson Aravinda Chakravarti Peter E Chen David J Cutler Carl S Kashuk Shin Lin Gonçalo R Abecasis Weihua Guan Yun Li Heather M Munro Zhaohui Steve Qin Daryl J Thomas Gilean McVean Adam Auton Leonardo Bottolo Niall Cardin Susana Eyheramendy Colin Freeman Jonathan Marchini Simon Myers Chris Spencer Matthew Stephens Peter Donnelly Lon R Cardon Geraldine Clarke David M Evans Andrew P Morris Bruce S Weir Tatsuhiko Tsunoda Todd A Johnson James C Mullikin Stephen T Sherry Michael Feolo Andrew Skol Houcan Zhang Changqing Zeng Hui Zhao Ichiro Matsuda Yoshimitsu Fukushima Darryl R Macer Eiko Suda Charles N Rotimi Clement A Adebamowo Ike Ajayi Toyin Aniagwu Patricia A Marshall Chibuzor Nkwodimmah Charmaine D M Royal Mark F Leppert Missy Dixon Andy Peiffer Renzong Qiu Alastair Kent Kazuto Kato Norio Niikawa Isaac F Adewole Bartha M Knoppers Morris W Foster Ellen Wright Clayton Jessica Watkin Richard A Gibbs John W Belmont Donna Muzny Lynne Nazareth Erica Sodergren George M Weinstock David A Wheeler Imtaz Yakub Stacey B Gabriel Robert C Onofrio Daniel J Richter Liuda Ziaugra Bruce W Birren Mark J Daly David Altshuler Richard K Wilson Lucinda L Fulton Jane Rogers John Burton Nigel P Carter Christopher M Clee Mark Griffiths Matthew C Jones Kirsten McLay Robert W Plumb Mark T Ross Sarah K Sims David L Willey Zhu Chen Hua Han Le Kang Martin Godbout John C Wallenburg Paul L'Archevêque Guy Bellemare Koji Saeki Hongguang Wang Daochang An Hongbo Fu Qing Li Zhen Wang Renwu Wang Arthur L Holden Lisa D Brooks Jean E McEwen Mark S Guyer Vivian Ota Wang Jane L Peterson Michael Shi Jack Spiegel Lawrence M Sung Lynn F Zacharia Francis S Collins Karen Kennedy Ruth Jamieson John Stewart

Nature 2007 Oct;449(7164):913-8

Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USA.

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https://www.genome.gov/Pages/Newsroom/CurrentNewsReleases/Le
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http://www.nature.com/doifinder/10.1038/nature06250
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http://dx.doi.org/10.1038/nature06250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687721PMC
October 2007

Citrin/mitochondrial glycerol-3-phosphate dehydrogenase double knock-out mice recapitulate features of human citrin deficiency.

J Biol Chem 2007 Aug 25;282(34):25041-52. Epub 2007 Jun 25.

Department of Molecular Metabolism and Biochemical Genetics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan.

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http://dx.doi.org/10.1074/jbc.M702031200DOI Listing
August 2007

Pyruvate ameliorates the defect in ureogenesis from ammonia in citrin-deficient mice.

J Hepatol 2006 May 8;44(5):930-8. Epub 2005 Nov 8.

Laboratory of Integrative Physiology in Veterinary Sciences, Osaka Prefecture University, 1-1 Gakuen-cho, Sakai, Osaka 599-8531, Japan.

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http://dx.doi.org/10.1016/j.jhep.2005.09.018DOI Listing
May 2006

Frequency and distribution in East Asia of 12 mutations identified in the SLC25A13 gene of Japanese patients with citrin deficiency.

J Hum Genet 2005 30;50(7):338-346. Epub 2005 Jul 30.

Department of Molecular Metabolism and Biochemical Genetics, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan.

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http://dx.doi.org/10.1007/s10038-005-0262-8DOI Listing
January 2006

Altered expression and deletion of RMO1 in osteosarcoma.

Int J Cancer 2005 May;114(5):738-46

Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/ijc.20786DOI Listing
May 2005

A novel locus of ectodermal dysplasia maps to chromosome 10q24.32-q25.1.

J Invest Dermatol 2005 Feb;124(2):338-42

Department of Biological Sciences, Quaid-I-Azam University, Islamabad, Pakistan.

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http://dx.doi.org/10.1111/j.0022-202X.2004.23594.xDOI Listing
February 2005

High-resolution FISH analysis.

Curr Protoc Hum Genet 2005 Feb;Chapter 4:Unit 4.5

Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA.

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http://doi.wiley.com/10.1002/0471142905.hg0405s44
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http://dx.doi.org/10.1002/0471142905.hg0405s44DOI Listing
February 2005

A novel missense mutation in the galactosyltransferase-I (B4GALT7) gene in a family exhibiting facioskeletal anomalies and Ehlers-Danlos syndrome resembling the progeroid type.

Am J Med Genet A 2004 Jul;128A(1):39-45

Program in Genetics and Genomic Biology, Department of Genetics, The Hospital for Sick Children, 9th Floor Elm Wing, Rm. 9115, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.

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http://doi.wiley.com/10.1002/ajmg.a.30005
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http://dx.doi.org/10.1002/ajmg.a.30005DOI Listing
July 2004

Characterization of the segmental duplication LCR7-20 in the human genome.

Genomics 2004 Feb;83(2):262-9

The Centre for Applied Genomics, Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1016/j.ygeno.2003.08.003DOI Listing
February 2004

Transcriptional activation of immediate-early gene ETR101 by human T-cell leukaemia virus type I Tax.

J Gen Virol 2003 Dec;84(Pt 12):3203-3214

Program of Genetics and Genomic Biology, Center for Applied Genomics, Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8.

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http://dx.doi.org/10.1099/vir.0.19283-0DOI Listing
December 2003

Increased prevalence of CFTR mutations and variants and decreased chloride secretion in primary sclerosing cholangitis.

Hum Genet 2003 Aug 3;113(3):286-92. Epub 2003 Jun 3.

Department of Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Dana 532, 330 Brookline Avenue, Boston, MA 02215, USA.

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http://link.springer.com/10.1007/s00439-003-0963-z
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http://dx.doi.org/10.1007/s00439-003-0963-zDOI Listing
August 2003

SARS genome patent: to manage and to share.

Authors:
Lap-Chee Tsui

Lancet 2003 Aug;362(9381):406

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http://dx.doi.org/10.1016/s0140-6736(03)14038-xDOI Listing
August 2003

Human chromosome 7: DNA sequence and biology.

Science 2003 May 10;300(5620):767-72. Epub 2003 Apr 10.

Department of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8.

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http://dx.doi.org/10.1126/science.1083423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882961PMC
May 2003

Genome-wide detection of segmental duplications and potential assembly errors in the human genome sequence.

Genome Biol 2003 17;4(4):R25. Epub 2003 Mar 17.

Program in Genetics and Genomic Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC154576PMC
http://dx.doi.org/10.1186/gb-2003-4-4-r25DOI Listing
May 2003

Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans.

Hum Mol Genet 2003 May;12(10):1131-43

Department of Experimental Therapeutics, Toronto General Research Institute, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/hmg/ddg124DOI Listing
May 2003

Glucose intolerance in children with cystic fibrosis.

J Pediatr 2003 Feb;142(2):128-32

Departments of Genetics and Population Health Sciences, The Hospital for Sick Children, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1067/mpd.2003.5DOI Listing
February 2003

Loci of intestinal distress in cystic fibrosis knockout mice.

Physiol Genomics 2003 Jan 15;12(2):79-84. Epub 2003 Jan 15.

Program of Genetics and Genomic Biology, Research Institute, The Hospital for Sick Children, and Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1152/physiolgenomics.00114.2002DOI Listing
January 2003

Genotype and phenotype correlations in patients with cystic fibrosis and pancreatitis.

Gastroenterology 2002 Dec;123(6):1857-64

Programmes in Integrative Biology, The Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1053/gast.2002.37042DOI Listing
December 2002

Detection of modifier loci influencing the lung phenotype of cystic fibrosis knockout mice.

Mamm Genome 2002 Nov;13(11):605-13

Program of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

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http://link.springer.com/content/pdf/10.1007/s00335-002-2190
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http://link.springer.com/10.1007/s00335-002-2190-7
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http://dx.doi.org/10.1007/s00335-002-2190-7DOI Listing
November 2002

Mapping of genetic factors influencing the weight of cystic fibrosis knockout mice.

Mamm Genome 2002 Nov;13(11):614-8

Program of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1007/s00335-002-2195-2DOI Listing
November 2002

CFTR mutation detection by multiplex heteroduplex (mHET) analysis on MDE gel.

Methods Mol Med 2002 ;70:3-19

Department of Genetics, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1385/1-59259-187-6:03DOI Listing
September 2002

Chromosomal regions containing high-density and ambiguously mapped putative single nucleotide polymorphisms (SNPs) correlate with segmental duplications in the human genome.

Hum Mol Genet 2002 Aug;11(17):1987-95

Program in Genetics & Genomic Biology, Research Institute, The Hospital for Sick Children, and Department of Molecular and Medical Genetics, University of Toronto, ON, Canada.

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http://dx.doi.org/10.1093/hmg/11.17.1987DOI Listing
August 2002

Refinement of the genomic structure of STX1A and mutation analysis in nondeletion Williams syndrome patients.

Am J Med Genet 2002 Apr;109(2):121-4

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1002/ajmg.10321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893211PMC
April 2002

Cystic fibrosis in Uruguay.

Genet Mol Res 2002 Mar 31;1(1):32-8. Epub 2002 Mar 31.

Departamento de Citogenética, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay.

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March 2002