Lanwei Xu

Lanwei Xu

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Lanwei Xu

Lanwei Xu

Publications by authors named "Lanwei Xu"

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29Publications

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Trib1 regulates T cell differentiation during chronic infection by restraining the effector program.

J Exp Med 2020 May;217(5)

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1084/jem.20190888DOI Listing
May 2020

TooManyCells identifies and visualizes relationships of single-cell clades.

Nat Methods 2020 Apr 2;17(4):405-413. Epub 2020 Mar 2.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41592-020-0748-5DOI Listing
April 2020

Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL.

PLoS One 2016 18;11(5):e0155408. Epub 2016 May 18.

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute of Medicine and Engineering, Institute for Immunology, Center for Personalized Diagnostics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0155408PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871414PMC
July 2017

High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia.

Blood 2016 11 26;128(18):2229-2240. Epub 2016 Sep 26.

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute of Medicine and Engineering, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; and.

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http://dx.doi.org/10.1182/blood-2016-01-692855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095757PMC
November 2016

Comparison of the expression of prognostic biomarkers between primary tumor and axillary lymph node metastases in breast cancer.

Int J Clin Exp Pathol 2015 1;8(5):5744-8. Epub 2015 May 1.

Department of Breast Surgery, Qilu Hospital of Shandong University Jinan 250012, Shandong, P. R. China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503162PMC
April 2016

Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells.

Blood 2013 Feb 31;121(6):905-17. Epub 2012 Oct 31.

Division of Hematology-Oncology and the University of Michigan Cancer Center, University of Michigan, Ann Arbor, MI, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2012-03-41
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http://dx.doi.org/10.1182/blood-2012-03-416503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567338PMC
February 2013

Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding.

Blood 2010 Dec 30;116(23):4948-57. Epub 2010 Aug 30.

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1182/blood-2009-10-247361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012589PMC
December 2010

Notch dimerization is required for leukemogenesis and T-cell development.

Genes Dev 2010 Nov 8;24(21):2395-407. Epub 2010 Oct 8.

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gad.1975210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964750PMC
November 2010

Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia.

Blood 2010 Aug 21;116(8):1321-8. Epub 2010 Apr 21.

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine & Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/blood-2009-07-229450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938240PMC
August 2010

Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.

Genes Dev 2009 Jul;23(14):1665-76

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://genesdev.cshlp.org/content/23/14/1665.full.pdf
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http://genesdev.cshlp.org/cgi/doi/10.1101/gad.1793709
Publisher Site
http://dx.doi.org/10.1101/gad.1793709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714710PMC
July 2009

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia.

J Clin Invest 2008 Sep;118(9):3181-94

Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1172/JCI35090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2491459PMC
September 2008

Potent antitumor effects of ZD6474 on neuroblastoma via dual targeting of tumor cells and tumor endothelium.

Mol Cancer Ther 2008 Feb 1;7(2):418-24. Epub 2008 Feb 1.

Department of Vascular Biology, Boston Children's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-07-0568DOI Listing
February 2008

Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia.

Cancer Cell 2006 Nov;10(5):401-11

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1016/j.ccr.2006.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839500PMC
November 2006

Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies.

Blood 2005 Dec 23;106(12):3898-906. Epub 2005 Aug 23.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, 611 BRB II/III, 421 Curie Blvd, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1182/blood-2005-01-0355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895093PMC
December 2005

Notch signaling controls the generation and differentiation of early T lineage progenitors.

Nat Immunol 2005 Jul 12;6(7):663-70. Epub 2005 Jun 12.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/ni1216DOI Listing
July 2005

Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.

Blood 2004 Sep 8;104(6):1696-702. Epub 2004 Jun 8.

Division of Hematology-Oncology, Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1182/blood-2004-02-0514DOI Listing
September 2004

Notch signaling augments T cell responsiveness by enhancing CD25 expression.

J Immunol 2003 Sep;171(6):2896-903

Departments of Medicine, Institute for Medicine and Engineering, The Abramson Family Cancer Research Institute, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.171.6.2896DOI Listing
September 2003

The biology of chronic myelogenous leukemia:mouse models and cell adhesion.

Oncogene 2002 Dec;21(56):8612-28

Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6160, USA.

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http://dx.doi.org/10.1038/sj.onc.1206089DOI Listing
December 2002

The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl.

Blood 2002 Apr;99(8):2957-68

Department of Pathology and Laboratory Medicine, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, USA.

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http://dx.doi.org/10.1182/blood.v99.8.2957DOI Listing
April 2002

Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.

Immunity 2002 Feb;16(2):231-43

Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/s1074-7613(02)00271-6DOI Listing
February 2002