Lamin B Cham, PhD - Institute of Immunology, University Hospital Essen

Lamin B Cham

PhD

Institute of Immunology, University Hospital Essen

Essen, Essen | Germany

Main Specialties: Clinical & Laboratory Immunology, Infectious Disease

Additional Specialties: Immunology and Infectious Disease

ORCID logohttps://orcid.org/0000-0002-6855-5657


Top Author

Lamin B Cham, PhD - Institute of Immunology, University Hospital Essen

Lamin B Cham

PhD

Introduction

I am currently working on immunological mechanisms during viral infections.

Primary Affiliation: Institute of Immunology, University Hospital Essen - Essen, Essen , Germany

Specialties:

Additional Specialties:

Research Interests:


View Lamin B Cham’s Resume / CV

Education

Apr 2017
Institute of Immunology
PhD student
Immunology and Infection
Sep 2016
Universite Cheikh Anta Diop de Dakar
MSc. Genetic
Graduated
Sep 2016
Universite Cheikh Anta Diop de Dakar
MSc. Genetic
Graduated
Jun 2013
University of the Gambia
BSc. Biology and Oublic Health
Graduated

Experience

Nov 2016
Best Young African Researcher Award

UNESCO-MARS

Publications

2Publications

30Reads

-Profile Views

2PubMed Central Citations

Functional CD169 on Macrophages Mediates Interaction with Dendritic Cells for CD8 T Cell Cross-Priming.

Cell Rep 2018 02;22(6):1484-1495

Cancer Center Amsterdam, Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, the Netherlands. Electronic address:

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Source
http://dx.doi.org/10.1016/j.celrep.2018.01.021DOI Listing
February 2018
30 Reads
2 Citations
7.210 Impact Factor

Qualitative Detection of Proviral-DNA of HIV-1 in Infants to Determine the Efficacy of Antiretroviral Therapy in the Prevention of Vertical Transmission of HIV-1 in The Gambia

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Background: The priority of the Gambia government is to eliminate maternal to child transmission of HIV and in line with this priority, the country implemented an antiretroviral therapy (ART) program. With this, all HIV infected pregnant and breastfeeding mothers and infants have access to ARV drugs. This study aims to determine the prevalence of vertical transmission of HIV among women receiving the ARV drugs. Methods: Dried blood spot samples were collected from 109 HIV-exposed infants enrolled in 13 PMTCT sites across the country. A qualitative detection of proviral-DNA of HIV-1 was performed using the Real Time Abbott PCR assay. Data from 105 mothers were analyzed using SPSS version 16.0 and association of risk factors to PCR results were analyzed using (Crosstabs) Pearson Chi-Square. The p-value of significant was set at p<0.05. Results: This study has found the prevalence of vertical transmission of HIV is 0.0% (0/64) among women that received the ARV prophylaxis then started ART, 7.1% (2/28) among mothers that received HIV prophylaxis only, and 38.4% (5/13) among women who neither receive HIV-prophylaxis nor ART during pregnancy or breastfeeding. Other risk factors of vertical transmission such as late initiation of treatment, default during treatment and first born of twins were found to be significantly associated with vertical transmission p=0.001, p=0.022 and p=0.000 respectively. Conclusion: This study has found that the early intervention of ART at the onset of pregnancy through breastfeeding can eliminates Maternal to Child transmission of HIV and a high risk of vertical transmission was found among women who neither receive prophylaxis nor ART. If the effectiveness of the antiretroviral therapy is maintain, the Gambia, in the near future will attain the WHO’s goal to eliminate Maternal to Child transmission of HIV.

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December 2016
6 Reads

Top co-authors

Karl S Lang
Karl S Lang

Institute of Immunology

1
Kees L Franken
Kees L Franken

Leiden University Medical Center

1
Juan J Garcia-Vallejo
Juan J Garcia-Vallejo

VU University Medical Center

1
Yvette van Kooyk
Yvette van Kooyk

Universität Heidelberg

1
David Sancho
David Sancho

Hospital de la Princesa

1
Paul R Crocker
Paul R Crocker

University of Dundee

1
Hakan Kalay
Hakan Kalay

VU University Medical Center

1
Salvador Iborra
Salvador Iborra

Centro de Biología Molecular Severo Ochoa

1