Dr. Lan K Nguyen, PhD - Systems Biology Ireland

Dr. Lan K Nguyen

PhD

Systems Biology Ireland

Ireland

Dr. Lan K Nguyen, PhD - Systems Biology Ireland

Dr. Lan K Nguyen

PhD

Introduction

Primary Affiliation: Systems Biology Ireland - Ireland

Publications

12Publications

137Reads

-Profile Views

187PubMed Central Citations

Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses.

J R Soc Interface 2014 Sep;11(98):20140383

Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland

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http://dx.doi.org/10.1098/rsif.2014.0383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233687PMC
September 2014
25 Reads
7 Citations

The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility.

Sci Signal 2014 Aug 19;7(339):ra78. Epub 2014 Aug 19.

Richard Dimbleby Department of Cancer Research, Randall Division of Cell and Molecular Biophysics, King's College London, Guy's Medical School Campus, London SE1 1UL, UK. Division of Cancer Studies, King's College London, London SE1 1UL, UK. Breakthrough Breast Cancer Research Unit, Research Oncology, King's College London, Guy's Hospital, London SE1 9RT, UK. UCL Cancer Institute, Paul O'Gorman Building, University College London, London WC1E 6BT, UK.

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http://dx.doi.org/10.1126/scisignal.2005157DOI Listing
August 2014
59 Reads
13 Citations
6.280 Impact Factor

Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling.

Nat Cell Biol 2014 Jul 15;16(7):673-84. Epub 2014 Jun 15.

1] Systems Biology Ireland, University College Dublin, Dublin 4, Ireland [2] Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Dublin 4, Ireland [3] School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland [4].

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http://dx.doi.org/10.1038/ncb2986DOI Listing
July 2014
3 Reads
32 Citations
19.680 Impact Factor

Polyubiquitin chain assembly and organization determine the dynamics of protein activation and degradation.

Front Physiol 2014 24;5. Epub 2014 Jan 24.

Systems Biology Ireland, University College Dublin Dublin, Ireland ; Conway Institute, University College Dublin Dublin, Ireland ; School of Medicine and Medical Science, University College Dublin Dublin, Ireland.

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http://dx.doi.org/10.3389/fphys.2014.00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901042PMC
January 2014
4 Reads
5 Citations

When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling.

Cell Commun Signal 2013 Jul 31;11:52. Epub 2013 Jul 31.

Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.

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http://dx.doi.org/10.1186/1478-811X-11-52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734146PMC
July 2013
7 Reads
44 Citations
3.380 Impact Factor

Hypoxia-inducible factor (HIF) network: insights from mathematical models.

Cell Commun Signal 2013 Jun 10;11(1):42. Epub 2013 Jun 10.

Systems Biology Ireland, University College Dublin, Dublin 4, Ireland.

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http://dx.doi.org/10.1186/1478-811X-11-42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686674PMC
June 2013
7 Reads
14 Citations
3.380 Impact Factor

A dynamic model of the hypoxia-inducible factor 1α (HIF-1α) network.

J Cell Sci 2013 Mar 6;126(Pt 6):1454-63. Epub 2013 Feb 6.

Systems Biology Ireland, University College Dublin, Dublin 4, Ireland.

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http://dx.doi.org/10.1242/jcs.119974DOI Listing
March 2013
6 Reads
30 Citations
5.432 Impact Factor

Signalling by protein phosphatases and drug development: a systems-centred view.

FEBS J 2013 Jan 14;280(2):751-65. Epub 2012 Mar 14.

Systems Biology Ireland, University College Dublin, Belfield, Ireland.

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http://dx.doi.org/10.1111/j.1742-4658.2012.08522.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368988PMC
January 2013
10 Citations
4.001 Impact Factor

Regulation of oscillation dynamics in biochemical systems with dual negative feedback loops.

Authors:
Lan K Nguyen

J R Soc Interface 2012 Aug 14;9(73):1998-2010. Epub 2012 Mar 14.

Systems Biology Ireland, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.

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http://dx.doi.org/10.1098/rsif.2012.0028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385767PMC
August 2012
1 Read
11 Citations

Switches, excitable responses and oscillations in the Ring1B/Bmi1 ubiquitination system.

PLoS Comput Biol 2011 Dec 15;7(12):e1002317. Epub 2011 Dec 15.

Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland.

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http://dx.doi.org/10.1371/journal.pcbi.1002317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240587PMC
December 2011
14 Reads
12 Citations

On the functional diversity of dynamical behaviour in genetic and metabolic feedback systems.

BMC Syst Biol 2009 May 11;3:51. Epub 2009 May 11.

Centre for Advanced Computational Solutions (C-fACS), Lincoln University, Christchurch, New Zealand.

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http://dx.doi.org/10.1186/1752-0509-3-51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705352PMC
May 2009
5 Reads
7 Citations
2.440 Impact Factor

On multiple regulatory mechanisms in the tryptophan operon system in Escherichia coli: in silico study of perturbation dynamics.

In Silico Biol 2008 ;8(5-6):485-510

Centre for Advanced Computational Solutions (C-fACS), Lincoln University, Christchurch, New Zealand.

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May 2009
6 Reads
2 Citations