Langping He

Langping He

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Langping He

Publications by authors named "Langping He"

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A novel pathogenic m.4412G>A MT-TM mitochondrial DNA variant associated with childhood-onset seizures, myopathy and bilateral basal ganglia changes.

Mitochondrion 2019 Jul 22;47:18-23. Epub 2019 Apr 22.

Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; NHS Highly Specialised Service for Rare Mitochondrial Disorders of Adults and Children, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4HH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2019.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617384PMC
July 2019

Expanding the phenotype of de novo -linked mitochondrial disease to include mild myopathy.

Neurol Genet 2018 Aug 20;4(4):e256. Epub 2018 Jul 20.

Medical Research Council Mitochondrial Biology Unit (M.S.K., E.R.S.K.), University of Cambridge, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, UK; Wellcome Centre for Mitochondrial Research (K.T., S.H., L.H., R.W.D.), Institute of Neuroscience, Newcastle University, UK; and Department of Neurology (X.R.O.), Perelman School of Medicine, Division of Neurology and Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania.

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http://dx.doi.org/10.1212/NXG.0000000000000256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055355PMC
August 2018

Confirming TDP2 mutation in spinocerebellar ataxia autosomal recessive 23 (SCAR23).

Neurol Genet 2018 08 1;4(4):e262. Epub 2018 Aug 1.

Genome Damage and Stability Centre (G.Z-V., K.W.C.), University of Sussex, Falmer, Brighton, United Kingdom; Wellcome Centre for Mitochondrial Research (F.B., K.T., L.H., R.T.), Institute of Neuroscience, Newcastle University, Tyne, United Kingdom; Sussex Drug Discovery Centre (S.W.), University of Sussex, Falmer, Brighton, United Kingdom; Department of Human Genetics (A.P.M.d.B.), Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands; and Medical Genetics (A.P.M.d.B., D.N.), Ochsner Health Center for Children, New Orleans, LA.

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http://dx.doi.org/10.1212/NXG.0000000000000262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089694PMC
August 2018

De novo variant is associated with decreased mitochondrial respiratory chain activities.

Neurol Genet 2017 Oct 22;3(5):e187. Epub 2017 Sep 22.

Wellcome Centre for Mitochondrial Research (E.W.S., C.L.A., L.H., G.F., R.M., R.W.T.), Institute of Neuroscience, Newcastle University, United Kingdom; Department of Molecular and Human Genetics (E.W.S.), Baylor College of Medicine, Houston, TX; Wellcome Centre for Mitochondrial Research (A.P.), Institute of Genetic Medicine, Newcastle University; Armistead Child Development Centre (K.N.), Kings Cross Hospital, Dundee, Scotland; Department of Clinical Neurosciences (P.F.C.), School of Clinical Medicine, University of Cambridge; and MRC Mitochondrial Biology Unit (P.F.C.), University of Cambridge, United Kingdom.

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http://dx.doi.org/10.1212/NXG.0000000000000187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610040PMC
October 2017

Impaired mitochondrial biogenesis is a common feature to myocardial hypertrophy and end-stage ischemic heart failure.

Cardiovasc Pathol 2016 Mar-Apr;25(2):103-12. Epub 2015 Sep 30.

Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Policlinico Umberto I, Viale Regina Elena 324, 00161, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.carpath.2015.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758811PMC
December 2016

Neuropathologic Characterization of Pontocerebellar Hypoplasia Type 6 Associated With Cardiomyopathy and Hydrops Fetalis and Severe Multisystem Respiratory Chain Deficiency due to Novel RARS2 Mutations.

J Neuropathol Exp Neurol 2015 Jul;74(7):688-703

From the Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne, UK (NZL, CLA, LH, GF, RM, RWT); East Anglian Medical Genetics Service, Cambridge University Hospital NHS foundations Trust, Cambridge Biomedical Campus, Cambridge, UK (KS, SP); Department of Paediatric Neurology, Addenbrooke's Hospital, Cambridge Biomedical Campus, Cambridge UK (DK); Neonatal Unit, The Rosie Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK (AO); The Centre for Fetal Care, Queen Charlotte's and Chelsea Hospital, Du Cane Road, London, UK (CL); Department of Clinical Neurosciences, Institute of Neurology, University College London, London, UK (RHK); Neurometabolic Unit, National Hospital for Neurology and Neurosurgery, London, UK (IPH); Oxford Medical Genetics Laboratories, Oxford University Hospitals NHS Trust, Oxford, UK (GKB); and Department of Histopathology, Cambridge University Hospital NHS foundations Trust, Cambridge, UK (AFD).

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http://dx.doi.org/10.1097/NEN.0000000000000209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470523PMC
July 2015

A Chinese physics institute's defense.

Authors:
Langping He

Science 2015 Apr;348(6233):405-6

Deputy Dean, Centre for Optical and Electromagnetic Research and Academy of Advanced Optoelectronics, South China Normal University, Guangzhou, Guangdong, 510006, China.

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http://dx.doi.org/10.1126/science.348.6233.405-cDOI Listing
April 2015

Clinical and molecular characteristics of mitochondrial DNA depletion syndrome associated with neonatal cholestasis and liver failure.

J Pediatr 2014 Mar 8;164(3):553-9.e1-2. Epub 2013 Dec 8.

Newcastle Mitochondrial Highly Specialized Services Diagnostic Laboratory, Wellcome Trust Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S00223476130137
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http://dx.doi.org/10.1016/j.jpeds.2013.10.082DOI Listing
March 2014

Mutation of the human mitochondrial phenylalanine-tRNA synthetase causes infantile-onset epilepsy and cytochrome c oxidase deficiency.

Biochim Biophys Acta 2014 Jan 24;1842(1):56-64. Epub 2013 Oct 24.

Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2013.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898479PMC
January 2014

Late-onset respiratory failure due to TK2 mutations causing multiple mtDNA deletions.

Neurology 2013 Dec 6;81(23):2051-3. Epub 2013 Nov 6.

From Newcastle University (C.L.A., A.M.S., P.R., K.J.K., E.L.B., L.H., K.C., R.H., D.M.T., G.S.G., R.W.T.), Newcastle upon Tyne, UK; Karolinska Institute (N.S., A.K.), Stockholm, Sweden; Hope Hospital (M.R.), Salford; and Royal Preston Hospital (A.V., J.N.), Preston, UK.

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http://dx.doi.org/10.1212/01.wnl.0000436931.94291.e6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854830PMC
December 2013

Cardiomyopathies due to homoplasmic mitochondrial tRNA mutations: morphologic and molecular features.

Hum Pathol 2013 Jul 17;44(7):1262-70. Epub 2013 Jan 17.

Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Policlinico Umberto I, Viale Regina Elena 324, 00161 Rome, Italy.

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http://dx.doi.org/10.1016/j.humpath.2012.10.011DOI Listing
July 2013

MPV17 mutation causes neuropathy and leukoencephalopathy with multiple mtDNA deletions in muscle.

Neuromuscul Disord 2012 Jul 14;22(7):587-91. Epub 2012 Apr 14.

Mitochondrial Research Group, Institute for Ageing and Health, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S09608966120009
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http://dx.doi.org/10.1016/j.nmd.2012.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387382PMC
July 2012

The clinical spectrum of the m.10191T>C mutation in complex I-deficient Leigh syndrome.

Dev Med Child Neurol 2012 Jun 27;54(6):500-6. Epub 2012 Feb 27.

Mitochondrial Research Group, Institute for Ageing and Health, Newcastle University, Newcastle Upon Tyne, UK.

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http://dx.doi.org/10.1111/j.1469-8749.2012.04224.xDOI Listing
June 2012

Maternally inherited mitochondrial DNA disease in consanguineous families.

Eur J Hum Genet 2011 Dec 29;19(12):1226-9. Epub 2011 Jun 29.

Mitochondrial Research Group and NCG Mitochondrial Laboratory, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1038/ejhg.2011.124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230363PMC
December 2011

Long-term survival of neonatal mitochondrial complex III deficiency associated with a novel BCS1L gene mutation.

Mol Genet Metab 2010 Aug 24;100(4):345-8. Epub 2010 Apr 24.

Mitochondrial Research Group, Institute for Ageing and Health, The Medical School, Newcastle University, Newcastle Upon Tyne NE2 4HH, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S109671921000174
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http://dx.doi.org/10.1016/j.ymgme.2010.04.010DOI Listing
August 2010

Somatic mitochondrial DNA deletions accumulate to high levels in aging human extraocular muscles.

Invest Ophthalmol Vis Sci 2010 Jul 17;51(7):3347-53. Epub 2010 Feb 17.

Mitochondrial Research Group, Institute for Ageing and Health, The Medical School, Newcastle University, Newcastle-upon-Tyne, United Kingdom.

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http://dx.doi.org/10.1167/iovs.09-4660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904001PMC
July 2010

Differences in RNA processing underlie the tissue specific phenotype of ISCU myopathy.

Biochim Biophys Acta 2010 Jun 4;1802(6):539-44. Epub 2010 Mar 4.

Department of Clinical Medicine, University of Bergen, Norway.

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http://dx.doi.org/10.1016/j.bbadis.2010.02.010DOI Listing
June 2010

Novel mutations in the TK2 gene associated with fatal mitochondrial DNA depletion myopathy.

Neuromuscul Disord 2008 Jul 27;18(7):557-60. Epub 2008 May 27.

Mitochondrial Research Group, The Medical School, Newcastle University, Newcastle Upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1016/j.nmd.2008.04.014DOI Listing
July 2008

The m.5650G>A mitochondrial tRNAAla mutation is pathogenic and causes a phenotype of pure myopathy.

Neuromuscul Disord 2008 Jan 6;18(1):63-7. Epub 2007 Sep 6.

Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne, England NE2 4HH, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S09608966070068
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http://dx.doi.org/10.1016/j.nmd.2007.07.007DOI Listing
January 2008

Prevalence of mitochondrial DNA disease in adults.

Ann Neurol 2008 Jan;63(1):35-9

Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://doi.wiley.com/10.1002/ana.21217
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http://dx.doi.org/10.1002/ana.21217DOI Listing
January 2008

An unusual case of congenital muscular dystrophy with normal serum CK level, external ophtalmoplegia, and white matter changes on brain MRI.

Eur J Paediatr Neurol 2007 Nov 29;11(6):381-4. Epub 2007 Mar 29.

Department of Pediatric Neurology, University Hospital and Masaryk University, Brno, Czech Republic.

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http://dx.doi.org/10.1016/j.ejpn.2007.01.010DOI Listing
November 2007

A novel Twinkle gene mutation in autosomal dominant progressive external ophthalmoplegia.

Neuromuscul Disord 2003 Sep;13(7-8):568-72

Department of Neurology, The Medical School, Framlington Place, University of Newcastle upon Tyne, NE2 4HH, Newcastle upon Tyne, UK.

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September 2003

Detection and quantification of mitochondrial DNA deletions in individual cells by real-time PCR.

Nucleic Acids Res 2002 Jul;30(14):e68

Department of Neurology, The Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC135769PMC
http://dx.doi.org/10.1093/nar/gnf067DOI Listing
July 2002