Lamya S Shihabuddin

Lamya S Shihabuddin

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Lamya S Shihabuddin

Lamya S Shihabuddin

Publications by authors named "Lamya S Shihabuddin"

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Viral delivery of a microRNA to Gba to the mouse central nervous system models neuronopathic Gaucher disease.

Neurobiol Dis 2019 Oct 21;130:104513. Epub 2019 Jun 21.

Rare and Neurologic Diseases Research Therapeutic Area, Sanofi, Framingham, MA 01701, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.104513DOI Listing
October 2019

Astrocyte transduction is required for rescue of behavioral phenotypes in the YAC128 mouse model with AAV-RNAi mediated HTT lowering therapeutics.

Neurobiol Dis 2019 Sep 28;129:29-37. Epub 2019 Apr 28.

Sanofi Rare and Neurological Diseases, Framingham, MA, USA.

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http://dx.doi.org/10.1016/j.nbd.2019.04.015DOI Listing
September 2019

Dysregulation of Mdm2 and Mdm4 alternative splicing underlies motor neuron death in spinal muscular atrophy.

Genes Dev 2018 08 16;32(15-16):1045-1059. Epub 2018 Jul 16.

Center for Motor Neuron Biology and Disease, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1101/gad.316059.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075148PMC
August 2018

No evidence for substrate accumulation in Parkinson brains with GBA mutations.

Mov Disord 2015 Jul 11;30(8):1085-9. Epub 2015 Jun 11.

Department of Clinical Neuroscience, UCL Institute of Neurology, London, UK.

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http://dx.doi.org/10.1002/mds.26278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529481PMC
July 2015

Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice.

Neurobiol Dis 2015 Apr 9;76:24-36. Epub 2015 Jan 9.

Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2014.12.030DOI Listing
April 2015

Gaucher-related synucleinopathies: the examination of sporadic neurodegeneration from a rare (disease) angle.

Prog Neurobiol 2015 Feb 6;125:47-62. Epub 2015 Jan 6.

Genzyme, a Sanofi Company, 49 New York Avenue, Framingham, MA 01701, USA.

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http://dx.doi.org/10.1016/j.pneurobio.2014.12.001DOI Listing
February 2015

iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis.

Nat Commun 2014 Jun 6;5:4028. Epub 2014 Jun 6.

1] Department of Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Tübingen 72076, Germany [2] Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen 72076, Germany.

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http://dx.doi.org/10.1038/ncomms5028DOI Listing
June 2014

Mutant GBA1 expression and synucleinopathy risk: first insights from cellular and mouse models.

Neurodegener Dis 2012 9;10(1-4):195-202. Epub 2012 Feb 9.

Genzyme, Sanofi Company, Framingham, Mass 01701, USA.

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http://dx.doi.org/10.1159/000335038DOI Listing
August 2012

Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis.

Neuron 2012 Jun;74(6):1031-44

Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.neuron.2012.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383626PMC
June 2012

Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice.

Hum Mol Genet 2012 May 9;21(10):2219-32. Epub 2012 Feb 9.

Centre for Molecular Medicine and Therapeutics, University of British Columbia, and Child and Family Research Institute, Vancouver, BC, Canada.

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http://dx.doi.org/10.1093/hmg/dds037DOI Listing
May 2012

Neural stem cell transplantation as a therapeutic approach for treating lysosomal storage diseases.

Neurotherapeutics 2011 Oct;8(4):659-67

Genzyme Corporation, 49 New York Avenue, Framingham, MA 01701-9322, USA.

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http://dx.doi.org/10.1007/s13311-011-0067-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250293PMC
October 2011

Relationship between neuropathology and disease progression in the SOD1(G93A) ALS mouse.

Exp Neurol 2011 Feb 9;227(2):287-95. Epub 2010 Dec 9.

Genzyme Corporation, 49 New York Ave, Framingham, MA 01701-9322, USA.

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http://dx.doi.org/10.1016/j.expneurol.2010.11.019DOI Listing
February 2011

Stem cell transplantation for neurometabolic and neurodegenerative diseases.

Neuropharmacology 2010 May 28;58(6):845-54. Epub 2009 Dec 28.

Genzyme Corporation, Science Center, Framingham, MA 01701, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00283908090038
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http://dx.doi.org/10.1016/j.neuropharm.2009.12.015DOI Listing
May 2010

Polysialic acid regulates the clustering, migration, and neuronal differentiation of progenitor cells in the adult hippocampus.

Dev Neurobiol 2008 Dec;68(14):1580-90

Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada M5G 1L9.

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http://dx.doi.org/10.1002/dneu.20681DOI Listing
December 2008

Adult rodent spinal cord-derived neural stem cells: isolation and characterization.

Methods Mol Biol 2008 ;438:55-66

Genzyme Corporation, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-59745-133-8_6DOI Listing
April 2008

Optimized preservation of CNS morphology for the identification of glycogen in the Pompe mouse model.

J Histochem Cytochem 2007 Oct 17;55(10):991-8. Epub 2007 May 17.

Department of Pathology, Genzyme Corporation, One Mountain Road, Framingham, MA 01701-9322, USA.

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http://dx.doi.org/10.1369/jhc.7A7239.2007DOI Listing
October 2007

Injection of mouse and human neural stem cells into neonatal Niemann-Pick A model mice.

Brain Res 2007 Apr 9;1140:195-204. Epub 2007 Jan 9.

Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.brainres.2007.01.011DOI Listing
April 2007

Mouse neural progenitor cells differentiate into oligodendrocytes in the brain of a knockout mouse model of Canavan disease.

Brain Res Dev Brain Res 2004 Oct;153(1):19-27

Pediatrics Rm # 3.350, Department of Pediatrics, Childrens Hospital, The University of Texas Medical Branch, Galveston, TX 77555-0359, USA.

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http://dx.doi.org/10.1016/j.devbrainres.2004.07.003DOI Listing
October 2004

Adult rodent spinal cord derived neural stem cells. Isolation and characterization.

Methods Mol Biol 2002 ;198:67-77

Genzyme Corporation, Framingham, MA, USA.

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http://dx.doi.org/10.1385/1-59259-186-8:067DOI Listing
October 2002