Lan Kluwe

Lan Kluwe

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Lan Kluwe

Publications by authors named "Lan Kluwe"

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Cytocompatibility of Titanium, Zirconia and Modified PEEK after Surface Treatment Using UV Light or Non-Thermal Plasma.

Authors:
Linna Guo Ralf Smeets Lan Kluwe Philip Hartjen Mike Barbeck Claudio Cacaci Martin Gosau Anders Henningsen

Int J Mol Sci 2019 Nov 8;20(22). Epub 2019 Nov 8.

Department of Oral and Maxillofacial Surgery, University Hospital Hamburg-Eppendorf, 20246 Hamburg, Germany.

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http://dx.doi.org/10.3390/ijms20225596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888564PMC
November 2019

Minimal Effect of Bevacizumab Treatment on Residual Vestibular Schwannomas after Partial Resection in Young Neurofibromatosis Type 2 Patients.

Authors:
Isabel Gugel Lan Kluwe Julian Zipfel Christian Teuber Marcos Tatagiba Victor-Felix Mautner Martin Ulrich Schuhmann Florian Grimm

Cancers (Basel) 2019 Nov 25;11(12). Epub 2019 Nov 25.

Department of Neurosurgery, University Hospital Tübingen, BW 72076 Tübingen, Germany.

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http://dx.doi.org/10.3390/cancers11121862DOI Listing
November 2019

Impact of Surgery on Long-Term Results of Hearing in Neurofibromatosis Type-2 Associated Vestibular Schwannomas.

Authors:
Isabel Gugel Florian Grimm Marina Liebsch Julian Zipfel Christian Teuber Lan Kluwe Victor-Felix Mautner Marcos Tatagiba Martin Ulrich Schuhmann

Cancers (Basel) 2019 Sep 16;11(9). Epub 2019 Sep 16.

Department of Neurosurgery, University Hospital Tübingen, 72076 Tübingen, BW, Germany.

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http://dx.doi.org/10.3390/cancers11091376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770212PMC
September 2019

Production and Characterization of Porous Fibroin Scaffolds for Regenerative Medical Application.

Authors:
Alexander Kopp Ralf Smeets Martin Gosau Reinhard E Friedrich Sandra Fuest Mehdi Behbahani Mike Barbeck Rico Rutkowski Simon Burg Lan Kluwe Anders Henningsen

In Vivo 2019 May-Jun;33(3):757-762

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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http://dx.doi.org/10.21873/invivo.11536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559917PMC
August 2019

Distinctive low epidermal nerve fiber density in schwannomatosis patients provides a major parameter for diagnosis and differential diagnosis.

Authors:
Said C Farschtschi Lan Kluwe Gerhard Schön Reinhard E Friedrich Jakob Matschke Markus Glatzel Joachim Weis Christian Hagel Victor-Felix Mautner

Brain Pathol 2019 Aug 19. Epub 2019 Aug 19.

Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1111/bpa.12780DOI Listing
August 2019

Management of NF2-associated vestibular schwannomas in children and young adults: influence of surgery and clinical factors on tumor volume and growth rate.

Authors:
Isabel Gugel Florian Grimm Christian Teuber Lan Kluwe Victor-Felix Mautner Marcos Tatagiba Martin Ulrich Schuhmann

J Neurosurg Pediatr 2019 Aug 23:1-9. Epub 2019 Aug 23.

1Department of Neurosurgery.

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http://dx.doi.org/10.3171/2019.6.PEDS1947DOI Listing
August 2019

Paeoniflorin inhibits tributyltin chloride-induced apoptosis in hypothalamic neurons via inhibition of MKK4-JNK signaling pathway.

Authors:
Chao Cong Lan Kluwe Shengnan Li Xiaofei Liu Yang Liu Huicong Liu Wenjia Gui Te Liu Lianwei Xu

J Ethnopharmacol 2019 Jun 13;237:1-8. Epub 2019 Mar 13.

Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 20032, China. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2019.03.030DOI Listing
June 2019

Vitamin D receptor expression and serum 25(OH)D concentration inversely associates with burden of neurofibromas.

Authors:
Lan Kluwe Christian Hagel Reinhard E Friedrich Claudia Schnabel Gerhard Schön Victor Mautner

Eur J Cancer Prev 2019 05;28(3):220-224

Department of Neurology.

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http://Insights.ovid.com/crossref?an=00008469-900000000-9923
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http://dx.doi.org/10.1097/CEJ.0000000000000467DOI Listing
May 2019

Enriching Stem/Progenitor Cells from Dental Pulp Cells by Low-density Culturing.

Authors:
Yao Zhao Yajie Zheng Wolfgang Eichhorn Jan Klatt Anders Henningsen Lan Kluwe Reinhard E Friedrich Martin Gosau Ralf Smeets

In Vivo 2019 Jan-Feb;33(1):23-29

Department of Oral and Maxillofacial Surgery, University Hospital Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.21873/invivo.11434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364054PMC
April 2019

Separating Response of Tumor and non-Tumor Cells to Drug by Quantifying a Mutation.

Authors:
Markus Kleinpoppen Christoph Moebius Katharina Grupp Lan Kluwe Marco Blessmann

Anticancer Res 2019 Apr;39(4):1777-1783

Division of Plastic, Reconstructive and Aesthetic Surgery, Center of Surgical Sciences, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.21873/anticanres.13284DOI Listing
April 2019

Cerebrovascular Insult as Presenting Symptom of Neurofibromatosis Type 2 in Children, Adolescents, and Young Adults.

Authors:
Isabel Gugel Victor-Felix Mautner Lan Kluwe Marcos Soares Tatagiba Martin Ulrich Schuhmann

Front Neurol 2018 10;9:733. Epub 2018 Sep 10.

Department of Neurosurgery, University Hospital Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.3389/fneur.2018.00733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139325PMC
September 2018

Plasma Electrolytic Oxidation of Titanium Implant Surfaces: Microgroove-Structures Improve Cellular Adhesion and Viability.

Authors:
Philip Hartjen Alexia Hoffmann Anders Henningsen Mike Barbeck Alexander Kopp Lan Kluwe Clarissa Precht Olivia Quatela Robert Gaudin Max Heiland Reinhard E Friedrich Christian Knipfer Daniel Grubeanu Ralf Smeets Ole Jung

In Vivo 2018 Mar-Apr;32(2):241-247

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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http://iv.iiarjournals.org/content/32/2/241.abstract
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http://dx.doi.org/10.21873/invivo.11230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905190PMC
August 2018

Phenotypic and genotypic overlap between mosaic NF2 and schwannomatosis in patients with multiple non-intradermal schwannomas.

Authors:
Hildegard Kehrer-Sawatzki Lan Kluwe Reinhard E Friedrich Anna Summerer Eleonora Schäfer Ute Wahlländer Cordula Matthies Isabel Gugel Said Farschtschi Christian Hagel David N Cooper Victor-Felix Mautner

Hum Genet 2018 Jul 13;137(6-7):543-552. Epub 2018 Jul 13.

Department of Neurology, University Hospital Hamburg Eppendorf, 20246, Hamburg, Germany.

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http://dx.doi.org/10.1007/s00439-018-1909-9DOI Listing
July 2018

Piezosurgery for Sagittal Split Osteotomy: Procedure Duration and Postoperative Sensory Perturbation.

Authors:
Robert Köhnke Andreas Kolk Lan Kluwe Oliver Ploder

J Oral Maxillofac Surg 2017 Sep 15;75(9):1941-1947. Epub 2017 May 15.

Head of Department of Oral and Maxillofacial Surgery, Academic Teaching Hospital Feldkirch, Feldkirch, Austria.

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http://dx.doi.org/10.1016/j.joms.2017.05.003DOI Listing
September 2017

Lack of evidence for prognostic value of epidermal growth factor receptor intron-1 CA repeats for oral carcinomas.

Authors:
Clarissa Precht Marco Blessmann Lan Kluwe Theresa Scheld Gerhard Schön Anders Henningsen Christina Pflug Ralf Smeets Max Heiland Alexander Gröbe

Eur J Oral Sci 2017 04 2;125(2):95-101. Epub 2017 Feb 2.

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://doi.wiley.com/10.1111/eos.12333
Publisher Site
http://dx.doi.org/10.1111/eos.12333DOI Listing
April 2017

Attachment, Viability and Adipodifferentiation of Pre-adipose Cells on Silk Scaffolds with and Without Co-expressed FGF-2 and VEGF.

Authors:
Henning Hanken Friedemann Göhler Ralf Smeets Max Heiland Alexander Gröbe Reinhard E Friedrich Philipp Busch Marco Blessmann Lan Kluwe Philip Hartjen

In Vivo 2016 09-10;30(5):567-72

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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March 2017

Digital PCR for discriminating mosaic deletions and for determining proportion of tumor cells in specimen.

Authors:
Lan Kluwe

Eur J Hum Genet 2016 11 8;24(11):1644-1648. Epub 2016 Jun 8.

Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1038/ejhg.2016.56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110055PMC
November 2016

Effector T cell subclasses associate with tumor burden in neurofibromatosis type 1 patients.

Authors:
Said Farschtschi Su-Jin Park Birgit Sawitzki Su-Jun Oh Lan Kluwe Victor F Mautner Andreas Kurtz

Cancer Immunol Immunother 2016 09 23;65(9):1113-21. Epub 2016 Jul 23.

Berlin-Brandenburg Center for Regenerative Therapies, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

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http://dx.doi.org/10.1007/s00262-016-1871-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995232PMC
September 2016

The importance of nerve microenvironment for schwannoma development.

Authors:
Alexander Schulz Robert Büttner Christian Hagel Stephan L Baader Lan Kluwe Johannes Salamon Victor-Felix Mautner Thomas Mindos David B Parkinson Jeffrey R Gehlhausen D Wade Clapp Helen Morrison

Acta Neuropathol 2016 08 28;132(2):289-307. Epub 2016 May 28.

Leibniz Institute on Aging, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745, Jena, Germany.

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http://dx.doi.org/10.1007/s00401-016-1583-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947119PMC
August 2016

The feasibility of immediately loading dental implants in edentulous jaws.

Authors:
Anders Henningsen Ralf Smeets Aria Wahidi Lan Kluwe Frank Kornmann Max Heiland Till Gerlach

J Periodontal Implant Sci 2016 Aug 30;46(4):234-43. Epub 2016 Aug 30.

Private Practice for Dentistry and Oral Surgery, Oppenheim, Germany .

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http://dx.doi.org/10.5051/jpis.2016.46.4.234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005811PMC
August 2016

Postoperative bleeding risk for oral surgery under continued rivaroxaban anticoagulant therapy.

Authors:
Henning Hanken Alexander Gröbe Max Heiland Ralf Smeets Lan Kluwe Johannes Wikner Robert Koehnke Ahmed Al-Dam Wolfgang Eichhorn

Clin Oral Investig 2016 Jul 26;20(6):1279-82. Epub 2015 Oct 26.

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, 52 Martinistrasse, Hamburg, 20246, Germany.

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http://dx.doi.org/10.1007/s00784-015-1627-9DOI Listing
July 2016

Increased Postoperative Bleeding Risk among Patients with Local Flap Surgery under Continued Clopidogrel Therapy.

Authors:
Wolfgang Eichhorn Martina Haase Lan Kluwe Jürgen Zeuch Ralf Smeets Henning Hanken Manfred Wehrmann Alexander Gröbe Max Heiland Moritz Birkelbach Carsten Rendenbach

Biomed Res Int 2015 6;2015:120903. Epub 2015 Aug 6.

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.

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http://dx.doi.org/10.1155/2015/120903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543372PMC
June 2016

A novel genetic- and cell-based tool for assessing the efficacy and toxicity of anticancer drugs in vitro.

Authors:
Lan Kluwe Wei Jiang Ina Alster Henning Hanken

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2016 Mar 10;160(1):64-9. Epub 2015 Nov 10.

Laboratory for Tumor Biology and Regenerative Medicine, Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.5507/bp.2015.057DOI Listing
March 2016

Assessing Specificity of Anticancer Drugs In Vitro.

Authors:
Lan Kluwe

J Vis Exp 2016 Mar 23(109):e53752. Epub 2016 Mar 23.

Department of Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf; Department of Neurology, University Medical Center Hamburg-Eppendorf; Laboratory for Tumor Biology and Regenerative Medicine, University Medical Center Hamburg-Eppendorf;

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http://dx.doi.org/10.3791/53752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841310PMC
March 2016

Postoperative bleeding risk for oral surgery under continued clopidogrel antiplatelet therapy.

Authors:
Alexander Gröbe Meike Fraederich Ralf Smeets Max Heiland Lan Kluwe Jürgen Zeuch Martina Haase Johannes Wikner Henning Hanken Jan Semmusch Ahmed Al-Dam Wolfgang Eichhorn

Biomed Res Int 2015 6;2015:823651. Epub 2015 Jan 6.

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany ; Department of Oral and Maxillofacial Surgery, General Hospital Balingen, Tuebinger Straße 30, 72336 Balingen, Germany.

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http://dx.doi.org/10.1155/2015/823651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303007PMC
October 2015

Efficacy and side-effects of a semi-individualized Chinese herb mixture "Tiáo Gēng Tāng" for menopausal syndrome in China.

Authors:
Man Jia Lan Kluwe Hui-Cong Liu Qian-Jue Tang Lian Liu Zhen-Zhen Wang Li-Xia Tian Li Zhao Ying-Chao Chen Reinhard E Friedrich Zhuo-Jun Sun Lian-Wei Xu

In Vivo 2015 Jan-Feb;29(1):109-15

Gynecology Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, P.R. China

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September 2015

Optimized in vitro procedure for assessing the cytocompatibility of magnesium-based biomaterials.

Authors:
Ole Jung Ralf Smeets Dario Porchetta Alexander Kopp Christoph Ptock Ute Müller Max Heiland Max Schwade Björn Behr Nadja Kröger Lan Kluwe Henning Hanken Philip Hartjen

Acta Biomater 2015 Sep 11;23:354-363. Epub 2015 Jun 11.

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Germany.

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http://dx.doi.org/10.1016/j.actbio.2015.06.005DOI Listing
September 2015

Quantitative associations of scalp and body subcutaneous neurofibromas with internal plexiform tumors in neurofibromatosis 1.

Authors:
Kimberly Jett Rosa Nguyen Darian Arman Patricia Birch Harleen Chohan Said Farschtschi Carsten Fuensterer Lan Kluwe Jan M Friedman Victor F Mautner

Am J Med Genet A 2015 Jul 21;167(7):1518-24. Epub 2015 Apr 21.

Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1002/ajmg.a.37068DOI Listing
July 2015

Nilotinib is more potent than imatinib for treating plexiform neurofibroma in vitro and in vivo.

Authors:
Jiang Wei Marcus Freytag Yvonne Schober Wolfgang A Nockher Victor F Mautner Reinhard E Friedrich Paul W Manley Lan Kluwe Andreas Kurtz

PLoS One 2014 23;9(10):e107760. Epub 2014 Oct 23.

Berlin Brandenburg Center for Regenerative Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany; Seoul National University, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul, Republic of Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107760PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207688PMC
June 2015

Is immediate bony microsurgical reconstruction after head and neck tumor ablation associated with a higher rate of local recurrence?

Authors:
Henning Hanken Ralf Wilkens Björn Riecke Ahmed Al-Dam Silke Tribius Lan Kluwe Ralf Smeets Max Heiland Wolfgang Eichhorn Alexander Gröbe

J Craniomaxillofac Surg 2015 Apr 23;43(3):373-5. Epub 2015 Jan 23.

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S10105182150001
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http://dx.doi.org/10.1016/j.jcms.2015.01.006DOI Listing
April 2015

Preclinical assessment of the anticancer drug response of plexiform neurofibroma tissue using primary cultures.

Authors:
Wei Jiang Victor F Mautner Reinhard E Friedrich Lan Kluwe

J Clin Neurol 2015 Apr;11(2):172-7

Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.3988/jcn.2015.11.2.172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387483PMC
April 2015

Lack of evidence for increased postoperative bleeding risk for dental osteotomy with continued aspirin therapy.

Authors:
Henning Hanken Ferdinand Tieck Lan Kluwe Ralf Smeets Max Heiland Clarissa Precht Marc Eichhorn Wolfgang Eichhorn

Oral Surg Oral Med Oral Pathol Oral Radiol 2015 Jan 16;119(1):17-9. Epub 2014 Sep 16.

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.oooo.2014.08.016DOI Listing
January 2015

Fractal dimension of time-resolved autofluorescence discriminates tumour from healthy tissues in the oral cavity.

Authors:
Jan Klatt Carola E Gerich Alexander Gröbe Jörg Opitz Jürgen Schreiber Henning Hanken Georg Salomon Max Heiland Lan Kluwe Marco Blessmann

J Craniomaxillofac Surg 2014 Sep 25;42(6):852-4. Epub 2013 Dec 25.

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1016/j.jcms.2013.12.004DOI Listing
September 2014

Postoperative bleeding risk for cutaneous surgery in the head and neck region with continued phenprocoumon therapy.

Authors:
Wolfgang Eichhorn Evgeny Barsukov Ahmed Al-Dam Alexander Gröbe Ralf Smeets Marc Eichhorn Max Heiland Lan Kluwe Marco Blessmann

J Craniomaxillofac Surg 2014 Jul 13;42(5):608-11. Epub 2013 Sep 13.

Department of Oral and Maxillofacial Surgery (Head: Prof. Dr. Max Heiland), University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany.

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http://dx.doi.org/10.1016/j.jcms.2013.08.006DOI Listing
July 2014

B-scan ultrasonographic monitoring of orthotopic xenografted plexiform neurofibroma in mice.

Authors:
Jacob Gleiss Maria Demestre Melanie Spyra Thomas Eschenhagen Christian Hagel Victor-F Mautner Lan Kluwe Reinhard E Friedrich

In Vivo 2013 Nov-Dec;27(6):723-7

DMD, Building O-10, Department of Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.

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http://iv.iiarjournals.org/content/27/6/723.full.pdf
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July 2014

Lack of evidence for increased risk of postoperative bleeding after cutaneous surgery in the head and neck in patients taking aspirin.

Authors:
Wolfgang Eichhorn Lan Kluwe Max Heiland Alexander Gröbe

Br J Oral Maxillofac Surg 2014 Jul 2;52(6):527-9. Epub 2014 Apr 2.

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bjoms.2014.02.020DOI Listing
July 2014

Differences of 25-hydroxyvitamin D3 concentrations in children and adults with neurofibromatosis type 1.

Authors:
Claudia Schnabel Stefan Dahm Thomas Streichert Wulf Thierfelder Lan Kluwe Victor F Mautner

Clin Biochem 2014 May 6;47(7-8):560-3. Epub 2014 Mar 6.

Department of Neurology, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

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http://dx.doi.org/10.1016/j.clinbiochem.2014.02.020DOI Listing
May 2014

Immunohistochemical and FISH analysis of EGFR and its prognostic value in patients with oral squamous cell carcinoma.

Authors:
Alexander Gröbe Wolfgang Eichhorn Meike Fraederich Lan Kluwe Yogesh Vashist Johannes Wikner Ralf Smeets Ronald Simon Guido Sauter Max Heiland Marco Blessmann

J Oral Pathol Med 2014 Mar 11;43(3):205-10. Epub 2013 Sep 11.

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1111/jop.12111DOI Listing
March 2014

P53 immunohistochemical expression does not correlate with clinical features in 207 carcinomas of the oral cavity and in the head and neck region.

Authors:
Alexander Gröbe Henning Hanken Ahmed Al-Dam Georg Cachovan Ralf Smeets Antje Krohn Till Clauditz Tobias Grob Ronald Simon Guido Sauter Lan Kluwe Max Heiland Marco Blessmann

Clin Oral Investig 2014 Jan 13;18(1):211-7. Epub 2013 Feb 13.

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246, Hamburg, Germany,

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http://dx.doi.org/10.1007/s00784-013-0939-xDOI Listing
January 2014

Efficacy and selectivity of nilotinib on NF1-associated tumors in vitro.

Authors:
Wei Jiang Claudia Schnabel Melanie Spyra Victor-F Mautner Reinhard E Friedrich Christian Hagel Paul W Manley Lan Kluwe

J Neurooncol 2014 Jan 31;116(2):231-6. Epub 2013 Oct 31.

Laboratory for Tumor Genetics, Department of Neurology, University Medical Center Hamburg-Eppendorf, Building O48, 4th Floor, Martinistr. 52, 20246, Hamburg, Germany.

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http://dx.doi.org/10.1007/s11060-013-1295-zDOI Listing
January 2014

Prognostic relevance of circulating tumor cells in blood and disseminated tumor cells in bone marrow of patients with squamous cell carcinoma of the oral cavity.

Authors:
Alexander Gröbe Marco Blessmann Henning Hanken Reinhard E Friedrich Gerhard Schön Johannes Wikner Katharina E Effenberger Lan Kluwe Max Heiland Klaus Pantel Sabine Riethdorf

Clin Cancer Res 2014 Jan 11;20(2):425-33. Epub 2013 Nov 11.

Authors' Affiliations: Departments of Oral and Maxillofacial Surgery, Medical Biometry and Epidemiology, and Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-13-1101DOI Listing
January 2014

Lack of evidence for predictive and prognostic value of cyclin D1 gene polymorphism CCND1 G870A for oral squamous cell carcinoma.

Authors:
Artun Atac Björn Riecke Alexandre T Assaf Alexander Gröbe Reinhard E Friedrich Max Heiland Jakob R Izbicki Lan Kluwe Marco Blessmann

Anticancer Res 2014 Jan;34(1):235-8

DMD, Department of Oral Maxillofacial Surgery, Building O10, University Medical Center Hamburg-Eppendorf, Martinistr. 52, D-20246 Hamburg, Germany.

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January 2014

Amplification of the PPFIA1 gene region on 11q13 in oral squamous cell carcinomas (OSCC).

Authors:
Marco Blessmann Ahmed Al-Dam Henning Hanken Alexandre T Assaf Björn Riecke Jan Klatt Ronald Simon Guido Sauter Max Heiland Lan Kluwe Alexander Gröbe

J Craniomaxillofac Surg 2013 Dec 26;41(8):845-9. Epub 2013 Feb 26.

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

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http://dx.doi.org/10.1016/j.jcms.2013.01.040DOI Listing
December 2013

Immunohistochemical analysis of p16 expression, HPV infection and its prognostic utility in oral squamous cell carcinoma.

Authors:
Alexander Gröbe Henning Hanken Lan Kluwe Maximilian Schöllchen Silke Tribius Philipp Pohlenz Till Clauditz Tobias Grob Ronald Simon Guido Sauter Max Heiland Marco Blessmann

J Oral Pathol Med 2013 Oct 31;42(9):676-81. Epub 2013 May 31.

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1111/jop.12086DOI Listing
October 2013

Sensitivity of malignant peripheral nerve sheath tumor cells to TRAIL is augmented by loss of NF1 through modulation of MYC/MAD and is potentiated by curcumin through induction of ROS.

Authors:
David E Reuss Jana Mucha Christian Hagenlocher Volker Ehemann Lan Kluwe Victor Mautner Andreas von Deimling

PLoS One 2013 21;8(2):e57152. Epub 2013 Feb 21.

CCU Neuropathology German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0057152PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578816PMC
August 2013

Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors.

Authors:
Su-Jin Park Birgit Sawitzki Lan Kluwe Victor F Mautner Nikola Holtkamp Andreas Kurtz

BMC Med 2013 Apr 23;11:109. Epub 2013 Apr 23.

Berlin-Brandenburg Center for Regenerative Therapies, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, 13353, Germany.

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http://dx.doi.org/10.1186/1741-7015-11-109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648455PMC
April 2013

Efficacy and side effects of chinese herbal medicine for menopausal symptoms: a critical review.

Authors:
Lian-Wei Xu Man Jia Roland Salchow Michael Kentsch Xue-Jun Cui Hong-Yong Deng Zhuo-Jun Sun Lan Kluwe

Evid Based Complement Alternat Med 2012 13;2012:568106. Epub 2013 Jan 13.

Gynecology Department, Yueyang Integrated Traditional Chinese Medicine and Western Medicine Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China ; HanseMerkur Traditional Chinese Medicine Centre, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

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http://dx.doi.org/10.1155/2012/568106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551256PMC
February 2013

Genomic imbalance of HMMR/RHAMM regulates the sensitivity and response of malignant peripheral nerve sheath tumour cells to aurora kinase inhibition.

Authors:
Pooja Mohan Joan Castellsague Jihong Jiang Kristi Allen Helen Chen Oksana Nemirovsky Melanie Spyra Kaiji Hu Lan Kluwe Miguel Angel Pujana Alberto Villanueva Victor F Mautner Jonathan J Keats Sandra E Dunn Conxi Lazaro Christopher A Maxwell

Oncotarget 2013 Jan;4(1):80-93

Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.18632/oncotarget.793DOI Listing
January 2013

Clinical presentation, immunohistochemistry and electron microscopy indicate neurofibromatosis type 2-associated gliomas to be spinal ependymomas.

Authors:
Christian Hagel Anat O Stemmer-Rachamimov Antje Bornemann Martin Schuhmann Christoph Nagel Susan Huson D Gareth Evans Scott Plotkin Cordula Matthies Lan Kluwe Victor-Felix Mautner

Neuropathology 2012 Dec 7;32(6):611-6. Epub 2012 Mar 7.

Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1111/j.1440-1789.2012.01306.xDOI Listing
December 2012

Growth dynamics of plexiform neurofibromas: a retrospective cohort study of 201 patients with neurofibromatosis 1.

Authors:
Rosa Nguyen Eva Dombi Brigitte C Widemann Jeffrey Solomon Carsten Fuensterer Lan Kluwe Jan M Friedman Victor-Felix Mautner

Orphanet J Rare Dis 2012 Oct 4;7:75. Epub 2012 Oct 4.

Department of Neurology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1186/1750-1172-7-75DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524754PMC
October 2012

Non-coding RNA ANRIL and the number of plexiform neurofibromas in patients with NF1 microdeletions.

Authors:
Tanja Mußotter Lan Kluwe Josef Högel Rosa Nguyen David N Cooper Victor-Felix Mautner Hildegard Kehrer-Sawatzki

BMC Med Genet 2012 Oct 26;13:98. Epub 2012 Oct 26.

Institute of Human Genetics, University of Ulm, Albert-Einstein-Allee, Ulm, Germany.

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http://dx.doi.org/10.1186/1471-2350-13-98DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500256PMC
October 2012

Dissecting the clinical phenotype associated with mosaic type-2 NF1 microdeletions.

Authors:
Hildegard Kehrer-Sawatzki Julia Vogt Tanja Mußotter Lan Kluwe David N Cooper Victor-Felix Mautner

Neurogenetics 2012 Aug 13;13(3):229-36. Epub 2012 May 13.

Institute of Human Genetics, University of Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany.

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http://dx.doi.org/10.1007/s10048-012-0332-yDOI Listing
August 2012

Ferritin light chain and squamous cell carcinoma antigen 1 are coreceptors for cellular attachment and entry of hepatitis B virus.

Authors:
Zhaojing Hao Li Zheng Lan Kluwe Weida Huang

Int J Nanomedicine 2012 16;7:827-34. Epub 2012 Feb 16.

Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.

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http://dx.doi.org/10.2147/IJN.S27803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284225PMC
June 2012

Allelic drop-out, allele imbalance, or loss of heterozygosity?

Authors:
Lan Kluwe

Genes Chromosomes Cancer 2012 May 1;51(5):521-2; author reply 523. Epub 2012 Feb 1.

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http://dx.doi.org/10.1002/gcc.21930DOI Listing
May 2012

Internal tumor burden in neurofibromatosis Type I patients with large NF1 deletions.

Authors:
Lan Kluwe Rosa Nguyen Julia Vogt Kathrin Bengesser Tanja Mussotter Reinhard E Friedrich Kimberly Jett Hildegard Kehrer-Sawatzki Victor-Felix Mautner

Genes Chromosomes Cancer 2012 May 1;51(5):447-51. Epub 2012 Feb 1.

Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1002/gcc.21931DOI Listing
May 2012

Tissue-specific differences in the proportion of mosaic large NF1 deletions are suggestive of a selective growth advantage of hematopoietic del(+/-) stem cells.

Authors:
Angelika C Roehl Tanja Mussotter David N Cooper Lan Kluwe Katharina Wimmer Josef Högel Marion Zetzmann Julia Vogt Victor-Felix Mautner Hildegard Kehrer-Sawatzki

Hum Mutat 2012 Mar 23;33(3):541-50. Epub 2012 Jan 23.

Institute of Human Genetics, University of Ulm, Albert-Einstein-Allee 11, Ulm, Germany.

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http://dx.doi.org/10.1002/humu.22013DOI Listing
March 2012

Characterization of the nonallelic homologous recombination hotspot PRS3 associated with type-3 NF1 deletions.

Authors:
Antje M Zickler Stephanie Hampp Ludwine Messiaen Kathrin Bengesser Tanja Mussotter Angelika C Roehl Katharina Wimmer Victor-Felix Mautner Lan Kluwe Meena Upadhyaya Eric Pasmant Nadia Chuzhanova Hans A Kestler Josef Högel Eric Legius Kathleen Claes David N Cooper Hildegard Kehrer-Sawatzki

Hum Mutat 2012 Feb 9;33(2):372-83. Epub 2011 Dec 9.

Institute of Human Genetics, University of Ulm, Albert-Einstein-Allee 11, Ulm, Germany.

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http://dx.doi.org/10.1002/humu.21644DOI Listing
February 2012

Atypical neurofibromas in neurofibromatosis type 1 are premalignant tumors.

Authors:
Eline Beert Hilde Brems Bruno Daniëls Ivo De Wever Frank Van Calenbergh Joseph Schoenaers Maria Debiec-Rychter Olivier Gevaert Thomas De Raedt Annick Van Den Bruel Thomy de Ravel Karen Cichowski Lan Kluwe Victor Mautner Raf Sciot Eric Legius

Genes Chromosomes Cancer 2011 Dec 24;50(12):1021-32. Epub 2011 Aug 24.

Department of Human Genetics, Catholic University Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/gcc.20921DOI Listing
December 2011

Delineation of the clinical phenotype associated with non-mosaic type-2 NF1 deletions: two case reports.

Authors:
Julia Vogt Rosa Nguyen Lan Kluwe Martin Schuhmann Angelika C Roehl Tanja Mußotter David N Cooper Victor-Felix Mautner Hildegard Kehrer-Sawatzki

J Med Case Rep 2011 Dec 12;5:577. Epub 2011 Dec 12.

Institute of Human Genetics, University of Ulm, Ulm, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269400PMC
December 2011

Chinese herb mix Tiáo-Gēng-Tāng possesses antiaging and antioxidative effects and upregulates expression of estrogen receptors alpha and beta in ovariectomized rats.

Authors:
Lian-wei Xu Lan Kluwe Ting-ting Zhang Sheng-nan Li Yan-yan Mou Zhen Sang Jun Ma Xiong Lu Zhuo-jun Sun

BMC Complement Altern Med 2011 Dec 30;11:137. Epub 2011 Dec 30.

Gynecology Department, Shanghai Yueyang Integrated Traditioanl Chinese Medicine and Western Medicine Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Gan He Road 110, Shanghai, China.

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http://dx.doi.org/10.1186/1472-6882-11-137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286390PMC
December 2011

Plexiform neurofibromas in children with neurofibromatosis type 1: frequency and associated clinical deficits.

Authors:
Rosa Nguyen Lan Kluwe Carsten Fuensterer Michael Kentsch Reinhard Edgar Friedrich Victor-Felix Mautner

J Pediatr 2011 Oct 31;159(4):652-5.e2. Epub 2011 May 31.

Phacomatosis Section, Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1016/j.jpeds.2011.04.008DOI Listing
October 2011

Cancer stem cell-like cells derived from malignant peripheral nerve sheath tumors.

Authors:
Melanie Spyra Lan Kluwe Christian Hagel Rosa Nguyen Jens Panse Andreas Kurtz Victor Felix Mautner Samuel David Rabkin Maria Demestre

PLoS One 2011 13;6(6):e21099. Epub 2011 Jun 13.

Department of Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0021099PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113907PMC
October 2011

Effects of splicing mutations on NF2-transcripts: transcript analysis and information theoretic predictions.

Authors:
James R Ellis Bianca Heinrich Victor-F Mautner Lan Kluwe

Genes Chromosomes Cancer 2011 Aug 11;50(8):571-84. Epub 2011 May 11.

Laboratory of Bioengineering and Physical Science, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892-5766, USA.

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http://dx.doi.org/10.1002/gcc.20876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142993PMC
August 2011

MIA is a potential biomarker for tumour load in neurofibromatosis type 1.

Authors:
Mateusz Kolanczyk Victor Mautner Nadine Kossler Rosa Nguyen Jirko Kühnisch Tomasz Zemojtel Aleksander Jamsheer Eike Wegener Boris Thurisch Sigrid Tinschert Nikola Holtkamp Su-Jin Park Patricia Birch David Kendler Anja Harder Stefan Mundlos Lan Kluwe

BMC Med 2011 Jul 4;9:82. Epub 2011 Jul 4.

Institute of Medical Genetics, Charité, Universitätsmedizin Berlin, Humboldt University, Augustenburger Platz 1, D-13353 Berlin, Germany.

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http://dx.doi.org/10.1186/1741-7015-9-82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224593PMC
July 2011

Monozygotic twins discordant for neurofibromatosis type 1 due to a postzygotic NF1 gene mutation.

Authors:
Julia Vogt Jürgen Kohlhase Susanne Morlot Lan Kluwe Victor-Felix Mautner David N Cooper Hildegard Kehrer-Sawatzki

Hum Mutat 2011 Jun;32(6):E2134-47

Institute of Human Genetics, University of Ulm, Ulm, Germany.

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http://doi.wiley.com/10.1002/humu.21476
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June 2011

Analysis of NF1 somatic mutations in cutaneous neurofibromas from patients with high tumor burden.

Authors:
Laura Thomas Lan Kluwe Nadia Chuzhanova Victor Mautner Meena Upadhyaya

Neurogenetics 2010 Oct 1;11(4):391-400. Epub 2010 Apr 1.

Institute of Medical Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, UK.

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October 2010

Intrachromosomal mitotic nonallelic homologous recombination is the major molecular mechanism underlying type-2 NF1 deletions.

Authors:
Angelika C Roehl Julia Vogt Tanja Mussotter Antje N Zickler Helene Spöti Josef Högel Nadia A Chuzhanova Katharina Wimmer Lan Kluwe Victor-Felix Mautner David N Cooper Hildegard Kehrer-Sawatzki

Hum Mutat 2010 Oct;31(10):1163-73

Institute of Human Genetics, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1002/humu.21340DOI Listing
October 2010

Gene expression analysis identifies potential biomarkers of neurofibromatosis type 1 including adrenomedullin.

Authors:
Trent R Hummel Walter J Jessen Shyra J Miller Lan Kluwe Victor F Mautner Margaret R Wallace Conxi Lázaro Grier P Page Paul F Worley Bruce J Aronow Elizabeth K Schorry Nancy Ratner

Clin Cancer Res 2010 Oct 25;16(20):5048-57. Epub 2010 Aug 25.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-0613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837895PMC
October 2010

A novel third type of recurrent NF1 microdeletion mediated by nonallelic homologous recombination between LRRC37B-containing low-copy repeats in 17q11.2.

Authors:
Kathrin Bengesser David N Cooper Katharina Steinmann Lan Kluwe Nadia A Chuzhanova Katharina Wimmer Marcos Tatagiba Sigrid Tinschert Victor-Felix Mautner Hildegard Kehrer-Sawatzki

Hum Mutat 2010 Jun;31(6):742-51

Institute of Human Genetics, University of Ulm, 89081 Ulm, Germany.

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http://dx.doi.org/10.1002/humu.21254DOI Listing
June 2010

Imatinib mesylate (Glivec) inhibits Schwann cell viability and reduces the size of human plexiform neurofibroma in a xenograft model.

Authors:
Maria Demestre Jan Herzberg Nikola Holtkamp Christian Hagel David Reuss Reinhard E Friedrich Lan Kluwe Andreas Von Deimling Victor-F Mautner Andreas Kurtz

J Neurooncol 2010 May 17;98(1):11-9. Epub 2009 Nov 17.

Department of Maxillofacial Surgery, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.

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http://link.springer.com/10.1007/s11060-009-0049-4
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May 2010

Extended runs of homozygosity at 17q11.2: an association with type-2 NF1 deletions?

Authors:
Angelika C Roehl David N Cooper Lan Kluwe Andreas Helbrich Katharina Wimmer Josef Högel Victor-Felix Mautner Hildegard Kehrer-Sawatzki

Hum Mutat 2010 Mar;31(3):325-34

Institute of Human Genetics, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1002/humu.21191DOI Listing
March 2010

Large intragenic deletions of the NF2 gene: breakpoints and associated phenotypes.

Authors:
Benjamin Abo-Dalo Kerstin Kutsche Victor Mautner Lan Kluwe

Genes Chromosomes Cancer 2010 Feb;49(2):171-5

Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1002/gcc.20733DOI Listing
February 2010

Genome-wide high-resolution analysis of DNA copy number alterations in NF1-associated malignant peripheral nerve sheath tumors using 32K BAC array.

Authors:
Kiran K Mantripragada Teresita Díaz de Ståhl Chris Patridge Uwe Menzel Robin Andersson Nadia Chuzhanova Lan Kluwe Abhijit Guha Victor Mautner Jan P Dumanski Meena Upadhyaya

Genes Chromosomes Cancer 2009 Oct;48(10):897-907

Institute of Medical Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, UK.

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http://dx.doi.org/10.1002/gcc.20695DOI Listing
October 2009

The spectrum of somatic and germline NF1 mutations in NF1 patients with spinal neurofibromas.

Authors:
Meena Upadhyaya Gill Spurlock Lan Kluwe Nadia Chuzhanova Emma Bennett Nick Thomas Abhijit Guha Victor Mautner

Neurogenetics 2009 Jul 17;10(3):251-63. Epub 2009 Feb 17.

Institute of Medical Genetics, Cardiff University, Heath Park, Cardiff Cf144XN, UK.

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http://dx.doi.org/10.1007/s10048-009-0178-0DOI Listing
July 2009

Ral overactivation in malignant peripheral nerve sheath tumors.

Authors:
Vidya Bodempudi Farnaz Yamoutpoor Weihong Pan Arkadiusz Z Dudek Tuba Esfandyari Mark Piedra Dusica Babovick-Vuksanovic Richard A Woo Victor F Mautner Lan Kluwe D Wade Clapp George H De Vries Stacey L Thomas Andreas Kurtz Luis F Parada Faris Farassati

Mol Cell Biol 2009 Jul 4;29(14):3964-74. Epub 2009 May 4.

Department of Medicine, KUMC-Molecular Medicine Laboratory, University of Kansas School of Medicine, 1000 Hixon, Mail Stop 4037, 3901 Rainbow Blvd., Kansas City, KS 66160, USA.

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http://dx.doi.org/10.1128/MCB.01153-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704746PMC
July 2009

Mechanisms of loss of heterozygosity in neurofibromatosis type 1-associated plexiform neurofibromas.

Authors:
Katharina Steinmann Lan Kluwe Reinhard E Friedrich Victor-Felix Mautner David N Cooper Hildegard Kehrer-Sawatzki

J Invest Dermatol 2009 Mar 18;129(3):615-21. Epub 2008 Sep 18.

Institute of Human Genetics, University of Ulm, Germany.

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http://dx.doi.org/10.1038/jid.2008.274DOI Listing
March 2009

Correlation of nonsense and frameshift mutations with severity of retinal abnormalities in neurofibromatosis 2.

Authors:
Matthias Feucht Lan Kluwe Victor-Felix Mautner Gisbert Richard

Arch Ophthalmol 2008 Oct;126(10):1376-80

Departments of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany..

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http://dx.doi.org/10.1001/archopht.126.10.1376DOI Listing
October 2008

Germline and somatic NF1 gene mutations in plexiform neurofibromas.

Authors:
Meena Upadhyaya Gill Spurlock Bisma Monem Nick Thomas Reinhard E Friedrich Lan Kluwe Victor Mautner

Hum Mutat 2008 Aug;29(8):E103-11

Institute of Medical Genetics, Cardiff University, Heath Park, Cardiff CF144XN, UK.

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http://dx.doi.org/10.1002/humu.20793DOI Listing
August 2008

Assessment of benign tumor burden by whole-body MRI in patients with neurofibromatosis 1.

Authors:
Victor-F Mautner Florence A Asuagbor Eva Dombi Carsten Fünsterer Lan Kluwe Ralf Wenzel Brigitte C Widemann Jan M Friedman

Neuro Oncol 2008 Aug 17;10(4):593-8. Epub 2008 Jun 17.

Department of Maxillofacial Surgery, University Hospital Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1215/15228517-2008-011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666233PMC
August 2008

Copy number variations in the NF1 gene region are infrequent and do not predispose to recurrent type-1 deletions.

Authors:
Katharina Steinmann Lan Kluwe David N Cooper Hilde Brems Thomas De Raedt Eric Legius Viktor-Felix Mautner Hildegard Kehrer-Sawatzki

Eur J Hum Genet 2008 May 23;16(5):572-80. Epub 2008 Jan 23.

Institute of Human Genetics, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1038/sj.ejhg.5202002DOI Listing
May 2008

Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type 1 individuals.

Authors:
Kiran K Mantripragada Matthew Caley Phil Stephens Christopher J Jones Lan Kluwe Abhijit Guha Victor Mautner Meena Upadhyaya

Genes Chromosomes Cancer 2008 Mar;47(3):238-46

Institute of Medical Genetics, School of Medicine, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1002/gcc.20525DOI Listing
March 2008

Absence of cutaneous neurofibromas in an NF1 patient with an atypical deletion partially overlapping the common 1.4 Mb microdeleted region.

Authors:
Hildegard Kehrer-Sawatzki Eva Schmid Carsten Fünsterer Lan Kluwe Victor-Felix Mautner

Am J Med Genet A 2008 Mar;146A(6):691-9

Department of Human Genetics, University of Ulm, Ulm, Germany.

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http://doi.wiley.com/10.1002/ajmg.a.32045
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March 2008

High-resolution DNA copy number profiling of malignant peripheral nerve sheath tumors using targeted microarray-based comparative genomic hybridization.

Authors:
Kiran K Mantripragada Gillian Spurlock Lan Kluwe Nadia Chuzhanova Rosalie E Ferner Ian M Frayling Jan P Dumanski Abhijit Guha Victor Mautner Meena Upadhyaya

Clin Cancer Res 2008 Feb;14(4):1015-24

Institute of Medical Genetics, Cardiff University, School of Medicine, Heath Park, Cardiff, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-1305DOI Listing
February 2008

Germline and somatic NF1 gene mutation spectrum in NF1-associated malignant peripheral nerve sheath tumors (MPNSTs).

Authors:
M Upadhyaya Lan Kluwe G Spurlock Bisma Monem E Majounie K Mantripragada Martino Ruggieri N Chuzhanova D G Evans R Ferner N Thomas A Guha V Mautner

Hum Mutat 2008 Jan;29(1):74-82

Institute of Medical Genetics, Cardiff University, Cardiff, United Kingdom.

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http://doi.wiley.com/10.1002/humu.20601
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January 2008

Type 2 NF1 deletions are highly unusual by virtue of the absence of nonallelic homologous recombination hotspots and an apparent preference for female mitotic recombination.

Authors:
Katharina Steinmann David N Cooper Lan Kluwe Nadia A Chuzhanova Cornelia Senger Eduard Serra Conxi Lazaro Montserrat Gilaberte Katharina Wimmer Viktor-Felix Mautner Hildegard Kehrer-Sawatzki

Am J Hum Genet 2007 Dec 31;81(6):1201-20. Epub 2007 Oct 31.

Institute of Human Genetics, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1086/522089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276354PMC
December 2007

Histopathology and clinical outcome of NF1-associated vs. sporadic malignant peripheral nerve sheath tumors.

Authors:
Christian Hagel Ulrich Zils Matthias Peiper Lan Kluwe Stefan Gotthard Reinhard E Friedrich David Zurakowski Andreas von Deimling Victor Felix Mautner

J Neurooncol 2007 Apr 17;82(2):187-92. Epub 2006 Nov 17.

Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, D-20246, Hamburg, Germany.

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http://link.springer.com/10.1007/s11060-006-9266-2
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April 2007

Conservation of hotspots for recombination in low-copy repeats associated with the NF1 microdeletion.

Authors:
Thomas De Raedt Matthew Stephens Ine Heyns Hilde Brems Daisy Thijs Ludwine Messiaen Karen Stephens Conxi Lazaro Katharina Wimmer Hildegard Kehrer-Sawatzki Dominique Vidaud Lan Kluwe Peter Marynen Eric Legius

Nat Genet 2006 Dec 19;38(12):1419-23. Epub 2006 Nov 19.

Department of Human Genetics, Catholic University Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/ng1920DOI Listing
December 2006

Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues.

Authors:
Shyra J Miller Fatima Rangwala Jon Williams Peter Ackerman Sue Kong Anil G Jegga Sergio Kaiser Bruce J Aronow Silke Frahm Lan Kluwe Victor Mautner Meena Upadhyaya David Muir Margaret Wallace Jussara Hagen Dawn E Quelle Mark A Watson Arie Perry David H Gutmann Nancy Ratner

Cancer Res 2006 Mar;66(5):2584-91

Division of Experimental Hematology, Cincinnati Children's Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA.

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March 2006

Unilateral vestibular schwannoma with other neurofibromatosis type 2-related tumors: clinical and molecular study of a unique phenotype.

Authors:
Manish Aghi Lan Kluwe Micah T Webster Lee B Jacoby Fred G Barker Robert G Ojemann Victor-Felix Mautner Mia MacCollin

J Neurosurg 2006 Feb;104(2):201-7

Neurosurgical Service, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02129, USA.

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http://dx.doi.org/10.3171/jns.2006.104.2.201DOI Listing
February 2006

Malignant peripheral nerve sheath tumors (MPNST) in neurofibromatosis type 1 (NF1): diagnostic findings on magnetic resonance images and mutation analysis of the NF1 gene.

Authors:
Reinhard E Friedrich Lan Kluwe C Fünsterer V F Mautner

Anticancer Res 2005 May-Jun;25(3A):1699-702

Maxillofacial Surgery Clinic, Eppendorf University Hospital, University of Hamburg, Germany.

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September 2005

Extensively high load of internal tumors determined by whole body MRI scanning in a patient with neurofibromatosis type 1 and a non-LCR-mediated 2-Mb deletion in 17q11.2.

Authors:
Hildegard Kehrer-Sawatzki Lan Kluwe Carsten Fünsterer Victor-Felix Mautner

Hum Genet 2005 May 18;116(6):466-75. Epub 2005 Mar 18.

Department of Human Genetics, University of Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Germany.

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http://dx.doi.org/10.1007/s00439-005-1265-4DOI Listing
May 2005

Screening for large mutations of the NF2 gene.

Authors:
Lan Kluwe Anders O H Nygren Abdellatif Errami Bianca Heinrich Cordula Matthies Marcos Tatagiba Victor Mautner

Genes Chromosomes Cancer 2005 Apr;42(4):384-91

Laboratory for Tumor Biology and Malformation, Department of Maxillofacial Surgery, University Hospital Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

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http://doi.wiley.com/10.1002/gcc.20138
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http://dx.doi.org/10.1002/gcc.20138DOI Listing
April 2005

Do hormonal contraceptives stimulate growth of neurofibromas? A survey on 59 NF1 patients.

Authors:
Marge Lammert Victor-Felix Mautner Lan Kluwe

BMC Cancer 2005 Feb 9;5:16. Epub 2005 Feb 9.

Department of Maxillofacial Surgery, University Hospital Eppendorf, Hamburg, Germany.

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http://bmccancer.biomedcentral.com/articles/10.1186/1471-240
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http://dx.doi.org/10.1186/1471-2407-5-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC549555PMC
February 2005

Prevalence of neurofibromatosis 1 in German children at elementary school enrollment.

Authors:
Marga Lammert Jan M Friedman Lan Kluwe Victor F Mautner

Arch Dermatol 2005 Jan;141(1):71-4

Department of Maxillofacial Surgery, University Hospital Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1001/archderm.141.1.71DOI Listing
January 2005

Somatic mitochondrial DNA mutations in neurofibromatosis type 1-associated tumors.

Authors:
Andreas Kurtz Maria Lueth Lan Kluwe Tingguo Zhang Rosemary Foster Victor-Felix Mautner Melanie Hartmann Duan-Jun Tan Robert L Martuza Reinhard E Friedrich Pablo Hernáiz Driever Lee-Jun C Wong

Mol Cancer Res 2004 Aug;2(8):433-41

Massachusetts General Hospital, Harvard Medical School, Charlestown, USA.

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http://mcr.aacrjournals.org/content/molcanres/2/8/433.full.p
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August 2004

Genetic and phenotypic characterization of tumor cells derived from malignant peripheral nerve sheath tumors of neurofibromatosis type 1 patients.

Authors:
Silke Frahm Victor-F Mautner Hilde Brems Eric Legius Maria Debiec-Rychter Reinhard E Friedrich Wolfram T Knöfel Matthias Peiper Lan Kluwe

Neurobiol Dis 2004 Jun;16(1):85-91

Laboratory of Brain Tumor Biology, Department of Neurosurgery, University Hospital Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1016/j.nbd.2004.01.006DOI Listing
June 2004

Sulindac derivatives inhibit cell growth and induce apoptosis in primary cells from malignant peripheral nerve sheath tumors of NF1-patients.

Authors:
Silke Frahm Andreas Kurtz Lan Kluwe Faris Farassati Reinhard E Friedrich Victor F Mautner

Cancer Cell Int 2004 May 17;4(1). Epub 2004 May 17.

Laboratory of Brain Tumor Biology, Department of Neurosurgery, University Hospital Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1186/1475-2867-4-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC425591PMC
May 2004

Screening 500 unselected neurofibromatosis 1 patients for deletions of the NF1 gene.

Authors:
Lan Kluwe Reiner Siebert Stefan Gesk Reinhard E Friedrich Sigrid Tinschert Hildegard Kehrer-Sawatzki Victor-F Mautner

Hum Mutat 2004 Feb;23(2):111-6

Laboratory for Tumor Biology and Development Disorders, Department of Maxillofacial Surgery, University Hospital Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1002/humu.10299DOI Listing
February 2004

Constitutional NF1 mutations in neurofibromatosis 1 patients with malignant peripheral nerve sheath tumors.

Authors:
Lan Kluwe Reinhard E Friedrich Matthias Peiper Jan Friedman Victor-F Mautner

Hum Mutat 2003 Nov;22(5):420

Department of Maxillofacial Surgery, University Hospital Hamburg-Eppendorf, Hamburg, Germany.

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http://doi.wiley.com/10.1002/humu.9193
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http://dx.doi.org/10.1002/humu.9193DOI Listing
November 2003

Polyneuropathy in neurofibromatosis 2: clinical findings, molecular genetics and neuropathological alterations in sural nerve biopsy specimens.

Authors:
Christian Hagel Matthias Lindenau Katrin Lamszus Lan Kluwe Dimitrios Stavrou Victor-Felix Mautner

Acta Neuropathol 2002 Aug 18;104(2):179-87. Epub 2002 Apr 18.

Department of Neuropathology, University Clinic Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

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http://dx.doi.org/10.1007/s00401-002-0535-7DOI Listing
August 2002