Publications by authors named "L Zhang"

83,537 Publications

Study of the micromorphology and health risks of arsenic in copper smelting slag tailings for safe resource utilization.

Ecotoxicol Environ Saf 2021 May 12;219:112321. Epub 2021 May 12.

School of Resources and Environmental Engineering, Anhui Province Engineering Laboratory for Mine Ecological Remediation, Anhui University, Hefei 230601, PR China. Electronic address:

Slag tailings are produced by "cooling-grinding-ball milling-flotation" and other processes of slag, while slag is produced by the flash smelting of the original ore. The utilization and environmental hazards of arsenic in slag tailings have become a focus of attention. This study on slag tailings reveals the presence of arsenic in copper smelting tailings from the mineralogy and leaching perspectives, and the noncarcinogenic and carcinogenic risks of arsenic to the human body were assessed by using the USEPA health risk model. The surface particles of the slag tailings were unevenly dispersed, and the mineral crystals were relatively complete. A small amount of secondary minerals had grown on the mineral surface. Most of the fine particles adhered to the surface of the main mineral to form inclusions. The mineral composition of the slag tailings was dominated by maghemite (FeO) and fayalite (FeSiO), and the arsenic-bearing minerals were unevenly distributed, where As (Ⅴ) fine particles were embedded in maghemite, amorphous phase and fayalite. There was a large amount of residual arsenic in the slag tailing particles, and the leaching content of arsenic in the toxicity leaching procedure was always lower than the limit of 5 mg/L. The health risk to the exposed population was evaluated by the USEPA health risk model. Since the exposed population in the industrial land is mainly adults, it is determined that the tailings will not cause harm to children's health. In this evaluation, the exposure duration (length of service of the workers) of 30 years, exposure frequency of 314 d/y and body weight of 60 kg (average weight of the workers) were taken as the parameters of three exposure pathways: hand-oral ingestion, respiratory system inhalation and skin contact. Therefore, longer activity time of the workers in the tailing workshop corresponds to a higher HI (hazard index). Although the arsenic in the slag tailings had a certain degree of bioavailability, it was not sufficient to adversely affect human health.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ecoenv.2021.112321DOI Listing
May 2021

Marine algae facilitate transfer of microplastics and associated pollutants into food webs.

Sci Total Environ 2021 May 7;787:147535. Epub 2021 May 7.

Key Laboratory of Coastal Environment and Resources of Zhejiang Province, School of Engineering, Westlake University, Hangzhou 310024, China; Institute of Advanced Technology, Westlake Institute for Advanced Study, Hangzhou 310024, Zhejiang Province, China. Electronic address:

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2021.147535DOI Listing
May 2021

Stigma and its influencing factors among breast cancer survivors in China: A cross-sectional study.

Eur J Oncol Nurs 2021 May 4;52:101972. Epub 2021 May 4.

School of Nursing, Sun Yat-sen University, Zhongshan 2 Rd 74#, Guangzhou, Guangdong, PR China. Electronic address:

Purpose: Although stigma has attracted considerable scholarly attention, few studies have focused on its influencing factors among discharged breast cancer survivors, especially in a Chinese cultural context. The present study therefore explores stigma and its influencing factors among breast cancer survivors in China.

Method: Between December 2017 and May 2018, 103 breast cancer survivors at the outpatient clinic of a tertiary cancer center in southern China were enrolled in a cross-sectional study. The research instruments comprised the Social Impact Scale (SIS), the General Self-Efficacy Scale (GSES), the Medical Coping Modes Questionnaire (MCMQ), and sociodemographic and disease-related questionnaires. Descriptive statistics, univariate analysis, and multivariable linear regression were used to explore the current status of stigma and to identify influencing factors.

Results: Of the respondents, 76.7% and 8.7%, respectively, reported moderate and high levels of stigma. The mean SIS score was 55.20 ± 12.15 (moderate), and the SIS subscale with the highest average score was financial insecurity. The results of a multivariable linear regression showed that body image (β = 0.32, P<0.001), spousal support (β = -0.47, P < 0.001), personal acceptance of the disease (β = -0.22, P<0.001), coping modes (resignation) (β = 0.14, P < 0.001), support from medical staff (β = -0.23, P < 0.001) and self-efficacy (β = -0.10, P = 0.037) were the main factors influencing stigma among breast cancer survivors (R = 0.83).

Conclusions: Stigma, among breast cancer survivors, which is influenced by various sociocultural factors, is a neglected issue requiring attention. Healthcare professionals should therefore formulate effective measures for alleviating stigma in this group by improving their self-efficacy and acceptance of the disease, reducing their poor body image and negative coping mode, and eliciting more support from their spouses and medical staff.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejon.2021.101972DOI Listing
May 2021

Long noncoding RNA LMO7DN inhibits cell proliferation by regulating the cell cycle in lung adenocarcinoma.

Pathol Res Pract 2021 May 10;223:153475. Epub 2021 May 10.

Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China. Electronic address:

In our previous study, we reported that the long noncoding RNA, LMO7 downstream neighbor (LMO7DN), has a strong prognostic value in lung adenocarcinoma (LUAD). In this study, we further investigated the role of LMO7DN in LUAD progression. LMO7DN was found to be expressed at low levels in LUAD tissues, and its high expression predicted good prognosis. Bioinformatics analysis indicated that LMO7DN was closely associated with the cell cycle. Furthermore, we found that cell proliferation was significantly enhanced following knockdown of LMO7DN, and the number of cells in the G2/M phase was markedly decreased, whereas there was no change in apoptosis. Thus, LMO7DN inhibits cell proliferation by affecting the cell cycle and is of significant prognostic value in LUAD.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.prp.2021.153475DOI Listing
May 2021

A validated UHPLC-MS/MS method for simultaneous determination of lumiracoxib and its hydroxylation and acyl glucuronidation metabolites in rat plasma: Application to a pharmacokinetic study.

J Pharm Biomed Anal 2021 Apr 27;201:114105. Epub 2021 Apr 27.

Institute of Heath & Medical Technology, Hefei Institute of Physical Science, Chinese Academy of Sciences, Hefei, 230031, Anhui Province, China. Electronic address:

Lumiracoxib is a selective cyclooxygenase-2 (COX-2) inhibitor. The aim of this study was to develop a simple and sensitive ultra-high performance liquid chromatography tandem mass spectrometric method (UHPLC-MS/MS) for the simultaneous determination of lumiracoxib and its circulating metabolites 4'-Hydroxyl-lumiracoxib and lumiracoxib-acyl-glucuronide in rat plasma. The analytes and diclofenac (internal standard, IS) were extracted using acetonitrile containing 0.2 % formic acid. Chromatographic separation was executed on ACQUITY BEH C column (2.1 × 50 mm, 1.7 μm) with water containing 0.2 % formic acid and acetonitrile as mobile phase. Mass detection was achieved in positive multiple reactions monitoring (MRM) mode, with precursor-to-product transitions at m/z 294.1 > 248.1, m/z 310.1 > 264.1, m/z 470.1 > 276.1 and m/z 296.0 > 250.0 for lumiracoxib, 4'-hydroxyl-lumiracoxib, lumiracoxib-acyl-glucuronide and for IS, respectively. The developed LC-MS/MS method was validated based on the guidance of U.S. Food and Drug Administration. The linearity was evident (r > 0.995) over the concentration ranges of 1-1000 ng/mL for lumiracoxib, 1-500 ng/mL for 4'-hydroxyl-lumiracoxib and 1-200 ng/mL for lumiracoxib-acyl-glucuronide, respectively. The precision (RSD) did not exceed 8.23 % and accuracy (RE) ranged from -7.85 % to 9.50 %. The extraction recovery was more than 80.54 %. All the analytes were demonstrated to be stable under the tested storage and processing conditions. The validated LC-MS/MS method has been successfully applied to the pharmacokinetic study of lumiracoxib and its metabolites in the rats after orally administered with lumiracoxib.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpba.2021.114105DOI Listing
April 2021