Publications by authors named "L Nong"

162 Publications

Primary resistance to alectinib in a patient with STRN-ALK-positive non-small cell lung cancer: A case report.

Thorac Cancer 2021 May 7. Epub 2021 May 7.

Department of Respiratory and Critical Care Medicine, Peking University First Hospital, Beijing, China.

Anaplastic lymphoma kinase (ALK) rearrangements are drivers of a subset of non-small cell lung cancer (NSCLC). The rapid progression of ALK inhibitors has significantly prolonged the progression-free survival of patients with ALK gene-sensitive mutations. However, the response of patients with rare ALK rearrangements to tyrosine kinase inhibitors remains unknown. Here, we report a rare case of striatin (STRN)-ALK-positive NSCLC showing primary resistance to first-line therapy alectinib and limited clinical activity of crizotinib in the alectinib-resistant setting.
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http://dx.doi.org/10.1111/1759-7714.13983DOI Listing
May 2021

Purification of polysaccharides from by using an aqueous two-phase system and evaluation of the physicochemical and antioxidant properties of polysaccharides .

Prep Biochem Biotechnol 2021 May 3:1-10. Epub 2021 May 3.

School of Food & Biological Engineering, Jiangsu University, Zhenjiang, China.

In this study, polysaccharides (PLPS) and proteins were simultaneously separated from . mycelia by using an aqueous two-phase system (ATPS) based on choline chloride ([Chol]Cl)/KHPO, and the physicochemical and antioxidant properties of PLPS after ATPS extraction were evaluated. Results demonstrated that the maximal extraction efficiencies of 68.53% ± 0.29% PLPS and 82.37% ± 0.41% proteins were obtained when the cholinium-based ATPS contained 68.9% KHPO, 20% [Chol]Cl, 10.0 mg mL crude water extract (1.0 mL), and distilled water (4.0 mL) at shaking time and temperature of 30 min and 21.2 °C, respectively. Compared with C-PLPS obtained using traditional ethanol precipitation and isolation protocols, PLPS had higher carbohydrate content (63.58% ± 1.12%), lower molecular weight (15.2 kDa, 80%), different monosaccharide compositions, and showed similar preliminary structural characterizations. Moreover, PLPS exhibited more evident scavenging effects on free radicals and antioxidant activities than C-PLPS. Therefore, the method of [Chol]Cl/KHPO ATPS can be developed as an effective strategy for the separation/purification of highly bioactive polysaccharides.
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http://dx.doi.org/10.1080/10826068.2021.1911815DOI Listing
May 2021

Assessing the response of vegetation change to drought during 2009-2018 in Yunnan Province, China.

Environ Sci Pollut Res Int 2021 Apr 22. Epub 2021 Apr 22.

College of Geography and Tourism, Zhaotong University, Zhaotong, Yunnan, 657000, China.

Yunnan Province in southwest China is characterized by a vast area, diverse climate types, rich ecosystem types, and unique biodiversity resources. With consideration of global climate change, there is an urgent need to evaluate the response of vegetation to drought in Yunnan. This study utilized the MOD13A3, MOD17A2, and Tropical Rainfall Measuring Mission (TRMM) 3B43 remote sensing products. The TRMM 3B43 downscaled monthly precipitation data were used to calculate the tropical rainfall condition index (TRCI) for Yunnan. The TRCI was used as a drought index, and the temporal and spatial changes in TRCI, gross primary productivity (GPP), and vegetation condition index (VCI) from 2009 to 2018 were explored. The response of vegetation to drought was evaluated under different time scales and varying land-use types. The results showed that during 2009-2018, (1) at an annual scale, the drought in Yunnan showed a weakening trend, and at a spatial scale, the drought showed a weakening trend from northwest to southeast. This weakening trend was more noticeable for cultivated land than for forest, grassland, and other land-use types. (2) GPP and VCI showed overall increasing trends at an annual scale, indicating gradual improvements in the GPP of vegetation and vegetation status, whereas the summer vegetation index showed a decreasing trend. (3) Although both the GPP and the growth state of vegetation were affected by drought, the responses of GPP and VCI to drought differed under different temporal scales and different land-use types. The responses of GPP and VCI to drought during spring were greater than those over other seasons, and the response of VCI to drought was more sensitive than that of GPP. Drought had a high impact on the GPP and vegetation growth of cultivated land and grassland with shallow root systems, whereas the impact of drought on forest was relatively stable.
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http://dx.doi.org/10.1007/s11356-021-13835-4DOI Listing
April 2021

[Semiquantitative parameters of F-FDG PET/CT, gene mutation states of epidermal growth factor receptor and anaplastic lymphoma kinase in prognosis evaluation of patients with lung adenocarcinoma].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Oct;53(2):246-254

Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China.

Objective: To explore the valuable predictors for evaluating progression-free survival (PFS) in patients with lung adenocarcinoma, we analyzed the potential roles of standardized uptake value (SUV)-derived parameters from F-FDG PET/CT, combining with the gene mutation states of epidermal growth factor receptor () and anaplastic lymphoma kinase (), and other clinical characteristics.

Methods: Data of 84 lung adenocarcinoma patients pre-treated, who underwent F-FDG PET/CT scans, gene mutations test, rearrangement assay and other relative tests, were retrospectively collected. Then a series of clinical parameters including / mutation status and SUV-derived features [maximum standardized uptake value (SUVmax), average of standardized uptake value (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG)] were evaluated. Best possible cutoff points for all measuring parameters were calculated using receiver operating characteristic curve (ROC) analysis. Survival analysis was performed using Cox proportional hazards model to determine the prognostic markers for progression-free survival (PFS). Survival curves were obtained through Log-rank test and Kaplan-Meier curve.

Results: The median follow-up period was 31 months (24 to 58 months). It was found that SUVmax (≥3.01), SUVmean (≥2.25), MTV (≥25.41 cm), and TLG (≥55.02) of the primary tumors were significantly associated with PFS in univariate Cox proportional hazards regression. Then regardless of age, gender, co-morbidity, / mutation status, and treatment program, TLG (≥ 55.02, =4.965, 95%: 1.360-18.133), TNM stage (Ⅲ/Ⅳ, =7.811, 95%: 2.977-20.489), pro-gastrin releasing peptide (proGRP) (≥45.65 ng/L, =4.070, 95%: 1.442-11.487), tissue polypeptide antigen (TPA) (≥68.20 U/L, =6.996, 95%: 1.458-33.574), alkaline phosphatase (ALP) (≥82.50 IU/L, =4.160, 95%: 1.416-12.219) and ratio of activated partial thromboplastin time (aPTTR) (≥1.16: =4.58, 95%: 1.913-10.946) showed the independently relevant to PFS through multivariate Cox proportional hazards analysis. The mutant (=0.343) and rearrangement (=0.608) were not significant either in survival analysis.

Conclusion: High SUV-derived parameters (SUVmax, SUVmean, MTV and TLG) might provide prognostic value to some extent. Especially, TLG, and other clinical features [TNM stage, proGRP, TPA, ALP, and aPTTR] could be independently and significantly associated with PFS of lung adenocarcinoma patients. However, / gene status could not be effectively relevant to PFS in lung adenocarcinoma patients.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072443PMC
October 2020

Primary pulmonary Hodgkin's lymphoma mimicking rheumatoid arthritis-associated organizing pneumonia: A case report.

Thorac Cancer 2021 Apr 3. Epub 2021 Apr 3.

Department of Respiratory and Critical Care Medicine, Peking University First Hospital, Beijing, China.

Primary pulmonary Hodgkin's lymphoma (PPHL) is an extremely rare disease. The nonspecific clinical and radiological features render the diagnosis a great challenge. Here, we present a case of PPHL mimicking rheumatoid arthritis-associated organizing pneumonia.
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http://dx.doi.org/10.1111/1759-7714.13952DOI Listing
April 2021