Publications by authors named "L Wang"

109,519 Publications

Patent analysis of chemical treatment technology for wastewater: Status and future trends.

Chemosphere 2022 Aug 8:135802. Epub 2022 Aug 8.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, Jiangsu, China; Yixing Environmental Research Institute of Nanjing University, Yixing 214200, Jiangsu, China. Electronic address:

In order to reveal the status and trends of chemical treatment for wastewater, the patents analysis from both structured and unstructured data was performed in this study. 35,838 patents recorded in the Derwent Innovation Index database were adopted. The results showed that China was the country with the largest number of patents in the field, and the United States was the main exporter of international technology flows. Chemical processes combined with biological and physical processes was the mainstream, and ozonation and electrochemical treatment were the major single technologies. Technology evolution path generally showed the transition from biological process-combined chemical treatment to electrochemical treatment and finally to physical process-combined chemical treatment. Furthermore, future trends were revealed from both patents and papers. It demonstrated that efficient removal of ammonia nitrogen, green water treatment agents and resourcezation of wastewater were the key innovation directions, and technologies with regard to efficient use of energy (including photocatalytic technology and microbial fuel cell) were the main research hotspots. Overall, this study provided a comprehensive understanding for the research and application of chemical treatment for wastewater technologies.
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http://dx.doi.org/10.1016/j.chemosphere.2022.135802DOI Listing
August 2022

Quantitative signal quality assessment for large-scale continuous scalp EEG from a big data perspective.

Physiol Meas 2022 Aug 11. Epub 2022 Aug 11.

School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan Province, chengdu, sichuan, 610054, CHINA.

Despite electroencephalogram (EEG) being a widely used neuroimaging technique with an excellent temporal resolution, in practice, the signals are heavily contaminated by artifacts masking responses of interest in an experiment. It is thus essential to guarantee a prompt and effective detection of artifacts that provides quantitative quality assessment (QA) on raw EEG data. This type of pipeline is crucial for large-scale EEG studies. However, current EEG QA studies are still limited. In this study, combined from a big data perspective, we therefore describe a quantitative signal quality assessment pipeline, a stable and general threshold-based QA pipeline that automatically integrates artifact detection and new QA measures to assess continuous resting-state raw EEG data. One simulation dataset and two resting-state EEG datasets from 42 healthy subjects and 983 clinical patients were utilized to calibrate the QA pipeline. The results demonstrated that 1) the QA indices selected are sensitive: they almost strictly and linearly decreased as the noise level increased; 2) stable, replicable QA thresholds are valid for other experimental and clinical EEG datasets; and 3) use of the QA pipeline on these datasets revealed that high-frequency noises are the most common noises in EEG practice. The QA pipeline is also deployed in the WeBrain cloud platform (https://webrain.uestc.edu.cn/, the Chinese EEG Brain Consortium portal). These findings suggested that the proposed QA pipeline may be a stable and promising approach for quantitative EEG signal quality assessment in large-scale EEG studies.
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http://dx.doi.org/10.1088/1361-6579/ac890dDOI Listing
August 2022

Nanocomposite of Conducting Polymer and Li Metal for Rechargeable High Energy Density Batteries.

ACS Appl Mater Interfaces 2022 Aug 11. Epub 2022 Aug 11.

Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China.

The structure and electrochemical performance of lithium (Li) metal degrade quickly owing to its hostless nature and high reactivity, hindering its practical application in rechargeable high energy density batteries. In order to enhance the electrochemical reversibility of metallic Li, we designed a Li/LiS-poly(acrylonitrile) (LSPAN) composite foil via a facile mechanical kneading approach using metallic Li and sulfurized poly(acrylonitrile) as the raw materials. The uniformly dispersed LiS-poly(acrylonitrile) (LiS-PAN) in a metallic Li matrix buffered the volume change on cycling, and its high Li ion conductivity enabled fast Li ion diffusion behavior of the composite electrode. As expected, the LSPAN electrode showed reduced voltage polarization, enhanced rate capability, and prolonged cycle life compared with the pure Li electrode. It exhibited stable cycling for 600 h with a symmetric cell configuration at 1 mA cm and 1 mA h cm, far outperforming the pure metallic Li counterpart (400 h). Also, the LiCoO||LSPAN full cells with a cathode mass loading of ∼16 mg cm worked stably for 100 cycles at 0.5 C with a high capacity retention of 96.5%, while the LiCoO||Li full cells quickly failed within only 50 cycles.
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http://dx.doi.org/10.1021/acsami.2c07917DOI Listing
August 2022

Butyrate-producing Eubacterium rectale suppresses lymphomagenesis by alleviating the TNF-induced TLR4/MyD88/NF-κB axis.

Cell Host Microbe 2022 Aug;30(8):1139-1150.e7

Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address:

Microbiota-induced tumorigenesis is well established in solid tumors of the gastrointestinal tract but rarely explored in hematologic malignancies. To determine the role of gut microbiota in lymphoma progression, we performed metagenomic sequencing on human primary gastrointestinal B cell lymphomas. We identified a distinct microbiota profile of intestinal lymphoma, with significantly decreased symbiotic microbes, particularly the genus Eubacterium and notably butyrate-producing Eubacterium rectale. Transfer of E. rectale-deficit microbiota of intestinal lymphoma patients to mice caused inflammation and tumor necrosis factor (TNF) production. Conversely, E. rectale treatment reduced TNF levels and the incidence of lymphoma in sensitized Eμ-Myc mice. Moreover, lipopolysaccharide from the resident microbiota of lymphoma patients and mice synergizes with TNF signaling and reinforces the NF-κB pathway via the MyD88-dependent TLR4 signaling, amalgamating in enhanced intestinal B cell survival and proliferation. These findings reveal a mechanism of inflammation-associated lymphomagenesis and a potential clinical rationale for therapeutic targeting of gut microbiota.
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http://dx.doi.org/10.1016/j.chom.2022.07.003DOI Listing
August 2022

Randomized Control Study on Hemoperfusion Combined with Hemodialysis versus Standard Hemodialysis: Effects on Middle-Molecular-Weight Toxins and Uremic Pruritus.

Blood Purif 2022 Aug 11:1-11. Epub 2022 Aug 11.

Department of Nephrology, Shanghai Sixth People's Hospital, Shanghai, China.

Introduction: Classic hemodialysis schedules present inadequate middle-molecular-weight toxin clearance due to limitations of membrane-based separation processes. Accumulation of uremic retention solutes may result in specific symptoms (e.g., pruritus) and may affect clinical outcome and patient's quality of life. Hemoperfusion (HP) is a blood purification modality based on adsorption that can overcome such limitations, and thus, it may be interesting to test the efficacy of at least one session per week of HP combined with hemodialysis. This is a randomized, open-label trial, controlled, multicenter clinical study to investigate the effect of long-term HP combined with hemodialysis on middle-molecular-weight toxins and uremic pruritus in maintenance hemodialysis (MHD) patients.

Methods: 438 MHD patients from 37 HD centers in China with end-stage kidney disease (63.9% males, mean age 51 years) suffering from chronic intractable pruritus were enrolled in the study. Eligible patients were randomized into four groups: low-flux hemodialysis (LFHD), high-flux hemodialysis (HFHD), HP + LFHD, and HP + HFHD at a 1:1:1:1 ratio. Beta-2 microglobulin (β2M) and parathyroid hormone (PTH) were measured at baseline, 3-6, and 12 months. At the same time points, the pruritus score was evaluated. The primary outcome was the reduction of β2M and PTH, while the secondary outcome was the reduction of the pruritus score.

Results: In the two groups HP + LFHD and HP + HFHD, there was a significant decrease of β2M and PTH levels after 12 months compared to the control groups. No significant differences were noted between HP + LFHD and HP + HFHD. Pruritus score reduction was 63% in the HP + LFHD group and 51% in the HP + HFHD group, respectively.

Conclusion: The long-term HP + HD can reduce β2M and PTH levels and improve pruritus in MHD patients independently on the use of high- or low-flux dialyzers, showing that the results are linked to the effect of adsorption.
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http://dx.doi.org/10.1159/000525225DOI Listing
August 2022
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