Publications by authors named "Lan Zhang"

1,308 Publications

  • Page 1 of 1

Alkali Metal Fluoride-Modified Tin Oxide for n-i-p Planar Perovskite Solar Cells.

ACS Appl Mater Interfaces 2021 Oct 14. Epub 2021 Oct 14.

Engineering Research Center of Environment-Friendly Functional Materials, Ministry of Education, Institute of Materials Physical Chemistry, Huaqiao University, Xiamen 361021, China.

The practical applications of perovskite solar cells (PSCs) are limited by further improvement of their stability and performance. Additive engineering and interface engineering are promising medicine to cure this stubborn disease. Herein, an alkali metal fluoride as an additive is introduced into the tin oxide (SnO) electron transport layer (ETL). The formation of coordination bonds of F ions with the oxygen vacancy of Sn ions decreases the trap-state density and improves the electron mobility; the hydrogen bond interaction between the F ion and amine group (FA) of perovskite inhibits the diffusion of organic cations and promotes perovskite (PVK) stability. Meanwhile, the alkali metal ions (K, Rb, and Cs) permeated into PVK fill the organic cation vacancies and ameliorate the crystal quality of PVK films. Consequently, a SnO-based planar PSC exhibits a power conversion efficiency (PCE) of 20.24%, while the PSC modified by CsF achieves a PCE of 22.51%, accompanied by effective enhancement of stability and negligible hysteresis. The research results provide a typical example for low-cost and multifunctional additives in high-performance PSCs.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.1c16519DOI Listing
October 2021

Patient characteristics and treatment utilization in fatal stimulant-involved overdoses in the ​​United States Veterans Health Administration.

Addiction 2021 Oct 14. Epub 2021 Oct 14.

Addiction Center, Department of Psychiatry, University of Michigan, Ann Arbor, MI.

Background And Aims: This study aimed to 1) describe trends in stimulant-alone and stimulant and other substance use overdose deaths from 2012 to 2018 and 2) measure patient and service use characteristics across stimulant-related overdose death profiles.

Design: Retrospective cohort study of patients who died from stimulant-involved overdose between annual years 2012 and 2018.

Setting: United States Veterans Health Administration (VHA) CASES: 3,631 patients died from stimulant-involved overdose, as identified through National Death Index.

Measurements: Stimulant-involved overdose deaths were categorized by stimulant type (cocaine or methamphetamine/other) and other substance co-involvement. Cause of death data were linked to patient characteristics including demographic and treatment use preceding overdose from VHA administrative data. We examined trends over time and compared treatment use factors between the following mutually-exclusive overdose profiles: cocaine alone, methamphetamine alone, cocaine+opioid, methamphetamine+opioid, any stimulant+other substance, and cocaine+methamphetamine.

Findings: The rate of overdose death was 3.06 times higher in 2018 than 2012, with increases across all toxicology profiles. Compared with cocaine-involved overdoses, methamphetamine-involved overdoses were less likely in people who were older (adjusted odds ratio (aOR)=0.22, 95% confidence interval (CI):0.06-0.87 aged 65+ vs. 18 to 29) and more likely among those who lived in rural areas (aOR=2.73, 95%CI:1.43-5.23). People who died from stimulant+opioid overdoses had lower odds of a stimulant use disorder diagnosis compared with stimulants alone deaths (cocaine: aOR=0.55, 95%CI:0.41-0.75, methamphetamine: aOR=0.44, 95%CI:0.29-0.68).

Conclusions: The rate of deaths among US Veterans from stimulant-related overdose was three times higher in 2018 than 2012. Key differences in characteristics of patients across overdose toxicology profiles, such as geographic location and healthcare use, point to distinct treatment needs based on stimulant use type.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/add.15714DOI Listing
October 2021

PEDF relieves kidney injury in type 2 diabetic nephropathy mice by reducing macrophage infiltration.

Endokrynol Pol 2021 Oct 14. Epub 2021 Oct 14.

Chongqing General Hospital, No.118 Xingguang Dadao, Liangjiang New District, Chongqing, China, 401147 chongqing, China.

Background: Pigment epithelium-derived factor (PEDF) is a multifunctional protein with anti-angiogenic, antioxidant and anti-inflammatory properties. PEDF is involved in the pathogenesis of diabetic retinopathy, but its exact role in diabetic kidney remains unclear. The present study aimed to investigate whether PEDF can alleviate renal damage in type 2 diabetic nephropathy mice by inhibiting macrophage infiltration.

Methods: The db/db mice were randomly divided into diabetes PEDF intervention group (DM-P78-PEDF), diabetes empty carrier intervention group (DM-Vehicle) and diabetes mellitus group (DM). Subsequently, they were injected subcutaneously P78-PEDF (0.3μg/g/d) and PBS for 6 weeks. The kidney weight to body weight ratio was observed of the rats. Automatic biochemical analyzer to determine fasting blood glucose (GLU), blood urea nitrogen (UREA), serum creatinine (CREA), hemoglobin (HGB) content. Histological and ultrastructural pathologic changes in the kidneys were examined through H&E and PAS staining. Kidney tissues levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interferon gamma (IFN-γ) were determined by ELISA. Expression of the macrophages infiltration and typing as well as that of PEDF, NF-κB, TLR4 was evaluated in the kidneys.

Results: PEDF was located in glomeruli and the expression of PEDF protein and mRNA in kidney of diabetic mice was declined significantly. Compared with diabetic mice treated with vehicle, continuous infusion of P78-PEDF could reduce blood urea nitrogen, serum creatinine (CREA), renal macrophage recruitment, inflammatory cytokines, histological changes and restore the expression of TLR4/NF-κB signaling pathway related factors in diabetic mice.

Conclusion: These findings highlight the importance of P78-PEDF peptide as a potential treatment in the occurrence and development of diabetic renal injury.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5603/EP.a2021.0085DOI Listing
October 2021

NELL1 Augments Osteogenesis and Inhibits Inflammation of Human Periodontal Ligament Stem Cells Induced by BMP9.

J Periodontol 2021 Oct 14. Epub 2021 Oct 14.

State Key Laboratory of Oral Diseases & National Clinical Research Center of Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Background: Periodontitis could lead to periodontal destruction such as the loss of alveolar bone. The issue that how to achieve the regeneration of alveolar bone and periodontal tissues under the inflammatory environment needs to be solved urgently. BMP9 is one of the most potent osteo-inductive BMPs and induces osteogenic differentiation of mesenchymal stem cells (MSCs). The aim of this study is to explore the possible effect of BMP9 on the osteogenic differentiation of inflammatory periodontal ligament stem cells (PDLSCs).

Methods: Human PDLSCs were cultured in osteo-inductive medium with 1μg/mL lipopolysaccharide Porphyromonas gingivitis (LPS-PG). Adenoviral vector expressing system was used to overexpress target genes. In vitro expression of osteogenic markers was assessed by quantitative reverse transcription PCR, western blotting, alkaline phosphatase assay, and alizarin red staining. Subcutaneous implantation nude mice models were used to evaluate the effects of BMP9 on PDLSCs in vivo. Micro-CT, H&E staining, and trichrome staining were performed to assess ectopic bone formation.

Results: In the LPS-PG induced inflammatory environment, BMP9 promoted osteogenic differentiation of PDLSCs, but upregulated the expression of inflammatory markers (P>0.05); NELL1 downregulated the expression of inflammation genes in PDLSCs induced by BMP9, while augmenting BMP9 induced osteogenesis of the cells both in vitro and in vivo. In the above process, the MAPK/p38/ERK signaling pathway was triggered by NELL1.

Conclusion: The combination use of BMP9 and NELL1 might have the potential to promote the regeneration of alveolar bone in periodontitis. This article is protected by copyright. All rights reserved.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/JPER.20-0517DOI Listing
October 2021

Detection of Metastatic Tumor Cells in the Bone Marrow Aspirate Smears by Artificial Intelligence (AI)-Based System.

Front Oncol 2021 27;11:742395. Epub 2021 Sep 27.

Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Introduction: Metastatic carcinomas of bone marrow (MCBM) are characterized as tumors of non-hematopoietic origin spreading to the bone marrow through blood or lymphatic circulation. The diagnosis is critical for tumor staging, treatment selection and prognostic risk stratification. However, the identification of metastatic carcinoma cells on bone marrow aspiration smears is technically challenging by conventional microscopic screening.

Objective: The aim of this study is to develop an automatic recognition system using deep learning algorithms applied to bone marrow cells image analysis. The system takes advantage of an artificial intelligence (AI)-based method in recognizing metastatic atypical cancer clusters and promoting rapid diagnosis.

Methods: We retrospectively reviewed metastatic non-hematopoietic malignancies in bone marrow aspirate smears collected from 60 cases of patients admitted to Zhongshan Hospital. High resolution digital bone marrow aspirate smear images were generated and automatically analyzed by AI based system. system was trained and validated using 20748 cell cluster images from randomly selected 50 MCBM patients. 5469 pre-classified cell cluster images from the remaining 10 MCBM patients were used to test the recognition performance between Morphogo and experienced pathologists.

Results: exhibited a sensitivity of 56.6%, a specificity of 91.3%, and an accuracy of 82.2% in the recognition of metastatic cancer cells. 's classification result was in general agreement with the conventional standard in the diagnosis of metastatic cancer clusters, with a Kappa value of 0.513. The test results between and pathologists H1, H2 and H3 agreement demonstrated a reliability coefficient of 0.827. The area under the curve (AUC) for to diagnose the cancer cell clusters was 0.865.

Conclusion: In patients with clinical history of cancer, the system was validated as a useful screening tool in the identification of metastatic cancer cells in the bone marrow aspirate smears. It has potential clinical application in the diagnostic assessment of metastatic cancers for staging and in screening MCBM during morphology examination when the symptoms of the primary site are indolent.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2021.742395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503678PMC
September 2021

n-type absorber by Cd doping achieves high-performance carbon-based CsPbIBr perovskite solar cells.

J Colloid Interface Sci 2021 Sep 24;608(Pt 1):40-47. Epub 2021 Sep 24.

Engineering Research Center of Environment-Friendly Functional Materials, Ministry of Education, PR China; Fujian Key Laboratory of Photoelectric Functional Materials, PR China; College of Materials Science & Engineering, Huaqiao University, Xiamen 361021, PR China. Electronic address:

High efficiency and stability have long been the key issues faced by perovskite solar cells (PSCs). It is found that the CsPbIBr all-inorganic perovskite has a suitable band gap and satisfactory stability, so it has attracted much attention. However, the many defects in the CsPbIBr film are one of the main problems hindering the improvement of power conversion efficiency (PCE) of the CsPbIBr PSCs. The substitution of trace impurities is undoubtedly a simple, cost-effective and efficient strategy. In this work, an appropriate amount of Cd (1.0% mol of Pb) is added into the CsPbIBr precursor solution to fabricate high quality CsPbIBr film with improved crystallinity, reduced trap density, suppressed photo-generated carrier recombination, displayed n-type doping and optimized energy level alignment. The corresponding carbon-based all-inorganic Cd-doped CsPbIBr PSCs achieve a maximum PCE of 10.63% with a high open circuit voltage (V) of 1.324 V, which are much higher than those of the control one with a PCE of 8.48% and an V of 1.235 V. The unencapsulated device can still retain more than 92% of the initial PCE when stored at ambient atmosphere (25 °C, relative humidity about 30%) for 40 days.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcis.2021.09.117DOI Listing
September 2021

Postpartum depression and postpartum post-traumatic stress disorder: prevalence and associated factors.

BMC Psychiatry 2021 Oct 5;21(1):487. Epub 2021 Oct 5.

Nursing Department, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, No.2699, West Gaoke Road, Pudong New Area, Shanghai, 201204, China.

Background: Despite the increased global interest from researchers in postpartum depression (PPD) and postpartum post-traumatic stress disorder (PP-PTSD), studies of PPD in China have shown a wide range of variability. Indeed, the prevalence and risk factors for PP-PTSD have received little attention in China.

Aim: To determine the prevalence of PPD and PP-PTSD in China, and to examine the relationships between a range of sociodemographic, pregnancy-related, and newborn-related variables, and PPD and PP-PTSD.

Methods: A cross-sectional study involving 1136 women who returned to the obstetrics clinic for routine postpartum examination were enrolled. The sociodemographic, pregnancy-related, and newborn-related characteristics were collected. Social support, and PPD and PP-PTSD symptoms were measured by the Perceived Social Support Scale (PSSS), the Edinburgh Postnatal Depression Scale (EPDS), and the Perinatal Post-traumatic Stress Questionnaire (PPQ).

Results: The prevalence rates of PPD and PP-PTSD symptoms were 23.5 and 6.1%, respectively. A multivariate model showed that the presence of PP-PTSD was the strongest risk factor for PPD symptoms and vice versa. Other risk factors for PPD included low sleep quality, low social support and newborn's incubator admission. In terms of PP-PTSD symptoms, risk factors included the presence of PPD symptoms, non-Han ethnicity, and low social support, while having one child was a protective factor.

Conclusions: This study addressed some gaps in the literature and provided a better understanding of PPD and PP-PTSD in China, which may contribute to early detection and intervention. Attention should be paid to women who are most susceptible to PPD and/or PP-PTSD, including those with low social support, low sleep quality, newborn's incubator admission, non-Han ethnicity, and women with siblings.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12888-021-03432-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491367PMC
October 2021

An incidental hepatic epithelioid hemangioendothelioma in a patient with chronic hepatitis: lost in the maze.

Rev Esp Enferm Dig 2021 Oct 5. Epub 2021 Oct 5.

Radiology, Gold Coast University Hospital, Australia.

A 60-year-old woman with a 20-years history of hepatitis B presented with 2 weeks of dull pain in the right upper quadrant and intermittent nausea. Abdominal MRI showed a solitary lesion in Segment VIII of the liver. It demonstrated multi-layered target appearance resembling a "maze" on diffusion-weighted image (DWI) and T2 weighted images (T2WI), and appeared as a low signal target with a hypointense core on the hepatobiliary phase. Histopathology confirmed hepatic epithelioid hemangioendothelioma (HEHE). Our case showed a solitary hepatic lesion with as many as six layers and overall appearances are more like a "maze", which was a diagnostic challenge. However, this maze-like manifestation actually makes hepatocellular carcinoma as the main differentials being very unlikely. Other differential diagnosis such as metastasis,cholangiocarcinoma or atypical hemangioma are also unlikely to show more than three layers. Core pattern, regarded as a noval imaging feature of HEHE, is different from general features of hepatocellular carcinoma or cholangiocarcinoma. Our case highlights that HEHE needs to be taken into consideration when a multi-layer appearing hepatic lesion is found incidentally in the cirrhotic liver.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.17235/reed.2021.8322/2021DOI Listing
October 2021

Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer.

J Med Chem 2021 Oct 3;64(19):14192-14216. Epub 2021 Oct 3.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.

Sirtuin-3 (SIRT3) is an NAD-dependent protein deacetylase localized primarily in the mitochondria with many links to different types of human cancers. Autophagy, which is a highly conserved lysosomal degradation process in eukaryotic cells, has been recently reported to be positively regulated by SIRT3 in cancer; therefore, activating SIRT3-modulated autophagy may be a promising strategy for drug discovery. In this study, we discovered a small-molecule activator of SIRT3 compound (ADTL-SA1215) with specific SIRT3 deacetylase activity by structure-guided design and high-throughput screening. Subsequently, compound inhibited the proliferation and migration of human breast carcinoma MDA-MB-231 cells by SIRT3-driven autophagy/mitophagy signaling pathways and Collectively, these results demonstrate that pharmacological activation of SIRT3 is a potential therapeutic approach of triple negative breast cancer (TNBC). More importantly, compound may be a first-in-class specific small-molecule activator of SIRT3 that would be utilized for future cancer drug development.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.0c02268DOI Listing
October 2021

Identification of Sitogluside as a Potential Skin-Pigmentation-Reducing Agent through Network Pharmacology.

Oxid Med Cell Longev 2021 23;2021:4883398. Epub 2021 Sep 23.

Department of Dermatology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.

Many traditional Chinese medicines (TCMs) with skin-whitening properties have been recorded in the and in folk prescriptions, and some literature confirms that their extracts do have the potential to inhibit pigmentation. However, no systematic studies have identified the specific regulatory mechanisms of the potential active ingredients. The aim of this study was to screen the ingredients in TCMs that inhibit skin pigmentation through a network pharmacology system and to explore underlying mechanisms. We identified 148 potential active ingredients from 14 TCMs, and based on the average "degree" of the topological parameters, the top five TCMs (, , , , and ) that were most likely to cause skin-whitening through anti-inflammatory processes were selected. Sitogluside, the most common ingredient in the top five TCMs, inhibits melanogenesis in human melanoma cells (MNT1) and murine melanoma cells (B16F0) and decreases skin pigmentation in zebrafish. Furthermore, mechanistic research revealed that sitogluside is capable of downregulating tyrosinase (TYR) expression by inhibiting the ERK and p38 pathways and inhibiting TYR activity. These results demonstrate that network pharmacology is an effective tool for the discovery of natural compounds with skin-whitening properties and determination of their possible mechanisms. Sitogluside is a novel skin-whitening active ingredient with dual regulatory effects that inhibit TYR expression and activity.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1155/2021/4883398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483913PMC
September 2021

Potential relationship between clinical symptoms and the root canal microbiomes of root filled teeth based on the next-generation sequencing.

Int Endod J 2021 Sep 30. Epub 2021 Sep 30.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases &, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Sichuan, China.

Aim: To detemine the microorganism in root canal systems of root filled teeth with periapical disease and their relationship with clinical symptoms using next-generation sequencing (NGS).

Methodology: The roots of 10 extracted teeth were collected from ten patients who presented with post-treatment apical periodontitis (6 with symptoms and 4 without symptoms). Each root was divided horizontally into two parts (apical and coronal segments) and cryo-pulverized. Microbial communities were detected using 16S rDNA hypervariable V3-V4 region. The diversity, principal coordinate analysis (PCoA) and linear discriminant analysis effect size (LEfSe) were performed in the symptomatic and asymptomatic groups (apical and coronal parts, respectively). A Mann-Whitney test and an analysis of similarities were applied for intergroup analysis, at a significance level of 5%.

Results: A total of 23 phyla, 257 genera, and 425 species were detected. Firmicutes was the most abundant phylum in all samples. Three phyla (Fusobacteria, Synergistetes and unidentified_Bacteria) and seven genera (Fusobacterium, Porphyromonas, Phocaeicola, Olsenella, Campylobacter, Tannerella and Fretibacterium) were significantly more abundant in the symptomatic patients (P < 0.05), whereas asymptomatic patients had more Sphingomonas. The species more significantly abundant in the symptomatic samples were Porphyromonas gingivalis, Phocaeicola abscessus, Campylobacter showae, Tannerella forsythia and Olsenella uli (P < 0.05).

Conclusions: A higher microbial diversity was observed in root filled teeth with post-treatment apical periodontitis compared to earlier reports. Several genera and species in root canal systems might be associated with clinical symptoms of post-treatment apical periodontitis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/iej.13640DOI Listing
September 2021

Relationships Among CEO Narcissism, Debt Financing and Firm Innovation Performance: Emotion Recognition Using Advanced Artificial Intelligence.

Front Psychol 2021 13;12:734777. Epub 2021 Sep 13.

School of Accounting, Jilin University of Finance and Economics, Changchun, Jilin, China.

Psychological research shows that as the main component of enterprise decision-making, CEOs are not completely rational, cognitive and psychological biases often influence their decision-making process. CEO narcissism has gradually attracted academic attention. Based on upper echelon theory and subconscious theory, this paper uses advanced artificial intelligence technology to quantify CEO narcissism as a kind of emotional intelligence. Taking A-share listed companies in China from 2010 to 2019 as research objects, this paper empirically tests the impact of CEO narcissism on debt financing and innovation performance. The results show that CEO narcissism has a significant positive impact on firm innovation performance. Debt financing plays a mediating role in the relationship between CEO narcissism and firm innovation performance. CEO narcissism can have a positive impact on firm innovation performance through debt financing. Compared with non-SOEs, SOEs' CEO narcissism has a more significant positive effect on debt financing and enterprise innovation performance. The research in this paper enriches psychology and organizational management and provides a reference for an enterprise's management decisions and for investors' investment decisions.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpsyg.2021.734777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473637PMC
September 2021

c-Myb facilitates immune escape of esophageal adenocarcinoma cells through the miR-145-5p/SPOP/PD-L1 axis.

Clin Transl Med 2021 Sep;11(9):e464

Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P. R. China.

Esophageal adenocarcinoma (EAC), a subtype of esophageal carcinoma, is a severe health problem associated with high death rate and poor prognosis. Immunotherapy has proven to be effective in many solid tumors, including EAC, but immune escape blocks its effectiveness. Thus, we explored the mechanisms and functional role of c-Myb in immune escape of EAC cells. Clinical EAC tissues were collected for determining the expression of c-Myb, speckled POZ protein (SPOP), and miR-145-5p. Functional assays were then performed to detect the interactions between c-Myb and SPOP as well as between SPOP and miR-145-5p. EAC cell invasion and migration were assessed. Next, T cells were sorted and cocultured with EAC cells with different treatments followed by detection of T-cell viability. In addition, a mouse model of EAC was constructed for relevant in vivo assays. c-Myb and miR-145-5p were highly expressed and SPOP had low expressions in EAC. c-Myb activated the transcription of miR-145-5p, which in turn targeted SPOP. Further, SPOP accelerated the ubiquitination of PD-L1 to enhance its expression. Overexpression of PD-L1 suppressed T-cell functions and promoted proliferative and migrative abilities of EAC cells to induce immune escape. The above findings were also confirmed in the ECA mouse model in vivo. Our findings uncovered that c-Myb can promote the immune escape of EAC cells by favoring the transcription of miR-145-5p and inhibiting SPOP-dependent ubiquitination and degradation of PD-L1, thus, presenting new target for EAC adjunct therapy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/ctm2.464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473478PMC
September 2021

Enhancing efficiency of perovskite solar cells from surface passivation of Co doped CuGaO nanocrystals.

J Colloid Interface Sci 2021 Sep 21;607(Pt 2):1280-1286. Epub 2021 Sep 21.

Engineering Research Center of Environment-Friendly Functional Materials, Ministry of Education, Fujian Key Laboratory of Photoelectric Functional Materials and College of Materials Science & Engineering, Huaqiao University, Xiamen 361021, PR China. Electronic address:

Before completely applying inorganic materials as hole transport materials (HTM) for perovskite solar cells (PSCs), modifying devices with inorganic oxides that have the potential as inorganic hole transporters is an effective way to improve device performance and stability. Co doped CuGaO nanocrystals (Co-CuGaO NCs) with sizes about 20 nm are synthesized by hydrothermal method and used for surface passivation at the interface of perovskite (PVK)/2,2',7,7'-Tetrakis[N,N-di (4-methoxyphenyl) amino]-9,9'-spirobifluorene (spiroOMeTAD). Co-CuGaO NCs have a larger bandgap with lower valance band compared with spiroOMeTAD, which is more beneficial to the conduction of holes and the blocking of electrons. Furthermore, the Co-CuGaO has a lower valance band energy compared with the original CuGaO, which reduces the energy gap between Co-CuGaO and PVK. Co-CuGaO NCs fully cover the upper surface of PVK, which helps prevent direct contact between PVK and oxygen and moisture. The Co-CuGaO NCs surface passivation also gives better hole transport as revealed by the ultraviolet photoelectron spectroscopy (UPS), steady-state photoluminescence (PL), and time-resolved photoluminescence (TRPL) data. When the concentration of Co-CuGaO NCs solution is set to 7.5 mg mL, the device exhibits a best PCE of 20.39% and maintains 84.34% of the initial power conversion efficiency (PCE) after stored 30 days under air atmosphere with 15 ± 5% humidity.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcis.2021.09.102DOI Listing
September 2021

In situ room-temperature rapidly fabricated imine-linked covalent organic framework coated fibers for efficient solid-phase microextraction of pyrethroids.

Anal Chim Acta 2021 Oct 28;1181:338886. Epub 2021 Jul 28.

Key Laboratory for Analytical Science of Food Safety and Biology (Ministry of Education & Fujian Province), College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China. Electronic address:

A facile and rapid strategy for preparation of covalent organic framework (COF) coated fibers at ambient temperature is urgently needed for solid-phase microextraction (SPME) technology. In this work, an in situ room-temperature rapid growth strategy was developed to high-efficiently fabricate imine-linked COF (TPB-DVA) coated fibers in as little as 30 min at room temperature, and the thickness of the coating reached 9 μm. The prepared TPB-DVA coated fiber offer high thermal and chemical stability, and outstanding service lifetime. Moreover, we generalize this strategy to other two imine-linked COF (TPB-DMTP and TFPB-TAPB) coated fibers and the fibers were fabricated at room temperature for 3 h and 12 h, respectively, which demonstrate the applicability of this strategy. Subsequently, a SPME-GC-MS/MS analytical method was developed for trace pyrethroids (PYs) detection, which exhibited high enhancement factors (EFs, 2700-13195), wide linear range (0.08-800 ng L), low limits of detection (LODs, 0.02-0.20 ng L), and good repeatability (RSD ≤ 8.5%, n = 6). Furthermore, the developed analytical method was applied to tea samples and trace PYs (1.31-4.32 ng L) were found with satisfactory recovery (80.2-119.8%). The above results demonstrated that the feasibility of the developed strategy for the facile and rapid fabrication of imine-linked COF coated fibers.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.aca.2021.338886DOI Listing
October 2021

Building biointegration of FeO-FeOOH coated titanium implant by regulating NIR irradiation in an infected model.

Bioact Mater 2022 Feb 29;8:1-11. Epub 2021 Jun 29.

State-key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China.

Killing bacteria, eliminating biofilm and building soft tissue integration are very important for percutaneous implants which service in a complicated environment. In order to endow Ti implants with above abilities, multifunctional coatings consisted of FeO-FeOOH nanograins as an outer layer and Zn doped microporous TiO as an inner layer were fabricated by micro-arc oxidation, hydrothermal treatment and annealing treatment. The microstructures, physicochemical properties and photothermal response of the coatings were observed; their antibacterial efficiencies and cell response as well as biofilm elimination and soft tissue integration were evaluated. The results show that with the increased annealing temperature, coating morphologies didn't change obviously, but lattices of β-FeOOH gradually disorganized into amorphous state and rearranged to form FeO The coating annealed at 450 °C (MA450) had nanocrystallized FeO and β-FeOOH. With a proper NIR irradiation strategy, MA450 killed adhered bacteria efficiently and increased fibroblast behaviors via up-regulating fibrogenic-related genes ; in an infected model, MA450 eliminated biofilm, reduced inflammatory response and improved biointegration with soft tissue. The good performance of MA450 was due to a synergic effect of photothermal response and released ions (Zn and Fe).
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bioactmat.2021.06.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424078PMC
February 2022

Effect of high-quality nursing on negative emotions and hope levels of patients undergoing oral and maxillofacial surgery.

Am J Transl Res 2021 15;13(8):9722-9728. Epub 2021 Aug 15.

Department of Head and Neck Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute Shenyang, Liaoning Province, China.

Objective: To investigate the effect of high-quality nursing on negative emotions and hope levels after oral and maxillofacial surgery (OMS).

Methods: A prospective study involving 120 patients who underwent OMS from December 2018 to January 2020 was conducted. The study subjects were classified into a study group and control group with 60 in each, using a random number table. Routine nursing was applied in the control group, while the study group was given high-quality nursing. Psychological status, hope levels, quality of life (QOL), complications and satisfaction rate were compared between patients in the two groups before and after intervention.

Results: After intervention, the scores of HAMA (Hamilton Anxiety Rating Scale) and HAMD (Hamilton Depression Rating Scale) of the two groups were both significantly reduced, and the decrease was significantly greater in the study group (all P<0.05). After intervention, the scores of Herth Hope Index (HHI) and Generic quality of life Inventory-74 (GQOLI-74) in the two groups were both elevated, and the increase was significantly greater in the study group (all P<0.01). As compared with the control group, the total incidence of complications in study group was significantly lower (P=0.04), while the satisfaction rate with nursing was higher (P=0.032).

Conclusion: High-quality nursing, with low incidence of complications and high overall satisfaction rate, can significantly relieve adverse emotions and promote QOL after OMS.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430088PMC
August 2021

Liquid Organic Fertilizer Amendment Alters Rhizosphere Microbial Community Structure and Co-occurrence Patterns and Improves Sunflower Yield Under Salinity-Alkalinity Stress.

Microb Ecol 2021 Sep 18. Epub 2021 Sep 18.

College of Natural Resources and Environment, Northwest A&F University, 3 Taicheng Road, Yangling, Xianyang, 712100, Shaanxi, People's Republic of China.

Response of rhizosphere microbial community structure and co-occurrence patterns to liquid organic fertilizer in sunflower cropland was investigated. Moderate and severe saline-alkaline soils were treated with liquid organic fertilizer containing mainly small molecular organic compounds (450 g L) at a rate of 4500 L ha year over 2 years. Compared with the untreated soils, organic fertilizer treatment increased soil nutrient concentrations by 13.8-137.1% while reducing soil pH and salinity by 5.6% and 54.7%, respectively. Organic fertilizer treatment also improved sunflower yield, plant number, and plant height by 28.6-67.3%. Following organic fertilizer treatment, fungal α-diversity was increased, and the effects of salinity-alkalinity stress on rhizosphere microbial communities were alleviated. The relative abundances of some halotolerant microbes and phytopathogenic fungi were reduced in organic fertilizer-treated soils, in contrast to increases in the relative abundances of plant growth-promoting microbes and organic matter decomposers, such as Nocardioides, Rhizophagus, and Stachybotrys. Network analysis revealed that severe salinity-alkalinity stress stimulated cooperation among bacteria, while organic fertilizer treatment tended to stimulate the ecosystem functions of fungi with higher proportions of fungi-bacteria and fungi-fungi links. More keystone taxa (e.g., Amycolatopsis, Variovorax, and Gemmatimonas) were positively correlated with soil nutrient concentrations and crop yield-related traits in organic fertilizer-treated soils. Overall, liquid organic fertilizer amendment could attenuate the adverse effects of salinity-alkalinity stress on sunflower yield by improving soil quality and optimizing rhizosphere microbial community structure and co-occurrence patterns.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00248-021-01870-0DOI Listing
September 2021

pH and charge reversal-driven nanoplatform for efficient delivery of therapeutics.

Colloids Surf B Biointerfaces 2021 Sep 14;208:112106. Epub 2021 Sep 14.

Henan Engineering Technology Research Center of Ultrasonic Molecular Imaging and Nanotechnology, Zhengzhou City, China; Department of Ultrasound, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou City, China. Electronic address:

Nanomedicine which delivers therapeutics to tumours holds great potential for cancer treatment. However, endosomal trapping and uncontrollable release usually limit the efficiency of nanomedicine. Herein, a smart mesoporous silica based nanoplatform was constructed, in which mesoporous silica nanoparticles (MSNs) serve as the core, capped with pH-induced charge-reversal polymer -PAH-cit- and cationic polyelectrolyte polyethyleneimine (PEI). The oppositely charged polymer can not only act as a gatekeeper for controlled release, but also mediated efficient endosomal escape of the therapeutics. Under the acidic endosomal environment, the hydrolysis of acid-cleavable bonds in PAH-Cit would trigger the charge reversal and endosomal escape of the nanoplatform for efficient drug release. Furthermore, the prepared nanoplatform demonstrated a higher tumor cell proliferation inhibition rate than free theruputics in vitro assays and significantly inhibited tumour growth in the 4T1 tumour model in mice. Therefore, our strategy offers a simple and general nanoplatform to delivery therapeutics to tumours with efficient endosomal escape and controlled release.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.colsurfb.2021.112106DOI Listing
September 2021

Enhanced photovoltage and stability of perovskite photovoltaics enabled by a cyclohexylmethylammonium iodide-based 2D perovskite passivation layer.

Nanoscale 2021 Sep 17;13(35):14915-14924. Epub 2021 Sep 17.

Fujian Institute of Research on Structure Matter, CAS, Xiamen 361021, Fujian, China.

Regardless of the impressive progress that perovskite solar cells (PSCs) have achieved, especially considering their power conversion efficiency (PCE) over 25%, traditional PSCs still contend with an inherent instability with exposure to humidity, which remains as a critical issue for the realization of commercial production. Herein, we proposed an effective pathway to relieve the instability of PSCs without sacrificing efficiency by introducing a 2D phase at the surface of the 3D perovskite film, based on a novel organic cyclohexylmethylammonium iodide (CMAI). The self-assembled thin 2D capping layer atop the 3D perovskite layer can not only reduce the ionic defects, but also serve as a protective barrier against moisture. Consequently, the champion device incorporating 2D perovskite capping layers delivered an open-circuit voltage () of 1.19 V, which contributes to an impressive PCE of 22.06% on account of the improved charge extraction and decreased non-radiative recombination. More importantly, an excellent long-term stability along with mitigated hysteresis was observed for the modified devices as a result of the suppressed ion migration and high humidity resistance of the 2D perovskite film. Our finding provides a comprehensive approach for simultaneously enhancing the efficiency and stability of PSCs through dimension engineering utilizing CMA-based 2D perovskite materials.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/d1nr03624fDOI Listing
September 2021

A comparative study of three stomatal conductance models for estimating evapotranspiration in a dune ecosystem in a semi-arid region.

Sci Total Environ 2021 Aug 26;802:149937. Epub 2021 Aug 26.

Department of Biological and Agricultural Engineering, Texas A&M University, College Station, TX 77843, USA.

The accurate simulation of stomatal conductance is crucial for not only revealing the carbon and water cycle processes of an ecosystem, but also to improve the accuracy of simulations of evapotranspiration (ET). This study coupled three stomatal conductance models, i.e. the Stannard (ST), Jarvis-Stewart (JS), and Ball-Berry (BB) models, with the Shuttleworth-Wallace (SW) model to estimate ET for a mobile dune ecosystem in the Horqin Sandy Land, North China. These models were calibrated and validated using eddy covariance (EC) measurements taken during the growing season between 2013 and 2018. The results indicated that the SW-BB model showed better performance in comparison to the SW-JS and SW-ST models at half-hourly and daily timescales. The stomatal conductance models incorporating soil moisture (SM) content generally showed better performance during the extreme drought period, with the rank of the three models according to performance being: SW-BB > SW-JS > SW-ST. The models showed the highest sensitivity to SM when incorporating the effect of SM on stomatal conductance, indicating that SM has an important effect on stomatal conductance and ET. The results of this study indicate that of the models assessed, the Ball-Berry stomatal conductance model coupled with the SW model is optimal for estimating ET in dune ecosystems with sparse vegetation.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2021.149937DOI Listing
August 2021

Development of a Prognostic Scoring System for Hepatocellular Carcinoma Patients With Main Portal Vein Tumor Thrombus Undergoing Conventional Transarterial Chemoembolization: An Analysis of 173 Patients.

Front Oncol 2021 26;11:671171. Epub 2021 Aug 26.

Department of Hepatic Oncology, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: Patients with hepatocellular carcinoma (HCC) with main portal vein tumor thrombus (mPVTT) have poor prognosis. Promising systemic therapies, such as target therapies, have limited benefits. The purpose of this study is to retrospectively evaluate the benefits of conventional TACE (c-TACE) and to establish a prognostic stratification of HCC patients with mPVTT.

Methods: This is a single center retrospective study conducted over 5 years (duration of performing c-TACE), on consecutive HCC patients with mPVTT receiving c-TACE. Univariable and multivariable analysis were used to explore factors independently associated with overall survival (OS). Based on Cox-regression analysis, prognostic models were developed and internally validated by bootstrap methods. Discrimination and performance were measured by Akaike information criterion, concordance index, and likelihood ratio test.

Results: A total of 173 patients were included. Median OS was 6.0 months (95%CI: 3.92~8.08). The independent variables correlated with survival were largest tumor diameter, tumor number, mPVTT extension, and AFP. In the final model, patients were assigned 2 points if largest tumor diameter ≥8 cm, or tumor number ≥2, 1point if main trunk was complete obstructed, or AFP ≥400 ng/ml. By summing up these points, patients were divided into three risk groups according to the score at the 15rd and 85th percentiles, in which median OS were 18, 7, and 3.5months, respectively (p<0.001). The model shown optimal discrimination, performance, and calibration.

Conclusions: c-TACE could provide survival benefits in HCC patients with mPVTT and the proposed prognostic stratification may help to identify good candidates for the treatment, and those for whom c-TACE may be futile.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2021.671171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427599PMC
August 2021

Tetrahydroxy stilbene glycoside regulates TGF-β/fractalkine/CX3CR1 based on network pharmacology in APP/PS1 mouse model.

Neuropeptides 2021 Sep 4;90:102197. Epub 2021 Sep 4.

Department of Pharmacy, Xuanwu Hospital of Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing Engineering Research Center for Nervous System Drugs, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China. Electronic address:

Alzheimer's disease (AD) is a serious, progressive neurodegenerative disease that involves irreversible neuronal death. Tetrahydroxy stilbene glycoside (TSG) is an active compound extracted from P. multiflorum, a traditional Chinese herbal medicine, but its role in neuroprotection is unclear. Herein, we aimed to validate the effects of TSG on APP/PS1 model mice and the underlying mechanism. RNA-seq was performed to identify differentially expressed genes in APP/PS1 mouse, with PCR and immunohistochemistry used for validation. Experiments were performed after bioinformatic analysis for verification. Neuronal damage was observed by H&E staining. Key proteins involved in the pathway such as CX3CR1, Iba1 and TGF-β were examined by immunohistochemical analysis. The KEGG analysis suggested that these genes might act by multiple pathways to build the pharmacological network of TSG in AD progression. These data provide the credible evidence that TSG improved neuronal damage and regulated neuroprotective mechanisms. Together, our work has detailed the whole and major genes in APP/PS1 model mouse regulated by TSG, and highlighted the anti-inflammatory function of TSG in mediating CX3CR1 and TGF-β as the TGF-β/fractalkine/CX3XR1 signaling pathway, especially in microglia. Moreover, TSG has potential value in synaptic transmission and neurotrophic action on neurodegenerative diseases. In summary, TSG is a promising candidate for preventing and treating the progression of AD.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.npep.2021.102197DOI Listing
September 2021

Management of unexpected difficult airway in perioperative period: A case report.

Authors:
Man Li Lan Zhang

Asian J Surg 2021 Sep 6. Epub 2021 Sep 6.

Department of Anesthesia, Sichuan Provincial Orthopedic Hospital (Chengdu Sports Hospital and Chengdu Research Institute for Sports Injury), Chengdu, China. Electronic address:

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.asjsur.2021.08.041DOI Listing
September 2021

The effect of rainfall runoff on phase partition of palladium in receiving water bodies and the underlying influential mechanism.

Chemosphere 2021 Aug 31;287(Pt 2):132109. Epub 2021 Aug 31.

College of Geography and Environmental Science, Hainan Normal University, Haikou, Hainan, 571158, China; Key Laboratory of Earth Surface Processes and Environmental Change of Tropical Islands, Hainan Province, China.

The influx of rainfall runoff intensifies phase partition of the pollutant in receiving water bodies, and the phase partition plays an important role in the speciation transformation and spatial partition of pollutants. In this study, the Meishe River on Hainan Island, China, was adopted as the research area, and palladium (Pd) was selected as the target pollutant. The purpose of this study was to explore phase partition of Pd in receiving water bodies and the underlying influential mechanism. The partition coefficients (Ks) of Pd between water and suspended particulate matter in receiving water bodies and rainfall runoff were 0.74 (0.1 × 10 - 8.75) and 2.74 (0.5 × 10 - 15.70), respectively. These results indicated that Pd dominated the dissolved phase in the receiving water bodies and that Pd dominated the particulate phase in rainfall runoff. Variations in the K value of Pd in the receiving water bodies were relatively smooth over time during the precipitation events in May and June. There were no significant differences in phase partition of Pd between the receiving water bodies and rainfall runoff. The K value for Pd in the receiving water bodies showed a fluctuating upward trend over time during the precipitation events in August, and the difference in K values of Pd between the receiving water bodies and the rainfall runoff were large. Variations in the K value of Pd among sections of the receiving water bodies could be roughly divided into two categories, namely, U and inverted-U types. After rainfall runoff converged for 20-25 min, the Pd phase transitions were more frequent within 7 m downstream of the outfall. The K value of Pd in the receiving water bodies was correlated with pH, Eh, and total suspended solid (TSS), and the correlation coefficients were 0.52, -0.57, and 0.84, respectively (p < 0.05). Compared with rainfall runoff, pH, Eh, TSS had less influence on phase partition of Pd in receiving water bodies. This might be attributed to the dilution effect of natural water and the unique dynamic mechanism of rivers.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2021.132109DOI Listing
August 2021

The Influence Mechanism of Information Interaction on Value Cocreation Based on the Smart Healthcare Context.

J Healthc Eng 2021 27;2021:8778092. Epub 2021 Aug 27.

School of Accounting, Jilin University of Finance and Economics, Changchun 130017, Jilin, China.

In recent years, the Chinese government has issued a series of deepening reform policies around smart healthcare, established a diversified technical basis and environmental protection, and deeply excavated the derivative value of healthcare information, aiming to provide high-quality healthcare services for patients. Information interaction in the context of smart healthcare is a kind of health information interaction completed by users with smart healthcare applications as the hub. It is an application form of social behavior and has an impact on value cocreation. Based on the theory of information interaction and value cocreation, this paper systematically reviews the research on information interaction and value cocreation in the smart healthcare context, analyzes the information interaction mode and information interaction mechanism in the smart healthcare context, constructs a theoretical model of the impact of information interaction on value cocreation, and empirically tests the relationship between information interaction and value cocreation in the smart healthcare context. The research of this paper aims to provide high-quality information interaction services for smart healthcare users, promote the dimensional management of information behavior in the context of smart healthcare, and promote the continuous improvement of the operation and management of smart healthcare.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1155/2021/8778092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418551PMC
August 2021

[Research progress in application of metal-organic framework-derived materials to sample pretreatment].

Se Pu 2021 Sep;39(9):941-949

Minjiang Teachers College, Fuzhou 350108, China.

Sample pretreatment technology plays a vital role throughout the analysis of complex samples. Sample pretreatment can not only increase the concentration of trace targets in the sample, but also effectively eliminate interference from the sample matrix in instrumental analysis. Adsorbent materials are a key component of sample pretreatment technology. Therefore, the development of efficient and stable new adsorbent materials has acquired significance in research on pretreatment technology. Porous materials are advantageous for use in diverse applications, such as in adsorbents, when they possess controllable nanostructures, a tailored pore surface chemistry, and abundant porosity, and are inexpensive. Particularly in recent years, porous materials derived from metal-organic frameworks (MOFs) feature excellent properties, such as diverse morphology and structure, adjustable pore size, high specific surface area, good thermal stability, and chemical resistance. MOF-derived materials, when used as adsorbents for sample pretreatment, offer the following advantages: (1) The porous materials derived from MOFs typically possess a larger specific surface area than other porous materials. This characteristic is beneficial to improve the extraction capacity and extraction efficiency via an increase in the contact area between the materials and targets; (2) The microscopic porous structure of MOF-derived materials can be easily tuned (by controlling the temperature and time during pyrolysis, gas atmosphere, and heating rate), which is conducive to improve the selectivity of sample pretreatment methods; (3) The metal active sites can be evenly distributed. Owing to the ordered distribution of metal ions in the precursor MOFs and a good periodic framework structure, the metal active sites of the derivatives formed can still maintain a corresponding distance. These metal active sites will not form agglomerates and affect the extraction performance; conversely, other porous materials often require extremely complicated processes to achieve a uniform distribution; (4) Heteroatoms such as nitrogen and sulfur can be easily doped on the framework of MOF-derived porous materials. This doping enables the materials to induce additional interactions such as hydrogen bonding and stacking for adsorbing target analytes. The excellent properties of MOF-derived materials make them promising for use in sample pretreatment. Novel sample pretreatment methods that use MOF-derived materials are constantly being developed. However, the use of MOF-derived materials is limited by the complex preparation process and high production cost of MOF precursors, along with difficulties in mass production. Further, the precise design or functionalization of MOF-derived materials according to the characteristics of targets is a new direction with immense challenges as well as application potential. This review summarizes the application of MOF-derived materials in sample pretreatment methods, including dispersive solid phase extraction (dSPE), magnetic solid phase extraction (MSPE), solid phase microextraction (SPME), stir bar sorptive extraction (SBSE), and dispersive micro solid phase extraction (DMSPE). The preparation methods, functional control, and enrichment efficiencies of various MOF-derived materials are also reviewed. Finally, the application prospects of MOF-derived materials in sample pretreatment are discussed to provide a clear outlook and reference for further related research.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3724/SP.J.1123.2021.05017DOI Listing
September 2021

Cornel Iridoid Glycoside Ameliorated Alzheimer's Disease-Like Pathologies and Necroptosis through RIPK1/MLKL Pathway in Young and Aged SAMP8 Mice.

Evid Based Complement Alternat Med 2021 23;2021:9920962. Epub 2021 Aug 23.

Department of Pharmacy, Xuanwu Hospital of Capital Medical University, National Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Beijing Engineering Research Center for Nervous System Drugs, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China.

Background: Aging is an important risk factor for sporadic Alzheimer's disease (AD) and other neurodegenerative diseases. Senescence-accelerated mouse-prone 8 (SAMP8) is used as an animal model for brain aging and sporadic AD research studies. The aim of the current study was to investigate the pharmacological effects of cornel iridoid glycoside (CIG), an active ingredient of , on AD-type pathological changes in young and aged SAMP8 mice.

Methods: Locomotor activity test was used to detect the aging process of SAMP8 mice. Nissl staining and immunohistochemical staining were applied to detect neurons and myelin basic protein-labelled myelin sheath. Western blotting was used to detect the expression levels of related proteins of synapse, APP processing, and necroptosis.

Results: The results showed that SAMP8 mice at the age of 6 and 14 months exhibited lower locomotor activity, age-related neuronal loss, demyelination, synaptic damage, and APP amyloidogenic processing. In addition, the increased levels of receptor-interacting protein kinase-1 (RIPK1), mixed lineage kinase domain-like protein (MLKL), and p-MLKL indicating necroptosis were found in the brain of SAMP8 mice. Intragastric administration of CIG for 2 months improved locomotor activity; alleviated neuronal loss and demyelination; increased the expression of synaptophysin, postsynaptic density protein 95, and AMPA receptor subunit 1; elevated the levels of soluble APP fragment and disintegrin and metalloproteinase 10 (ADAM10); and decreased the levels of RIPK1, -MLKL, and MLKL in the brain of young and aged SAMP8 mice.

Conclusion: This study denoted that CIG might be a potential drug for aging-related neurodegenerative diseases such as AD.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1155/2021/9920962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407981PMC
August 2021

Predicting the different progressions of early pressure injury by ultraviolet photography in rat models.

Int Wound J 2021 Sep 1. Epub 2021 Sep 1.

Device Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.

Early pressure injury (PI) can result in either spontaneous healing (SH) or deterioration into ulcer (DU). However, determining whether PI will progress into SH or DU on the basis of non-blanchable erythema only is difficult. In this study, we constructed two animal PI models to mimic SH and DU injuries and observed haemorrhage by using ultraviolet (UV) photography to develop potential clinical indicators for predicting the progression of early PI. Macroscopy, UV photography, and skin temperature observations were obtained. In the SH group, macroscopic observation showed the erythema was obvious at 0.5 hours after decompression and faded gradually had almost disappeared at 72 hours. In the DU group, the erythema persisted, and an erosion appeared at 24 hours after decompression and expanded at 36 hours. The erythema developed into an obvious ulcer at 48 hours and enlarged at 72 hours. The obvious ulcer found at 48 hours through macroscopic observation was clearly visible at 36 hours with UV photography, and a significant difference in grey values between the two groups was found at as early as 18 hours (P < .05). This study provided evidence showing that UV photography can predict the different progression stages of early PI. Additionally, when combined with the transparent disc method, UV photography also can be used to identify the circulatory disorders of early PI, such as haemorrhage or hyperaemia and even congestion.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/iwj.13681DOI Listing
September 2021

Antibiotic Use in Neonatal Intensive Care Units in China: A Multicenter Cohort Study.

J Pediatr 2021 Aug 28. Epub 2021 Aug 28.

Department of Neonatology, Children's Hospital of Fudan University, Shanghai, China. Electronic address:

Objective: To provide national-level antibiotic use data from Chinese neonatal intensive care units to inform future antimicrobial stewardship using a large contemporary cohort of preterm infants in China.

Study Design: This retrospective cohort study enrolled all infants less than 34 weeks of gestation admitted to 25 tertiary neonatal intensive care units across China between May 1, 2015, and April 30, 2018. The antibiotic use rate (AUR) was defined as the number of days an infant was prescribed with 1 or more antibiotics divided by the total length of hospital stay.

Results: Among 24 597 eligible infants, 21 736 (88.4%) infants received antibiotics. The median AUR was 441 per 1000 patient-days (IQR, 242-692 per 1000 patient-days). The median duration of each antibiotic course was 9 days (IQR, 6-14 days). Overall, 64.6% infants received broad-spectrum antibiotics, with a median broad-spectrum AUR of 250 per 1000 patient-days (IQR, 0-500 per 1000 patient-days), accounting for 70.7% of all antibiotic use days. Overall, 68.7% of all antibiotic use occurred among infants without infection-related morbidities, with a median duration of 8 days (IQR, 6-13 days) for each course. Only 22.9% episodes of culture-negative sepsis were prescribed with antibiotics for 7 or fewer days, and 34.7% were treated with antibiotics for more than 14 days. For early antibiotic use, the median duration of antibiotic therapy within 7 days after birth was 7 days (IQR, 4-7 days).

Conclusions: A high AUR among infants without infections, prolonged antibiotic durations, and excessive use of broad-spectrum antibiotics were the main problems of antibiotic use in Chinese neonatal intensive care units and should be high-impact focuses for future stewardship interventions.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2021.08.067DOI Listing
August 2021
-->