Publications by authors named "Lam C Tsoi"

79Publications

Characterization of circular RNA transcriptomes in psoriasis and atopic dermatitis reveals disease-specific expression profiles.

Exp Dermatol 2020 Oct 28. Epub 2020 Oct 28.

Department of Biomedicine, Faculty of Health, Aarhus University, Arhus C, Denmark.

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http://dx.doi.org/10.1111/exd.14227DOI Listing
October 2020

Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies.

Immunity 2020 Oct;53(4):878-894.e7

Institute for Medical Engineering & Science (IMES), MIT, Cambridge, Massachusetts, USA; Department of Immunology, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA; Harvard Stem Cell Institute, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2020.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562821PMC
October 2020

"Autoinflammatory psoriasis"-genetics and biology of pustular psoriasis.

Cell Mol Immunol 2020 Aug 19. Epub 2020 Aug 19.

Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1038/s41423-020-0519-3DOI Listing
August 2020

Circadian control of interferon-sensitive gene expression in murine skin.

Proc Natl Acad Sci U S A 2020 03 4;117(11):5761-5771. Epub 2020 Mar 4.

Department of Biological Chemistry, University of California, Irvine, CA 92697;

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http://dx.doi.org/10.1073/pnas.1915773117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084068PMC
March 2020

Staphylococcus aureus Colonization Is Increased on Lupus Skin Lesions and Is Promoted by IFN-Mediated Barrier Disruption.

J Invest Dermatol 2020 May 23;140(5):1066-1074.e4. Epub 2019 Dec 23.

Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, Michigan, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183889PMC
May 2020

Niche-Specific Factors Dynamically Regulate Sebaceous Gland Stem Cells in the Skin.

Dev Cell 2019 11 26;51(3):326-340.e4. Epub 2019 Sep 26.

Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2019.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832854PMC
November 2019

TIGAR: An Improved Bayesian Tool for Transcriptomic Data Imputation Enhances Gene Mapping of Complex Traits.

Am J Hum Genet 2019 08 20;105(2):258-266. Epub 2019 Jun 20.

Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698804PMC
August 2019

Making New Connections-Chromosome Conformation Capture for Identification of Disease-Associated Target Genes.

J Invest Dermatol 2019 03;139(3):514-517

Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.11.026DOI Listing
March 2019

A Transethnic Mendelian Randomization Study Identifies Causality of Obesity on Risk of Psoriasis.

J Invest Dermatol 2019 06 5;139(6):1397-1400. Epub 2018 Dec 5.

Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.11.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028352PMC
June 2019

Neutrophil Extracellular Traps Induce Human Th17 Cells: Effect of Psoriasis-Associated TRAF3IP2 Genotype.

J Invest Dermatol 2019 06 5;139(6):1245-1253. Epub 2018 Dec 5.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA; Ann Arbor Veterans Affairs Hospital, Ann Arbor, Michigan, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.11.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092801PMC
June 2019

Drug Repurposing Prediction for Immune-Mediated Cutaneous Diseases using a Word-Embedding-Based Machine Learning Approach.

J Invest Dermatol 2019 03 17;139(3):683-691. Epub 2018 Oct 17.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan USA; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387843PMC
March 2019

Research Techniques Made Simple: Using Genome-Wide Association Studies to Understand Complex Cutaneous Disorders.

J Invest Dermatol 2018 03;138(3):e23-e29

Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA; Ann Arbor Veterans Affairs Hospital, Ann Arbor, Michigan, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X183002
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http://dx.doi.org/10.1016/j.jid.2018.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903459PMC
March 2018

The Promise of Genomic Studies on Human Diseases: From Basic Science to Clinical Application.

Int J Genomics 2017 29;2017:5093167. Epub 2017 Mar 29.

Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, USA.

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http://dx.doi.org/10.1155/2017/5093167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564070PMC
March 2017

Simple Analysis of Deposited Gene Expression Datasets for the Non-Bioinformatician: How to Use GEO for Fibrosis Research.

Methods Mol Biol 2017 ;1627:511-525

Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1007/978-1-4939-7113-8_31DOI Listing
May 2018

Psoriasis: a mixed autoimmune and autoinflammatory disease.

Curr Opin Immunol 2017 Dec 22;49:1-8. Epub 2017 Jul 22.

Department of Dermatology, University of Michigan, 1910 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2017.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705427PMC
December 2017

A rare coding allele in is protective for psoriatic arthritis.

Ann Rheum Dis 2017 Jul 13;76(7):1321-1324. Epub 2017 May 13.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2016-210592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530346PMC
July 2017

GRHL3 binding and enhancers rearrange as epidermal keratinocytes transition between functional states.

PLoS Genet 2017 04 26;13(4):e1006745. Epub 2017 Apr 26.

Department of Biological Chemistry, School of Medicine, University of California Irvine, Irvine, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425218PMC
April 2017

The Molecular Revolution in Cutaneous Biology: The Era of Global Transcriptional Analysis.

J Invest Dermatol 2017 05;137(5):e87-e91

Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.02.817DOI Listing
May 2017

A Review of Recent Advancement in Integrating Omics Data with Literature Mining towards Biomedical Discoveries.

Int J Genomics 2017 26;2017:6213474. Epub 2017 Feb 26.

Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Computational Medicine & Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.

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https://www.hindawi.com/journals/ijg/2017/6213474/
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http://dx.doi.org/10.1155/2017/6213474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346376PMC
February 2017

Dual Role of Act1 in Keratinocyte Differentiation and Host Defense: TRAF3IP2 Silencing Alters Keratinocyte Differentiation and Inhibits IL-17 Responses.

J Invest Dermatol 2017 07 6;137(7):1501-1511. Epub 2017 Mar 6.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA; Ann Arbor Veterans Affairs Health System, Ann Arbor, Michigan, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.12.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554967PMC
July 2017

Epigenome-wide association data implicates DNA methylation-mediated genetic risk in psoriasis.

Clin Epigenetics 2016 5;8:131. Epub 2016 Dec 5.

Institute and Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Meishan Road 81, Hefei, 230032 Anhui Province China.

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http://dx.doi.org/10.1186/s13148-016-0297-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139011PMC
April 2017

Graphical algorithm for integration of genetic and biological data: proof of principle using psoriasis as a model.

Bioinformatics 2015 Apr 4;31(8):1243-9. Epub 2014 Dec 4.

Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA, Department of Dermatology, University of Michigan, Ann Arbor, MI, USA, and Ann Arbor Veterans Affairs Hospital, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1093/bioinformatics/btu799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393514PMC
April 2015

Fine mapping major histocompatibility complex associations in psoriasis and its clinical subtypes.

Am J Hum Genet 2014 Aug 31;95(2):162-72. Epub 2014 Jul 31.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA; Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, Manchester M13 9PT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129407PMC
August 2014

Finding pathway-modulating genes from a novel Ontology Fingerprint-derived gene network.

Nucleic Acids Res 2014 Oct 24;42(18):e138. Epub 2014 Jul 24.

School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA

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http://dx.doi.org/10.1093/nar/gku678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191379PMC
October 2014

Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms.

J Invest Dermatol 2014 Jul 17;134(7):1828-1838. Epub 2014 Jan 17.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA; Ann Arbor Veterans Affairs Hospital, University of Michigan, Ann Arbor, Michigan, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2014.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057954PMC
July 2014

β-arrestin-selective G protein-coupled receptor agonists engender unique biological efficacy in vivo.

Mol Endocrinol 2013 Feb 11;27(2):296-314. Epub 2013 Jan 11.

Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1210/me.2012-1091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683806PMC
February 2013

Signaling network prediction by the Ontology Fingerprint enhanced Bayesian network.

BMC Syst Biol 2012 17;6 Suppl 3:S3. Epub 2012 Dec 17.

Bioinformatics Graduate Program, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1186/1752-0509-6-S3-S3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524013PMC
June 2013

Consistent Differential Expression Pattern (CDEP) on microarray to identify genes related to metastatic behavior.

BMC Bioinformatics 2011 Nov 11;12:438. Epub 2011 Nov 11.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 135 Cannon St, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1186/1471-2105-12-438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251006PMC
November 2011

Philometrids of the southern flounder Paralichthys lethostigma: a multidimensional approach to determine their diversity.

J Parasitol 2011 Jun 11;97(3):466-75. Epub 2011 Jan 11.

Department of Biology, College of Charleston, Fort Johnson Road, Charleston, South Carolina 29412, USA.

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http://dx.doi.org/10.1645/GE-2564.1DOI Listing
June 2011

Evaluation of genome-wide association study results through development of ontology fingerprints.

Bioinformatics 2009 May 5;25(10):1314-20. Epub 2009 Apr 5.

Bioinformatics Graduate Program, Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, SC, USA.

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http://dx.doi.org/10.1093/bioinformatics/btp158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732313PMC
May 2009

Text-mining approach to evaluate terms for ontology development.

J Biomed Inform 2009 Oct 24;42(5):824-30. Epub 2009 Mar 24.

Bioinformatics Graduate Program, Department of Biostatistics, Bioinformatics & Epidemiology, Medical University of South Carolina, 135 Cannon Street, Suite 303, Charleston, SC 29424, USA.

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http://dx.doi.org/10.1016/j.jbi.2009.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153945PMC
October 2009

Development of the philometrids Philometra overstreeti and philometroides paralichthydis in the experimentally infected copepod Oithona colcarva.

Folia Parasitol (Praha) 2008 Dec;55(4):313-5

Department of Biology, College of Charleston, 58 Coming St., Charleston, South Carolina 29401, USA.

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http://dx.doi.org/10.14411/fp.2008.040DOI Listing
December 2008

A role for Fli-1 in B cell proliferation: implications for SLE pathogenesis.

Clin Immunol 2008 Oct 9;129(1):19-30. Epub 2008 Aug 9.

Department of Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA.

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http://dx.doi.org/10.1016/j.clim.2008.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562591PMC
October 2008

A method of microarray data storage using array data type.

Comput Biol Chem 2007 Apr 12;31(2):143-7. Epub 2007 Jan 12.

Bioinformatics Graduate Program, College of Graduate Study, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1016/j.compbiolchem.2007.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709412PMC
April 2007