Publications by authors named "Laia Alsina"

55Publications

The Long Road to Biologic Therapies for Asthma in Pediatric Patients.

Arch Bronconeumol 2020 Sep 23. Epub 2020 Sep 23.

Servicio de Alergología e Inmunología Clínica, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, Barcelona, España. Electronic address:

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September 2020

Biologics as a therapeutic approach for a Th17-mediated severe dermatitis in skin barrier disorders.

Allergy 2020 11 24;75(11):3007-3008. Epub 2020 Aug 24.

Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain.

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November 2020

Single-cycle rituximab-induced immunologic changes in children: Enhanced in neuroimmunologic disease?

Neurol Neuroimmunol Neuroinflamm 2020 07 6;7(4). Epub 2020 May 6.

From the Clinical Immunology and Primary Immunodeficiencies Unit (A.D.-M., A.E.-S., A.G.-G., L.A.), Pediatric Allergy and Clinical Immunology Department (A.D.-M., Y.G., M.P., A.E.-S., A.G.-G., A.M.P., L.A.), Hospital Sant Joan de Déu, Barcelona, Spain; Institut de Recerca Sant Joan de Déu (A.D.-M., Y.G., M.P., A.E.-S., J.A., A.G.-G., A.M.P., L.A.), Barcelona, Spain; Clinical Immunology Unit Hospital Sant Joan de Déu-Hospital Clínic (A.D.-M., A.V., M.P., M.J., A.E.-S., A.G.-G., A.M.P., L.A.), Barcelona, Spain; Universitat de Barcelona (J.A., L.A., M.J.), Spain; Immunology Department (A.V., M.J.), Biomedical Diagnostics Center, Hospital Clinic-IDIBAPS, Barcelona, Spain; Pediatric Neuroimmunology Unit (C.M.-A., T.A.), Neurology Department, Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain; Neuroimmunology Program (T.A.), Institut D'Investigacions Biomèdiques (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain; Pediatric Rheumatology Division (J.A.), Hospital Sant Joan de Déu, Barcelona, Spain; and Pediatric Nephrology Department (Á.M.), Hospital Sant Joan de Déu, Barcelona, Spain.

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July 2020

Characterization of the clinical and immunologic phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations.

J Allergy Clin Immunol 2020 Oct 9;146(4):901-911. Epub 2020 Apr 9.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; CIBSS (Centre for Integrative Biological Signalling Studies), University of Freiburg, Freiburg, Germany; RESIST - Cluster of Excellence 2155 to Hanover Medical School, Satellite Center Freiburg, Freiburg, Germany; Institute of Immunology and Transplantation, Royal Free Hospital and University College London, London, United Kingdom; DZIF (German Center for Infection Research) Satellite Center Freiburg, Freiburg, Germany; Rheumatology and Clinical Immunology, Center for Chronic Immunodeficiency, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

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October 2020

Molecular analysis of the novel L243R mutation in STXBP2 reveals impairment of degranulation activity.

Int J Hematol 2020 Mar 21;111(3):440-450. Epub 2019 Dec 21.

Immunology Division, Hospital Universitari Vall d'Hebron (HUVH), Jeffrey Model Foundation Excellence Center, Barcelona, Catalonia, Spain.

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March 2020

[The new scenario of primary immunodeficiencies and the role of the clinical immunologist in the specialised clinic].

An Pediatr (Barc) 2020 02 7;92(2):117-118. Epub 2019 Nov 7.

Unidad de Inmunología Clínica e Inmunodeficiencias Primarias, Servicio de Alergología e Inmunología Clínica, Hospital Universitari Sant Joan de Déu, Unidad de Inmunología Clínica Sant Joan de Déu-Hospital Clínic, Barcelona, España; Institut de Recerca Sant Joan de Déu, Barcelona; Universitat de Barcelona. Electronic address:

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February 2020

Meningococcal Serogroup B Disease in Vaccinated Children.

J Pediatric Infect Dis Soc 2020 Sep;9(4):454-459

Malalties Infeccioses i Resposta Inflamatòria Sistèmica en Pediatria, Institut de Recerca Pediàtrica, Hospital Sant Joan de Déu, Barcelona, Spain.

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September 2020

Toll-like receptor 3 deficiency in autoimmune encephalitis post-herpes simplex encephalitis.

Neurol Neuroimmunol Neuroinflamm 2019 11 5;6(6). Epub 2019 Sep 5.

From the Neuroimmunology Program (T.A., M.P.-P., J.D.), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain; Pediatric Neuroimmunology Unit (T.A.), Neurology Department, Sant Joan de Déu (SJD) Children's Hospital, University of Barcelona, Barcelona, Spain; Clinical Immunology and Primary Immunodeficiencies Unit (B.J.B., A.D.-M., L.A., A.E.-S.), Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Universitat de Barcelona, Spain; Clinical Immunology Unit (A.V., A.E.-S., R.R.-G., M.J., L.A.), Hospital Sant Joan de Déu-Hospital Clínic Barcelona, Barcelona, Spain; Laboratory of Immunogenetics of Human Diseases (R.P.d.D.), IdiPAZ Institute for Health Research, La Paz Hospital, Madrid, Spain; Innate Immunity Group (R.P.d.D.), IdiPAZ Institute for Health Research, La Paz Hospital, Madrid, Spain; Interdepartmental Group of Immunodeficiencies (R.P.d.D.), Madrid, Spain; Neurology Department (J.D.), University of Pennsylvania, Philadelphia; and Catalan Institute for Research and Advanced Studies (ICREA) (J.D.), Barcelona, Spain.

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November 2019

Hyaline fibromatosis syndrome: Clinical update and phenotype-genotype correlations.

Hum Mutat 2018 12 17;39(12):1752-1763. Epub 2018 Sep 17.

Department of Genetic and Molecular Medicine, Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain.

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December 2018

Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: a prospective observational study and retrospective analysis.

Lancet Neurol 2018 09 23;17(9):760-772. Epub 2018 Jul 23.

Neuroimmunology Program, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain; Service of Neurology, Hospital Clínic, University of Barcelona, Barcelona, Spain; Department of Neurology, University of Pennsylvania, PA, USA; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain. Electronic address:

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September 2018

Severe BCG-osis Misdiagnosed as Multidrug-Resistant Tuberculosis in an IL-12Rβ1-Deficient Peruvian Girl.

J Clin Immunol 2018 08 23;38(6):712-716. Epub 2018 Jul 23.

Functional Unit of Clinical Immunology and Primary Immunodeficiencies, Hospital Sant Joan de Déu, University of Barcelona, Pediatric Research Institute Sant Joan de Déu, Barcelona, Spain.

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August 2018

B Regulatory Cells: Players in Pregnancy and Early Life.

Int J Mol Sci 2018 Jul 19;19(7). Epub 2018 Jul 19.

Functional Unit of Clinical Immunology and Primary Immunodeficiencies, Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, University of Barcelona, Pediatric Research Institute Sant Joan de Déu, 08950 Barcelona, Spain.

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July 2018

[Haemophagocytic syndromes: The importance of early diagnosis and treatment].

An Pediatr (Barc) 2018 Aug 2;89(2):124.e1-124.e8. Epub 2018 Jun 2.

Unidad de Inmunología Clínica e Inmunodeficiencias Primarias, Sección de Alergia e Inmunología Clínica pediátrica, Hospital Sant Joan de Déu, Institut de Recerca Pediàtrica Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, España.

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August 2018

Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects.

J Allergy Clin Immunol 2018 12 4;142(6):1932-1946. Epub 2018 May 4.

Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Institute of Immunology and Transplantation, Royal Free Hospital, University College London, London, United Kingdom. Electronic address:

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December 2018

[The Anales de Pediatría editors annual report].

An Pediatr (Barc) 2018 Jun 1;88(6):299-305. Epub 2018 May 1.

Editores asociados.

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June 2018

Immunological Changes in Blood of Newborns Exposed to Anti-TNF-α during Pregnancy.

Front Immunol 2017 21;8:1123. Epub 2017 Sep 21.

Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Institut de Recerca Pediàtrica Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain.

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September 2017

Evans Syndrome as First Manifestation of Primary Immunodeficiency in Clinical Practice.

J Pediatr Hematol Oncol 2017 10;39(7):490-494

Departments of *Allergy and Clinical Immunology ‡Hematology and Oncology, Hospital Sant Joan de Dèu, Institut de Recerca Pediàtrica Hospital Sant Joan de Dèu, Esplugues de Llobregat §Immunology Department, Hospital Clinic-IDIBAPS, Universitat de Barcelona †Functional Unit of Clinical Immunology SJD-Clinic, Barcelona, Spain.

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October 2017

Characterization of the Highly Prevalent Regulatory CD24CD38 B-Cell Population in Human Cord Blood.

Front Immunol 2017 7;8:201. Epub 2017 Mar 7.

Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Institut de Recerca Pediàtrica Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain; Functional Unit of Clinical Immunology, Sant Joan de Déu-Hospital Clinic, Barcelona, Spain.

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March 2017

Natural Killer Cell Receptors and Cytotoxic Activity in Phosphomannomutase 2 Deficiency (PMM2-CDG).

PLoS One 2016 14;11(7):e0158863. Epub 2016 Jul 14.

Departamento de Bioquímica, Biología Molecular B e Inmunología, Facultad de Medicina, IMIB-University of Murcia, Murcia, Spain.

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July 2017

Cholecystitis and nephrotic syndrome complicating Epstein-Barr virus primary infection.

Paediatr Int Child Health 2017 Feb 29;37(1):74-77. Epub 2016 Jan 29.

d Department of Allergy and Clinical Immunology , Hospital Sant Joan de Déu , Barcelona , Spain.

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February 2017

Clues to management of neonatally diagnosed BTK deficiency.

Pediatr Allergy Immunol 2016 06 16;27(4):428-30. Epub 2016 Mar 16.

Department of Pediatric Allergy and Clinical Immunology, Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain.

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June 2016

Association of Polymorphisms in IRAK1, IRAK4 and MyD88, and Severe Invasive Pneumococcal Disease.

Pediatr Infect Dis J 2015 Sep;34(9):1008-13

From the *Pediatrics Department, †Pediatric Intensive Care Department, Hospital Sant Joan de Déu, Universitat de Barcelona; ‡Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Universitat de Barcelona, Sant Joan de Déu - Clínic Immunology Functional Unit; §Immunology Department, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Sant Joan de Déu - Clínic Immunology Functional Unit; and ¶Microbiology Department, Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain.

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September 2015

Non-Hodgkin lymphoma in pediatric patients with common variable immunodeficiency.

Eur J Pediatr 2015 Aug 10;174(8):1069-76. Epub 2015 Mar 10.

Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu-Universitat de Barcelona, Passeig Sant Joan de Déu, 2, 08950, Esplugues de Llobregat, Barcelona, Spain,

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August 2015

A narrow repertoire of transcriptional modules responsive to pyogenic bacteria is impaired in patients carrying loss-of-function mutations in MYD88 or IRAK4.

Nat Immunol 2014 Dec 26;15(12):1134-42. Epub 2014 Oct 26.

1] Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, Texas, USA. [2] Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA. [3] Sidra Medical and Research Center, Doha, Qatar.

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December 2014

Immunomodulation in sepsis: the role of endotoxin removal by polymyxin B-immobilized cartridge.

Mediators Inflamm 2013 22;2013:507539. Epub 2013 Oct 22.

Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Passeig Sant Joan de Déu, 2.08950, Universitat de Barcelona, Esplugues de Llobregat, Barcelona, Spain.

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June 2014

Impaired cellular immune response to tetanus toxoid but not to cytomegalovirus in effectively HAART-treated HIV-infected children.

Vaccine 2013 May 5;31(20):2417-9. Epub 2013 Apr 5.

Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu-Universitat de Barcelona, Barcelona, Spain.

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May 2013

Specific oral desensitization in children with IgE-mediated cow's milk allergy. Evolution in one year.

Eur J Pediatr 2012 Sep 11;171(9):1389-95. Epub 2012 May 11.

Allergy and Clinical Immunology Section, Hospital Sant Joan de Déu, Universitat de Barcelona, Passeig Sant Joan de Déu, 2, 08950 Esplugues, Barcelona, Spain.

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September 2012

Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity.

J Exp Med 2011 Sep 12;208(10):2083-98. Epub 2011 Sep 12.

1St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY, USA; Laboratory of Human Genetics of Infectious Diseases, National Institute of Health and Medical Research, Paris, France;Necker Medical School, Paris Descartes University, Paris 75015, France.

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September 2011

Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency.

Medicine (Baltimore) 2010 Nov;89(6):403-425

From Study Center of Primary Immunodeficiencies, Assistance Publique Hôpitaux de Paris (CP); Necker Hospital, Paris, France. Laboratory of Human Genetics of Infectious Diseases (CP, HvB, PG, MC, CLK, L. Abel, AP, JLC), Necker Branch, INSERM U980, Paris, France. Paris Descartes University (CP, HvB, PG, MC, CLK, L. Abel, AP, JLC), Paris, France. Department of Pediatric Pneumology and Immunology (HvB), Charité Hospital-Humboldt University, Berlin, Germany. Prince Naif Center for Immunology Research (PG, SAM, SAH, AAG, JLC), College of Medicine, King Saud University, Riyadh, Saudi Arabia. Division of Infectious Diseases (OL); and Division of Immunology (DM, RSG), Children's Hospital Boston (OL), Boston, Massachusetts. Harvard Medical School (OL, DM, RSG), Boston, Massachusetts. University of Manchester (PDA), Royal Manchester Children's Hospital, Manchester, United Kingdom. Department of Pediatrics (HT, TH), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Department of Pediatrics (JCK, CBC), Division of Pediatric Infectious Diseases, Vanderbilt University, Nashville, Tennessee. Centre of Chronic Immunodeficiency (SE), University of Freiburg, Freiburg, Germany. Department of Infectious and Pediatric Immunology (LM), Medical and Health Science Center, University of Debrecen, Debrecen, Hungary. Department of Pediatrics (SAM, SAH, AAG), King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. Department of Pediatrics (NKDG), Division of Allergy and Immunology, University of South Florida and All Children's Hospital, St. Petersburg, Florida. Laboratory of Clinical Infectious Diseases (SMH, JIG), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland. University of Oxford and Oxford Radcliffe Hospital (HC), Oxford, United Kingdom. Division of Infectious and Immunological Diseases (DPS), Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada. Department of Immunology (CRG), Dr Negrin University Hospital of Gran Canaria, Las Palmas de Gran Canaria, Spain. Department of Pediatrics (EC), Unit of Infectious Diseases, Insular-Materno-Infantil University Hospital, Las Palmas de Gran Canaria, Spain. Schneider Children's Medical Center (BZG), Petah Tiqva, Israel. Division of Immunology and Allergy (C. Roifman), Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada. Department of Neurology (HY), Miyagi Children's Hospital, Sendai, Japan. Department of Pediatrics (SN), National Defense Medical College, Saitama, Japan. Pediatrics, Microbiology and Immunology (JD), SUNY Upstate Medical University, Syracuse, New York. Dalhousie University (ACI), Halifax, Nova Scotia, Canada. Royal Children's Hospital (MT, JS), Parkville, Victoria, Australia. University Children Hospital Ljubljana (SEZ), Ljubljana, Slovenia. Unité transversale d'Allergologie, Néphrologie et Immunologie Clinique (CH), Centre hospitalier universitaire de Tours, Tours, France. Department of Clinical Biochemistry and Immunology (DSK, RD), Addenbrookes Hospital, Cambridge, United Kingdom. Paediatric Immunology and Molecular Immunology Unit (AJT), Institute of Child Health, London, United Kingdom. Department of Clinical Immunology (EGD), Great Ormond St Hospital, London, United Kingdom. Immunology Department (CB), Derriford Hospital,Plymouth, United Kingdom. University Hospital Archet 2 (NS), Nice, France. Lenval Foundation (DDR), Children's Hospital, Nice, France. Cerrahpasa Medical School (YC), Istanbul University, Istanbul, Turkey. Clinical Pathology and Pediatric Department (JV, MG), General Hospital of Santo António, Porto, Portugal. Pediatric Department (ABV), Hospital S. João, Porto, Portugal. Pediatric Department (C. Rodrigo, FA, MM), Germans Trias i Pujol Hospital,Barcelona Autonomous University, Barcelona, Spain. Immunology Department-CDB (JIA), Hospital Clínic-IDIBAPS, Barcelona University, Barcelona, Spain. Pediatric Department (L. Alsina, CF), Hospital Sant Joan de Deu, Barcelona University, Barcelona, Spain. Immunology Department (JR), Universitäts-Kinderspital Zürich, Zürich, Switzerland. Pediatrics and Microbiology and Molecular Genetics (JMV), Medical College of Wisconsin, Milwaukee, Wisconsin. Experimental Laboratory Medicine (XB), Department of Medical Diagnostic Sciences, Biomedical Science Group, Catholic University Leuven, Leuven, Belgium. St. Giles Laboratory of Human Genetics of Infectious Diseases (JLC), Rockefeller Branch, The Rockefeller University, New York, New York. Pediatric Hematology-Immunology Unit (JLC), Necker Hospital, Assistance Publique Hôpitaux de Paris, Paris, France.

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November 2010

Picture of the month. Acquired secondary syphilis.

Arch Pediatr Adolesc Med 2007 Feb;161(2):199-200

Department of Dermatology, Hospital Sant Joan de Déu, Barcelona, Spain.

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February 2007