Lakshmi Santhanam

Lakshmi Santhanam

UNVERIFIED PROFILE

Are you Lakshmi Santhanam?   Register this Author

Register author
Lakshmi Santhanam

Lakshmi Santhanam

Publications by authors named "Lakshmi Santhanam"

Are you Lakshmi Santhanam?   Register this Author

55Publications

496Reads

-Profile Views

Oxidative Stress Contributes to Microvascular Endothelial Dysfunction in Men and Women With Major Depressive Disorder.

Circ Res 2019 Feb;124(4):564-574

From the Noll Laboratory, Department of Kinesiology, Pennsylvania State University, University Park (J.L.G., L.M.A.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.118.313764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375800PMC
February 2019

Knockdown of transglutaminase-2 prevents early age-induced vascular changes in mice1.

Acta Cir Bras 2018 Nov;33(11):991-999

PhD, Associate Professor, Division of Surgical Techniques and Experimental Surgery, Department of Surgery, UNIFESP, Sao Paulo-SP, Brazil. Conception and design of the study, critical revision, final approval.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/s0102-865020180110000006DOI Listing
November 2018

Hypoxia Triggers SENP1 (Sentrin-Specific Protease 1) Modulation of KLF15 (Kruppel-Like Factor 15) and Transcriptional Regulation of Arg2 (Arginase 2) in Pulmonary Endothelium.

Arterioscler Thromb Vasc Biol 2018 04 22;38(4):913-926. Epub 2018 Feb 22.

From the Departments of Anesthesiology and Critical Care Medicine (D.P., Y.N., M.C.R., D.H., A.B., L.S., D.B., L.R.), Cell Biology (L.R.), Biomedical Engineering (D.B., L.R.), and Pediatrics, and the Center for Cell Dynamics (L.R.), Division of Cardiology (G.K., T.L.), and Division of Pulmonary and Critical Care Medicine, Department of Medicine (L.A.S.), Johns Hopkins Medical Institutions, Baltimore, MD.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/ATVBAHA.117.310660DOI Listing
April 2018

Acute lysyl oxidase inhibition alters microvascular function in normotensive but not hypertensive men and women.

Am J Physiol Heart Circ Physiol 2018 03 22;314(3):H424-H433. Epub 2017 Nov 22.

The Pennsylvania State University , University Park, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpheart.00521.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899263PMC
March 2018

Imatinib Is Protective Against Ischemia-Reperfusion Injury in an Ex Vivo Rabbit Model of Lung Injury.

Ann Thorac Surg 2018 03 28;105(3):950-956. Epub 2017 Dec 28.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, Maryland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.athoracsur.2017.10.002DOI Listing
March 2018

Alterations in endothelin type B receptor contribute to microvascular dysfunction in women who have had preeclampsia.

Clin Sci (Lond) 2017 Dec 23;131(23):2777-2789. Epub 2017 Nov 23.

Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, U.S.A.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/CS20171292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922254PMC
December 2017

Increased Angiotensin II Sensitivity Contributes to Microvascular Dysfunction in Women Who Have Had Preeclampsia.

Hypertension 2017 08 26;70(2):382-389. Epub 2017 Jun 26.

From the Department of Kinesiology, Pennsylvania State University, University Park, (A.E.S., L.M.A.); and Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (S.J., L.S.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520653PMC
August 2017

Impaired Hydrogen Sulfide-Mediated Vasodilation Contributes to Microvascular Endothelial Dysfunction in Hypertensive Adults.

Hypertension 2017 05 27;69(5):902-909. Epub 2017 Mar 27.

From the Department of Kinesiology, Noll Laboratory, The Pennsylvania State University, University Park (J.L.G., J.L.K., S.W.S., L.M.A.); Department of Exercise Science, Shenandoah University, Winchester, VA (J.L.K.); and Departments of Anesthesia and Critical Care Medicine and Bioengineering, Johns Hopkins University School of Medicine, Baltimore, MD (S.J., L.S.).

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.116.
Publisher Site
http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.08964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391285PMC
May 2017

Cystathionine γ-lyase protects vascular endothelium: a role for inhibition of histone deacetylase 6.

Am J Physiol Heart Circ Physiol 2017 Apr 10;312(4):H711-H720. Epub 2017 Feb 10.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland;

View Article

Download full-text PDF

Source
http://www.physiology.org/doi/10.1152/ajpheart.00724.2016
Publisher Site
http://dx.doi.org/10.1152/ajpheart.00724.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407166PMC
April 2017

Role of tissue transglutaminase in age-associated ventricular stiffness.

Amino Acids 2017 03 20;49(3):695-704. Epub 2016 Jul 20.

Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 1150, Baltimore, MD, 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00726-016-2295-zDOI Listing
March 2017

Arginase Inhibition Reverses Endothelial Dysfunction, Pulmonary Hypertension, and Vascular Stiffness in Transgenic Sickle Cell Mice.

Anesth Analg 2016 09;123(3):652-8

From the *Department of Anesthesiology and Critical Care Medicine and †Department of Medicine, Division of Cardiology, Johns Hopkins Medical Institution, Baltimore, Maryland; ‡Department of Anesthesiology and Pain Medicine, Yonsei University, College of Medicine, Seoul, South Korea; and §Department of Urology, Johns Hopkins Medical Institution, Baltimore, Maryland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1213/ANE.0000000000001378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032625PMC
September 2016

MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery.

Am J Physiol Heart Circ Physiol 2016 Jan 30;310(1):H71-9. Epub 2015 Oct 30.

Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland;

View Article

Download full-text PDF

Source
http://www.physiology.org/doi/10.1152/ajpheart.00574.2014
Publisher Site
http://dx.doi.org/10.1152/ajpheart.00574.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796461PMC
January 2016

Evidence for a functional vasodilatatory role for hydrogen sulphide in the human cutaneous microvasculature.

J Physiol 2015 May 25;593(9):2121-9. Epub 2015 Mar 25.

Department of Kinesiology, Noll Laboratory, The Pennsylvania State University, University Park, PA, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1113/JP270054
Publisher Site
http://dx.doi.org/10.1113/JP270054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422566PMC
May 2015

Melanopsin mediates light-dependent relaxation in blood vessels.

Proc Natl Acad Sci U S A 2014 Dec 17;111(50):17977-82. Epub 2014 Nov 17.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1420258111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273372PMC
December 2014

Measuring ascending aortic stiffness in vivo in mice using ultrasound.

J Vis Exp 2014 Dec 2(94). Epub 2014 Dec 2.

Department of Biomedical Engineering, Johns Hopkins University; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3791/52200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354463PMC
December 2014

Exercise, vascular stiffness, and tissue transglutaminase.

J Am Heart Assoc 2014 Apr 10;3(2):e000599. Epub 2014 Apr 10.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/JAHA.113.000599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187484PMC
April 2014

Nitroprusside inhibits calcium-induced impairment of red blood cell deformability.

Transfusion 2014 Feb 19;54(2):434-44. Epub 2013 Jun 19.

Department of Anesthesiology/Critical Care Medicine, The Johns Hopkins Hospital; Molecular Dynamics Section, National Institute on Aging, National Institutes of Health; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/trf.12291DOI Listing
February 2014

Contribution of arginase activation to vascular dysfunction in cigarette smoking.

Atherosclerosis 2013 Nov 4;231(1):91-4. Epub 2013 Sep 4.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.atherosclerosis.2013.08.026DOI Listing
November 2013

A physiologic and biochemical profile of clinically rejected lungs on a normothermic ex vivo lung perfusion platform.

J Surg Res 2013 Jul 27;183(1):75-83. Epub 2012 Nov 27.

Department of Surgery, Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00224804120185
Publisher Site
http://dx.doi.org/10.1016/j.jss.2012.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150088PMC
July 2013

Rho-Kinase activity and cutaneous vasoconstriction is upregulated in essential hypertensive humans.

Microvasc Res 2013 May 26;87:58-64. Epub 2013 Feb 26.

Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mvr.2013.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517969PMC
May 2013

Nitric oxide regulates tissue transglutaminase localization and function in the vasculature.

Amino Acids 2013 Jan 8;44(1):261-9. Epub 2011 Oct 8.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 1150, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00726-011-1090-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744185PMC
January 2013

Inhaled hydrogen sulfide improves graft function in an experimental model of lung transplantation.

J Surg Res 2012 Dec 27;178(2):593-600. Epub 2012 Jun 27.

Division of Cardiac Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jss.2012.06.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131866PMC
December 2012

Hydrogen sulfide decreases reactive oxygen in a model of lung transplantation.

J Surg Res 2012 Nov 18;178(1):494-501. Epub 2012 Mar 18.

Division of Cardiac Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jss.2012.02.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389187PMC
November 2012

Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve.

Eur J Appl Physiol 2012 Aug 8;112(8):2933-41. Epub 2011 Dec 8.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University Medicine, Tower 711, 600 N Wolfe St., Baltimore, MD 21287, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00421-011-2257-9DOI Listing
August 2012

Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin.

J Appl Physiol (1985) 2012 Jun 12;112(12):2019-26. Epub 2012 Apr 12.

Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/japplphysiol.01354.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378394PMC
June 2012

S-nitrosation of arginase 1 requires direct interaction with inducible nitric oxide synthase.

Mol Cell Biochem 2011 Sep 1;355(1-2):83-9. Epub 2011 May 1.

Johns Hopkins University School of Medicine, 720 Rutland Ave Ross 1150, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11010-011-0841-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744166PMC
September 2011

Nitric oxide regulates non-classical secretion of tissue transglutaminase.

Commun Integr Biol 2011 Sep 1;4(5):584-6. Epub 2011 Sep 1.

Department of Anesthesiology and Critical Care Medicine; Johns Hopkins University School of Medicine Baltimore, MD USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cib.4.5.16512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204136PMC
September 2011

Oral atorvastatin therapy restores cutaneous microvascular function by decreasing arginase activity in hypercholesterolaemic humans.

J Physiol 2011 Apr 21;589(Pt 8):2093-103. Epub 2011 Feb 21.

Department of Kinesiology and Intercollege Program in Physiology, Pennsylvania State University, University Park, PA 16802, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1113/jphysiol.2010.203935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090606PMC
April 2011

Dietary inhibition of xanthine oxidase attenuates radiation-induced endothelial dysfunction in rat aorta.

J Appl Physiol (1985) 2010 May 18;108(5):1250-8. Epub 2010 Feb 18.

Department of Biomedical Engineering, Johns Hopkins Medical Institutions, 600 N. Wolfe St., Tower 711, Baltimore, MD 21287, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/japplphysiol.00946.2009DOI Listing
May 2010

Cyclohexanone contamination from extracorporeal circuits impairs cardiovascular function.

Am J Physiol Heart Circ Physiol 2009 Jun 1;296(6):H1926-32. Epub 2009 May 1.

Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://www.physiology.org/doi/10.1152/ajpheart.00184.2009
Publisher Site
http://dx.doi.org/10.1152/ajpheart.00184.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716145PMC
June 2009

Selective fluorescent labeling of S-nitrosothiols (S-FLOS): a novel method for studying S-nitrosation.

Nitric Oxide 2008 Nov 30;19(3):295-302. Epub 2008 Jul 30.

The Johns Hopkins School of Medicine, Anesthesiology and CCM, 720 Rutland Avenue, Traylor 621, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.niox.2008.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705760PMC
November 2008

Arginase and vascular aging.

J Appl Physiol (1985) 2008 Nov 21;105(5):1632-42. Epub 2008 Aug 21.

Department of Biomedical Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://www.physiology.org/doi/10.1152/japplphysiol.90627.200
Publisher Site
http://dx.doi.org/10.1152/japplphysiol.90627.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584835PMC
November 2008

Single exposure gamma-irradiation amplifies xanthine oxidase activity and induces endothelial dysfunction in rat aorta.

Radiat Environ Biophys 2007 Jun 26;46(2):179-86. Epub 2007 Jan 26.

Biomedical Engineering, Johns Hopkins Medical Institutions, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00411-006-0090-zDOI Listing
June 2007

Sos-mediated activation of rac1 by p66shc.

J Cell Biol 2006 Mar 6;172(6):817-22. Epub 2006 Mar 6.

Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1083/jcb.200506001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063726PMC
March 2006

Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism.

Proc Natl Acad Sci U S A 2006 Mar 13;103(12):4759-64. Epub 2006 Mar 13.

Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0506589103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1450243PMC
March 2006

Structural diversity of peroxidase-catalyzed oxidation products of o-methoxyphenols.

Org Lett 2004 Jun;6(12):1975-8

Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, New York 12180, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ol049448lDOI Listing
June 2004