Laila C Schenkel

Laila C Schenkel

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Laila C Schenkel

Laila C Schenkel

Publications by authors named "Laila C Schenkel"

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15Publications

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Genomic DNA Methylation-Derived Algorithm Enables Accurate Detection of Malignant Prostate Tissues.

Front Oncol 2018 23;8:100. Epub 2018 Apr 23.

Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada.

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http://dx.doi.org/10.3389/fonc.2018.00100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925605PMC
April 2018

Genomic DNA Methylation Signatures Enable Concurrent Diagnosis and Clinical Genetic Variant Classification in Neurodevelopmental Syndromes.

Am J Hum Genet 2018 01;102(1):156-174

Department of Pathology and Laboratory Medicine, Western University, London, ON N6A5C1, Canada; Molecular Genetics Laboratory, Molecular Diagnostics Division, London Health Sciences Centre, London, ON N6A5W9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777983PMC
January 2018

Clinical Validation of a Genome-Wide DNA Methylation Assay for Molecular Diagnosis of Imprinting Disorders.

J Mol Diagn 2017 11 12;19(6):848-856. Epub 2017 Aug 12.

Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada; Molecular Genetics Laboratory, Molecular Diagnostics Division, London Health Sciences Centre, London, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2017.07.002DOI Listing
November 2017

Clinical Validation of Copy Number Variant Detection from Targeted Next-Generation Sequencing Panels.

J Mol Diagn 2017 11 15;19(6):905-920. Epub 2017 Aug 15.

Molecular Genetics Laboratory, Molecular Diagnostics Division, London Health Sciences Centre, London, Ontario, Canada; Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2017.07.004DOI Listing
November 2017

Constitutional Epi/Genetic Conditions: Genetic, Epigenetic, and Environmental Factors.

J Pediatr Genet 2017 Mar 8;6(1):30-41. Epub 2016 Nov 8.

Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada; London Regional Cancer Program, London Health Sciences Centre, London, Ontario, Canada; Children's Health Research Institute, London, Ontario, Canada.

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http://dx.doi.org/10.1055/s-0036-1593849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288004PMC
March 2017

The defining DNA methylation signature of Floating-Harbor Syndrome.

Sci Rep 2016 12 9;6:38803. Epub 2016 Dec 9.

Department of Pathology and Laboratory Medicine, Western University, 1151 Richmond Street, London, N6A 3K7, Canada.

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http://dx.doi.org/10.1038/srep38803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146968PMC
December 2016

DNA methylation analysis in constitutional disorders: Clinical implications of the epigenome.

Crit Rev Clin Lab Sci 2016 12;53(3):147-65. Epub 2016 Jan 12.

a Departments of Pathology and Laboratory Medicine .

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http://dx.doi.org/10.3109/10408363.2015.1113496DOI Listing
November 2016

Clinical Validation of Fragile X Syndrome Screening by DNA Methylation Array.

J Mol Diagn 2016 11 29;18(6):834-841. Epub 2016 Aug 29.

Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada; London Regional Cancer Program, London Health Sciences Center, London, Ontario, Canada; Children's Health Research Institute, London Health Sciences Center, London, Ontario, Canada; Molecular Genetics Laboratory, London Health Sciences Center, London, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2016.06.005DOI Listing
November 2016

Clinical Next-Generation Sequencing Pipeline Outperforms a Combined Approach Using Sanger Sequencing and Multiplex Ligation-Dependent Probe Amplification in Targeted Gene Panel Analysis.

J Mol Diagn 2016 09 2;18(5):657-667. Epub 2016 Jul 2.

Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada; Molecular Genetics Laboratory, Molecular Diagnostics Division, London Health Sciences Centre, Children's Health Research Institute, London, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2016.04.002DOI Listing
September 2016

Choline supplementation restores substrate balance and alleviates complications of Pcyt2 deficiency.

J Nutr Biochem 2015 Nov 8;26(11):1221-34. Epub 2015 Jul 8.

Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada N1G 2W1. Electronic address:

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http://dx.doi.org/10.1016/j.jnutbio.2015.05.014DOI Listing
November 2015

Mechanism of choline deficiency and membrane alteration in postural orthostatic tachycardia syndrome primary skin fibroblasts.

FASEB J 2015 May 2;29(5):1663-75. Epub 2014 Dec 2.

*Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada; University of North Carolina Nutrition Research Institute, Kannapolis, North Carolina, USA; Department of Nutrition, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA; Toxicology Services Incorporated, Chapel Hill, North Carolina, USA; and The Laboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA

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http://dx.doi.org/10.1096/fj.14-258566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415014PMC
May 2015