Ladan Fazli

Ladan Fazli

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Ladan Fazli

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BMI1 is directly regulated by androgen receptor to promote castration-resistance in prostate cancer.

Oncogene 2020 Jan 28;39(1):17-29. Epub 2019 Aug 28.

Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1038/s41388-019-0966-4DOI Listing
January 2020

Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28.

Mol Cell 2020 Jan 13. Epub 2020 Jan 13.

Experimental Dermatology, Department of Dermatology, TU-Dresden, Dresden 01307, Germany; Center for Regenerative Therapies Dresden, TU-Dresden, Dresden 01307, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.12.023DOI Listing
January 2020

Plasma Circulating Tumor DNA and Clonal Hematopoiesis in Metastatic Renal Cell Carcinoma.

Clin Genitourin Cancer 2020 Jan 8. Epub 2020 Jan 8.

Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, British Columbia, Canada; Department of Medical Oncology, BC Cancer, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.clgc.2019.12.018DOI Listing
January 2020

Characterization of a Prostate- and Prostate Cancer-Specific Circular RNA Encoded by the Androgen Receptor Gene.

Mol Ther Nucleic Acids 2019 Dec 24;18:916-926. Epub 2019 Oct 24.

Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2019.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883311PMC
December 2019

RNA Splicing of the BHC80 Gene Contributes to Neuroendocrine Prostate Cancer Progression.

Eur Urol 2019 Aug 23;76(2):157-166. Epub 2019 Mar 23.

Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03022838193019
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http://dx.doi.org/10.1016/j.eururo.2019.03.011DOI Listing
August 2019

Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function.

Proc Natl Acad Sci U S A 2019 Jul 2;116(29):14573-14582. Epub 2019 Jul 2.

Division of Urology, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1908547116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642419PMC
July 2019

Correction: A molecular portrait of epithelial-mesenchymal plasticity in prostate cancer associated with clinical outcome.

Oncogene 2019 03;38(13):2436

Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1038/s41388-018-0587-3DOI Listing
March 2019

Roles of the HOXA10 gene during castrate-resistant prostate cancer progression.

Endocr Relat Cancer 2019 03;26(3):279-292

Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia, Canada.

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https://erc.bioscientifica.com/view/journals/erc/26/3/ERC-18
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http://dx.doi.org/10.1530/ERC-18-0465DOI Listing
March 2019

A molecular portrait of epithelial-mesenchymal plasticity in prostate cancer associated with clinical outcome.

Oncogene 2019 02 7;38(7):913-934. Epub 2018 Sep 7.

Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1038/s41388-018-0488-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514858PMC
February 2019

SRRM4 gene expression correlates with neuroendocrine prostate cancer.

Prostate 2019 01 28;79(1):96-104. Epub 2018 Aug 28.

Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/pros.23715DOI Listing
January 2019

Automatic grading of prostate cancer in digitized histopathology images: Learning from multiple experts.

Med Image Anal 2018 12 24;50:167-180. Epub 2018 Sep 24.

Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, BC, Canada; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.media.2018.09.005DOI Listing
December 2018

Loss of Nuclear Functions of HOXA10 Is Associated With Testicular Cancer Proliferation.

Front Oncol 2018 7;8:594. Epub 2018 Dec 7.

Department of Urologic Sciences, Vancouver Prostate Centre, The University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.3389/fonc.2018.00594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292994PMC
December 2018

Autophagy inhibition improves the chemotherapeutic efficacy of cruciferous vegetable-derived diindolymethane in a murine prostate cancer xenograft model.

Invest New Drugs 2018 08 2;36(4):718-725. Epub 2018 Apr 2.

INRS-Institut Armand-Frappier, 531 boulevard des Prairies, Laval, QC, H7V 1B7, Canada.

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http://dx.doi.org/10.1007/s10637-018-0595-8DOI Listing
August 2018

Heterochromatin Protein 1α Mediates Development and Aggressiveness of Neuroendocrine Prostate Cancer.

Cancer Res 2018 05 27;78(10):2691-2704. Epub 2018 Feb 27.

Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-3677DOI Listing
May 2018

Histone demethylase JMJD1A promotes alternative splicing of AR variant 7 (AR-V7) in prostate cancer cells.

Proc Natl Acad Sci U S A 2018 05 30;115(20):E4584-E4593. Epub 2018 Apr 30.

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1802415115
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http://dx.doi.org/10.1073/pnas.1802415115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960326PMC
May 2018

Long term deficiency of vitamin D in germ cell testicular cancer survivors.

Oncotarget 2018 Apr 20;9(30):21078-21085. Epub 2018 Apr 20.

Department of Medicine and Surgery, Division of Medical Oncology, Centro di Riferimento Tumori Rari Regione Campania, University of Naples "Federico II", Napoli, Italy.

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http://dx.doi.org/10.18632/oncotarget.24925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940414PMC
April 2018

The role of netrin-1 in metastatic renal cell carcinoma treated with sunitinib.

Oncotarget 2018 Apr 27;9(32):22631-22641. Epub 2018 Apr 27.

Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.18632/oncotarget.25201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978253PMC
April 2018

Moving Towards Precision Urologic Oncology: Targeting Enzalutamide-resistant Prostate Cancer and Mutated Forms of the Androgen Receptor Using the Novel Inhibitor Darolutamide (ODM-201).

Eur Urol 2018 01 26;73(1):4-8. Epub 2017 Aug 26.

Department of Urologic Sciences, The Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2017.08.012DOI Listing
January 2018

MR measurement of luminal water in prostate gland: Quantitative correlation between MRI and histology.

J Magn Reson Imaging 2017 09 27;46(3):861-869. Epub 2017 Jan 27.

Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/jmri.25624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557632PMC
September 2017

Persistence of senescent prostate cancer cells following prolonged neoadjuvant androgen deprivation therapy.

PLoS One 2017 24;12(2):e0172048. Epub 2017 Feb 24.

Department of Urology University of Wisconsin School of Medicine and Public Health, Highland Ave, Madison, Wisconsin, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172048PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325224PMC
September 2017

A Role for the Hedgehog Effector Gli1 in Mediating Stent-induced Ureteral Smooth Muscle Dysfunction and Aperistalsis.

Urology 2017 Jun 8;104:242.e1-242.e8. Epub 2017 Feb 8.

Department of Urologic Sciences, The Stone Centre at Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.urology.2017.01.029DOI Listing
June 2017

c-Myc Antagonises the Transcriptional Activity of the Androgen Receptor in Prostate Cancer Affecting Key Gene Networks.

EBioMedicine 2017 Apr 5;18:83-93. Epub 2017 Apr 5.

Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, Oslo, Norway; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway; PCUK/Movember Centre of Excellence, CCRCB, Queen's University, Belfast, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405195PMC
April 2017

Molecular Dissection of Complete Response to Receptor Tyrosine Kinase Inhibition in Type II Papillary Renal Cell Carcinoma.

Clin Genitourin Cancer 2017 02 27;15(1):e145-e150. Epub 2016 May 27.

Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2016.05.019DOI Listing
February 2017

Suppression of LIM and SH3 Domain Protein 1 (LASP1) Negatively Regulated by Androgen Receptor Delays Castration Resistant Prostate Cancer Progression.

Prostate 2017 02 24;77(3):309-320. Epub 2016 Oct 24.

Vancouver Prostate Centre and Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/pros.23269DOI Listing
February 2017

c-MYC drives histone demethylase PHF8 during neuroendocrine differentiation and in castration-resistant prostate cancer.

Oncotarget 2016 11;7(46):75585-75602

Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52246, USA.

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http://dx.doi.org/10.18632/oncotarget.12310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342763PMC
November 2016

Histologic Grading of Prostatic Adenocarcinoma Can Be Further Optimized: Analysis of the Relative Prognostic Strength of Individual Architectural Patterns in 1275 Patients From the Canary Retrospective Cohort.

Am J Surg Pathol 2016 11;40(11):1439-1456

*Cleveland Clinic, Cleveland, OH †University of Texas MD Anderson Cancer Center, Houston ††University of Texas Health Sciences Center San Antonio, San Antonio, TX ‡Canary Foundation, Palo Alto #University of California- San Francisco, San Francisco ‡‡Stanford University Medical Center, Stanford, CA §Fred Hutchinson Cancer Research Center ∥University of Washington Medical Center, Seattle, WA **Eastern Virginia Medical School, Norfolk, VA ¶University of British Columbia, Vancouver, BC, Canada.

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http://pdfs.journals.lww.com/ajsp/2016/11000/Histologic_Grad
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http://dx.doi.org/10.1097/PAS.0000000000000736DOI Listing
November 2016

UGT2B17 Expedites Progression of Castration-Resistant Prostate Cancers by Promoting Ligand-Independent AR Signaling.

Cancer Res 2016 11 22;76(22):6701-6711. Epub 2016 Sep 22.

Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-1518DOI Listing
November 2016

Effect of contrast media on urinary cytopathology specimens.

Can Urol Assoc J 2016 Aug;10(7-8):228-233

Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.5489/cuaj.3874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110417PMC
August 2016

Clusterin knockdown sensitizes prostate cancer cells to taxane by modulating mitosis.

EMBO Mol Med 2016 07 1;8(7):761-78. Epub 2016 Jul 1.

The Vancouver Prostate Centre and Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada

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http://dx.doi.org/10.15252/emmm.201506059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931290PMC
July 2016

Real-time and label free determination of ligand binding-kinetics to primary cancer tissue specimens; a novel tool for the assessment of biomarker targeting.

Sens Biosensing Res 2016 Jul;9:23-30

Centre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen, Denmark; Department of Infectious Diseases, Copenhagen University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.sbsr.2016.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942562PMC
July 2016

The MCT4 Gene: A Novel, Potential Target for Therapy of Advanced Prostate Cancer.

Clin Cancer Res 2016 06 11;22(11):2721-33. Epub 2016 Jan 11.

The Vancouver Prostate Centre, Vancouver General Hospital and Department of Urologic Sciences, The University of British Columbia, Vancouver, British Columbia, Canada. Department of Experimental Therapeutics, BC Cancer Research Centre, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1624DOI Listing
June 2016

Not all NOTCH Is Created Equal: The Oncogenic Role of NOTCH2 in Bladder Cancer and Its Implications for Targeted Therapy.

Clin Cancer Res 2016 06 14;22(12):2981-92. Epub 2016 Jan 14.

The Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, Canada. Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.

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http://clincancerres.aacrjournals.org/content/early/2016/01/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-15-2360DOI Listing
June 2016

HoxA13 Stimulates Myometrial Cells to Secrete IL-1β and Enhance the Expression of Contraction-Associated Proteins.

Endocrinology 2016 05 16;157(5):2129-39. Epub 2016 Mar 16.

Vancouver Prostate Centre (H.L., Y.Y., Y.S., L.F., X.D.), Department of Urologic Sciences, University of British Columbia, Vancouver, Canada V6H 3Z6; Department of Physiology and Pharmacology (D.S.), University of Calgary, Calgary, Canada T2N 4N1; and Department of Obstetrics and Gynaecology (S.L., X.D.), University of Toronto, Toronto, Canada M5G 1E2.

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http://dx.doi.org/10.1210/en.2015-2005DOI Listing
May 2016

Targeting Cancer Stem Cells in Castration-Resistant Prostate Cancer.

Clin Cancer Res 2016 Feb 21;22(3):670-9. Epub 2015 Oct 21.

Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas. Graduate Institute of Cancer Biology, China Medical University Hospital, Taichung, Taiwan, Republic of China.

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http://clincancerres.aacrjournals.org/content/early/2015/11/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-15-0190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738061PMC
February 2016

Targeting HER2 with T-DM1, an Antibody Cytotoxic Drug Conjugate, is Effective in HER2 Over Expressing Bladder Cancer.

J Urol 2015 Oct 3;194(4):1120-31. Epub 2015 Jun 3.

Vancouver Prostate Centre and Department of Urologic Sciences, University of British Columbia (TH, RS, HZO, WJ, IM, SA, TD, TT, NL, LF, PCB), Vancouver, British Columbia, Canada; Department of Urology, Institute of Biomedical and Health Science, Hiroshima University (TH), Hiroshima, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2015.05.087DOI Listing
October 2015

Downregulation of c-SRC kinase CSK promotes castration resistant prostate cancer and pinpoints a novel disease subclass.

Oncotarget 2015 Sep;6(26):22060-71

Tumor Initiation & Maintenance Program, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.18632/oncotarget.4279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673146PMC
September 2015

The Steroidogenic Enzyme AKR1C3 Regulates Stability of the Ubiquitin Ligase Siah2 in Prostate Cancer Cells.

J Biol Chem 2015 Aug 9;290(34):20865-79. Epub 2015 Jul 9.

From the Marlene and Stewart Greenebaum Cancer Center, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201,

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http://dx.doi.org/10.1074/jbc.M115.662155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543648PMC
August 2015

The Placental Gene PEG10 Promotes Progression of Neuroendocrine Prostate Cancer.

Cell Rep 2015 Aug 30;12(6):922-36. Epub 2015 Jul 30.

Vancouver Prostate Centre, University of British Columbia, Vancouver, BC V6H 3Z6, Canada; Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.07.012DOI Listing
August 2015

Progesterone receptor expression during prostate cancer progression suggests a role of this receptor in stromal cell differentiation.

Prostate 2015 Jul 1;75(10):1043-50. Epub 2015 Apr 1.

Department of Urologic Sciences, The Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1002/pros.22988DOI Listing
July 2015

A low carbohydrate, high protein diet suppresses intratumoral androgen synthesis and slows castration-resistant prostate tumor growth in mice.

J Steroid Biochem Mol Biol 2015 Jun 19;150:35-45. Epub 2015 Mar 19.

Vancouver Prostate Centre, Vancouver, British Columbia, Canada; Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia V6H-3Z6, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09600760150009
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http://dx.doi.org/10.1016/j.jsbmb.2015.03.006DOI Listing
June 2015

Hsp27 Inhibition with OGX-427 Sensitizes Non-Small Cell Lung Cancer Cells to Erlotinib and Chemotherapy.

Mol Cancer Ther 2015 May 4;14(5):1107-16. Epub 2015 Mar 4.

The Vancouver Prostate Centre and Department of Urological Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1158/1535-7163.MCT-14-0866DOI Listing
May 2015

Targeting Integrin-Linked Kinase Suppresses Invasion and Metastasis through Downregulation of Epithelial-to-Mesenchymal Transition in Renal Cell Carcinoma.

Mol Cancer Ther 2015 Apr 5;14(4):1024-34. Epub 2015 Feb 5.

Vancouver Prostate Centre and Department of Urologic Science, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1158/1535-7163.MCT-14-0771DOI Listing
April 2015

Clusterin facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival.

Nat Commun 2014 Dec 12;5:5775. Epub 2014 Dec 12.

The Vancouver Prostate Centre and Department of Urological Sciences, University of British Columbia, Vancouver, British Columbia, Canada V6H 3Z6.

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http://dx.doi.org/10.1038/ncomms6775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275590PMC
December 2014