Publications by authors named "Laouali Boubou"

3 Publications

  • Page 1 of 1

Pediatric Bacterial Meningitis Surveillance in Niger: Increased Importance of Neisseria meningitidis Serogroup C, and a Decrease in Streptococcus pneumoniae Following 13-Valent Pneumococcal Conjugate Vaccine Introduction.

Clin Infect Dis 2019 09;69(Suppl 2):S133-S139

World Health Organization (WHO) Collaborating Centre for New Vaccines Surveillance, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, United Kingdom.

Background: Meningitis is endemic in Niger. Haemophilus influenzae type b (Hib) vaccine and the 13-valent pneumococcal conjugate vaccine (PCV13) were introduced in 2008 and 2014, respectively. Vaccination campaign against Neisseria meningitidis serogroup A was carried out in 2010-2011. We evaluated changes in pathogen distribution using data from hospital-based surveillance in Niger from 2010 through 2016.

Methods: Cerebrospinal fluid (CSF) specimens from children <5 years old with suspected meningitis were tested to detect vaccine-preventable bacterial pathogens. Confirmatory identification and serotyping/grouping of Streptococcus pneumoniae, N. meningitidis, and H. influenzae were done. Antimicrobial susceptibility testing and whole genome sequencing were performed on S. pneumoniae isolates.

Results: The surveillance included 2580 patients with suspected meningitis, of whom 80.8% (2085/2580) had CSF collected. Bacterial meningitis was confirmed in 273 patients: 48% (131/273) was N. meningitidis, 45% (123/273) S. pneumoniae, and 7% (19/273) H. influenzae. Streptococcus pneumoniae meningitis decreased from 34 in 2014, to 16 in 2016. PCV13 serotypes made up 88% (7/8) of S. pneumoniae meningitis prevaccination and 20% (5/20) postvaccination. Neisseria meningitidis serogroup C (NmC) was responsible for 59% (10/17) of serogrouped N. meningitidis meningitis. Hib caused 67% (2/3) of the H. influenzae meningitis isolates serotyped. Penicillin resistance was found in 16% (4/25) of S. pneumoniae isolates. Sequence type 217 was the most common lineage among S. pneumoniae isolates.

Conclusions: Neisseria meningitidis and S. pneumoniae remain important causes of meningitis in children in Niger. The decline in the numbers of S. pneumoniae meningitis post-PCV13 is encouraging and should continue to be monitored. NmC is the predominant serogroup causing N. meningitidis meningitis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/ciz598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761310PMC
September 2019

[Epidemiological and bacteriological features of surgical site infections (ISO) in the Division of Surgery at the Niamey National Hospital (HNN)].

Pan Afr Med J 2018 14;31:33. Epub 2018 Sep 14.

Faculté de Sciences de la Santé, Laboratoire de Bactériologie Virologie, Université Abdou Moumouni de Niamey, Niger.

This study aims to evaluate the epidemiological and bacteriological features of bacterial strains isolated from surgical site infections (ISO) at the Niamey National Hospital. We conducted a retrospective, descriptive study over a period of 24 months. All strains isolated from bacteriological samplings from patients with a surgical site infection have been identified and tested for antibiotic sensitivity according to conventional methods. The bacteriological analysis allowed the isolation of 126 bacterial strains with a predominance of S.aureus (n=39, 31%) followed by Escherichia coli (n=29, 23%) and Pseudomonas aeruginosa (n=12, 9.5%). The strains of Escherichia coli were 100% sensitive to imipenem. They showed marked ampicillin, amoxicillin, clavulanic acid and ticarcillin resistance. They had variable resistance to aminoglycoside antibiotics (62% to gentamycin, and 78% to amikacin) and to fluoroquinolones (nalidixic acid 74%, pefloxacine 33%, ofloxacin 69%, ciprofloxacin 61%). All enterobacterial isolates were sensitive to imipenem. The strains of S.aureus showed resistance to penicillin G (88.6%) and oxacillin (83%). They also showed resistance to vancomycin and teicoplanin (37% and 57% respectively). By contrast, they were sensitive to lincomycin and aminoglycoside antibiotics tested. In the light of these results, we believe that it will be necessary to improve prophylaxis protocol and probabilistic antibiotic therapy in the Surgical Division and to conduct periodic surveillance studies of the ISO.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.11604/pamj.2018.31.33.15921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430836PMC
April 2019

Prevalence of Bordetella infection in a hospital setting in niamey, niger.

J Trop Pediatr 2014 Jun 14;60(3):223-30. Epub 2014 Feb 14.

Epicentre, Paris, France.

Bordetella pertussis still poses an important health threat in developing countries. In Niger, notified pertussis cases are few despite the low diphtheria-tetanus-pertussis/pentavalent vaccine coverage. We aimed to estimate the prevalence of B. pertussis in children aged <5 years consulting at a pediatric ward. A 5-month study in 2011 recruited 342 children with respiratory symptoms at the National Hospital of Niamey. Nasopharyngeal aspirates were tested by culture and real-time polymerase chain reaction. Overall, 34 (11.2%) of the 305 available nasopharyngeal aspirates tested by real-time polymerase chain reaction were positive for a Bordetella spp., with an estimated prevalence of 8.2 cases per 1000 children aged <5. None was notified to the surveillance network. A single specimen was positive on culture. This study, the first to provide laboratory-confirmed data on pertussis in Niger, highlights the need to sensitize health care personnel to actively notify clinical cases and to integrate laboratory diagnosis in the existing surveillance system.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/tropej/fmu001DOI Listing
June 2014
-->