Publications by authors named "L U Signori"

36 Publications

Acute ingestion of a high-fructose drink impairs vascular autonomic modulation and reflex control of blood pressure in first-degree relatives of diabetic patients.

Diabetes Res Clin Pract 2021 May 2:108793. Epub 2021 May 2.

Cardiology Institute (IC)/Cardiology University Foundation (FUC) of Rio Grande do Sul, Porto Alegre, Brazil; Physical Therapy Department, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Brazil.

First-degree relatives of diabetes patients, despite being euglycemic, presented impaired BRS and exacerbation of sympathetic modulation after ingestion of a high fructose drink when challenged to orthostatic stress. This finding alerts the importance of early autonomic dysfunction even in clinically healthy people, especially in face of a stressful situation.
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http://dx.doi.org/10.1016/j.diabres.2021.108793DOI Listing
May 2021

Venetoclax-Based Regimens for Relapsed/Refractory Acute Myeloid Leukemia in a Real-Life Setting: A Retrospective Single-Center Experience.

J Clin Med 2021 Apr 14;10(8). Epub 2021 Apr 14.

SOD Ematologia, Università degli Studi di Firenze e Azienda Ospedaliera Universitaria Careggi, 50139 Firenze, Italy.

Relapsed/refractory (R/R) acute myeloid leukemia (AML) is a largely unmet medical need, owing to the lack of standardized, effective treatment approaches, resulting in an overall dismal outcome. The only curative option for R/R AML patients is allogeneic hematopoietic stem cell transplantation (HSCT) which is only applicable in a fraction of patients due to the scarce efficacy and high toxicity of salvage regimens. Recently, a number of targeted agents with relatively favorable toxicity profiles have been explored in clinical trials for R/R AML patients. The Bcl-2 inhibitor venetoclax, in combination with hypomethylating agents or low dose cytarabine, has produced impressive results for newly diagnosed AML, while its role in R/R disease is not well defined yet. We retrospectively analyzed the clinical outcomes of 47 R/R AML patients treated with venetoclax-based regimens between March 2018 and December 2020 at our institution. Overall, we report a composite complete response rate of 55% with an overall acceptable toxicity profile. Outcomes were particularly favorable for NPM1 mutated patients, unlike for FLT3-ITD positive patients irrespective of NPM1 status. For patients treated with intention to transplant, the procedure could be finally performed in 54%. These findings suggest a role for venetoclax-based regimens in R/R AML patients and support the design of prospective studies.
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http://dx.doi.org/10.3390/jcm10081684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070927PMC
April 2021

Oxidative stress is involved in LLLT mechanism of action on skin healing in rats.

Braz J Med Biol Res 2021 26;54(6):e10293. Epub 2021 Apr 26.

Centro de Ciências da Saúde, Departamento de Morfologia, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil.

The skin injury healing process involves the main phases of homoeostasis, inflammation, proliferation, and remodeling. The present study aimed to analyze the effects of low-level laser therapy (LLLT) on hematological dynamics, oxidative stress markers, and its relation with tissue healing following skin injury. Wistar rats were divided into control, sham, skin injury, and skin injury LLLT. The biochemical and morphological analyses were performed in the inflammatory (1 and 3 days) and regenerative phases (7, 14, and 21 days) following injury. The skin injury was performed in the dorsal region, between the intrascapular lines, using a surgical punch. LLLT (Al-Ga-In-P, λ=660 nm, energy density of 20 J/cm2, 30 mW power, and a time of 40 s) was applied at the area immediately after injury and on every following day according to the experimental subgroups. LLLT maintained hematocrit and hemoglobin levels until the 3rd day of treatment. Surprisingly, LLLT increased total leukocytes levels compared to control until the 3rd day. The effects of LLLT on mitochondrial activity were demonstrated by the significant increase in MTT levels in both inflammatory and regenerative phases (from the 1st to the 7th day), but only when associated with skin injury. The results indicated that LLLT modulated the inflammatory response intensity and accelerated skin tissue healing by a mechanism that involved oxidative damage reduction mostly at early stages of skin healing (inflammatory phase).
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http://dx.doi.org/10.1590/1414-431X202010293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075128PMC
April 2021

Combined aerobic and strength training for fitness outcomes in heart failure: meta-analysis and meta-regression.

Disabil Rehabil 2021 Mar 31:1-12. Epub 2021 Mar 31.

Program in Functional Rehabilitation, Federal University of Santa Maria, Santa Maria, Brazil.

Purpose: To compare the effects of combined training (CT) versus aerobic training (AT) or versus control on VO peak and quadriceps muscle strength in patients with heart failure (HF).

Materials And Methods: Major electronic databases were searched, from inception to November 2020, for randomized clinical trials comparing the effects of CT against AT or control on VO peak and/or quadriceps muscle strength in patients with HF. Random effects meta-analyses were conducted, calculating the standardized mean difference (SMD).

Results: Twenty-eight articles were included. An increase on VO peak (SMD = 0.77, 95%CI 0.39-1.14, =80.1%) and quadriceps muscle strength (SMD = 0.67, 95%CI 0.18-1.16, =0%) was found in CT compared to control. CT increased quadriceps muscle strength, versus AT (SMD = 0.44, 95%CI 0.15-0.74, =0%). There were no differences between CT and AT on VO peak (SMD=-0.01, 95%CI -0.36 to 0.34, =65%). Time of session and training duration moderate the effects of CT over control on VO peak.

Conclusions: CT promotes increases on quadriceps muscle strength and aerobic capacity over control and provides additional gains on quadriceps muscle strength, having the same effects on VO peak compared to AT. A longer time of session is associated with greater benefits to aerobic capacity.Implications for rehabilitationCombining aerobic and strength training increases the functional capacity and quadriceps muscle strength in heart failure patients.Using longer sessions of training has a greater impact on aerobic capacity.
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http://dx.doi.org/10.1080/09638288.2021.1900411DOI Listing
March 2021

Multilineage Dysplasia as Assessed by Immunophenotype in Acute Myeloid Leukemia: A Prognostic Tool in a Genetically Undefined Category.

Cancers (Basel) 2020 Oct 30;12(11). Epub 2020 Oct 30.

Struttura Operativa Dipartimentale Ematologia, Azienda Ospedaliero-Universitaria Careggi, 50134 Firenze, Italy.

Acute myeloid leukemia (AML) "with myelodysplasia-related changes (MRC)" is considered a separate entity by the World Health Organization (WHO) classification of myeloid neoplasms. While anamnestic and cytogenetic criteria provide objective attribution to this subset, with clear unfavorable prognostic significance, the actual role of multi-lineage dysplasia (MLD) as assessed by morphology is debated. The aim of our work was to study MLD by a technique alternative to morphology, which is multiparameter flow cytometry (MFC), in a large series of 302 AML patients intensively treated at our Center. The correlation with morphology we observed in the unselected analysis reiterated the capability of the MFC-based approach at highlighting dysplasia. MLD data, estimated through an immune-phenotypic score (IPS), provided no insight into prognosis when considered overall nor within well-defined genetic categories. Of interest, IPS-related dysplasia conveyed significant prognostic information when we focused on genetically undefined patients, triple-negative for , and (TN-AML). In this context, the lack of dysplastic features (IPS_0) correlated with a significantly higher CR rate and longer survival compared to patients showing dysplasia in one or both (neutrophil and erythroid) cell lineages. The impact of IPS category maintained its validity after censoring at allogeneic HSCT and in a multivariate analysis including baseline and treatment-related covariates. In a subgroup featured by the lack of genetic determinants, our data could help address the relative unmet needs in terms of risk assessment and treatment strategy, and provide insight into prediction of response in the rapidly evolving therapeutic scenario of AML.
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http://dx.doi.org/10.3390/cancers12113196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693580PMC
October 2020