Publications by authors named "Lanyue Zhang"

18 Publications

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A comparative study on chemical compositions and biological activities of four essential oils: Cymbopogon citratus (DC.) Stapf, Cinnamomum cassia (L.) Presl, Salvia japonica Thunb. and Rosa rugosa Thunb.

J Ethnopharmacol 2021 Nov 28;280:114472. Epub 2021 Jul 28.

School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, China. Electronic address:

Ethnopharmacological Relevance: Essential oils (EOs) are important active ingredients in Chinese herbal medicine. Cymbopogon citratus (DC.) Stapf, Cinnamomum cassia (L.) Presl, Salvia japonica Thunb., and Rosa rugosa Thunb. are used in local and traditional medicine to treat inflammation-related diseases. While the constituents and bioactivities of EOs of the above four Chinese herbals have been reported previously, but their anti-inflammatory and antioxidant activities have not been systematically evaluated.

Aim Of The Study: The purpose of this study was to research the chemical constituents, anti-inflammatory activities, and antioxidant activities of EOs of four Chinese herbal medicines.

Materials And Methods: Fresh plant materials were collected both in August 2018. The compositions of EOs were determined by the gas chromatography-mass spectrometry (GC-MS) method. TPA (12-O-tetradecylphophenol-13-acetate)-induced mouse ear model was evaluated the anti-inflammatory activities of EOs. The reduction of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), cyclooxygenase-2 (COX-2) and RelA protein of the nuclear factor kappa-B (NF-κB) in the signal pathway (P65) were measured. The antioxidant activities of EOs from four plants were determined by using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging method.

Results: A total of 217 compounds were separated and identified from four EOs, mainly including trans-cinnamylaldehyde (68.75%), citronellal (38.16%), linalool (1.02-33.73%), geraniol (19.39%) and citronellol (17.18%). All four EOs reduced the damage of the ear tissue and had certain anti-inflammatory effects, and the EOs of C. citratus (CyCEOs) and S. japonica (SJEOs) had the best anti-inflammatory activities among others, even better than ibuprofen. The four EOs exhibited different DPPH radical-scavenging activities (IC, 0.101-1.017%), where most of them were much lower than that of EOs of C. citratus (CiCEOs) (IC, 0.101%) and EOs of R. rugosa (RREOs) (IC, 0.142%).

Conclusions: The main components determine diverse propertise of these four EOs, our results suggested that four EOs presented anti-inflammatory and antioxidant effect via reducing the expression of TNF-a, IL-6, COX-2, and NF-κB p65, which may provide a new approach for development of new anti-inflammatory drugs.
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http://dx.doi.org/10.1016/j.jep.2021.114472DOI Listing
November 2021

Revealing the Immune Infiltration Landscape and Identifying Diagnostic Biomarkers for Lumbar Disc Herniation.

Front Immunol 2021 27;12:666355. Epub 2021 May 27.

Department of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Intervertebral disc (IVD) degeneration and its inflammatory microenvironment ultimately led to discogenic pain, which is thought to originate in the nucleus pulposus (NP). In this study, key genes involved in NP tissue immune infiltration in lumbar disc herniation (LDH) were identified by bioinformatic analysis. Gene expression profiles were downloaded from the Gene Expression Omnibus (GEO) database. The CIBERSORT algorithm was used to analyze the immune infiltration into NP tissue between the LDH and control groups. Hub genes were identified by the WGCNA R package in Bioconductor and single-cell sequencing data was analyzed using R packages. Gene expression levels were evaluated by quantitative real-time polymerase chain reaction. The immune infiltration profiles varied significantly between the LDH and control groups. Compared with control tissue, LDH tissue contained a higher proportion of regulatory T cells and macrophages, which are associated with the macrophage polarization process. The most significant module contained three hub genes and four subclusters of NP cells. Functional analysis of these genes was performed, the hub gene expression pattern was confirmed by PCR, and clinical features of the patients were investigated. Finally, we identified TGF-β and MAPK signaling pathways as crucial in this process and these pathways may provide diagnostic markers for LDH. We hypothesize that the hub genes expressed in the specific NP subclusters, along with the infiltrating macrophages play important roles in the pathogenesis of IVD degeneration and ultimately, disc herniation.
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http://dx.doi.org/10.3389/fimmu.2021.666355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190407PMC
May 2021

Glabridin Liposome Ameliorating UVB-Induced Erythema and Lethery Skin by Suppressing Inflammatory Cytokine Production.

J Microbiol Biotechnol 2021 Apr;31(4):630-636

Hua An Tang Biotech Group Co., Ltd., Guangzhou 510000, P.R. China.

Glabridin, a compound of the flavonoid, has shown outstanding skin-whitening and anti-aging properties, but its water insolubility limits its wide application. Therefore, glabridin liposome (GL) has been developed to improve its poor bioavailability, while there are few studies to evaluate its amelioration of UVB- induced photoaging. This study is performed to investigate the amelioration of GL against UVB- induced cutaneous photoaging. The prepared GL has a spheroidal morphology with an average diameter of 200 nm. The GL shows lower cytotoxicity than glabridin, but it has a more effective role in inhibition of melanin. Moreover, the application of GL can effectively relieve UV radiation induced erythema and leathery skin, associated with the down-regulated expression of inflammatory cytokines (TNF-α, IL-6 and IL-10). Taken together, these results demonstrate that GL has potentials as topical therapeutic agents against UVB radiation induced skin damage through inhibiting inflammation.
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http://dx.doi.org/10.4014/jmb.2011.11006DOI Listing
April 2021

Luteolin attenuates imiquimod-induced psoriasis-like skin lesions in BALB/c mice via suppression of inflammation response.

Biomed Pharmacother 2020 Nov 10;131:110696. Epub 2020 Sep 10.

Guangdong Provincial Key Laboratory of Emergency Test for Dangerous Chemicals, Guangdong Institute of Analysis, Guangzhou, 510070, PR China. Electronic address:

Psoriasis is considered as a common chronic immune-mediated skin disorder characterized by abnormal keratinocyte proliferation. Luteolin, an anti-inflammatory natural flavonoid with well-accepted inhibition effect against keratinocyte proliferation, was hypothesized to have a potential therapeutic effect for psoriasis. In this paper, we investigated the relieving effect of luteolin against imiquimod-induced psoriasis-like lesions on BALB/c mice and its possible anti-inflammatory mechanisms in lipopolysaccharide-stimulated macrophages (RAW264.7 cells). We found that luteolin ameliorated psoriasis-like skin lesions, suppressed the cutaneous infiltration of macrophages, T cells and neutrophils, and downregulated the expression of cytokines like IL-6, IL-1β, TNF-α, IL-17A and IL-23 in both skin lesions and eyeball blood of model mice. In vitro, we observed luteolin significantly suppressed the levels of psoriasis-related pro-inflammatory cytokines, such as IL-17A, IL-6, TNF-α and IL-23, and inflammatory mediators like nitric oxide NO, inducible NOS, COX-2 in RAW264.7 cells. The anti-inflammatory activity was accomplished by inhibiting NF-κB expression and activation. This study demonstrates luteolin is effective in alleviating psoriasis-like skin lesions and downregulating inflammatory response via NF-κB pathway, suggesting luteolin as a potential molecule for further therapeutic research of inflammation-related skin diseases like psoriasis.
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http://dx.doi.org/10.1016/j.biopha.2020.110696DOI Listing
November 2020

Chemical composition of and essential oils and prevention of UV-B radiation-induced skin photoaging.

Nat Prod Res 2020 Aug 28:1-4. Epub 2020 Aug 28.

Hua An Tang Biotech Group Co., Ltd, Guangzhou, PR China.

essential oils (BBEOs) and essential oils (MSEOs) have exhibited outstanding antioxidant, anti-bacterial and anti-inflammatory activities. However, their anti-photoaging ability is still unclear. In this study, the chemical compositions of BBEOs and MSEOs are firstly determined by GC-MS analysis, and then their anti-photoaging is evaluated via an ultraviolet radiation (UV-B) induced mice skin-injury model. A total of 35 and 33 components are identified from BBEOs and MSEOs, and their dominant compositions are caryophyllene (18.54%) and borneol (18.33%) in BBEOs, and β-elemene (29.10%), γ-terpinene (17.01%) and (E)-β-ocymene (11.69%) in MSEOs. According to the skin injury model, the application of BBEOs and MSEOs to mice skin can effectively inhibit skin photoaging by down-regulating the expression of inflammatory factors including TNF-α, IL-6 and IL-10. Clearly, both essential oils reveal the potential as additives in cosmetics for anti-photoaging.
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http://dx.doi.org/10.1080/14786419.2020.1809401DOI Listing
August 2020

The effects and mechanism of collagen peptide and elastin peptide on skin aging induced by D-galactose combined with ultraviolet radiation.

J Photochem Photobiol B 2020 Sep 19;210:111964. Epub 2020 Jul 19.

Université Paris Diderot, Paris, France. Electronic address:

Background: The content of collagen and elastin occupies a large proportion of skin evaluation, and collagen peptide (CP) and elastin peptide (EP) are widely used drugs, which have anti-inflammatory effects. In addition, CP and EP can also be used as therapeutic agents for skin repair. However, previous studies have never thoroughly verified the effects of oral administration of CP and EP on skin repair.

Aim: To study the effects and mechanism of oral administration of CP and EP on skin aging induced by combinatorial treatment with D-galactose and ultraviolet radiation.

Results: In animal experiments, the combined oral administration of CP and EP increased the contents of collagen and elastin in animal skin, accompanying with significantly upregulated expression of hyaluronic acid and hydroxyproline, as well as significantly reduced expression of MMP-3 and IL-1α. In addition, the combined therapy also significantly increased the expression of seven collagen and elastin synthesis-related factors including IGF-1, LOX, SMAD2, JNK, SP1, TβRII and TGF-β.

Conclusion: Oral administration of CP and EP can repair skin aging induced by the combined treatment with D-galactose and ultraviolet radiation and the effects of CP and EP appeared synergistic.
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http://dx.doi.org/10.1016/j.jphotobiol.2020.111964DOI Listing
September 2020

Design, Synthesis and Anti-Tumor Activity of Novel Benzimidazole-Chalcone Hybrids as Non-Intercalative Topoisomerase II Catalytic Inhibitors.

Molecules 2020 Jul 12;25(14). Epub 2020 Jul 12.

School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.

Chemical diversification of type II topoisomerase (Topo II) inhibitors remains indispensable to extend their anti-tumor therapeutic values which are limited by their side effects. Herein, we designed and synthesized a novel series of benzimidazole-chalcone hybrids (BCHs). These BCHs showed good inhibitory effect in the Topo II mediated DNA relaxation assay and anti-proliferative effect in 4 tumor cell lines. and were the most potent, with IC values less than 5 μM, superior to etoposide. Mechanistic studies indicated that the BCHs functioned as non-intercalative Topo II catalytic inhibitors. Moreover, and demonstrated versatile properties against tumors, including inhibition on the colony formation and cell migration, and promotion of apoptosis of A549 cells. The structure-activity relationship and molecular docking analysis suggested possible contribution of the chalcone motif to the Topo II inhibitory and anti-proliferative potency. These results indicated that and could be promising lead compounds for further anti-tumor drug research.
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http://dx.doi.org/10.3390/molecules25143180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397320PMC
July 2020

Histone deacetylase inhibitors impair the host immune response against Mycobacterium tuberculosis infection.

Tuberculosis (Edinb) 2019 09 27;118:101861. Epub 2019 Aug 27.

Laboratory of Molecular Biology, Beijing Key Laboratory for Drug Resistance Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, 101149, China. Electronic address:

Histone deacetylase inhibitors (HDACi), a novel class of anti-cancer drug, have been recently reported to suppress host immunity and increase susceptibility to infection. Tuberculosis, a leading infectious disease killer caused by Mycobacterium tuberculosis (M.tb), is basically the product of the interaction between bacterial virulence and host resistance. However, the effects of HDACi in host immunity against M.tb is largely unknown. In this study, we found that HDACi including Trichostatin A (TSA) and suberoylanilide hydroxamic acid (SAHA) significantly impaired phagocytosis and killing activity of macrophage. In line with these findings, we noted that M.tb induced reactive oxygen species (ROS) production and autophagy are significantly suppressed by TSA. Transcriptome analysis revealed that the suppression of autophagy by TSA might due to its inhibiting autophagy-regulating genes such as CACNA2D3, which regulates intracellular Ca levels. Finally, we confirmed that HDACi including TSA and SAHA significantly exacerbated the histopathological damage and M.tb load in the lung of M.tb infected mice. Taken together, our results indicated that HDACi at least TSA and SAHA significantly impaired macrophage immunity against M.tb and therefore increase susceptibility to TB, our findings raised the concern that the potential side effects of HDACi on latent TB reactivation should be considered in clinic.
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http://dx.doi.org/10.1016/j.tube.2019.101861DOI Listing
September 2019

Application of the CRISPRi system to repress sepF expression in Mycobacterium smegmatis.

Infect Genet Evol 2019 08 6;72:183-190. Epub 2018 Jul 6.

Beijing Key Laboratory for Drug Resistance Tuberculosis Research, Laboratory of Molecular Biology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China. Electronic address:

Despite technical advances in introducing genomic deletions and modulating gene expression, direct inactivation of essential genes in mycobacteria remains difficult. In this study, we described clustered regularly interspaced short palindromic repeat interference (CRISPRi) technology to repress the expression of sepF (MSMEG_4219) based on nuclease-deficient CRISPR-associated protein 9 (Cas9) and small guide RNA (sgRNA) specific to the target sequence in Mycobacterium smegmatis. Using this CRISPRi approach, we achieved the repression of sepF by up to 98% in M. smegmatis without off-target effects. The depleted Msm_sepF strains resulted in growth and morphology changes including elongated, filamentous and branched bacterial cells, but the levels of the interacting partners ftsZ and murG were not modified in M. smegmatis. The sepF gene was proven to be an essential gene in M. smegmatis. This study provided an improved and detailed technical procedure for the application of CRISPRi technology in mycobacteria, and this approach was demonstrated to be a simple and efficient tool for regulating the expression of essential genes in M. smegmatis.
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http://dx.doi.org/10.1016/j.meegid.2018.06.033DOI Listing
August 2019

The Chemical Compositions of Angelica pubescens Oil and Its Prevention of UV-B Radiation-Induced Cutaneous Photoaging.

Chem Biodivers 2018 Oct 7;15(10):e1800235. Epub 2018 Oct 7.

Institute of Natural Medicine & Green Chemistry, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, 510006, P. R. China.

Angelica pubescens, a plant of the family Umbelliferae, has been widely used as traditional Chinese medicine for the treatment of many diseases. However, there has been minimal modern research focused on the pharmacological activity of oils extracted from Angelica pubescens, in particular, the potential anti-photoaging effects. Therefore, in the present study, we analyzed the chemical composition of Angelica pubescens oil (AO) and evaluated its bioactivity against photoaging in ultraviolet (UV) -B radiation-induced hairless mice. Overall, we identified and analyzed 93 compounds from the AO by gas chromatography-mass spectrometry (GC/MS). The top ten compounds were as follows: osthole (44.608%), glutaric acid hexadecyl pent-4-en-1-yl ester (5.758%), α-bisabolol (3.795%), eugenol (3.637%), (Z)-docos-13-enamide (3.286%), (3S,3aR)-3-butyl-3a,4,5,6-tetrahydro-3H-2-benzofuran-1-one (3.043%), m-cresol (2.841%), trans-sesquisabinene hydrate (2.128%), 4-hydroxy-2-methylacetophenone (1.735%), and (Z)-9-pentadecenol (1.509%). Application of AO improved the condition of UV-B radiation-induced damaged skin, and the mechanism of action was found to be related to inhibition of the production of inflammatory cytokines. These results highlight the potential application of AO for the development of skin care products.
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http://dx.doi.org/10.1002/cbdv.201800235DOI Listing
October 2018

miR-155-5p Promotes Progression of Acute Respiratory Distress Syndrome by Inhibiting Differentiation of Bone Marrow Mesenchymal Stem Cells to Alveolar Type II Epithelial Cells.

Med Sci Monit 2018 Jun 24;24:4330-4338. Epub 2018 Jun 24.

Department of Pulmonary Disease, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong, China (mainland).

BACKGROUND We investigated whether microRNA-155-5p is involved in the differentiation of bone marrow mesenchymal stem cells (BMSCs) into alveolar type II epithelial (AT II) cells by regulating the Wnt signaling pathway, thus participating in the development of acute respiratory distress syndrome (ARDS). MATERIAL AND METHODS Serum levels of microRNA-155-5p in 50 ARDS patients and 50 normal controls were detected by quantitative real-time PCR (qRT-PCR). Marrow mesenchymal stem cells (MCSs) were isolated from mouse bone marrow and identified by flow cytometry. Subsequently, the effect of microRNA-155-5p on differentiation of BMSCs into AT II cells was evaluated by detecting the expression levels of AT II-specific genes. The expression levels of proteins in the Wnt signaling pathway after overexpression or knockdown of microRNA-155-5p were detected by Western blot. RESULTS Serum levels of microRNA-155-5p in ARDS patients were significantly higher than that in normal controls. Expression levels of AT II-specific genes were enhanced after downregulating microRNA-155-5p in BMSCs. MicroRNA-155-5p overexpression showed the opposite result. Furthermore, microRNA-155-5p inhibited the expression levels of proteins in the Wnt signaling pathway. CONCLUSIONS MicroRNA-155-5p can attenuate the differentiation of BMSCs into AT II cells by inhibiting the Wnt signaling pathway, thus promoting the progression of ARDS.
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http://dx.doi.org/10.12659/MSM.910316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049011PMC
June 2018

Atorvastatin and Caffeine in Combination Regulates Apoptosis, Migration, Invasion and Tumorspheres of Prostate Cancer Cells.

Pathol Oncol Res 2020 Jan 24;26(1):209-216. Epub 2018 May 24.

Allan H. Conney Laboratory for Anticancer Research, Guangdong University of Technology, Guangzhou, 510006, People's Republic of China.

Atorvastatin is the most prescribed cholesterol-lowering statin, while caffeine enhances chemo-sensitivity and induces apoptosis of tumor cells through its DNA repair-inhibiting effect. The present study investigated the effects and mechanisms of atorvastatin and caffeine in combination on human prostate cancer cells cultured in vitro. Cell growth were determined by the trypan blue exclusion assay. The cell apoptosis and colony formation were determined by morphological assessment. The ability of cell migration and invasion were performed using a scratch wound-healing and Transwell assay. Tumorspheres were formed in suspension under the condition of non-adherence and serum-free medium. Finally, the western blot assay was used to determine the levels of proteins. The combination synergistically suppressed proliferation and induced apoptotic death. Meanwhile, the migration, invasion, and the formation of tumorspheres were significantly inhibited by the combination. We found that atorvastatin and caffeine in combination downregulated phospho-Akt, phospho-Erk1/2, anti-apoptotic Bcl-2 and Survivin protein levels. Results of the present study indicate treatment with the combination of caffeine and atorvastatin may be an effective strategy for inhibiting the growth of prostate cancer and should be evaluated clinically.
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http://dx.doi.org/10.1007/s12253-018-0415-7DOI Listing
January 2020

Phenethyl isothiocyanate in combination with dibenzoylmethane inhibits the androgen-independent growth of prostate cancer cells.

Food Funct 2018 Apr;9(4):2398-2408

Allan H. Conney Laboratory for Anticancer Research, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, P. R. China.

Phenethyl isothiocyanate (PEITC) is a naturally occurring compound found in some cruciferous vegetables. Dibenzoylmethane (DBM) is a minor constituent of licorice. Both compounds have been shown to exert anticancer activities. In the present study, we determined the effects of PEITC and DBM alone or in combination on androgen-independent growth of human prostate cancer cells cultured in vitro and prostate VCaP xenograft tumors in severe combined immunodeficient (SCID) mice. PEITC and DBM in combination had stronger effects on inhibiting the growth and inducing apoptosis than either compound alone in cultured prostate cancer cells. The combination also strongly inhibited cell migration and the formation of tumorspheres in VCaP cells. Mechanistic studies showed that the combined effects of PEITC and DBM on growth inhibition and apoptosis were associated with suppression of nuclear factor-κB (NF-κB), and a decrease in the levels of survivin and phospho-Akt (pAkt). In the in vivo study, SCID mice bearing VCaP tumors were surgically castrated and treated with PEITC and/or DBM. Treatment with PEITC and DBM in combination resulted in a strong inhibition of the progression of androgen-dependent VCaP prostate tumors to androgen independence. Our results indicate that administration of DBM and PEITC in combination may be an effective strategy for inhibiting/delaying the progression of prostate cancer to androgen independence.
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http://dx.doi.org/10.1039/c7fo01983aDOI Listing
April 2018

Variation on Composition and Bioactivity of Essential Oils of Four Common Curcuma Herbs.

Chem Biodivers 2017 Nov 23;14(11). Epub 2017 Nov 23.

Institute of Natural Medicine & Green Chemistry, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, Guangdong, 510006, P. R. China.

Chemical compositions, antioxidative, antimicrobial, anti-inflammatory, and cytotoxic activities of essential oils extracted from four common Curcuma species (Curcuma longa, Curcuma phaeocaulis, Curcuma wenyujin, and Curcuma kwangsiensis) rhizomes in P. R. China are comparatively studied. In total, 47, 49, 35, and 30 compounds are identified in C. longa, C. phaeocaulis, C. wenyujin, and C. kwangsiensis essential oils by GC/MS, and their richest compounds are ar-turmerone (21.67%), elemenone (19.41%), curdione (40.23%) and (36.47%), respectively. Moreover, C. kwangsiensis essential oils display the strongest DPPH (2,2-diphenyl-1-picrylhydrazyl) radical-scavenging activity (IC , 3.47 μg/ml), much higher than ascorbic acid (6.50 μg/ml). C. phaeocaulis oils show the best antibacterial activities against Escherichia coli (MIC, 235.54 μg/ml), Pseudomonas aeruginosa (391.31 μg/ml) and Staphylococcus aureus (378.36 μg/ml), while C. wenyujin and C. kwangsiensis oils show optimum activities against Candida albicans (208.61 μg/ml) and Saccharomyces cerevisiae (193.27 μg/ml), respectively. C. phaeocaulis (IC , 4.63 μg/ml) and C. longa essential oils (73.05 μg/ml) have the best cytotoxicity against LNCaP and HepG2, respectively. C. kwangsiensis oils also exhibit the strongest anti-inflammatory activities by remarkably down-regulating expression of COX-2 and TNF-α. Therefore, due to their different chemical compositions and bioactivities, traditional Chinese Curcuma herbs should be differentially served as natural additives for food, pharmaceutical, and cosmetic.
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http://dx.doi.org/10.1002/cbdv.201700280DOI Listing
November 2017

Distribution and diversity of twelve Curcuma species in China.

Nat Prod Res 2018 Feb 19;32(3):327-330. Epub 2017 Jul 19.

a School of Chemical Engineering and Light Industry , Institute of Natural Medicine & Green Chemistry, Guangdong University of Technology , Guangzhou , China.

Genus Curcuma a wild species presents an important source of valuable characters for improving the cultivated Curcuma varieties. Based on the collected germplasms, herbariums, field surveys and other literatures, the ecogeographical diversity of Genus Curcuma and its potential distributions under the present and future climate are analysed by DIVA-GIS. The results indicate Genus Curcuma is distributed over 17 provinces in China, and particularly abundant in Guangxi and Guangdong provinces. The simulated current distributions are close to the actual distribution regions. In the future climate, the suitable areas for four Curcuma species will be extended, while for other three species the regions will be significantly decreased, and thus these valuable resources need protecting.
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http://dx.doi.org/10.1080/14786419.2017.1350667DOI Listing
February 2018

Sound Source Localization Using Non-Conformal Surface Sound Field Transformation Based on Spherical Harmonic Wave Decomposition.

Sensors (Basel) 2017 May 10;17(5). Epub 2017 May 10.

Science and Technology on Underwater Acoustic Laboratory, Harbin Engineering University, Harbin 150001, China.

Spherical microphone arrays have been paid increasing attention for their ability to locate a sound source with arbitrary incident angle in three-dimensional space. Low-frequency sound sources are usually located by using spherical near-field acoustic holography. The reconstruction surface and holography surface are conformal surfaces in the conventional sound field transformation based on generalized Fourier transform. When the sound source is on the cylindrical surface, it is difficult to locate by using spherical surface conformal transform. The non-conformal sound field transformation by making a transfer matrix based on spherical harmonic wave decomposition is proposed in this paper, which can achieve the transformation of a spherical surface into a cylindrical surface by using spherical array data. The theoretical expressions of the proposed method are deduced, and the performance of the method is simulated. Moreover, the experiment of sound source localization by using a spherical array with randomly and uniformly distributed elements is carried out. Results show that the non-conformal surface sound field transformation from a spherical surface to a cylindrical surface is realized by using the proposed method. The localization deviation is around 0.01 m, and the resolution is around 0.3 m. The application of the spherical array is extended, and the localization ability of the spherical array is improved.
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http://dx.doi.org/10.3390/s17051087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470477PMC
May 2017

Variation in Essential Oil and Bioactive Compounds of Curcuma kwangsiensis Collected from Natural Habitats.

Chem Biodivers 2017 Jul 15;14(7). Epub 2017 Jun 15.

Institute of Natural Medicine & Green Chemistry, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, Guangdong, 510006, P. R. China.

The chemical compositions of essential oils (EOs) extracted from Curcuma kwangsiensis rhizomes collected from six natural habitats in P. R. China were evaluated using gas chromatography/mass spectrometry (GC/MS). Fifty-seven components were identified from the six EOs, and their main constituents were 8,9-dehydro-9-formyl-cycloisolongifolene (2.37 - 42.59%), germacrone (6.53 - 22.20%), and l-camphor (0.19 - 6.12%). The six EOs exhibited different DPPH radical-scavenging activities (IC , 2.24 - 31.03 μg/ml), with the activity of most of EOs being much higher than that of Trolox C (IC , 10.49 μg/ml) and BHT (IC , 54.13 μg/ml). Most EOs had potent antimicrobial effects against the tested bacteria and fungus. They also exhibited cytotoxicity against B16 (IC , 4.44 - 147.4 μg/ml) and LNCaP cells (IC , 73.94 - 429.25 μg/ml). The EOs showed excellent anti-inflammatory action by significantly downregulating expression of pro-inflammatory cytokines, cyclooxygenase-2, and tumor necrosis factor-α. This study provides insight into the interrelation among growth location, phytoconstituents, and bioactivities, and the results indicate the potential of C. kwangsiensis as natural nutrients, medicines, and others additives.
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http://dx.doi.org/10.1002/cbdv.201700020DOI Listing
July 2017

An electrokinetic route to rapid synthesis of nickel hydroxide and nickel oxide nanotubes.

J Nanosci Nanotechnol 2010 Aug;10(8):5191-5

Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China.

An electrokinetic route was developed for the synthesis of Ni(OH)2 nanotubes in the nanochannel of anodic alumina oxide (AAO) template. The nanotubes in the template were then converted to NiO nanotubes by calcination in air at 300 degrees. Uniform ordered nanotubes were obtained after selecting proper experimental conditions, such as the ionic concentration, the reaction time and the kind of nickel salts. X-ray diffraction (XRD) analysis indicated that the as-prepared Ni(OH)2 nanotubes were crystalline. Thermogravimetric analysis (TGA) was employed to determine the correlation between temperature and weight lose of the nanotubes. The transmission electron microscope (TEM) and scanning electron microscope (SEM) were used to characterize the morphology and structure of the nanotubes.
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http://dx.doi.org/10.1166/jnn.2010.2216DOI Listing
August 2010
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