Publications by authors named "Laki Buluwela"

25Publications

Author Correction: The responses of cancer cells to PLK1 inhibitors reveal a novel protective role for p53 in maintaining centrosome separation.

Authors:
Linda Smith Raed Farzan Simak Ali Laki Buluwela Adrian T Saurin David W Meek

Sci Rep 2018 Mar 22;8(1):5237. Epub 2018 Mar 22.

Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, The University of Dundee, Dundee, DD1 9, SY, United Kingdom.

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March 2018

ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment.

Authors:
Hetal Patel Manikandan Periyasamy Georgina P Sava Alexander Bondke Brian W Slafer Sebastian H B Kroll Marion Barbazanges Richard Starkey Silvia Ottaviani Alison Harrod Eric O Aboagye Laki Buluwela Matthew J Fuchter Anthony G M Barrett R Charles Coombes Simak Ali

Mol Cancer Ther 2018 06 15;17(6):1156-1166. Epub 2018 Mar 15.

Division of Cancer, Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom.

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June 2018

Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance.

Authors:
Lesley-Ann Martin Ricardo Ribas Nikiana Simigdala Eugene Schuster Sunil Pancholi Tencho Tenev Pascal Gellert Laki Buluwela Alison Harrod Allan Thornhill Joanna Nikitorowicz-Buniak Amandeep Bhamra Marc-Olivier Turgeon George Poulogiannis Qiong Gao Vera Martins Margaret Hills Isaac Garcia-Murillas Charlotte Fribbens Neill Patani Zheqi Li Matthew J Sikora Nicholas Turner Wilbert Zwart Steffi Oesterreich Jason Carroll Simak Ali Mitch Dowsett

Nat Commun 2017 11 30;8(1):1865. Epub 2017 Nov 30.

Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, London, SW7 3RP, UK.

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November 2017

The responses of cancer cells to PLK1 inhibitors reveal a novel protective role for p53 in maintaining centrosome separation.

Authors:
Linda Smith Raed Farzan Simak Ali Laki Buluwela Adrian T Saurin David W Meek

Sci Rep 2017 11 23;7(1):16115. Epub 2017 Nov 23.

Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, The University of Dundee, Dundee, DD1 9, SY, United Kingdom.

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November 2017

p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells.

Authors:
Manikandan Periyasamy Anup K Singh Carolina Gemma Christian Kranjec Raed Farzan Damien A Leach Naveenan Navaratnam Hajnalka L Pálinkás Beata G Vértessy Tim R Fenton John Doorbar Frances Fuller-Pace David W Meek R Charles Coombes Laki Buluwela Simak Ali

Nucleic Acids Res 2017 Nov;45(19):11056-11069

Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK.

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November 2017

Expression of CDK7, Cyclin H, and MAT1 Is Elevated in Breast Cancer and Is Prognostic in Estrogen Receptor-Positive Breast Cancer.

Authors:
Hetal Patel Rezvan Abduljabbar Chun-Fui Lai Manikandan Periyasamy Alison Harrod Carolina Gemma Jennifer H Steel Naina Patel Claudia Busonero Dena Jerjees Judit Remenyi Sally Smith Jennifer J Gomm Luca Magnani Balázs Győrffy Louise J Jones Frances Fuller-Pace Sami Shousha Laki Buluwela Emad A Rakha Ian O Ellis R Charles Coombes Simak Ali

Clin Cancer Res 2016 Dec 14;22(23):5929-5938. Epub 2016 Jun 14.

Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom.

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December 2016

Prognostic significance of androgen receptor expression in invasive breast cancer: transcriptomic and protein expression analysis.

Authors:
Mohammad A Aleskandarany Rezvan Abduljabbar Ibraheem Ashankyty Ahmed Elmouna Dena Jerjees Simak Ali Laki Buluwela Maria Diez-Rodriguez Carlos Caldas Andrew R Green Ian O Ellis Emad A Rakha

Breast Cancer Res Treat 2016 Sep 11;159(2):215-27. Epub 2016 Aug 11.

Division of Cancer and Stem Cells, Molecular Pathology Research Unit, School of Medicine, University of Nottingham and Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham, NG5 1PB, UK.

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September 2016

APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer.

Authors:
Manikandan Periyasamy Hetal Patel Chun-Fui Lai Van T M Nguyen Ekaterina Nevedomskaya Alison Harrod Roslin Russell Judit Remenyi Anna Maria Ochocka Ross S Thomas Frances Fuller-Pace Balázs Győrffy Carlos Caldas Naveenan Navaratnam Jason S Carroll Wilbert Zwart R Charles Coombes Luca Magnani Laki Buluwela Simak Ali

Cell Rep 2015 Oct 24;13(1):108-121. Epub 2015 Sep 24.

Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK. Electronic address:

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October 2015

LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner.

Authors:
Holly B Kramer Chun-Fui Lai Hetal Patel Manikandan Periyasamy Meng-Lay Lin Stephan M Feller Frances V Fuller-Pace David W Meek Simak Ali Laki Buluwela

Nucleic Acids Res 2016 Jan 22;44(2):582-94. Epub 2015 Sep 22.

Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK

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January 2016

Expression profiling of nuclear receptors in breast cancer identifies TLX as a mediator of growth and invasion in triple-negative breast cancer.

Authors:
Meng-Lay Lin Hetal Patel Judit Remenyi Christopher R S Banerji Chun-Fui Lai Manikandan Periyasamy Ylenia Lombardo Claudia Busonero Silvia Ottaviani Alun Passey Philip R Quinlan Colin A Purdie Lee B Jordan Alastair M Thompson Richard S Finn Oscar M Rueda Carlos Caldas Jesus Gil R Charles Coombes Frances V Fuller-Pace Andrew E Teschendorff Laki Buluwela Simak Ali

Oncotarget 2015 Aug;6(25):21685-703

Department of Surgery & Cancer, Imperial College London, London, UK.

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August 2015

LMTK3 Represses Tumor Suppressor-like Genes through Chromatin Remodeling in Breast Cancer.

Authors:
Yichen Xu Hua Zhang Van Thuy Mai Nguyen Nicos Angelopoulos Joao Nunes Alistair Reid Laki Buluwela Luca Magnani Justin Stebbing Georgios Giamas

Cell Rep 2015 Aug 23;12(5):837-49. Epub 2015 Jul 23.

Division of Cancer, Imperial College London, Department of Surgery and Cancer, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK. Electronic address:

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August 2015

Prognostic and biological significance of peroxisome proliferator-activated receptor-gamma in luminal breast cancer.

Authors:
Rezvan Abduljabbar Methaq Mueen Al-Kaabi Ola H Negm Dena Jerjees Abir A Muftah Abhik Mukherjee Chun F Lai Laki Buluwela Simak Ali Patrick J Tighe Andrew Green Ian Ellis Emad Rakha

Breast Cancer Res Treat 2015 Apr 21;150(3):511-22. Epub 2015 Mar 21.

Division of Cancer and Stem Cells, School of Medicine, University Of Nottingham, City Hosital Campus, Nottingham, NG5 1PB, UK,

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April 2015

Engineered repressors are potent inhibitors of androgen receptor activity.

Authors:
Greg N Brooke Sue M Powell Derek N Lavery Jonathan Waxman Laki Buluwela Simak Ali Charlotte L Bevan

Oncotarget 2014 Feb;5(4):959-69

Department of Surgery and Cancer, Imperial Centre for Translational and Experimental Medicine, Imperial College London, W12 0NN, UK.

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February 2014

Prolonged exposure to bradykinin and prostaglandin E2 increases TRPV1 mRNA but does not alter TRPV1 and TRPV1b protein expression in cultured rat primary sensory neurons.

Authors:
Shilpa Mistry Cleoper C Paule Angelika Varga Andy Photiou Agnes Jenes Antonio Avelino Laki Buluwela Istvan Nagy

Neurosci Lett 2014 Apr 11;564:89-93. Epub 2014 Feb 11.

Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road. London, SW10 9NH, United Kingdom. Electronic address:

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April 2014

Anandamide produced by Ca(2+)-insensitive enzymes induces excitation in primary sensory neurons.

Authors:
Angelika Varga Agnes Jenes Timothy H Marczylo Joao Sousa-Valente Jie Chen Jonothan Austin Srikumaran Selvarajah Fabiana Piscitelli Anna P Andreou Anthony H Taylor Fiona Kyle Mohammed Yaqoob Sue Brain John P M White Laszlo Csernoch Vincenzo Di Marzo Laki Buluwela Istvan Nagy

Pflugers Arch 2014 Jul 10;466(7):1421-35. Epub 2013 Oct 10.

Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK.

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July 2014

Co-regulated gene expression by oestrogen receptor α and liver receptor homolog-1 is a feature of the oestrogen response in breast cancer cells.

Authors:
Chun-Fui Lai Koen D Flach Xanthippi Alexi Stephen P Fox Silvia Ottaviani Paul T R Thiruchelvam Fiona J Kyle Ross S Thomas Rosalind Launchbury Hui Hua Holly B Callaghan Jason S Carroll R Charles Coombes Wilbert Zwart Laki Buluwela Simak Ali

Nucleic Acids Res 2013 Dec 17;41(22):10228-40. Epub 2013 Sep 17.

Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK, Department of Molecular Pathology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands and Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, UK.

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December 2013

Characterisation of the androgen regulation of glycine N-methyltransferase in prostate cancer cells.

Authors:
Silvia Ottaviani Greg N Brooke Ciara O'Hanlon-Brown Jonathan Waxman Simak Ali Laki Buluwela

J Mol Endocrinol 2013 Dec 7;51(3):301-12. Epub 2013 Nov 7.

Department of Surgery and Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine, London W12 0NN, UK School of Biological Sciences, University of Essex, Colchester, UK.

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December 2013

Discovery of a new class of liver receptor homolog-1 (LRH-1) antagonists: virtual screening, synthesis and biological evaluation.

Authors:
Jullien Rey Haipeng Hu Fiona Kyle Chun-Fui Lai Laki Buluwela R Charles Coombes Eric A Ortlund Simak Ali James P Snyder Anthony G M Barrett

ChemMedChem 2012 Nov 7;7(11):1909-14. Epub 2012 Sep 7.

Department of Chemistry, Imperial College London, London, SW7 2AZ (England).

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November 2012

A simple laboratory practical to illustrate RNA mediated gene interference using drosophila cell culture.

Authors:
Laki Buluwela Tahereh Kamalati Andy Photiou Dean A Heathcote Michael D Jones Simak Ali

Biochem Mol Biol Educ 2010 Nov;38(6):393-9

Department of Oncology, Hammersmith Hospital Campus, Imperial College London, Du Cane road, London W12 0NN United Kingdom.

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November 2010

Antiestrogens and their therapeutic applications in breast cancer and other diseases.

Authors:
Simak Ali Laki Buluwela R Charles Coombes

Annu Rev Med 2011 ;62:217-32

Division of Cancer, Department of Surgery and Oncology, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom.

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May 2011

Transient over-expression of estrogen receptor-α in breast cancer cells promotes cell survival and estrogen-independent growth.

Authors:
Robert S Tolhurst Ross S Thomas Fiona J Kyle Hetal Patel Manikandan Periyasamy Andrew Photiou Paul T R Thiruchelvam Chun-Fui Lai Marwa Al-Sabbagh Rosemary A Fisher Sayka Barry Tatjana Crnogorac-Jurcevic Lesley-Ann Martin Mitch Dowsett R Charles Coombes Tahereh Kamalati Simak Ali Laki Buluwela

Breast Cancer Res Treat 2011 Jul 22;128(2):357-68. Epub 2010 Aug 22.

Division of Cancer, Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.

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July 2011

The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cells.

Authors:
Paul T R Thiruchelvam Chun-Fui Lai Hui Hua Ross S Thomas Antoni Hurtado William Hudson Andrew R Bayly Fiona J Kyle Manikandan Periyasamy Andrew Photiou Alan C Spivey Eric A Ortlund Richard J Whitby Jason S Carroll R Charles Coombes Laki Buluwela Simak Ali

Breast Cancer Res Treat 2011 Jun 6;127(2):385-96. Epub 2010 Jul 6.

Department of Oncology, Imperial College London, Hammersmith Hospital, London, UK.

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June 2011

Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines.

Authors:
John Patrick Alao Eric W-F Lam Simak Ali Laki Buluwela Walter Bordogna Peter Lockey Rana Varshochi Alexandra V Stavropoulou R Charles Coombes David M Vigushin

Clin Cancer Res 2004 Dec;10(23):8094-104

Department of Cancer Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, United Kingdom.

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December 2004

Silencing of androgen-regulated genes using a fusion of AR with the PLZF transcriptional repressor.

Authors:
Joanna Pike David Holmes Tahereh Kamalati Derek Davies Robert Tolhurst Danish Mazhar Sam Fishpool Rajai al-Jehani Jonathan Waxman Arthur Zelent Nicholas R Lemoine Simak Ali Laki Buluwela

Oncogene 2004 Sep;23(45):7561-70

Department of Cancer Medicine, Imperial College London, Du Cane Road, W12 0NN, UK.

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September 2004

Expression of MUCI splice variants correlates with invasive growth of breast cancer cell lines.

Authors:
Bernd C Schmid Laki Buluwela QiuYan Liu Barbara Fasching Dan Tong Margit Stimpfl Obermair Andreas Sepp Leodolter Robert Zeillinger

Breast Cancer Res Treat 2002 Dec;76(3):211-9

Molecular Oncology Group, Division of Gynecology, Department of Obstetrics and Gynecology, University of Vienna, Vienna, Austria.

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December 2002