Publications by authors named "Lalaoui A"

10 Publications

  • Page 1 of 1

Atypical Presentation of Celiac Disease: Recurrent Acute Small Bowel Obstruction.

Clin Med Insights Case Rep 2021 13;14:1179547620986152. Epub 2021 Jan 13.

Pediatric B Department, Mother-Child Pole, Mohammed VI University Hospital, Marrakesh, Morocco.

Context: Intussusception is the most common cause of small bowel obstruction in children under 4 years of age. Intussusception is not a widely recognized complication of celiac disease.

Case Report: We present a clinical case of a 23-month-old boy with a 1-month history of watery diarrhea complicated by 2 episodes of intestinal obstruction, both had required surgery. He presented with acute and severe abdominal distention with bilious vomiting, and an appearance of intussusception on abdominal ultrasound. Upon further investigation, the diarrhea was found to be malabsorptive. The diagnosis of celiac disease was confirmed by the presence of specific serum autoantibodies (IgA Tissue transglutaminase and endomysium Antibodies >200 UI/ml with normal serum IgA level). He started a gluten-free diet and his symptoms were almost completely resolved.

Conclusion: Recurrent intussusception may be associated with celiac disease, so celiac serology is recommended in children with recurrent intussusceptions. However, intestinal tuberculosis and lymphoma associated with enteropathy should be considered in the differential diagnosis. Intussusception in celiac disease is usually transient and should be managed expectantly rather than early surgical reduction.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/1179547620986152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809297PMC
January 2021

A New Presentation: Aphallia, Vesicoureteral Reflux, Rectovesical Fistula, and Adrenal Insufficiency.

Case Rep Pediatr 2020 23;2020:8826520. Epub 2020 Nov 23.

Pediatric B Department-Mother-Child Pole, Mohammed VI University Hospital, Marrakesh, Morocco.

Aphallia or penile agenesis is a rare congenital malformation with an estimated incidence rate of 1 in 10 to 30 million births. More than half of aphallia cases have associated anomalies including caudal axis, cardiovascular, genitourinary, and gastrointestinal anomalies. The penile agenesis associated with adrenal insufficiency has never been reported in an infant. We report a rare case of a newborn that was diagnosed as a case of aphallia with vesicorectal fistula and vesicoureteral reflux, complicated by adrenal insufficiency with salt-wasting crisis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/8826520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704127PMC
November 2020

Update of a colorimetric method for quantitative determination of galactose in blood samples: A simple and rapid method for the early detection of inherited metabolic diseases.

Carbohydr Res 2020 Dec 17;498:108179. Epub 2020 Oct 17.

Metabolic Platform, Biochemistry Laboratory, Team for Childhood, Health and Development Faculty of Medicine, Cadi Ayad University, Marrakech, Morocco. Electronic address:

Background: A colorimetric microassay for the quantitative determination of galactose in the blood was taken and updated. This method helps in diagnosis and follow-up of several inherited metabolic diseases connected to galactose metabolism deficiency such as galactosemia, glycogenosis, glycosylation, tyrosinemia and citrin deficiency. Galactose assay in the blood presents difficulties due to interference with glucose. In this study, we update a method to get around these difficulties.

Method: This procedure was based on the incubation of whole blood with orcinol in a strongly acidic solution to form a galactose and glucose complexes able to absorb at two different wavelengths.

Results: The standard curve analysis for the individual solutions of these two sugars showed a wide range of linearity from 0 to 200 mg / l. Under optimal experimental conditions, the stirring time of the orcinol is 3 minutes, the heating time of the reaction is 20 minutes at 56 ° C, and the duration of the incubation in the dark is 40 minutes. The analysis is carried out on fresh blood. The maximum absorbance of galactose and glucose is respectively 569 nm and 421 nm. An adapted diagnosis algorithm was developed based on our results.

Conclusion: this method could help in screening and identifying patients with hypergalactosemia that need further investigations. It could represent a promising method for neonatal screening in countries with limited resources.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.carres.2020.108179DOI Listing
December 2020

Podocyte Antigen Staining to Identify Distinct Phenotypes and Outcomes in Membranous Nephropathy: A Retrospective Multicenter Cohort Study.

Am J Kidney Dis 2020 11 12;76(5):624-635. Epub 2020 Jul 12.

Division of Nephrology, Cliniques universitaires Saint-Luc, Brussels, Belgium; Institut de Recherche Expérimentale et Clinique, UCLouvain, Brussels, Belgium. Electronic address:

Rationale & Objective: Membranous nephropathy (MN) is characterized by the deposition of immune complexes along glomerular basement membranes. M-Type phospholipase A receptor (PLAR), thrombospondin type 1 domain-containing 7A (THSD7A), exostosin 1 and 2 (EXT1/2), and neural epidermal growth factor-like 1 protein (NELL-1) have been identified as established or potential podocyte antigens in MN. We investigated the association of podocyte antigen staining with MN clinical phenotype and outcomes.

Study Design: Multicenter retrospective cohort study.

Setting & Participants: 177 consecutive patients with MN unrelated to lupus erythematosus, identified after screening of 3,875 native kidney biopsies performed in the Belgian UCLouvain Kidney Disease Network from 2000 through 2018.

Predictor: Positive immunostaining for podocyte antigens on archived kidney biopsy samples.

Outcomes: Association with different phenotypes (baseline characteristics of patients and pathologic findings on kidney biopsy), time to cancer and to kidney failure.

Analytical Approach: Kaplan-Meier estimates and Cox regression analyses to assess time to cancer and kidney failure.

Results: 177 patients were followed up for a median of 4.0 (IQR, 1.3-8.0) years. Diagnosis of PLAR-positive (PLAR), THSD7A, and double-negative (PLAR/THSD7A) MN was made in 117 (66.1%), 6 (3.4%), and 54 (30.5%) patients, respectively. Progression to kidney failure was similar in all groups. Although the number of patients with THSD7AMN was small, they showed a higher incidence (50%) and increased risk for developing cancer during follow-up (adjusted HR, 5.0 [95% CI, 1.4-17.9]; P=0.01). 8% and 5% of patients with double-negative MN stained positively for EXT1/2 and NELL-1, respectively. Most patients with EXT1/2MN were women, had features of systemic autoimmunity, and showed glomerular C1q deposits.

Limitations: Retrospective design; small number of patients in the THSD7A group; lack of evaluation of immunoglobulin G subclasses deposition.

Conclusions: Our real-world data describe the relative prevalence of subgroups of MN and support the hypothesis that a novel classification of MN based on podocyte antigen staining may be clinically relevant.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.ajkd.2020.04.013DOI Listing
November 2020

Implementation of an Affordable Method for MPS Diagnosis from Urine Screening to Enzymatic Confirmation: Results of a Pilot Study in Morocco.

Clin Lab 2020 03;66(3)

Background: Rapid and accurate diagnosis of mucopolysaccharidoses (MPS) is still a challenge due to poor access to screening and diagnostic methods and to their extensive clinical heterogeneity. The aim of this work is to perform laboratory biochemical testing for confirming the diagnosis of mucopolysaccharidosis (MPS) for the first time in Morocco.

Methods: Over a period of twelve months, 88 patients suspected of having Mucopolysaccharidosis (MPS) were referred to our laboratory. Quantitative and qualitative urine glycosaminoglycan (GAG) analyses were performed, and enzyme activity was assayed on dried blood spots (DBS) using fluorogenic substrates. Enzyme activity was measured as normal, low, or undetectable.

Results: Of the 88 patients studied, 26 were confirmed to have MPS; 19 MPS I (Hurler syndrome; OMIM #607014/Hurler-Scheie syndrome; OMIM #607015), 2 MPS II (Hunter syndrome; OMIM #309900), 2 MPS IIIA (Sanfilippo syndrome; OMIM #252900), 1 MPS IIIB (Sanfilippo syndrome; OMIM #252920) and 2 MPS VI (Maroteaux-Lamy syndrome; OMIM #253200). Parental consanguinity was present in 80.76% of cases. Qualitative urinary glycosaminoglycan (uGAGs) assays showed abnormal profiles in 31 cases, and further quantitative urinary GAG evaluation and Thin Layer Chromatography (TLC) provided important additional information about the likely MPS diagnosis. The final diagnosis was confirmed by specific enzyme activity analysis in the DBS samples.

Conclusions: The present study shows that the adoption of combined urinary substrate analysis and enzyme assays using dried blood spots can facilitate such diagnosis, offer an important tool for an appropriate supporting care, and a specific therapy, when available.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.7754/Clin.Lab.2019.190720DOI Listing
March 2020

46th Medical Maghrebian Congress. November 9-10, 2018. Tunis.

Authors:
A Alami Aroussi A Fouad A Omrane A Razzak A Aissa A Akkad A Amraoui A Aouam A Arfaoui A Belkouchi A Ben Chaaben A Ben Cheikh A Ben Khélifa A Ben Mabrouk A Benhima A Bezza A Bezzine A Bourrahouat A Chaieb A Chakib A Chetoui A Daoudi A Ech-Chenbouli A Gaaliche A Hassani A Kassimi A Khachane A Labidi A Lalaoui A Masrar A McHachi A Nakhli A Ouakaa A Siati A Toumi A Zaouali A Y Condé Abdeddayem Haggui Abdelaziz Belaguid Abdelkader Jalil El Hangouche Abdelkarim Gharbi Abdelmajid Mahfoudh Abderrazek Bouzouita Abir Aissaoui Abir Ben Hamouda Abir Hedhli Adel Ammous Afef Bahlous Afef Ben Halima Ahlem Belhadj Ahlem Bezzine Ahlem Blel Ahlem Brahem Ahmed Banasr Ahmed Meherzi Ahmed Saadi Ahmed Sellami Ahmed Turki Aicha Ben Miled Aida Ben Slama Aida Daib Alaa Zommiti Ali Chadly Ali Jmaa Ali Mtiraoui Alia Ksentini Alia Methnani Alya Zehani Amal Kessantini Amani Farah Amani Mankai Amani Mellouli Amani Zaouali Amany Touil Ameni Hssine Amine Ben Safta Amine Derouiche Amine Jmal Amir Ferjani Amira Djobbi Amira Dridi Amna Aridhi Anis Bahdoudi Anis Ben Amara Anis Benzarti Anouar Youssef Ben Slama Anouer Oueslati Aouatef Soltani Aschraf Chadli Asma Aloui Asma Belghuith Sriha Asma Bouden Asma Laabidi Asma Mensi Asma Ouakaa Asma Sabbek Asma Zribi Assia Green Atef Ben Nasr Aymen Azaiez Aza Yeades Azza Belhaj Azza Mediouni Azza Sammoud Azza Slim B Amine B Chelly B Jatik B Lmimouni Bachir Daouahi Badereddine Ben Khelifa Bechir Louzir Ali Dorra Besma Dhahri C Ben Nasrallah C Chefchaouni C Konzi C Loussaief C Makni Chadli Dziri Chaker Bouguerra Chaker Kays Chekib Zedini Cherif Dhouha Cherif Mohamed Chiraz Aichaouia Chiraz Dhieb D Fofana Dalila Gargouri Dhekra Chebil Dhilel Issaoui Donia Gouiaa Dorra Brahim Dorra Essid Dorra Jarraya Dorra Trad E Ben Hmida E Sboui Ehsen Ben Brahim Elyes Baati Emna Talbi Eya Chaari Eya Hammami Ezzeddine Ghazouani F Ayari F Ben Hariz F Bennaoui F Chebbi F Chigr F Guemira F Harrar F Z Benmoula F Z Ouali F M R Maoulainine Faten Bouden Faten Fdhila Fatiha Améziani Fatma Bouhaouala Fatma Charfi Fatma Chermiti Ben Abdallah Fatma Hammemi Fatma Jarraya Fatma Khanchel Fatma Ourda Fatma Sellami Fatma Trabelsi Ferdaous Yangui Feten Fekih Romdhane Fethi Mellouli Fethi Nacef Jomli Fethia Mghaieth G Draiss G Elamine G Kablouti G Touzani G B Manzeki Ghada Garali Ghassen Drissi Ghazi Besbes H Abaza H Azzouz H Said Latiri H Rejeb H Ben Ammar H Ben Brahim H Ben Jeddi H Ben Mahjouba H Besbes H Dabbebi H Douik H El Haoury H Elannaz H Elloumi H Hachim H Iraqi H Kalboussi H Khadhraoui H Khouni H Mamad H Metjaouel H Naoui H Zargouni H O Elmalki Habib Feki Habib Haouala Habib Jaafoura Habiba Drissa Habiba Mizouni Hager Kamoun Haifa Ouerda Haifa Zaibi Haithem Chiha Hajer Kamoun Hajer Saibi Hajer Skhiri Hamza Boussaffa Hamza Majed Hana Blibech Hana Daami Hana Harzallah Hanan Rkain Hanen Ben Massoud Hanene Jaziri Hanène Ben Said Haroun Ayed Hassen Harrabi Hatem Chaabouni Hayet Ladida Debbache Hayett Harbi Haythem Yacoub Hela Abroug Hela Ghali Hela Kchir Hela Msaad Héla Ghali Héla Manai Hend Riahi Hiba Bousselmi Hiba Limem Hichem Aouina Hichem Jerraya Houda Ben Ayed Houda Chahed Houda Snéne I Lahlou Amine I Nouiser I Ait Sab I Chelly I Elboukhani I Ghanmi I Kallala I Kooli Ibtissem Bouasker Ilhem Fetni Imen Bachouch Imen Bouguecha Imen Chaabani Imen Gazzeh Imen Samaali Imen Youssef Imen Zemni Imene Bachouche Imène Youssef Ines Bouannene Ines Kasraoui Ines Laouini Ines Mahjoubi Ines Maoudoud Ines Riahi Ines Selmi Ines Tka Islem Hadj Khalifa Islem Mejri Ismail Béjia J Bellagha Jallel Boubaker Jalloul Daghfous Jamel Dammak Jamila Hleli Jihen Ben Amar Jihen Jedidi Jihen Marrakchi K Kaoutar K Arjouni K Ben Helel K Benouhoud K Rjeb Kacem Imene Kais Samoud Kaouther El Jeri Karem Abid Kays Chaker Khadija Abid Khadija Bouzghaîa Khaled Kamoun Khaled Zitouna Khalil Oughlani Khaoula Lassoued Khaoula Letaif Khaouther Hakim L Cherif Alami L Benhmidoune L Boumhil L Bouzgarrou L Dhidah L Ifrine Lamia Kallel Latifa Merzougui Leila Errguig Leila Mouelhi Lina Sahli M Maoua M Rejeb M Ben Rejeb M Bouchrik M Bouhoula M Bourrous M Bouskraoui M El Belhadji M El Belhadji M Essakhi M Essid M Gharbaoui M Haboub M Iken M Krifa M Lagrine M Leboyer M Najimi M Rahoui M Sabbah M Sbihi M Zouine M C Chefchaouni M H Gharbi M M El Fakiri M R Tagajdid Maha Shimi Maha Touaibia Mahbouba Jguirim Maher Barsaoui Maissa Belghith Maissa Ben Jmaa Makram Koubaa Makram Tbini Malak Boughdir Mamia Ben Salah Manel Ben Fraj Manel Ben Halima Manel Ben Khalifa Manel Bousleh Manel Limam Manel Mabrouk Manel Mallouli Manel Rebeii Mariem Ayari Mariem Belhadj Mariem Ben Hmida Mariem Boughattas Mariem Drissa Mariem El Ghardallou Mariem Fejjeri Mariem Hamza Mariem Jaidane Mariem Jrad Mariem Kacem Mariem Mersni Mariem Mjid Mariem Sabbah Mariem Serghini Mariem Triki Maroua Ben Abbes Maroua Boussaid Maroua Gharbi Maroua Hafi Maroua Slama Maroua Trigui Marouen Taoueb Marouene Chakroun Marwa Ben Cheikh Marwa Chebbi Marwa Hadj Taieb Marwa Kacem Mehdi Ben Khelil Mehdi Hammami Mehdi Khalfallah Mehdi Ksiaa Mehdi Mechri Mehdi Mrad Mehdi Sboui Mejda Bani Melek Hajri Menel Mellouli Mohamed Allouche Mohamed Amine Mesrati Mohamed Amine Mseddi Mohamed Amri Mohamed Bejaoui Mohamed Bellali Mohamed Ben Amor Mohamed Ben Dhieb Mohamed Ben Moussa Mohamed Chebil Mohamed Cherif Mohamed Fourati Mohamed Kahloul Mohamed Khaled Mohamed Machghoul Mohamed Mansour Mohamed Morched Abdesslem Mohamed Ali Ben Chehida Mohamed Ali Chaouch Mohamed Ali Essid Mohamed Ali Meddeb Mohamed Chawki Gharbi Mohamed Habib Elleuch Mohamed Hédi Loueslati Mohamed Mehdi Sboui Mohamed Nabil Mhiri Mohamed Osman Kilani Mohamed Riadh Ben Slama Mohamed Ridha Charfi Mohamed Said Nakhli Mohamed Sami Mourali Mohamed Selim El Asli Mohamed Taher Lamouchi Mohammed Cherti Mohsen Khadhraoui Mokhtar Bibi Moncef Hamdoun Mondher Kassis Mongi Touzi Monia Ben Khaled Monia Fekih Monia Khemiri Monia Ouederni Monjia Hchicha Monther Kassis Mossadak Ben Attia Moufida Yahyaoui Mouna Ben Azaiez Mouna Bousnina Mounir Ben Jemaa Mounir Ben Yahia Mounir Daghfous Mourad Haj Slimen Msadak Assidi N Belhadj N Ben Mustapha N El Idrissislitine N Hikki N Kchir N Mars N Meddeb N Ouni N Rada N Rezg N Trabelsi Nabiha Bouafia Nabil Haloui Nacéra Benfenatki Naceur Bergaoui Naceur Yomn Nadia Ben Mustapha Nadia Maamouri Nadia Mehiri Nadia Siala Najeh Beltaief Najet Aridhi Najet Sidaoui Najia Walid Najla Mechergui Najla Mnif Nariméne Ben Chekaya Nawel Bellil Nawel Dhouib Nazek Achour Nejib Kaabar Nejib Mrizak Nejla Mnif Nesrine Chaouech Nesrine Hasni Nesrine Issaoui Nidhal Ati Nidhal Balloumi Nidhal Haj Salem Nizar Ladhari Nora Akif Nora Liani Nouha Hajji Nouha Trad Nour Elleuch Nour El Houda Marzouki Noureddine Larbi Nourelhouda M'barek Nouri Rebai Noursaf Bibani Nozha Ben Salah O Belmaachi O Elmaalel O Jlassi O Mihoub Olfa Ben Zaid Olfa Bouallègue Olfa Bousnina Olfa Bouyahia Olfa El Maalel Omar Fendri Ons Azzabi Ons Borgi Ons Ghdes Oussama Ben Rejeb R Rachid R Abi R Bahiri R Boulma R Elkhayat R Habbal R Rachid R Tamouza Rabaa Jomli Rabiaa Ben Abdallah Racha Smaoui Radhouene Debbeche Radhouene Fakhfakh Rafik El Kamel Rahma Gargouri Raja Jouini Ramzi Nouira Rana Fessi Rania Bannour Rania Ben Rabeh Rania Kacem Rania Khmakhem Raouf Ben Younes Raouf Karray Rezaik Cheikh Riadh Ben Malek Ridha Ben Slama Ridha Kouki Rim Baati Rim Bechraoui Rim Fakhfakh Rim Fradi Rim Lahiani Rim Ridha Rim Zainine Roua Kallel S Rostom S Ben Abdallah S Ben Hammamia S Benchérifa S Benkirane S Chatti S El Guedri S El Oussaoui S Elkochri S Elmoussaoui S Enbili S Gara S Haouet S Khammeri S Khefecha S Khtrouche S Macheghoul S Mallouli S Rharrit S Skouri Saan Helali Sabrine Boulehmi Sahar Abid Sahbi Naouar Saida Zelfani Salah Ben Amar Salem Ajmi Salem Braiek Salem Yahiaoui Salima Ghezaiel Salma Ben Toumia Salma Thabeti Salsabil Daboussi Salwa Ben Abderahman Samar Rhaiem Sami Ben Rhouma Samia Rekaya Samir Haddad Samir Kammoun Samira Merai Samira Mhamdi Rabaa Ben Ali Sana Gaaloul Sana Ouali Sana Taleb Saoussen Zrour Sarah Hamdi Sarah Zaghdoudi Sarra Ammari Sarra Ben Abderrahim Sarra Karaa Sarra Maazaoui Sarra Saidani Sarra Stambouli Seif Mokadem Selim Boudiche Selim Zaghbib Shema Ayedi Sinda Jardek Siwar Bouselmi Sonda Chtourou Sondos Manoubi Sonia Bahri Sonia Halioui Sonia Jrad Sonia Mazigh Sonia Ouerghi Sonia Toujani Soraya Fenniche Souad Aboudrar Souad Meriem Amari Souhaiel Karouia Soumaya Bourgou Soumaya Halayem Soumaya Rammeh Sourour Yaïch Syrine Ben Nasrallah Syrine Chouchane Syrine Ftini Syrine Makni Syrine Manoubi Syrine Miri Syrine Saadi Syrine Azza Manoubi T Khalfallah Takwa Mechergui Taoufiq Dakka Tarek Barhoumi Tej El Baha M'rad Thouraya Ajmi Trad Dorra Uta Ouali W Hannachi Wael Ferjaoui Wafa Aissi Wafa Dahmani Wafa Dhouib Wafa Koubaa Wafa Zhir Wafe Gheriani Wajdi Arfa Wajih Dougaz Wajih Sahnoun Walid Naija Y Sami Y Bouteraa Y Elhamdaoui Y Hama Yacine Ouahchi Yassine Guebsi Yassine Nouira Yosr Daly Yosra Mahjoubi Yosra Mejdoub Yosra Mosbahi Yosra Said Yosra Zaimi Yosra Zgueb Yousr Dridi Yousra Mesbahi Youssef Gharbi Youssef Hellal Z Hechmi Z Zid Z Elmouatassim Z Ghorbel Z Habbadi Zahra Marrakchi Zaki Hidouri Zeineb Abbes Zeineb Ouhachi Zied Khessairi Zied Khlayfia Zied Mahjoubi Zied Moatemri

Tunis Med 2019 Jan;97(1):177-258

View Article and Find Full Text PDF

Download full-text PDF

Source
January 2019

Poster abstracts of the 18th Pan Arab Cancer Congress. TUNISIA. April 19-21, 2018.

Authors:
J Aarab Ibtissem Abbess Fathi Abdalla Z Abdelaziz S Abdelfattah I Abdelli K Abdelmajid Zied Abdelsselem N Abdelwahed Nihed Abdessayed Bassem Abid K Abid R Abidi Asma Abudabbous Sana Abujanah Afaf Aburwais E Acacha Nessrine Acharfi Nejmeddine Affes R Aftis I Ahalli Mr Aid D Aissaoui A Alaoui M Alaoui Salaheddin Albatran Aldehmani Mamdouh Rabia Alkikkli A Allam S Aloulou Omar Alqawi Mussa A Alragig Ali Alsharksi K Oualla L Amaadour L Amaadour N Ameziane A Ammari H Ammour R Amrane N Annad E Aouati S Aouichat S Aouragh S Arifi Md Astra M Atassi Nidhal Ati K Atoui L Atreche S Ayachi I Ayadi Mohammed Ali Ayadi Mouna Ayadi Jihene Ayari Haroun Ayed K Ayed Henda Ayedi Ines Ayedi M Azegrar Heifa Azzouz Fathi Babdalla R Bachiri Z Bachiri M Baghdad R Bahloul A Bahouli M Bahri I Baississ Hanae Bakkali Mehdi Balti O Baraket Hayfa Bargaoui Rim Batti Ahlem Bedioui R Begag Z Behourah Imtinene Belaid Asma Belaïd Amine Ben Abdallah Ichrak Ben Abdallah Slim Ben Ahmed Tarek Ben Ahmed M Ben Azaiz M A Ben Chehida Leila Ben Fatma D Ben Ghachem T Ben Ghachem J Ben Hassouna S Ben Hmida Sonia Ben Nasr Dalel Ben Nejima K Ben Rahal M Ben Rejeb S Ben Rhouma I Ben Safta A Ben Salem Yosr Ben Zargouna Ichrak Benabdallah H Benabdella Mohamed Zied Benabdessalem Khaled Benahmed Slim Benahmed Hazem Benameur S Benasr Fz Benbrahim W Benbrahim Z Benbrahim Ma Benchehida Yasser Bencheikh Tarek Bendhiab Leila Benfatma A Bengueddach M Benhami Jamel Benhassouna W Benhbib Noureddine Benjaafar R Benkali Wala Benkridis A Benlaloui Mahmoud Benmaitig A Benmansour M Benmouhoub Farouk Benna H Benna Marouan Benna Mehdi Benna H Bennabdellah Khaled Benrahal Ines Bensafta Hanène Bensalah A Bensalem Mohammed Bensaud Riadh Benslama M Benyoub K Benzid H Bergaoui M Beroual S Berrad Y Berrazaga Z Bezzaz Hanene Bhiri M Bibi Mohamed Yassine Binous Ahlem Blel Jamela M Boder N Bouaouina Hanen Bouaziz S Bouchoucha Tahia Boudawara Zaher Boudawara A Bouderbala Rima Bouhali Malek Bouhani R Boujarnija Salah Boujelben Nadia Boujelbene I Boukerzaza H Boukhari W Boulfoul R Boulma N Boumansour A Bouned A Bounedjar I Bouraoui Saadia Bouraoui Rym Bourigua M Bourmech Hamza Bousaffa A Bousahba C Bousrih A Boussarsar Hammouda Boussen Selwa Boutayeb Khaled Bouzaidi Faten Bouzaiene H Bouzaiene Z Bouzerzour Kamel Bouzid N Bouzid Dw Bouzidi W Bouzidi Abderrazek Bouzouita S Brahimi A Brahmia Abdelbaset Buhmeida Kais Chaaben Hatem Chaabouni Mohamed Chaabouni Kais Chaabène H Chaari Ines Chaari M Chaari Imene Chabchoub K Chabeene K Chaker Marouene Chakroun M Charfi Slim Charfi R Chargui Md Charles Mohamed Chebil Khadidja Cheikchouk Beya Chelly Ines Chelly N Cheraiet Aziz Cherif Mohamed Cherif A Cherifi T Chikhrouhou A Chikouche A Chirouf Nesrine Chraiet Y Collan Zhanglin Cui Habiba Dabbebi Amira Daldoul I Damouche H Daoud N Daoud J Daoued Khadija Darif Dalia O Darwish Z Derbouz Amine Derouiche T T Dhibe Tarek Dhibet A Djallaoui N Djami K Djebbes H Djedi S Djeghim L Djellali A Djellaoui K Djilat R Djouabi H Doumbia Mustafa Drah M Dridi Mohamed Hsairi S Elabbassi Fz Elallia Zohra Elati M Elattassi Houda Elbenna Mohamed A Elfagieh Omran Elfaitori Hebatallah Elfannas Amine Elghali Mohamed Amine Elghali Salah Elgonti O Elamine Elhadj R Elhazzaz H Elkacemi Khaoula Elkinany Youssri Elkissi F Elloumi Olfa Elmaalel I S Elmajjaou S Elmajjaoui H Elmhabrech Fz Elmrabet Wesam A Elsaghayer Adam Elzagheid Fatma Emaetig H Erraichi Mejda Essid Nada Ewshah Faten Ezzairi Raja Faleh Sourour Fallah Amr Lotfy Farag L Farhat R Fehri Jihène Feki Sami Fendri Sana Fendri Z Fessi Taha Filali A Fissah M Fourati N Fourati Mounir Frikha C S Fuchs Azza Gabssi F Gachi Selma Gadria A Gammoudi I Ganzoui Asma Gargoura Imen Ghaddabb Imen Gharbi Maroua Gharbi E Ghazouani N Gheriani Abdelmonom Ghorbel L Ghorbel A Ghozi Rafik Ghrissi Amine Gouader A Goucha A Guebsi I Guellil Fatma Guermazi Sondess Guesmi Wafa Guetari N Habak A Haddad S Haddad Abderrazek Haddaoui I Hadef Abdelbasit Faraj Hader A Hadiji F Hadjarab Myriam Hadoussa Nadia Hadoussa Ch Hafsa Mariem Hafsia Ahmed Hajji M Hajmansour S Hamdi Z Hamici S Hamida Fehmi Hamila Selim Hamissa Boussen Hammouda Slim Haouet I Harhira Ayed Haroun K Hassouni A Hdiji Monia Hechiche L Hejjane C Hellal Manseurs Henni K Herbegue L Hichami M Hikem Alaa Hmad Lina Hmida S Hmissa Makrem Hochlaf A Houas M Houhani Ali Huwidi Chau Ian B N Ibrahim Noha Y Ibrahim H Idir Dhilel Issaoui A Itaimi A E Izem Olfa Jaidane Daoud Jamel H Jamous Medsalah Jarrar Mohamed Salah Jarrar Saber Jarray M Jebsi Hafedh Jmal Abdallah Juwid Ons Kaabia A Kablouti Imene Kacem K Kacem M Y Kaid M Kallel R Kallel H Kammoun Syrjänen Kari Sarra Karrit Hela Kchir Nidhameddine Kchir T Kebdani N Kechad H Kehili E Kerboua Hassib Keskes Nora N Kessi N Khababa H Khaldi Afef Khanfir B Khater A Khelif S Khemiri K Khennouf H Khouni S Khrouf Zahra Kmira L Kochbati Asma Korbi N Kouadri F Kouhen M Krarti M Handoussa Yanzhi Hsu Ons Laakom Matti Laato Soumaya Labidi Fz Lahlali A Lahmidi A Lalaoui Naija Lamia A Lamri Feryel Letaief M R Letaief M Aldehmani A Rafael A M Liepa Faten Limaiem K Limam H Loughlimi F Ltaief Nadia Maamouri Mohamed Mabrouk R Madouri N Mahjoub Z Mahjoubi M Mahrsi Hochlef Makrem W Mallek Moez Manitta L Mansoura Houyem Mansouri Maher Maoua W Maoui Chakroun Marouene K Marzouk S Masmoudi Fatma May I Meddeb Khedija Meddeb S Meddour Fatma Medhioub Nesrine Mejri Mohamed Rochdi Melizi N Mellas Rihab Melliti A Melzi N Merair F Z Merrouki C Mersali O Messalbi Lina Messaoudi S Messioud K Messoudi Sarra Mestiri Amal Mezlini Amel Mezlini F Mghirbi H Mhabrech A Mhiri N Midoun Rabia Milud B Missaoui Aymen Mnasser Wafa Mnejja Moncef Mokni Amina Mokrani Mokrani Mokrani R Moujahed Y Moukasse A Mouzount Karima Mrad Mohamed Hedi Mraidha Nejib Mrizak Rafik Mzali Y Mzid F M'ghirbi Abdelwaheb Nakhli Chiraz Nasr Salsabil Nasri Gef Noubigh Daoud Nouha L Nouia Y Nouira A Noureddine O Nouri Atsushi Ohtsu H Ouahbi K Oualla Y Ouanes H Ouaz A Ouikene N Ouldbessi Iqbal Parker S Pyrhonen H Rachdi K Rahal Khaled Rahal M Rahoui Henda Raies Soumaya Rameh K Reguieg Haitham Rejab R Rejiba Mohamed Salah Rhim S Riahi N Rouimel N Saad Saoud K Saadi Myriam Saadi A Sadou Ines Saguem T Sahnoun H Sahnoune Saida Sakhri A Sallemi Asma Sassi W Sbika C Sedkaoui S Sefiane A Sellami Pyrhönen Seppo H Sfaoua Syrine Sghaier Ali Shagan W Siala I Slim M Slimene S Soltani S Souilah Marwa Souissi Badreddine Sriha Badreddine Youssef Swaisi A Taibi T Taktak Ghofran Talbi S W Talha Soha M Talima S Tbessi N Tebani S Tebra S Tebramrad D Telaijia A Tenni Ahmedou Tolba Yassen Topov K Touil Nabil Toumi W Toumi N Tounsi Aymen Trigui R Trigui W Triki Maroua Walha Ines Werda Haythem Yacoub Yosra Yahyaoui A Yaich R Yaici M Yamouni I Yeddes D Yekrou Ma Yousfi N Yousfi M A Youssfi L Zaabar Sonia Zaied I Zaim Walid Zakhama S Zayed Alia Zehani I Zemni Yosr Zenzri S Zeraoula O Zouiten Olfa Zoukar Ws Zrafi Aref Zribi Naji Zubia

Tunis Med 2018 Apr;96(4):177-182

View Article and Find Full Text PDF

Download full-text PDF

Source
April 2018

Rationale and design of the Investigator-Steered Project on Intravascular Renal Denervation for Management of Drug-Resistant Hypertension (INSPiRED) trial.

Blood Press 2014 06 17;23(3):138-46. Epub 2014 Apr 17.

Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences, University of Leuven , Leuven , Belgium.

Unlabelled: The SYMPLICITY studies showed that renal denervation (RDN) is feasible as novel treatment for resistant hypertension. However, RDN is a costly and invasive procedure, the long-term efficacy and safety of which has not yet been proven. Therefore, we designed the INSPiRED trial to compare the blood pressure lowering efficacy and safety of RDN vs usual medical therapy. INSPiRED is a randomized controlled trial enrolling 240 treatment-resistant hypertensive patients at 16 expert hypertension centres in Belgium. Eligible patients, aged 20-69 years old, have a 24-h ambulatory blood pressure of 130 mmHg systolic or 80 mmHg diastolic or more, while taking at least three antihypertensive drugs. They are randomized to RDN (EnligHTN(TM), SJM system) plus usual care (intervention group) or usual care alone (control group) in a ratio of 1:1. The primary endpoints for efficacy and safety, measured after 6 months, are the baseline-adjusted between-group differences in 24h systolic blood pressure and in glomerular filtration rate as estimated by the Chronic Kidney Disease Epidemiology Collaboration equation. Follow-up will continue up to 36 months after randomization. INSPiRED is powered to demonstrate a 10-mmHg difference in systolic blood pressure between randomized groups with a two-sided p-value of 0.01 and 90% power. It will generate long-term efficacy and safety data, identify the subset of treatment-resistant hypertensive patients responsive to RDN, provide information on cost-effectiveness, and by doing so INSPiRED will inform guideline committees and health policy makers.

Trial Registration: ClinicalTrials.gov Identifier: NCT 01505010.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3109/08037051.2014.899297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059255PMC
June 2014

Tacrolimus and low-dose steroid immunosuppression preserves bone mass after renal transplantation.

Transpl Int 2002 Mar 28;15(2-3):73-80. Epub 2002 Feb 28.

Department of Nephrology, Hopital Saint-Luc, Université Catholique de Louvain, 10 Ave. Hippocrate, 1200 Brussels, Belgium.

Bone loss, a recognized complication of renal transplantation (TP), is mainly attributed to steroids. The effect of other immunosuppressive agents on patients' bone mass is difficult to distinguish from that of steroids. In this study, we evaluate the evolution of bone mass density over the first 12 months following renal TP in two groups of patients given either low-dose steroids with tacrolimus ( n=7) or normal-dose steroids and cyclosporine ( n=19). Bone mineral density (BMD) of the lumbar spine, total hip, and hip subregions and total-body bone mineral content (BMC) were measured by dual-energy X-ray absorptiometry within the first 15 days, and 1 year after TP. Biological markers of bone turnover (serum calcium, phosphate, total alkaline phosphatase activity, intact parathyroid hormone, bone-specific alkaline phosphatase, calcitriol, and urinary pyridinolines) were regularly measured during follow-up. After TP, renal function improved rapidly in all patients. One year after TP, bone mass had decreased significantly in the cyclosporine group in all investigated sites. By contrast it had increased in the tacrolimus group. In order to compare the evolution of bone mass in patients given similar amounts of steroids, the cyclosporine group was subdivided in tertiles according to the 1-year cumulative oral intake of prednisolone. A significant bone loss was still observed in the low-steroid cyclosporine subgroup but not in the tacrolimus group, despite the similar steroids intake (3.5+/-0.5 g and 2.7+/-1 g, respectively). Bone gain in the tacrolimus group occurred despite a previous longer dialysis duration and a higher number of postmenopausal women who were not receiving hormone substitutes. Long-term evaluation of bone density (3-5 years post-TP) confirmed the bone gain in the tacrolimus patients. Interestingly, the profile of the biological markers of bone turnover appeared better in patients prescribed tacrolimus than in those given cyclosporine, though the differences did not reach statistical significance. Weconclude that tacrolimus associated with low-dose steroids might better preserve bone mass after renal TP than cyclosporine and normal doses of steroids.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00147-001-0377-6DOI Listing
March 2002

Increase of physical activity level after successful renal transplantation: a 5 year follow-up study.

Nephrol Dial Transplant 2001 Jan;16(1):134-40

Physical Medicine and Rehabilitation, Université Catholique de Louvain, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

Background: Physical activity (PA) level of end-stage renal disease (ESRD) patients after renal transplantation (TP) is a largely unexplored field, although it is an important component of quality of life.

Methods: Using the Baecke self-administered and the Five-City Project 7-day PA recall questionnaires, PA level was estimated in 32 consecutive ESRD patients (12 males, 20 females; mean age 45.9+/-13.1 years; mean dialysis duration 23.5+/-21.8 months) admitted for renal TP and to whom no exercise programme of any kind was proposed. PA were recorded 1, 3, 6, 12 and 60 months after TP.

Results: Immediate pre-TP PA level of renal transplant candidates was between 18 and 35% less than that of age-matched healthy subjects (P < 0.05), depending on gender and questionnaire. After an immediate decrease in PA level 1 month post-TP, mean PA level increased and reached a plateau 1 year after TP. This gain in PA capacity reached 30%, as compared with pre-TP values (P = 0.06 to P < 0.01). During the fifth year after TP, the mean level of PA was unchanged. A more qualitative analysis, allowed by the sub-score comparisons, showed that although the occupational status of the patients remained the same, they participated significantly more in moderate and even high intensity PA (leisure, sports, household chores) after TP.

Conclusions: Most renal graft recipients are spontaneously more active after TP, an observation consistent with a better quality of life. Therefore, they should be advised precisely about how to resume more strenuous activities such as sports in order to avoid cardiac or musculoskeletal disorders in relation to their weakened pre-TP condition.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/ndt/16.1.134DOI Listing
January 2001