Lakshmi A Devi

Lakshmi A Devi

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Lakshmi A Devi

Lakshmi A Devi

Publications by authors named "Lakshmi A Devi"

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The role of the neuropeptide PEN receptor, GPR83, in the reward pathway: Relationship to sex-differences.

Neuropharmacology 2019 Oct 12;157:107666. Epub 2019 Jun 12.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, NY, NY, USA; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, NY, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2019.107666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677605PMC
October 2019

Opioid-Induced Signaling and Antinociception Are Modulated by the Recently Deorphanized Receptor, GPR171.

J Pharmacol Exp Ther 2019 Oct 15;371(1):56-62. Epub 2019 Jul 15.

Department of Biology, Utah State University, Logan, Utah (M.V.M., L.A., E.N.B.) and Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York (I.G., L.A.D.)

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http://dx.doi.org/10.1124/jpet.119.259242DOI Listing
October 2019

Targeting Cannabinoid 1 and Delta Opioid Receptor Heteromers Alleviates Chemotherapy-Induced Neuropathic Pain.

ACS Pharmacol Transl Sci 2019 Aug 5;2(4):219-229. Epub 2019 Jun 5.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.

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http://dx.doi.org/10.1021/acsptsci.9b00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764458PMC
August 2019

Targeting the Recently Deorphanized Receptor GPR83 for the Treatment of Immunological, Neuroendocrine and Neuropsychiatric Disorders.

Prog Mol Biol Transl Sci 2018 25;159:1-25. Epub 2018 Aug 25.

Department of Pharmacological Sciences, Freidman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

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http://dx.doi.org/10.1016/bs.pmbts.2018.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317364PMC
July 2019

Neuropeptide PEN and Its Receptor GPR83: Distribution, Signaling, and Regulation.

ACS Chem Neurosci 2019 Apr 21;10(4):1884-1891. Epub 2019 Feb 21.

Department of Pharmacological Sciences , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.

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http://pubs.acs.org/doi/10.1021/acschemneuro.8b00559
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http://dx.doi.org/10.1021/acschemneuro.8b00559DOI Listing
April 2019

Regulation of an Opioid Receptor Chaperone Protein, RTP4, by Morphine.

Mol Pharmacol 2019 01 22;95(1):11-19. Epub 2018 Oct 22.

Departments of Frontier Life Science (W.F.) and Therapeutic Innovation and Pharmacology (M.Y., H.U.), Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; and Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York (I.G., A.G., L.A.D.)

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http://molpharm.aspetjournals.org/lookup/doi/10.1124/mol.118
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http://dx.doi.org/10.1124/mol.118.112987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277927PMC
January 2019

Exploring Morphine-Triggered PKC-Targets and Their Interaction with Signaling Pathways Leading to Pain via TrkA.

Proteomes 2018 Oct 6;6(4). Epub 2018 Oct 6.

Department of Biochemistry, Chemistry Institute, University of São Paulo, Sao Paulo 05508-220, Brazil.

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http://www.mdpi.com/2227-7382/6/4/39
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http://dx.doi.org/10.3390/proteomes6040039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313901PMC
October 2018

Orphan neuropeptides and receptors: Novel therapeutic targets.

Pharmacol Ther 2018 05 22;185:26-33. Epub 2017 Nov 22.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2017.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899030PMC
May 2018

The BigLEN-GPR171 Peptide Receptor System Within the Basolateral Amygdala Regulates Anxiety-Like Behavior and Contextual Fear Conditioning.

Neuropsychopharmacology 2017 Dec 20;42(13):2527-2536. Epub 2017 Apr 20.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1038/npp.2017.79DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686498PMC
December 2017

Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states.

PLoS One 2017 1;12(11):e0187306. Epub 2017 Nov 1.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187306PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665533PMC
December 2017

Two delta opioid receptor subtypes are functional in single ventral tegmental area neurons, and can interact with the mu opioid receptor.

Neuropharmacology 2017 Sep 21;123:420-432. Epub 2017 Jun 21.

Department of Neurology, The Wheeler Center for the Neurobiology of Addiction, Alcoholism and Addiction Research Group, University of California San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2017.06.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563499PMC
September 2017

Detection of Receptor Heteromerization Using In Situ Proximity Ligation Assay.

Curr Protoc Pharmacol 2016 12 13;75:2.16.1-2.16.31. Epub 2016 Dec 13.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.

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http://dx.doi.org/10.1002/cpph.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758307PMC
December 2016

G Protein-Coupled Receptor Heteromers.

Annu Rev Pharmacol Toxicol 2016 22;56:403-25. Epub 2015 Oct 22.

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029; email:

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http://dx.doi.org/10.1146/annurev-pharmtox-011613-135952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147582PMC
September 2016

Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity.

Proc Natl Acad Sci U S A 2016 May 9;113(21):6041-6. Epub 2016 May 9.

Department of Pharmacology & Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029;

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http://dx.doi.org/10.1073/pnas.1521825113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889365PMC
May 2016

Identification of GPR83 as the receptor for the neuroendocrine peptide PEN.

Sci Signal 2016 04 26;9(425):ra43. Epub 2016 Apr 26.

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/scisignal.aad0694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147544PMC
April 2016

Morphine Regulated Synaptic Networks Revealed by Integrated Proteomics and Network Analysis.

Mol Cell Proteomics 2015 Oct 6;14(10):2564-76. Epub 2015 Jul 6.

From the ‡Department of Pharmacology and Systems Therapeutics, §Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, 10029;

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http://dx.doi.org/10.1074/mcp.M115.047977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597137PMC
October 2015

Advancements in therapeutically targeting orphan GPCRs.

Front Pharmacol 2015 8;6:100. Epub 2015 May 8.

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY USA.

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http://dx.doi.org/10.3389/fphar.2015.00100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424851PMC
May 2015

Heteromers of μ-δ opioid receptors: new pharmacology and novel therapeutic possibilities.

Br J Pharmacol 2015 Jan 1;172(2):375-87. Epub 2014 Jul 1.

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1111/bph.12663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292954PMC
January 2015

G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives.

Pharmacol Rev 2014 10;66(2):413-34. Epub 2014 Feb 10.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes on Drug Abuse, Department of Health and Human Services, 333 Cassell Drive, Baltimore, Maryland 21224.

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http://dx.doi.org/10.1124/pr.113.008052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973609PMC
December 2014

Molecular characterization of eluxadoline as a potential ligand targeting mu-delta opioid receptor heteromers.

Biochem Pharmacol 2014 Dec 28;92(3):448-56. Epub 2014 Sep 28.

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2014.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769596PMC
December 2014

Antibodies to probe endogenous G protein-coupled receptor heteromer expression, regulation, and function.

Front Pharmacol 2014 3;5:268. Epub 2014 Dec 3.

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai New York, NY, USA ; The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai New York, NY, USA.

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http://dx.doi.org/10.3389/fphar.2014.00268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253664PMC
December 2014

Revolution in GPCR signalling: opioid receptor heteromers as novel therapeutic targets: IUPHAR review 10.

Br J Pharmacol 2014 Sep;171(18):4155-76

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1111/bph.12798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241085PMC
September 2014

Opioid receptor function is regulated by post-endocytic peptide processing.

J Biol Chem 2014 Jul 20;289(28):19613-26. Epub 2014 May 20.

From the Department of Pharmacology and Systems Therapeutics and the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029

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http://dx.doi.org/10.1074/jbc.M113.537704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094072PMC
July 2014

Hemopressin, an inverse agonist of cannabinoid receptors, inhibits neuropathic pain in rats.

Peptides 2014 Jun 3;56:125-31. Epub 2014 Apr 3.

Laboratory of Neuromodulation and Experimental Pain, Department of Anatomy, University of São Paulo, São Paulo, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.peptides.2014.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112957PMC
June 2014

Orally active opioid μ/δ dual agonist MGM-16, a derivative of the indole alkaloid mitragynine, exhibits potent antiallodynic effect on neuropathic pain in mice.

J Pharmacol Exp Ther 2014 Mar 17;348(3):383-92. Epub 2013 Dec 17.

Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International University, Chiba, Japan (K.Ma., N.M., K.T., S.H.); Department of Toxicology (K.Ma., M.N., T.S.) and Department of Pharmacology (K.Ma., M.N.), Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan; Department of Molecular Structure and Biological Function, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (T.N., K.Mi., M.K., H.T.); and Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York (L.A.D.).

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http://dx.doi.org/10.1124/jpet.113.208108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067406PMC
March 2014

An integrated quantitative proteomics and systems biology approach to explore synaptic protein profile changes during morphine exposure.

Neuropsychopharmacology 2014 Jan 18;39(1):88-103. Epub 2013 Sep 18.

Department of Pharmacology and Systems Therapeutics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1038/npp.2013.227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857660PMC
January 2014

Disease-specific heteromerization of G-protein-coupled receptors that target drugs of abuse.

Prog Mol Biol Transl Sci 2013 ;117:207-65

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, USA.

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http://dx.doi.org/10.1016/B978-0-12-386931-9.00009-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973131PMC
December 2013

GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding.

Proc Natl Acad Sci U S A 2013 Oct 16;110(40):16211-6. Epub 2013 Sep 16.

Department of Pharmacology and Systems Therapeutics, Ichan School of Medicine at Mount Sinai, New York, NY 10029.

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http://dx.doi.org/10.1073/pnas.1312938110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791715PMC
October 2013

G-protein-coupled heteromers: regulation in disease.

Methods Enzymol 2013 ;521:219-38

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1016/B978-0-12-391862-8.00012-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976561PMC
July 2013

Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy.

J Hepatol 2013 Jul 26;59(1):98-104. Epub 2013 Feb 26.

Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.jhep.2013.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686909PMC
July 2013

Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity.

Proc Natl Acad Sci U S A 2013 Jul 1;110(29):12072-7. Epub 2013 Jul 1.

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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http://dx.doi.org/10.1073/pnas.1222044110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718106PMC
July 2013

Dimerization with cannabinoid receptors allosterically modulates delta opioid receptor activity during neuropathic pain.

PLoS One 2012 14;7(12):e49789. Epub 2012 Dec 14.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0049789PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522681PMC
June 2013

Grand opening of structure-guided design for novel opioids.

Trends Pharmacol Sci 2013 Jan 3;34(1):6-12. Epub 2012 Nov 3.

Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.tips.2012.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534797PMC
January 2013

Cannabinoid receptor 2-mediated attenuation of CXCR4-tropic HIV infection in primary CD4+ T cells.

PLoS One 2012 20;7(3):e33961. Epub 2012 Mar 20.

Department of Infectious Diseases, Department of Medicine, Immunology Institute, Mount Sinai School of Medicine, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033961PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309010PMC
August 2012

Structural biology: How opioid drugs bind to receptors.

Nature 2012 May 16;485(7398):314-7. Epub 2012 May 16.

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http://dx.doi.org/10.1038/485314aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589518PMC
May 2012

Opioid receptor heteromers in analgesia.

Expert Rev Mol Med 2012 Apr 10;14:e9. Epub 2012 Apr 10.

Department of Pharmacology and Systems Therapeutics, The Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1017/erm.2012.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805500PMC
April 2012

Functional relevance of μ-δ opioid receptor heteromerization: a role in novel signaling and implications for the treatment of addiction disorders: from a symposium on new concepts in mu-opioid pharmacology.

Drug Alcohol Depend 2012 Mar 23;121(3):167-72. Epub 2011 Nov 23.

Department of Pharmacology and Systems Therapeutics, The Mount Sinai School of Medicine, New York, NY 10029, United States.

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http://dx.doi.org/10.1016/j.drugalcdep.2011.10.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288266PMC
March 2012

Mice deficient in endothelin-converting enzyme-2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord.

J Neurochem 2011 Dec 1;119(5):1074-85. Epub 2011 Nov 1.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2011.07513.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217172PMC
December 2011

Potentiation of μ-opioid receptor-mediated signaling by ketamine.

J Neurochem 2011 Oct 20;119(2):294-302. Epub 2011 Sep 20.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2011.07361.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856727PMC
October 2011

Possible involvement of β-endorphin in a loss of the coordinated balance of μ-opioid receptors trafficking processes by fentanyl.

Synapse 2011 Sep 11;65(9):962-6. Epub 2011 Apr 11.

Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.

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http://doi.wiley.com/10.1002/syn.20930
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http://dx.doi.org/10.1002/syn.20930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575095PMC
September 2011

The highs and lows of cannabinoid receptor expression in disease: mechanisms and their therapeutic implications.

Pharmacol Rev 2011 Sep 13;63(3):461-70. Epub 2011 Jul 13.

Department of Pharmacology and Systems Therapeutics, Box 1603, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

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http://dx.doi.org/10.1124/pr.110.003491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141881PMC
September 2011

Role of antibodies in developing drugs that target G-protein-coupled receptor dimers.

Mt Sinai J Med 2010 Jul-Aug;77(4):374-80

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1002/msj.20199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917817PMC
June 2011

G protein-coupled receptor heteromerization: a role in allosteric modulation of ligand binding.

Mol Pharmacol 2011 Jun 17;79(6):1044-52. Epub 2011 Mar 17.

Mount Sinai School of Medicine, Department of Pharmacology and System Therapeutics, New York, NY 10029, USA.

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http://dx.doi.org/10.1124/mol.110.070847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102551PMC
June 2011

AT1R-CB₁R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II.

EMBO J 2011 May 3;30(12):2350-63. Epub 2011 May 3.

Department of Pharmacology and Systems Therapeutics, New York Mount Sinai School of Medicine, New York, NY, USA.

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http://emboj.embopress.org/cgi/doi/10.1038/emboj.2011.139
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http://dx.doi.org/10.1038/emboj.2011.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116274PMC
May 2011

Exploring a role for heteromerization in GPCR signalling specificity.

Biochem J 2011 Jan;433(1):11-8

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1042/BJ20100458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115900PMC
January 2011

Hemoglobin-derived peptides as novel type of bioactive signaling molecules.

AAPS J 2010 Dec 2;12(4):658-69. Epub 2010 Sep 2.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1208/s12248-010-9217-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976993PMC
December 2010

Escorts take the lead molecular chaperones as therapeutic targets.

Prog Mol Biol Transl Sci 2010 ;91:121-49

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, USA.

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http://dx.doi.org/10.1016/S1877-1173(10)91005-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125676PMC
September 2010

Increased abundance of opioid receptor heteromers after chronic morphine administration.

Sci Signal 2010 Jul 20;3(131):ra54. Epub 2010 Jul 20.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/scisignal.2000807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125674PMC
July 2010

The propeptide precursor proSAAS is involved in fetal neuropeptide processing and body weight regulation.

J Neurochem 2010 Jun 26;113(5):1275-84. Epub 2010 Mar 26.

Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06706.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510705PMC
June 2010

Modulation of opiate-related signaling molecules in morphine-dependent conditioned behavior: conditioned place preference to morphine induces CREB phosphorylation.

Neuropsychopharmacology 2010 Mar 2;35(4):955-66. Epub 2009 Dec 2.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://www.nature.com/articles/npp2009199
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http://dx.doi.org/10.1038/npp.2009.199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820136PMC
March 2010

Receptor heteromerization and drug discovery.

Trends Pharmacol Sci 2010 Mar 7;31(3):124-30. Epub 2010 Jan 7.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY10029, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01656147090020
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http://dx.doi.org/10.1016/j.tips.2009.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834828PMC
March 2010

Cannabinoid-opioid interactions during neuropathic pain and analgesia.

Curr Opin Pharmacol 2010 Feb 25;10(1):80-6. Epub 2009 Oct 25.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.coph.2009.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818338PMC
February 2010

Quantitative neuroproteomics of the synapse.

Methods Mol Biol 2010 ;615:227-46

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1007/978-1-60761-535-4_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066061PMC
February 2010

Novel endogenous peptide agonists of cannabinoid receptors.

FASEB J 2009 Sep 20;23(9):3020-9. Epub 2009 Apr 20.

Department of Pharmacology and Systems Therapeutics, Mt. Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1096/fj.09-132142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735371PMC
September 2009

Systems approach to explore components and interactions in the presynapse.

Proteomics 2009 Jun;9(12):3303-15

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1002/pmic.200800767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766278PMC
June 2009

Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4.

Proc Natl Acad Sci U S A 2008 Oct 3;105(41):16045-50. Epub 2008 Oct 3.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1073/pnas.0804106105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572960PMC
October 2008

Regulation of CB1 cannabinoid receptor trafficking by the adaptor protein AP-3.

FASEB J 2008 Jul 11;22(7):2311-22. Epub 2008 Feb 11.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

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http://dx.doi.org/10.1096/fj.07-102731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127579PMC
July 2008

Antibodies against G-protein coupled receptors: novel uses in screening and drug development.

Comb Chem High Throughput Screen 2008 Jul;11(6):463-7

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125642PMC
http://dx.doi.org/10.2174/138620708784911465DOI Listing
July 2008

Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2.

J Med Chem 2008 Jun 29;51(12):3378-87. Epub 2008 May 29.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

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http://pubs.acs.org/doi/abs/10.1021/jm7015478
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http://dx.doi.org/10.1021/jm7015478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706147PMC
June 2008

Post-activation-mediated changes in opioid receptors detected by N-terminal antibodies.

J Biol Chem 2008 Apr 6;283(16):10735-44. Epub 2008 Feb 6.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1074/jbc.M709454200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447646PMC
April 2008

Teaching resources. Using web-based discussion forums as a model of the peer-review process and a tool for assessment.

Sci Signal 2008 ;1(9):tr2

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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April 2008

Inquiry learning. Integrating content detail and critical reasoning by peer review.

Science 2008 Feb;319(5867):1189-90

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/science.1149875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038128PMC
February 2008

An emerging role for the delta opioid receptor in the regulation of mu opioid receptor function.

ScientificWorldJournal 2007 Nov 2;7:64-73. Epub 2007 Nov 2.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1100/tsw.2007.219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901224PMC
November 2007

Receptor heterodimerization leads to a switch in signaling: beta-arrestin2-mediated ERK activation by mu-delta opioid receptor heterodimers.

FASEB J 2007 Aug 23;21(10):2455-65. Epub 2007 Mar 23.

Department of Pharmacology and Biological Chemistry, Mt. Sinai School of Medicine, One Gustave L. Levy Pl., New York, NY 10029, USA.

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http://dx.doi.org/10.1096/fj.06-7793comDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131006PMC
August 2007

Use of proteomics for the identification of novel drug targets in brain diseases.

J Neurochem 2007 Jul 10;102(2):306-15. Epub 2007 Apr 10.

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York 10029, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2007.04536.xDOI Listing
July 2007

D2 receptors regulate dopamine transporter function via an extracellular signal-regulated kinases 1 and 2-dependent and phosphoinositide 3 kinase-independent mechanism.

Mol Pharmacol 2007 May 31;71(5):1222-32. Epub 2007 Jan 31.

Integrative Neuroscience Section, National Institute on Drug Abuse Intramural Research Program/National Institutes of Health/Department of Health and Human Services, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1124/mol.106.027763DOI Listing
May 2007

Conformation state-sensitive antibodies to G-protein-coupled receptors.

J Biol Chem 2007 Feb 4;282(8):5116-24. Epub 2006 Dec 4.

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1074/jbc.M609254200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856726PMC
February 2007

The emerging functions of endocannabinoid signaling during CNS development.

Trends Pharmacol Sci 2007 Feb 10;28(2):83-92. Epub 2007 Jan 10.

Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm SE-17177, Sweden.

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http://dx.doi.org/10.1016/j.tips.2006.12.004DOI Listing
February 2007

Peptidomics of Cpefat/fat mouse hypothalamus and striatum: effect of chronic morphine administration.

J Mol Neurosci 2006 ;28(3):277-84

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY, USA.

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http://link.springer.com/10.1385/JMN:28:3:277
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January 2007

Morphine administration alters the profile of hippocampal postsynaptic density-associated proteins: a proteomics study focusing on endocytic proteins.

Mol Cell Proteomics 2007 Jan 6;6(1):29-42. Epub 2006 Oct 6.

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1074/mcp.M600184-MCP200DOI Listing
January 2007

Neuroproteomics of the synapse and drug addiction.

J Pharmacol Exp Ther 2006 Aug 27;318(2):461-8. Epub 2006 Apr 27.

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

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http://dx.doi.org/10.1124/jpet.105.091520DOI Listing
August 2006

The use of receptor-specific antibodies to study G-protein-coupled receptors.

Mt Sinai J Med 2006 Jul;73(4):673-81

Department of Pharmacology and Biological Chemistry, Box 1603, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

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July 2006

mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis.

Br J Pharmacol 2006 Jun 8;148(4):387-95. Epub 2006 May 8.

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1038/sj.bjp.0706757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1751792PMC
June 2006

Quantification of VGF- and pro-SAAS-derived peptides in endocrine tissues and the brain, and their regulation by diet and cold stress.

Brain Res 2006 May 2;1089(1):21-32. Epub 2006 May 2.

Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.brainres.2006.02.124DOI Listing
May 2006

A role for transmembrane domains V and VI in ligand binding and maturation of the angiotensin II AT1 receptor.

Biol Chem 2006 Mar;387(3):269-76

Department of Biophysics, Escola Paulista de Medicina, UNIFESP, São Paulo 04023-062, Brazil.

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http://dx.doi.org/10.1515/BC.2006.036DOI Listing
March 2006

Targeting opioid receptor heterodimers: strategies for screening and drug development.

AAPS J 2006 Mar 10;8(1):E153-9. Epub 2006 Mar 10.

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1208/aapsj080118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751434PMC
March 2006

The G alpha(o/i)-coupled cannabinoid receptor-mediated neurite outgrowth involves Rap regulation of Src and Stat3.

J Biol Chem 2005 Sep 26;280(39):33426-34. Epub 2005 Jul 26.

Department of Pharmacology, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1074/jbc.M502812200DOI Listing
September 2005

Serotonin receptor activation leads to neurite outgrowth and neuronal survival.

Brain Res Mol Brain Res 2005 Aug;138(2):228-35

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.molbrainres.2005.04.016DOI Listing
August 2005

Embryonic gene expression and pro-protein processing of proSAAS during rodent development.

J Neurochem 2005 Jun;93(6):1454-62

Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2005.03138.xDOI Listing
June 2005